SIMILAR PATTERNS OF AMINO ACIDS FOR 4HIV_D_DVAD2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 109PRO A 107THR A 111 | None | 0.78A | 4hivD-1cptA:undetectable | 4hivD-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASELARGE SUBUNIT (Desulfovibriodesulfuricans) |
PF00374(NiFeSe_Hases) | 3 | THR B 493PRO B 491THR B 492 | NoneFNE B 543 (-3.7A)FNE B 543 (-3.8A) | 0.85A | 4hivD-1e3dB:undetectable | 4hivD-1e3dB:4.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 3 | THR A 5PRO A 8THR A 7 | None | 0.85A | 4hivD-1eg1A:undetectable | 4hivD-1eg1A:4.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fuu | YEAST INITIATIONFACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 3 | THR A 194PRO A 192THR A 193 | None | 0.80A | 4hivD-1fuuA:undetectable | 4hivD-1fuuA:2.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7w | DIHYDROPYRIMIDINEDEHYDROGENASE (Sus scrofa) |
PF01180(DHO_dh)PF07992(Pyr_redox_2)PF14691(Fer4_20)PF14697(Fer4_21) | 3 | THR A 555PRO A 553THR A 554 | None | 0.83A | 4hivD-1h7wA:undetectable | 4hivD-1h7wA:1.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 84PRO A 72THR A 70 | None | 0.87A | 4hivD-1j3eA:undetectable | 4hivD-1j3eA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 149PRO A 146THR A 147 | None | 0.83A | 4hivD-1j3uA:undetectable | 4hivD-1j3uA:2.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 97PRO A 95THR A 99 | None | 0.83A | 4hivD-1jioA:undetectable | 4hivD-1jioA:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 149PRO A 137THR A 135 | None | 0.87A | 4hivD-1lrrA:undetectable | 4hivD-1lrrA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 139PRO A 136THR A 137 | None | 0.88A | 4hivD-1ml4A:undetectable | 4hivD-1ml4A:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 3 | THR A 63PRO A 60THR A 61 | None | 0.88A | 4hivD-1nwaA:undetectable | 4hivD-1nwaA:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qaf | PROTEIN (COPPERAMINE OXIDASE) (Escherichiacoli) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3)PF07833(Cu_amine_oxidN1) | 3 | THR A 687PRO A 614THR A 688 | None | 0.83A | 4hivD-1qafA:undetectable | 4hivD-1qafA:2.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyi | HYPOTHETICAL PROTEIN (Staphylococcusaureus) |
PF13242(Hydrolase_like) | 3 | THR A 245PRO A 241THR A 243 | None | 0.81A | 4hivD-1qyiA:undetectable | 4hivD-1qyiA:2.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sie | POLYOMAVIRUS COATPROTEIN VP1 (Mus musculuspolyomavirus 1) |
PF00718(Polyoma_coat) | 3 | THR A 147PRO A 144THR A 150 | None | 0.87A | 4hivD-1sieA:undetectable | 4hivD-1sieA:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tf1 | NEGATIVE REGULATOROF ALLANTOIN ANDGLYOXYLATEUTILIZATION OPERONS (Escherichiacoli) |
PF01614(IclR) | 3 | THR A 100PRO A 98THR A 99 | None | 0.81A | 4hivD-1tf1A:undetectable | 4hivD-1tf1A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tg5 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Arabidopsisthaliana) |
PF00903(Glyoxalase) | 3 | THR A 95PRO A 93THR A 94 | None | 0.86A | 4hivD-1tg5A:undetectable | 4hivD-1tg5A:3.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ujt | KIAA1568 PROTEIN (Homo sapiens) |
PF00041(fn3) | 3 | THR A 111PRO A 29THR A 112 | None | 0.87A | 4hivD-1ujtA:undetectable | 4hivD-1ujtA:9.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 3 | THR A 36PRO A 37THR A 37 | None | 0.86A | 4hivD-1zlrA:undetectable | 4hivD-1zlrA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 37PRO C 36THR C 241 | None | 0.75A | 4hivD-1zrtC:undetectable | 4hivD-1zrtC:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwt | MAJOR STRUCTURALSUBUNIT OFBUNDLE-FORMING PILUS (Escherichiacoli) |
PF05307(Bundlin) | 3 | THR A 99PRO A 137THR A 136 | None | 0.88A | 4hivD-1zwtA:undetectable | 4hivD-1zwtA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c34 | INHIBITOR OFCYSTEINE PEPTIDASES (Leishmaniamexicana) |
PF09394(Inhibitor_I42) | 3 | THR A 32PRO A 30THR A 31 | None | 0.88A | 4hivD-2c34A:undetectable | 4hivD-2c34A:8.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c6r | DNA-BINDING STRESSRESPONSE PROTEIN,DPS FAMILY (Deinococcusradiodurans) |
PF00210(Ferritin) | 3 | THR A 165PRO A 163THR A 164 | None | 0.87A | 4hivD-2c6rA:undetectable | 4hivD-2c6rA:3.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kgy | POSSIBLE EXPORTEDPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 3 | THR A 17PRO A 15THR A 16 | None | 0.82A | 4hivD-2kgyA:undetectable | 4hivD-2kgyA:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 3 | THR B 56PRO B 54THR B 55 | None | 0.81A | 4hivD-2pffB:undetectable | 4hivD-2pffB:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6f | EXCINUCLEASE ABCSUBUNIT A (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 3 | THR A 857PRO A 855THR A 856 | None | 0.88A | 4hivD-2r6fA:undetectable | 4hivD-2r6fA:2.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | THR A 230PRO A 186THR A 228 | None | 0.80A | 4hivD-2v9qA:undetectable | 4hivD-2v9qA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wgr | GLUTATHIONEPEROXIDASE (Schistosomamansoni) |
PF00255(GSHPx) | 3 | THR A 153PRO A 151THR A 152 | NonePOP A1170 (-4.4A)None | 0.88A | 4hivD-2wgrA:undetectable | 4hivD-2wgrA:10.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 3 | THR A 278PRO A 274THR A 276 | NoneFAD A 600 ( 4.9A)None | 0.81A | 4hivD-2z5xA:undetectable | 4hivD-2z5xA:1.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 3 | THR A 547PRO A 545THR A 546 | NoneCYN A 605 ( 3.6A)CYN A 605 (-3.7A) | 0.82A | 4hivD-3ayxA:undetectable | 4hivD-3ayxA:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb8 | CDP-4-KETO-6-DEOXY-D-GLUCOSE-3-DEHYDRASE (Yersiniapseudotuberculosis) |
PF01041(DegT_DnrJ_EryC1) | 3 | THR A 123PRO A 121THR A 122 | PLP A 500 (-4.6A)NonePLP A 500 (-4.5A) | 0.80A | 4hivD-3bb8A:undetectable | 4hivD-3bb8A:2.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dao | PUTATIVE PHOSPHATE ([Eubacterium]rectale) |
PF08282(Hydrolase_3) | 3 | THR A 69PRO A 82THR A 80 | None | 0.86A | 4hivD-3daoA:undetectable | 4hivD-3daoA:9.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | THR A 704PRO A 700THR A 702 | None | 0.79A | 4hivD-3fg6A:undetectable | 4hivD-3fg6A:3.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzd | SELENOCYSTEINE LYASE (Homo sapiens) |
PF00266(Aminotran_5) | 3 | THR C 188PRO C 186THR C 187 | None | 0.88A | 4hivD-3gzdC:undetectable | 4hivD-3gzdC:4.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 3 | THR A 166PRO A 165THR A 147 | None | 0.87A | 4hivD-3h1qA:undetectable | 4hivD-3h1qA:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hoa | THERMOSTABLECARBOXYPEPTIDASE 1 (Thermusthermophilus) |
PF02074(Peptidase_M32) | 3 | THR A 259PRO A 246THR A 260 | None | 0.86A | 4hivD-3hoaA:undetectable | 4hivD-3hoaA:2.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ik4 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Herpetosiphonaurantiacus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | THR A 4PRO A 2THR A 3 | None | 0.79A | 4hivD-3ik4A:undetectable | 4hivD-3ik4A:3.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 638PRO A 635THR A 636 | None | 0.67A | 4hivD-3ikmA:undetectable | 4hivD-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 3 | THR A 124PRO A 121THR A 122 | None CL A 465 (-4.1A) CL A 465 (-4.1A) | 0.78A | 4hivD-3k9dA:undetectable | 4hivD-3k9dA:3.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 3 | THR A 21PRO A 19THR A 20 | None | 0.85A | 4hivD-3kh5A:undetectable | 4hivD-3kh5A:3.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 3 | THR A 294PRO A 292THR A 293 | None | 0.86A | 4hivD-3khkA:undetectable | 4hivD-3khkA:2.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krv | HYDROLASE (Geobacillusstearothermophilus) |
PF04199(Cyclase) | 3 | THR A 48PRO A 195THR A 46 | None | 0.88A | 4hivD-3krvA:undetectable | 4hivD-3krvA:5.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0o | TRANSCRIPTIONTERMINATION FACTORRHO (Thermotogamaritima) |
PF00006(ATP-synt_ab)PF07497(Rho_RNA_bind)PF07498(Rho_N) | 3 | THR A 311PRO A 145THR A 144 | None | 0.87A | 4hivD-3l0oA:undetectable | 4hivD-3l0oA:5.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 139PRO A 136THR A 137 | None | 0.85A | 4hivD-3lxmA:undetectable | 4hivD-3lxmA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9v | FAD-DEPENDENTOXIDOREDUCTASE (Actinomadurakijaniata) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | THR A 51PRO A 50THR A 53 | None | 0.83A | 4hivD-3m9vA:undetectable | 4hivD-3m9vA:5.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mh9 | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
no annotation | 3 | THR C 114PRO C 117THR C 116 | None | 0.88A | 4hivD-3mh9C:undetectable | 4hivD-3mh9C:5.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpg | DIHYDROOROTASE (Bacillusanthracis) |
PF01979(Amidohydro_1) | 3 | THR A 391PRO A 389THR A 390 | None | 0.86A | 4hivD-3mpgA:undetectable | 4hivD-3mpgA:2.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 3 | THR A 119PRO A 116THR A 117 | None CL A 453 ( 4.6A) CL A 453 ( 4.4A) | 0.77A | 4hivD-3my7A:undetectable | 4hivD-3my7A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 3 | THR A 129PRO A 125THR A 127 | None | 0.83A | 4hivD-3nz4A:undetectable | 4hivD-3nz4A:1.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3op7 | AMINOTRANSFERASECLASS I AND II (Streptococcussuis) |
PF00155(Aminotran_1_2) | 3 | THR A 154PRO A 152THR A 153 | None | 0.86A | 4hivD-3op7A:undetectable | 4hivD-3op7A:2.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p40 | NEUROFASCIN (Homo sapiens) |
PF13927(Ig_3) | 3 | THR A 367PRO A 366THR A 410 | None | 0.82A | 4hivD-3p40A:undetectable | 4hivD-3p40A:2.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 3 | THR L 554PRO L 552THR L 553 | NoneNFU L1004 (-3.6A)NFU L1004 (-3.8A) | 0.82A | 4hivD-3rgwL:undetectable | 4hivD-3rgwL:1.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sc2 | SERINECARBOXYPEPTIDASE II(CPDW-II) (Triticumaestivum) |
PF00450(Peptidase_S10) | 3 | THR B 346PRO B 342THR B 344 | None | 0.82A | 4hivD-3sc2B:undetectable | 4hivD-3sc2B:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 3 | THR L 533PRO L 531THR L 532 | NoneFCO L 601 (-3.5A)FCO L 601 (-3.7A) | 0.78A | 4hivD-3uscL:undetectable | 4hivD-3uscL:2.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1r | LIP (Serratiamarcescens) |
PF12790(T6SS-SciN) | 3 | THR A 145PRO A 142THR A 143 | None | 0.87A | 4hivD-4a1rA:undetectable | 4hivD-4a1rA:5.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 3 | THR A 423PRO A 420THR A 421 | None | 0.83A | 4hivD-4av6A:undetectable | 4hivD-4av6A:2.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bil | DNA MATURASE B (Escherichiavirus T7) |
no annotation | 3 | THR A 261PRO A 263THR A 259 | None | 0.87A | 4hivD-4bilA:undetectable | 4hivD-4bilA:2.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 3 | THR A 297PRO A 299THR A 295 | None | 0.72A | 4hivD-4btpA:undetectable | 4hivD-4btpA:3.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 647PRO A 649THR A 650 | None | 0.86A | 4hivD-4byfA:undetectable | 4hivD-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 3 | THR A 536PRO A 534THR A 535 | NoneNFU A1004 (-3.8A)NFU A1004 (-3.7A) | 0.81A | 4hivD-4c3oA:undetectable | 4hivD-4c3oA:2.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euf | PUTATIVE REDUCTASECA_C0462 (Clostridiumacetobutylicum) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 3 | THR A 284PRO A 286THR A 168 | None | 0.86A | 4hivD-4eufA:undetectable | 4hivD-4eufA:1.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1h | TYROSYL-DNAPHOSPHODIESTERASE 2 (Danio rerio) |
PF03372(Exo_endo_phos) | 3 | THR A 211PRO A 209THR A 210 | None | 0.77A | 4hivD-4f1hA:undetectable | 4hivD-4f1hA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fd0 | LEUCINE RICHHYPOTHETICAL PROTEIN (Bacteroidescaccae) |
PF07523(Big_3)PF13306(LRR_5) | 3 | THR A 217PRO A 192THR A 194 | None | 0.82A | 4hivD-4fd0A:undetectable | 4hivD-4fd0A:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdw | LEUCINE RICHHYPOTHETICAL PROTEIN (Bacteroidesovatus) |
PF07523(Big_3)PF13306(LRR_5) | 3 | THR A 217PRO A 192THR A 194 | None | 0.80A | 4hivD-4fdwA:undetectable | 4hivD-4fdwA:4.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | THR A 268PRO A 186THR A 187 | None | 0.87A | 4hivD-4fnqA:undetectable | 4hivD-4fnqA:1.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j4s | NUCLEOCAPSID PROTEIN (SFTSphlebovirus) |
PF05733(Tenui_N) | 3 | THR A 115PRO A 112THR A 113 | None | 0.88A | 4hivD-4j4sA:undetectable | 4hivD-4j4sA:4.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k24 | ANTI-UPAR ANTIBODY,HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 117PRO H 147THR H 116 | None | 0.71A | 4hivD-4k24H:undetectable | 4hivD-4k24H:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 3 | THR A 259PRO A 255THR A 257 | None | 0.81A | 4hivD-4ovjA:undetectable | 4hivD-4ovjA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 3 | THR A 111PRO A 113THR A 143 | None | 0.81A | 4hivD-4pmhA:undetectable | 4hivD-4pmhA:3.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry1 | PERIPLASMIC SOLUTEBINDING PROTEIN (Pectobacteriumatrosepticum) |
PF13416(SBP_bac_8) | 3 | THR A 301PRO A 303THR A 165 | None | 0.77A | 4hivD-4ry1A:undetectable | 4hivD-4ry1A:3.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 3 | THR A 166PRO A 168THR A 162 | None | 0.77A | 4hivD-4s3jA:undetectable | 4hivD-4s3jA:2.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u16 | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 231PRO A 228THR A 229 | None | 0.88A | 4hivD-4u16A:undetectable | 4hivD-4u16A:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7v | CELLULASE (Xanthomonascitri) |
PF00150(Cellulase) | 3 | THR A 171PRO A 135THR A 168 | None | 0.87A | 4hivD-4w7vA:undetectable | 4hivD-4w7vA:3.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | THR A 305PRO A 302THR A 303 | None | 0.83A | 4hivD-4wzbA:undetectable | 4hivD-4wzbA:4.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnz | LIGHT CHAIN OFANTIBODY VRC06B (Homo sapiens) |
no annotation | 3 | THR L 97PRO L 8THR L 10 | None | 0.78A | 4hivD-4xnzL:undetectable | 4hivD-4xnzL:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 285PRO A 287THR A 288 | None | 0.80A | 4hivD-4xvhA:undetectable | 4hivD-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bw8 | UBIQUITIN-LIKEPROTEIN MDY2 (Saccharomycescerevisiae) |
PF16843(Get5_bdg) | 3 | THR D 23PRO D 25THR D 21 | None | 0.74A | 4hivD-5bw8D:undetectable | 4hivD-5bw8D:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwd | BENZYLSUCCINATESYNTHASE ALPHA CHAIN (Thaueraaromatica) |
PF01228(Gly_radical)PF02901(PFL-like) | 3 | THR A 618PRO A 517THR A 619 | None | 0.84A | 4hivD-5bwdA:undetectable | 4hivD-5bwdA:2.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 3 | THR A 116PRO A 113THR A 114 | None | 0.84A | 4hivD-5bwyA:undetectable | 4hivD-5bwyA:2.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dac | PUTATIVEUNCHARACTERIZEDPROTEIN,PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF13476(AAA_23) | 3 | THR A1241PRO A1239THR A1240 | None | 0.83A | 4hivD-5dacA:undetectable | 4hivD-5dacA:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1946PRO D1943THR D1944 | None | 0.74A | 4hivD-5disD:undetectable | 4hivD-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5giv | CARBOXYPEPTIDASE 1 (Deinococcusradiodurans) |
PF02074(Peptidase_M32) | 3 | THR A 249PRO A 236THR A 250 | None | 0.88A | 4hivD-5givA:undetectable | 4hivD-5givA:1.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs8 | HTH-TYPETRANSCRIPTIONALREGULATOR YODB (Bacillussubtilis) |
PF01638(HxlR) | 3 | THR A 39PRO A 43THR A 41 | None | 0.75A | 4hivD-5hs8A:undetectable | 4hivD-5hs8A:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ify | GLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Burkholderiavietnamiensis) |
PF00483(NTP_transferase) | 3 | THR A 56PRO A 83THR A 81 | None | 0.82A | 4hivD-5ifyA:undetectable | 4hivD-5ifyA:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 3 | THR A 146PRO A 143THR A 144 | NoneACT A1005 (-3.9A)ACT A1005 (-3.3A) | 0.75A | 4hivD-5j78A:undetectable | 4hivD-5j78A:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 203PRO A 200THR A 201 | None | 0.75A | 4hivD-5jfmA:undetectable | 4hivD-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj3 | PRE-MRNA-SPLICINGFACTOR BUD31 (Saccharomycescerevisiae) |
PF01125(G10) | 3 | THR L 24PRO L 21THR L 22 | None | 0.84A | 4hivD-5lj3L:undetectable | 4hivD-5lj3L:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 3 | THR A 199PRO A 201THR A 228 | NoneNoneTAM A 303 (-3.9A) | 0.84A | 4hivD-5mqzA:undetectable | 4hivD-5mqzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngk | GLUCOSYLCERAMIDASE (Bacteroidesthetaiotaomicron) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 3 | THR A 69PRO A 67THR A 68 | None | 0.77A | 4hivD-5ngkA:undetectable | 4hivD-5ngkA:1.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnn | CTATC (Chaetomiumthermophilum) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A2209PRO A2207THR A2208 | None | 0.88A | 4hivD-5nnnA:undetectable | 4hivD-5nnnA:4.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2v | NUCLEOLYSIN TIA-1ISOFORM P40 (Homo sapiens) |
PF00076(RRM_1) | 3 | THR A 83PRO A 6THR A 82 | None | 0.87A | 4hivD-5o2vA:undetectable | 4hivD-5o2vA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | METHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITA (Methanothermococcusthermolithotrophicus) |
PF00374(NiFeSe_Hases) | 3 | THR F 121PRO F 119THR F 120 | None | 0.87A | 4hivD-5odrF:undetectable | 4hivD-5odrF:3.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 388PRO D 385THR D 386 | None | 0.77A | 4hivD-5of4D:undetectable | 4hivD-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u03 | CTP SYNTHASE 1 (Homo sapiens) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | THR A 428PRO A 426THR A 427 | None | 0.84A | 4hivD-5u03A:undetectable | 4hivD-5u03A:2.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udh | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR A 131PRO A 127THR A 129 | None | 0.88A | 4hivD-5udhA:undetectable | 4hivD-5udhA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujz | SCFV (Homo sapiens) |
PF07686(V-set) | 3 | THR G 104PRO G 8THR G 10 | None | 0.82A | 4hivD-5ujzG:undetectable | 4hivD-5ujzG:3.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 502PRO A 504THR A 505 | None | 0.71A | 4hivD-5w1uA:undetectable | 4hivD-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w81 | CYSTIC FIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (Danio rerio) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF14396(CFTR_R) | 3 | THR A 500PRO A 539THR A 538 | None | 0.86A | 4hivD-5w81A:undetectable | 4hivD-5w81A:1.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x0e | FREE SERINE KINASE (Thermococcuskodakarensis) |
PF02195(ParBc) | 3 | THR A 101PRO A 203THR A 223 | NoneNoneSEP A 302 (-3.9A) | 0.88A | 4hivD-5x0eA:undetectable | 4hivD-5x0eA:6.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 3 | THR A1076PRO A1073THR A1074 | None | 0.88A | 4hivD-6bq1A:undetectable | 4hivD-6bq1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 3 | THR A1828PRO A1820THR A1826 | None | 0.86A | 4hivD-6fb3A:undetectable | 4hivD-6fb3A:undetectable |