SIMILAR PATTERNS OF AMINO ACIDS FOR 4HFP_D_15UD402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1a0j	TRYPSIN (Salmo salar)	PF00089 (Trypsin)	6	HIS A 57 LEU A 99 ASP A 189 VAL A 213 TRP A 215 GLY A 226	SO4 A 248 (-3.9A) None BEN A 246 (-3.0A) None None BEN A 246 (-3.3A)	0.38A	4hfpD-1a0jA: 33.7	4hfpD-1a0jA: 37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1a5i	PLASMINOGEN ACTIVATOR (Desmodus rotundus)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	0GJ A 245 (-2.7A) 0GJ A 245 (-3.1A) 0GJ A 245 (-3.4A) None 0GJ A 245 ( 4.2A)	0.31A	4hfpD-1a5iA: 32.8	4hfpD-1a5iA: 32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1bqy	PLASMINOGEN ACTIVATOR (Trimeresurus stejnegeri)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	0GJ A 1 ( 2.7A) 0GJ A 1 (-3.1A) None None 0GJ A 1 ( 4.3A)	0.26A	4hfpD-1bqyA: 31.9	4hfpD-1bqyA: 32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	PF00084 (Sushi) PF00089 (Trypsin)	5	HIS A 460 ASP A 611 VAL A 638 TRP A 640 GLY A 648	SO4 A2001 ( 3.9A) None None None None	0.33A	4hfpD-1elvA: 31.2	4hfpD-1elvA: 28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ept	PORCINE E-TRYPSIN (Sus scrofa)	PF00089 (Trypsin)	6	HIS A 57 LEU B 99 ASP C 189 VAL C 213 TRP C 215 GLY C 226	None	0.42A	4hfpD-1eptA: 2.2	4hfpD-1eptA: 15.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	0G6 A 1 (-2.7A) 0G6 A 1 (-2.8A) None None 0G6 A 1 (-3.3A)	0.35A	4hfpD-1fxyA: 32.7	4hfpD-1fxyA: 36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1h4w	TRYPSIN IVA (Homo sapiens)	PF00089 (Trypsin)	6	HIS A 57 LEU A 99 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None None BEN A 250 (-2.9A) None None BEN A 250 (-3.3A)	0.34A	4hfpD-1h4wA: 33.9	4hfpD-1h4wA: 36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1h9h	TRYPSIN (Sus scrofa)	PF00089 (Trypsin)	6	HIS E 57 LEU E 99 ASP E 189 VAL E 213 TRP E 215 GLY E 226	None	0.37A	4hfpD-1h9hE: 33.6	4hfpD-1h9hE: 38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1id5	THROMBIN (Bos taurus)	PF00089 (Trypsin)	7	HIS H 57 ILE H 174 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	None	0.40A	4hfpD-1id5H: 42.4	4hfpD-1id5H: 87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1id5	THROMBIN (Bos taurus)	PF00089 (Trypsin)	5	LEU H 99 ASP H 189 ALA H 190 VAL H 213 GLY H 226	None	0.66A	4hfpD-1id5H: 42.4	4hfpD-1id5H: 87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1j17	TRYPSIN II, ANIONIC (Rattus norvegicus)	PF00089 (Trypsin)	6	HIS T 57 ASP T 189 ALA T 190 VAL T 213 TRP T 215 GLY T 226	SO4 T 600 (-3.8A) ZEN T 1 ( 3.8A) ZEN T 1 (-3.8A) ZEN T 1 (-4.1A) ZEN T 1 (-3.4A) ZEN T 1 (-3.7A)	0.28A	4hfpD-1j17T: 34.3	4hfpD-1j17T: 37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kae	HISTIDINOL DEHYDROGENASE (Escherichia coli)	PF00815 (Histidinol_dh)	5	LEU A 313 ILE A 330 ALA A 278 ALA A 274 VAL A 309	None	1.08A	4hfpD-1kaeA: undetectable	4hfpD-1kaeA: 18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1kig	FACTOR XA (Bos taurus)	PF00089 (Trypsin)	6	HIS H 57 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	None	0.44A	4hfpD-1kigH: 34.5	4hfpD-1kigH: 39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1mbq	TRYPSIN (Oncorhynchus keta)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None BEN A1222 (-2.9A) None None BEN A1222 (-3.4A)	0.28A	4hfpD-1mbqA: 33.6	4hfpD-1mbqA: 37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1mkx	PRETHROMBIN-2 (Bos taurus)	PF00089 (Trypsin) PF09396 (Thrombin_light)	8	HIS K 57 TYR K 60 TRP K 60 LEU K 99 ILE K 174 VAL K 213 TRP K 215 GLY K 226	None	0.41A	4hfpD-1mkxK: 36.6	4hfpD-1mkxK: 86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1mkx	PRETHROMBIN-2 (Bos taurus)	PF00089 (Trypsin) PF09396 (Thrombin_light)	6	LEU K 99 ILE K 174 GLU K 146 VAL K 213 TRP K 215 GLY K 226	None	0.90A	4hfpD-1mkxK: 36.6	4hfpD-1mkxK: 86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	PF00089 (Trypsin)	6	HIS H 57 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	CR9 H 256 (-3.9A) CR9 H 256 (-2.4A) CR9 H 256 (-2.9A) CR9 H 256 (-4.3A) None CR9 H 256 (-3.0A)	0.36A	4hfpD-1o5fH: 34.8	4hfpD-1o5fH: 39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1pq5	TRYPSIN (Fusarium oxysporum)	PF00089 (Trypsin)	5	HIS A 56 ASP A 189 VAL A 210 TRP A 212 GLY A 223	ARG A 703 (-4.3A) ARG A 703 (-2.0A) ARG A 703 (-4.5A) None ARG A 703 (-2.6A)	0.33A	4hfpD-1pq5A: 32.2	4hfpD-1pq5A: 34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	PF00084 (Sushi) PF00089 (Trypsin)	5	HIS A 483 ASP A 627 VAL A 653 TRP A 655 GLY A 667	None NA A 800 ( 4.6A) GOL A 701 (-4.9A) None GOL A 701 ( 4.0A)	0.23A	4hfpD-1q3xA: 34.5	4hfpD-1q3xA: 28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1umb	2-OXO ACID DEHYDROGENASE ALPHA SUBUNIT (Thermus thermophilus)	PF00676 (E1_dh)	5	HIS A 98 LEU A 51 ILE A 322 ASP A 295 ALA A 70	None	1.02A	4hfpD-1umbA: undetectable	4hfpD-1umbA: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vkm	CONSERVED HYPOTHETICAL PROTEIN TM1464 (Thermotoga maritima)	PF04227 (Indigoidine_A)	5	HIS A 23 ALA A 99 GLU A 17 ALA A 94 VAL A 78	None None UNL A 600 (-2.9A) None None	1.12A	4hfpD-1vkmA: undetectable	4hfpD-1vkmA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1w8o	BACTERIAL SIALIDASE (Micromonospora viridifaciens)	PF00754 (F5_F8_type_C) PF10633 (NPCBM_assoc) PF13088 (BNR_2)	5	TRP A 357 LEU A 401 ALA A 375 ALA A 317 GLY A 382	None	1.08A	4hfpD-1w8oA: undetectable	4hfpD-1w8oA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wky	ENDO-BETA-1,4-MANNAN ASE (Bacillus sp. JAMB-602)	PF00150 (Cellulase)	5	TRP A 282 ASP A 88 GLU A 117 ALA A 61 GLY A 90	None	1.03A	4hfpD-1wkyA: undetectable	4hfpD-1wkyA: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1woi	AGMATINASE (Deinococcus radiodurans)	PF00491 (Arginase)	5	LEU A 127 ASP A 82 ALA A 83 ALA A 103 VAL A 107	None	1.14A	4hfpD-1woiA: undetectable	4hfpD-1woiA: 19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ym0	FIBRINOTIC ENZYME COMPONENT B (Eisenia fetida)	PF00089 (Trypsin)	6	HIS A 57 LEU A 99 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None	0.55A	4hfpD-1ym0A: 35.6	4hfpD-1ym0A: 33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1zlr	COAGULATION FACTOR XI (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	368 A 901 (-4.0A) 368 A 901 (-2.8A) 368 A 901 (-3.7A) None 368 A 901 (-3.5A)	0.22A	4hfpD-1zlrA: 34.6	4hfpD-1zlrA: 36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ayi	AMINOPEPTIDASE T (Thermus thermophilus)	PF02073 (Peptidase_M29)	5	HIS A 345 ILE A 280 ALA A 318 VAL A 317 TRP A 379	ZN A 501 (-3.9A) None ZN A 501 ( 4.7A) None None	1.11A	4hfpD-2ayiA: undetectable	4hfpD-2ayiA: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dkd	PHOSPHOACETYLGLUCOSA MINE MUTASE (Candida albicans)	PF00408 (PGM_PMM_IV) PF02878 (PGM_PMM_I)	5	HIS A 176 LEU A 175 ILE A 137 ALA A 27 GLY A 74	None	1.06A	4hfpD-2dkdA: undetectable	4hfpD-2dkdA: 19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2eek	TRYPSIN-1 (Gadus morhua)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None BEN A 301 (-2.7A) None None BEN A 301 (-3.2A)	0.29A	4hfpD-2eekA: 33.0	4hfpD-2eekA: 37.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	PF00089 (Trypsin)	6	HIS A 57 ASP A 189 ALA A 190 VAL A 213 TRP A 215 GLY A 226	None DT8 A 700 (-3.5A) DT8 A 700 (-3.6A) DT8 A 700 ( 4.1A) DT8 A 700 (-3.9A) DT8 A 700 (-3.5A)	0.42A	4hfpD-2ei8A: 35.1	4hfpD-2ei8A: 40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2f91	HEPATOPANCREAS TRYPSIN (Astacus leptodactylus)	PF00089 (Trypsin)	6	HIS A 57 LEU A 99 ASP A 189 VAL A 213 TRP A 215 GLY A 227	None	0.35A	4hfpD-2f91A: 34.3	4hfpD-2f91A: 36.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2og7	ASPARAGINE OXYGENASE (Streptomyces coelicolor)	PF02668 (TauD)	5	LEU A 130 ALA A 35 GLU A 46 ALA A 48 GLY A 37	None	1.09A	4hfpD-2og7A: undetectable	4hfpD-2og7A: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ojh	UNCHARACTERIZED PROTEIN ATU1656/AGR_C_3050 (Agrobacterium fabrum)	PF07676 (PD40)	5	HIS A 88 TRP A 131 LEU A 62 ALA A 285 ALA A 44	None	1.12A	4hfpD-2ojhA: undetectable	4hfpD-2ojhA: 23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	PF00089 (Trypsin)	6	HIS A 57 ASP A 189 ALA A 190 VAL A 213 TRP A 215 GLY A 226	None BEN A 245 (-3.0A) BEN A 245 (-3.9A) None None BEN A 245 (-3.4A)	0.28A	4hfpD-2oq5A: 34.5	4hfpD-2oq5A: 36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pkq	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE B (Spinacia oleracea)	PF00044 (Gp_dh_N) PF02672 (CP12) PF02800 (Gp_dh_C)	5	ILE O 91 ALA O 120 ALA O 122 VAL O 100 GLY O 95	None NDP O 363 ( 3.7A) None None NDP O 363 (-4.8A)	1.13A	4hfpD-2pkqO: undetectable	4hfpD-2pkqO: 20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	PF00089 (Trypsin)	7	ILE C 209 ASP C 229 ALA C 230 GLU C 232 VAL C 255 TRP C 257 GLY C 268	G44 C 101 (-3.9A) G44 C 101 (-2.6A) G44 C 101 (-3.8A) None None G44 C 101 (-4.1A) G44 C 101 (-3.0A)	0.65A	4hfpD-2pksC: 15.6	4hfpD-2pksC: 99.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2po4	VIRION RNA POLYMERASE (Escherichia virus N4)	no annotation	5	LEU A 816 ILE A 882 ASP A 929 ALA A 568 GLY A 926	None	1.12A	4hfpD-2po4A: undetectable	4hfpD-2po4A: 12.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2psy	KALLIKREIN-5 (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None	0.45A	4hfpD-2psyA: 14.9	4hfpD-2psyA: 34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qko	POSSIBLE TRANSCRIPTIONAL REGULATOR, TETR FAMILY PROTEIN (Rhodococcus jostii)	PF00440 (TetR_N)	5	LEU A 109 ALA A 31 ALA A 15 VAL A 18 GLY A 26	None	0.97A	4hfpD-2qkoA: undetectable	4hfpD-2qkoA: 21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	PF00089 (Trypsin)	6	HIS B 485 ASP B 631 ALA B 632 VAL B 657 TRP B 659 GLY B 668	None	0.32A	4hfpD-2qy0B: 32.8	4hfpD-2qy0B: 37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	None	0.27A	4hfpD-2r0lA: 34.5	4hfpD-2r0lA: 34.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	PF00089 (Trypsin)	5	HIS U 57 ASP U 189 VAL U 213 TRP U 215 GLY U 226	4PG U 300 (-3.9A) 4PG U 300 (-2.8A) None None 4PG U 300 (-3.2A)	0.42A	4hfpD-2r2wU: 35.0	4hfpD-2r2wU: 31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vpw	THIOSULFATE REDUCTASE (Thermus thermophilus)	PF00384 (Molybdopterin) PF01568 (Molydop_binding) PF04879 (Molybdop_Fe4S4)	5	HIS A 697 ILE A 417 ASP A 466 ALA A 632 GLY A 439	MGD A1765 (-3.5A) None MGD A1765 (-2.8A) MGD A1765 (-2.9A) MGD A1765 (-3.1A)	1.08A	4hfpD-2vpwA: undetectable	4hfpD-2vpwA: 15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2whl	BETA-MANNANASE (Salipaludibacillus agaradhaerens)	PF00150 (Cellulase)	5	TRP A 251 ASP A 57 GLU A 86 ALA A 30 GLY A 59	MAN A1301 (-4.5A) None None None None	1.02A	4hfpD-2whlA: undetectable	4hfpD-2whlA: 21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2zec	TRYPTASE BETA 2 (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 59 ASP A 203 VAL A 227 TRP A 229 GLY A 240	None 11N A 1 (-2.6A) None None 11N A 1 (-3.6A)	0.37A	4hfpD-2zecA: 33.1	4hfpD-2zecA: 35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3a75	GAMMA-GLUTAMYLTRANSP EPTIDASE LARGE CHAIN (Bacillus subtilis)	PF01019 (G_glu_transpept)	5	LEU A 64 ALA A 157 ALA A 74 VAL A 75 GLY A 162	None	1.12A	4hfpD-3a75A: undetectable	4hfpD-3a75A: 19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3beu	TRYPSIN (Streptomyces griseus)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	SO4 A 246 ( 3.8A) BEN A 247 (-3.0A) None None BEN A 247 (-3.5A)	0.22A	4hfpD-3beuA: 31.3	4hfpD-3beuA: 33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bkn	BACTERIOFERRITIN (Mycolicibacterium smegmatis)	PF00210 (Ferritin)	5	HIS A 28 TRP A 35 LEU A 27 GLU A 85 ALA A 89	None	1.16A	4hfpD-3bknA: undetectable	4hfpD-3bknA: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3c4q	PREDICTED GLYCOSYLTRANSFERASES (Corynebacterium glutamicum)	PF00534 (Glycos_transf_1) PF13439 (Glyco_transf_4)	5	ILE A 261 ALA A 322 GLU A 316 ALA A 334 VAL A 332	None None UDP A 600 (-3.2A) None None	1.09A	4hfpD-3c4qA: undetectable	4hfpD-3c4qA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dme	CONSERVED EXPORTED PROTEIN (Bordetella pertussis)	PF01266 (DAO)	5	LEU A 201 ALA A 12 ALA A 33 VAL A 32 GLY A 16	None None None None FAD A 500 (-4.6A)	0.88A	4hfpD-3dmeA: undetectable	4hfpD-3dmeA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dmy	PROTEIN FDRA (Escherichia coli)	PF00549 (Ligase_CoA) PF02629 (CoA_binding)	5	LEU A 120 ILE A 224 ALA A 528 GLU A 524 GLY A 182	None	1.14A	4hfpD-3dmyA: undetectable	4hfpD-3dmyA: 18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	PF00089 (Trypsin)	6	ASP H 189 ALA H 190 GLU H 192 VAL H 213 TRP H 215 GLY H 226	0G6 H 1 (-2.8A) 0G6 H 1 (-3.4A) 0G6 H 1 ( 4.0A) None 0G6 H 1 (-4.1A) 0G6 H 1 ( 3.9A)	0.74A	4hfpD-3f6uH: 35.4	4hfpD-3f6uH: 39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	PF00089 (Trypsin)	6	HIS H 57 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	0G6 H 1 (-3.2A) 0G6 H 1 (-2.8A) 0G6 H 1 (-3.4A) None 0G6 H 1 (-4.1A) 0G6 H 1 ( 3.9A)	0.38A	4hfpD-3f6uH: 35.4	4hfpD-3f6uH: 39.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3fcp	L-ALA-D/L-GLU EPIMERASE, A MUCONATE LACTONIZING ENZYME (Klebsiella pneumoniae)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	LEU A 35 ASP A 115 ALA A 112 ALA A 108 VAL A 38	None	1.15A	4hfpD-3fcpA: undetectable	4hfpD-3fcpA: 20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3gov	MASP-1 (Homo sapiens)	PF00089 (Trypsin)	6	HIS B 490 ASP B 640 ALA B 641 VAL B 666 TRP B 668 GLY B 679	None	0.30A	4hfpD-3govB: 36.2	4hfpD-3govB: 36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gvy	BACTERIOFERRITIN (Rhodobacter sphaeroides)	PF00210 (Ferritin)	5	HIS A 28 TRP A 35 LEU A 27 GLU A 85 ALA A 89	None	0.97A	4hfpD-3gvyA: undetectable	4hfpD-3gvyA: 21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3gym	PROSTASIN (Homo sapiens)	PF00089 (Trypsin)	6	HIS A 57 ASP A 189 ALA A 190 VAL A 213 TRP A 215 GLY A 226	None	0.40A	4hfpD-3gymA: 33.8	4hfpD-3gymA: 36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3h7a	SHORT CHAIN DEHYDROGENASE (Rhodopseudomonas palustris)	PF00106 (adh_short)	5	ASP A 62 ALA A 63 GLU A 110 ALA A 112 VAL A 89	ASP A 62 ( 0.6A) ALA A 63 ( 0.0A) GLU A 110 ( 0.6A) ALA A 112 ( 0.0A) VAL A 89 ( 0.6A)	1.01A	4hfpD-3h7aA: undetectable	4hfpD-3h7aA: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hwr	2-DEHYDROPANTOATE 2-REDUCTASE (Cupriavidus pinatubonensis)	PF02558 (ApbA) PF08546 (ApbA_C)	5	LEU A 70 ILE A 5 ALA A 107 ALA A 119 VAL A 118	None	0.99A	4hfpD-3hwrA: undetectable	4hfpD-3hwrA: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3icc	PUTATIVE 3-OXOACYL-(ACYL CARRIER PROTEIN) REDUCTASE (Bacillus anthracis)	PF13561 (adh_short_C2)	5	TYR A 73 ILE A 140 ALA A 21 ALA A 32 VAL A 31	TYR A 73 ( 1.3A) ILE A 140 ( 0.7A) ALA A 21 ( 0.0A) ALA A 32 ( 0.0A) VAL A 31 ( 0.6A)	1.05A	4hfpD-3iccA: undetectable	4hfpD-3iccA: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3jug	BETA-MANNANASE (Bacillus sp. N16-5)	PF00150 (Cellulase)	5	TRP A 282 ASP A 88 GLU A 117 ALA A 61 GLY A 90	None	1.02A	4hfpD-3jugA: undetectable	4hfpD-3jugA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kx6	FRUCTOSE-BISPHOSPHAT E ALDOLASE (Babesia bovis)	PF00274 (Glycolytic)	5	LEU A 221 GLU A 15 ALA A 17 VAL A 182 GLY A 180	PEG A 401 ( 4.6A) None None None None	1.05A	4hfpD-3kx6A: undetectable	4hfpD-3kx6A: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kzz	SNAP-TAG (Homo sapiens)	PF01035 (DNA_binding_1) PF02870 (Methyltransf_1N)	5	LEU A 168 GLU A 159 ALA A 145 VAL A 148 GLY A 156	None OBG A 181 (-3.7A) OBG A 181 (-3.4A) OBG A 181 (-4.3A) None	1.14A	4hfpD-3kzzA: undetectable	4hfpD-3kzzA: 23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3nxp	PRETHROMBIN-1 (Homo sapiens)	PF00051 (Kringle) PF00089 (Trypsin) PF09396 (Thrombin_light)	7	HIS A 457 TYR A 460 TRP A 460 LEU A 499 ILE A 574 VAL A 613 GLY A 626	None	0.73A	4hfpD-3nxpA: 29.6	4hfpD-3nxpA: 99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3omn	CYTOCHROME C OXIDASE, AA3 TYPE, SUBUNIT I (Rhodobacter sphaeroides)	PF00115 (COX1)	5	TRP A 439 LEU A 34 ILE A 515 ALA A 428 VAL A 111	None DMU A 7 (-4.3A) DMU A 7 ( 4.4A) None HEA A 1 (-4.5A)	1.05A	4hfpD-3omnA: undetectable	4hfpD-3omnA: 17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ppc	5-METHYLTETRAHYDROPT EROYLTRIGLUTAMATE--H OMOCYSTEINE METHYLTRANSFERASE (Candida albicans)	PF01717 (Meth_synt_2) PF08267 (Meth_synt_1)	6	HIS A 667 LEU A 671 ILE A 654 ALA A 589 ALA A 637 GLY A 593	None	1.31A	4hfpD-3ppcA: undetectable	4hfpD-3ppcA: 17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	PF00089 (Trypsin)	9	HIS B 57 TYR B 60 LEU B 99 ILE B 174 ALA B 190 GLU B 192 VAL B 213 TRP B 215 GLY B 226	None	0.80A	4hfpD-3r3gB: 43.1	4hfpD-3r3gB: 97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	PF00089 (Trypsin)	10	HIS B 57 TYR B 60 TRP B 60 LEU B 99 ILE B 174 ASP B 189 ALA B 190 VAL B 213 TRP B 215 GLY B 226	None	0.57A	4hfpD-3r3gB: 43.1	4hfpD-3r3gB: 97.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tx8	SUCCINYL-DIAMINOPIME LATE DESUCCINYLASE (Corynebacterium glutamicum)	PF01546 (Peptidase_M20) PF07687 (M20_dimer)	5	LEU A 22 ILE A 356 ALA A 75 ALA A 132 GLY A 164	None	0.93A	4hfpD-3tx8A: undetectable	4hfpD-3tx8A: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ze7	PERIPLASMIC [NIFESE] HYDROGENASE, LARGE SUBUNIT, SELENOCYSTEINE-CONTA INING (Desulfovibrio vulgaris)	PF00374 (NiFeSe_Hases)	5	ILE B 104 ASP B 91 ALA B 96 VAL B 404 GLY B 193	None	1.14A	4hfpD-3ze7B: undetectable	4hfpD-3ze7B: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4bxw	FACTOR XA (Pseudonaja textilis)	PF00089 (Trypsin) PF14670 (FXa_inhibition)	5	HIS A 211 ASP A 356 ALA A 357 VAL A 380 GLY A 393	0GJ A1411 (-2.8A) 0GJ A1411 (-2.7A) 0GJ A1411 (-3.4A) None 0GJ A1411 (-3.3A)	0.27A	4hfpD-4bxwA: 33.1	4hfpD-4bxwA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dmm	3-OXOACYL-[ACYL-CARR IER-PROTEIN] REDUCTASE (Synechococcus elongatus)	PF13561 (adh_short_C2)	5	LEU A 87 ILE A 140 ALA A 25 ALA A 36 VAL A 35	None	1.12A	4hfpD-4dmmA: undetectable	4hfpD-4dmmA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ej6	PUTATIVE ZINC-BINDING DEHYDROGENASE (Sinorhizobium meliloti)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	LEU A 43 ILE A 324 GLU A 143 ALA A 107 GLY A 115	None	1.14A	4hfpD-4ej6A: undetectable	4hfpD-4ej6A: 19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	PF00089 (Trypsin)	6	HIS H 483 ASP H 627 ALA H 633 VAL H 653 TRP H 655 GLY H 667	None	0.54A	4hfpD-4fxgH: 35.0	4hfpD-4fxgH: 35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4hzh	PROTHROMBIN (Homo sapiens)	PF00051 (Kringle) PF00089 (Trypsin) PF09396 (Thrombin_light)	6	HIS A 363 TYR A 367 LEU A 416 ILE A 499 VAL A 545 GLY A 558	None	0.86A	4hfpD-4hzhA: 29.9	4hfpD-4hzhA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4hzh	PROTHROMBIN (Homo sapiens)	PF00051 (Kringle) PF00089 (Trypsin) PF09396 (Thrombin_light)	7	HIS A 363 TYR A 367 TRP A 370 LEU A 416 ALA A 525 VAL A 545 GLY A 558	None	0.79A	4hfpD-4hzhA: 29.9	4hfpD-4hzhA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ilk	STARVATION SENSING PROTEIN RSPB (Escherichia coli)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	LEU A 165 ILE A 241 ALA A 207 VAL A 177 GLY A 173	None NAI A 401 ( 4.8A) None None None	1.14A	4hfpD-4ilkA: undetectable	4hfpD-4ilkA: 21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	PF00089 (Trypsin)	5	HIS E 478 ASP E 639 VAL E 665 TRP E 667 GLY E 680	None	0.59A	4hfpD-4iw4E: 32.9	4hfpD-4iw4E: 34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4j9t	DESIGNED UNNATURAL AMINO ACID DEPENDENT METALLOPROTEIN (Micromonospora viridifaciens)	PF13088 (BNR_2)	5	TRP A 357 LEU A 401 ALA A 375 ALA A 317 GLY A 382	None	1.06A	4hfpD-4j9tA: undetectable	4hfpD-4j9tA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kem	MANDELATE RACEMASE/MUCONATE LACTONIZING ENZYME (Azospirillum lipoferum)	PF13378 (MR_MLE_C)	5	LEU A 387 ILE A 6 ALA A 57 ALA A 11 GLY A 59	None	1.03A	4hfpD-4kemA: undetectable	4hfpD-4kemA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4n2x	DL-2-HALOACID DEHALOGENASE (Methylobacterium sp. CPA1)	PF10778 (DehI)	5	ILE A 152 ALA A 233 ALA A 126 VAL A 237 GLY A 71	None	0.91A	4hfpD-4n2xA: undetectable	4hfpD-4n2xA: 24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oso	REDUCTASE HOMOLOG (Streptomyces cyanogenus)	PF13561 (adh_short_C2)	5	LEU A 91 ILE A 142 ALA A 23 ALA A 34 VAL A 33	None	1.11A	4hfpD-4osoA: undetectable	4hfpD-4osoA: 19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	3KM A 900 ( 4.4A) 3KM A 900 (-2.9A) None None 3KM A 900 (-3.2A)	0.36A	4hfpD-4r0iA: 36.0	4hfpD-4r0iA: 35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4wwy	TRYPSIN-1 (Homo sapiens)	PF00089 (Trypsin)	6	HIS A 57 LEU A 99 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None	0.62A	4hfpD-4wwyA: 33.8	4hfpD-4wwyA: 36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wyr	ACETYL-COA ACETYLTRANSFERASE (Clostridium acetobutylicum)	PF00108 (Thiolase_N) PF02803 (Thiolase_C)	5	LEU A 389 ALA A 254 ALA A 9 VAL A 359 GLY A 354	None	1.03A	4hfpD-4wyrA: undetectable	4hfpD-4wyrA: 20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ylq	COAGULATION FACTOR VII (Homo sapiens)	PF00089 (Trypsin)	5	HIS H 57 ASP H 189 VAL H 213 TRP H 215 GLY H 226	0Z7 H 501 (-2.6A) 0Z7 H 501 (-2.3A) 0Z7 H 501 ( 4.7A) TMA H 508 ( 3.9A) 0Z7 H 501 (-3.0A)	0.26A	4hfpD-4ylqH: 34.4	4hfpD-4ylqH: 35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5brr	TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens)	PF00089 (Trypsin)	6	HIS E 57 ASP E 189 ALA E 190 ALA E 195 TRP E 215 GLY E 226	None	0.46A	4hfpD-5brrE: 34.9	4hfpD-5brrE: 32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	PF00089 (Trypsin)	5	HIS A 57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	None	0.22A	4hfpD-5f8zA: 34.6	4hfpD-5f8zA: 39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gl6	RIBOSOME MATURATION FACTOR RIMP (Mycolicibacterium smegmatis)	PF02576 (DUF150) PF17384 (DUF150_C)	5	LEU A 121 ILE A 153 ALA A 144 VAL A 136 GLY A 126	None	1.16A	4hfpD-5gl6A: undetectable	4hfpD-5gl6A: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5m60	BETA-1,3-GLUCANASE (Chaetomium thermophilum)	PF12708 (Pectate_lyase_3)	5	TYR A 591 LEU A 586 ALA A 643 VAL A 646 GLY A 621	None	0.94A	4hfpD-5m60A: undetectable	4hfpD-5m60A: 15.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5o32	COMPLEMENT FACTOR I (Homo sapiens)	PF00089 (Trypsin)	5	ASP I 519 ALA I 520 VAL I 544 TRP I 546 GLY I 557	None	0.83A	4hfpD-5o32I: 31.2	4hfpD-5o32I: 32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oy0	PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2 (Synechocystis sp. PCC 6803)	no annotation	5	LEU b 476 ASP b 272 ALA b 488 TRP b 494 GLY b 259	CLA b1836 (-4.3A) None CLA b1837 ( 4.1A) CLA b1836 ( 4.1A) CLA b1820 ( 4.0A)	1.14A	4hfpD-5oy0b: undetectable	4hfpD-5oy0b: 12.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	PF00089 (Trypsin) PF09064 (Tme5_EGF_like)	8	HIS B 58 TYR B 62 LEU B 111 ILE B 194 ASP B 214 ALA B 215 VAL B 240 GLY B 253	0G6 B 501 (-2.5A) 0G6 B 501 (-3.7A) 0G6 B 501 ( 3.8A) None 0G6 B 501 (-2.9A) 0G6 B 501 (-3.4A) None 0G6 B 501 (-3.6A)	0.40A	4hfpD-5to3B: 44.4	4hfpD-5to3B: 88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	PF00089 (Trypsin) PF09064 (Tme5_EGF_like)	6	TYR B 62 LEU B 111 ILE B 194 ALA B 215 GLU B 217 VAL B 240	0G6 B 501 (-3.7A) 0G6 B 501 ( 3.8A) None 0G6 B 501 (-3.4A) 0G6 B 501 (-3.8A) None	1.37A	4hfpD-5to3B: 44.4	4hfpD-5to3B: 88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	PF00089 (Trypsin) PF09064 (Tme5_EGF_like)	8	TYR B 62 TRP B 65 LEU B 111 ILE B 194 ASP B 214 ALA B 215 VAL B 240 GLY B 253	0G6 B 501 (-3.7A) 0G6 B 501 (-4.8A) 0G6 B 501 ( 3.8A) None 0G6 B 501 (-2.9A) 0G6 B 501 (-3.4A) None 0G6 B 501 (-3.6A)	0.52A	4hfpD-5to3B: 44.4	4hfpD-5to3B: 88.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u63	THIOREDOXIN REDUCTASE (Haemophilus influenzae)	PF07992 (Pyr_redox_2)	5	TYR A 192 LEU A 202 ALA A 242 ALA A 162 VAL A 151	None	0.95A	4hfpD-5u63A: undetectable	4hfpD-5u63A: 22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	no annotation	5	HIS A 475 ASP A 626 VAL A 653 TRP A 655 GLY A 663	None	0.48A	4hfpD-5ubmA: 31.7	4hfpD-5ubmA: 35.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5uff	RBC36 (Petromyzon marinus)	no annotation	5	LEU A 170 ILE A 140 ALA A 215 ALA A 201 VAL A 194	None	1.15A	4hfpD-5uffA: undetectable	4hfpD-5uffA: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ysm	CYTOCHROME P450 (Amycolatopsis mediterranei)	no annotation	5	TRP A 342 GLU A 63 ALA A 65 VAL A 59 GLY A 43	None	1.16A	4hfpD-5ysmA: undetectable	4hfpD-5ysmA: 14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6b74	COAGULATION FACTOR XII (Homo sapiens)	no annotation	5	HIS B 57 ASP B 189 ALA B 190 TRP B 215 GLY B 226	SO4 B 304 (-3.8A) BEN B 301 (-2.7A) BEN B 301 (-4.1A) None BEN B 301 (-3.1A)	0.44A	4hfpD-6b74B: 34.3	4hfpD-6b74B: 16.87

[["4HFP_D_15UD402_1","1a0j","Salmo salar","TRYPSIN","PF00089(Trypsin)",6,"HIS A  57;LEU A  99;ASP A 189;VAL A 213;TRP A 215;GLY A 226","SO4 A 248 (-3.9A);None;BEN A 246 (-3.0A);None;None;BEN A 246 (-3.3A)","0.38A","4hfpD-1a0jA:33.7","4hfpD-1a0jA:37.35"],["4HFP_D_15UD402_1","1a5i","Desmodus rotundus","PLASMINOGEN ACTIVATOR","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;ALA A 190;TRP A 215;GLY A 226","0GJ A 245 (-2.7A);0GJ A 245 (-3.1A);0GJ A 245 (-3.4A);None;0GJ A 245 ( 4.2A)","0.31A","4hfpD-1a5iA:32.8","4hfpD-1a5iA:32.17"],["4HFP_D_15UD402_1","1bqy","Trimeresurus stejnegeri","PLASMINOGEN ACTIVATOR","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","0GJ A   1 ( 2.7A);0GJ A   1 (-3.1A);None;None;0GJ A   1 ( 4.3A)","0.26A","4hfpD-1bqyA:31.9","4hfpD-1bqyA:32.83"],["4HFP_D_15UD402_1","1elv","Homo sapiens","COMPLEMENT C1S COMPONENT","PF00084(Sushi);PF00089(Trypsin)",5,"HIS A 460;ASP A 611;VAL A 638;TRP A 640;GLY A 648","SO4 A2001 ( 3.9A);None;None;None;None","0.33A","4hfpD-1elvA:31.2","4hfpD-1elvA:28.00"],["4HFP_D_15UD402_1","1ept","Sus scrofa","PORCINE E-TRYPSIN","PF00089(Trypsin)",6,"HIS A  57;LEU B  99;ASP C 189;VAL C 213;TRP C 215;GLY C 226","None","0.42A","4hfpD-1eptA:2.2","4hfpD-1eptA:15.56"],["4HFP_D_15UD402_1","1fxy","Homo sapiens","COAGULATION FACTOR XA-TRYPSIN CHIMERA","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","0G6 A   1 (-2.7A);0G6 A   1 (-2.8A);None;None;0G6 A   1 (-3.3A)","0.35A","4hfpD-1fxyA:32.7","4hfpD-1fxyA:36.82"],["4HFP_D_15UD402_1","1h4w","Homo sapiens","TRYPSIN IVA","PF00089(Trypsin)",6,"HIS A  57;LEU A  99;ASP A 189;VAL A 213;TRP A 215;GLY A 226","None;None;BEN A 250 (-2.9A);None;None;BEN A 250 (-3.3A)","0.34A","4hfpD-1h4wA:33.9","4hfpD-1h4wA:36.82"],["4HFP_D_15UD402_1","1h9h","Sus scrofa","TRYPSIN","PF00089(Trypsin)",6,"HIS E  57;LEU E  99;ASP E 189;VAL E 213;TRP E 215;GLY E 226","None","0.37A","4hfpD-1h9hE:33.6","4hfpD-1h9hE:38.13"],["4HFP_D_15UD402_1","1id5","Bos taurus","THROMBIN","PF00089(Trypsin)",7,"HIS H  57;ILE H 174;ASP H 189;ALA H 190;VAL H 213;TRP H 215;GLY H 226","None","0.40A","4hfpD-1id5H:42.4","4hfpD-1id5H:87.50"],["4HFP_D_15UD402_1","1id5","Bos taurus","THROMBIN","PF00089(Trypsin)",5,"LEU H  99;ASP H 189;ALA H 190;VAL H 213;GLY H 226","None","0.66A","4hfpD-1id5H:42.4","4hfpD-1id5H:87.50"],["4HFP_D_15UD402_1","1j17","Rattus norvegicus","TRYPSIN II, ANIONIC","PF00089(Trypsin)",6,"HIS T  57;ASP T 189;ALA T 190;VAL T 213;TRP T 215;GLY T 226","SO4 T 600 (-3.8A);ZEN T   1 ( 3.8A);ZEN T   1 (-3.8A);ZEN T   1 (-4.1A);ZEN T   1 (-3.4A);ZEN T   1 (-3.7A)","0.28A","4hfpD-1j17T:34.3","4hfpD-1j17T:37.35"],["4HFP_D_15UD402_1","1kae","Escherichia coli","HISTIDINOL DEHYDROGENASE","PF00815(Histidinol_dh)",5,"LEU A 313;ILE A 330;ALA A 278;ALA A 274;VAL A 309","None","1.08A","4hfpD-1kaeA:undetectable","4hfpD-1kaeA:18.99"],["4HFP_D_15UD402_1","1kig","Bos taurus","FACTOR XA","PF00089(Trypsin)",6,"HIS H  57;ASP H 189;ALA H 190;VAL H 213;TRP H 215;GLY H 226","None","0.44A","4hfpD-1kigH:34.5","4hfpD-1kigH:39.02"],["4HFP_D_15UD402_1","1mbq","Oncorhynchus keta","TRYPSIN","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","None;BEN A1222 (-2.9A);None;None;BEN A1222 (-3.4A)","0.28A","4hfpD-1mbqA:33.6","4hfpD-1mbqA:37.25"],["4HFP_D_15UD402_1","1mkx","Bos taurus","PRETHROMBIN-2","PF00089(Trypsin);PF09396(Thrombin_light)",8,"HIS K  57;TYR K  60;TRP K  60;LEU K  99;ILE K 174;VAL K 213;TRP K 215;GLY K 226","None","0.41A","4hfpD-1mkxK:36.6","4hfpD-1mkxK:86.87"],["4HFP_D_15UD402_1","1mkx","Bos taurus","PRETHROMBIN-2","PF00089(Trypsin);PF09396(Thrombin_light)",6,"LEU K  99;ILE K 174;GLU K 146;VAL K 213;TRP K 215;GLY K 226","None","0.90A","4hfpD-1mkxK:36.6","4hfpD-1mkxK:86.87"],["4HFP_D_15UD402_1","1o5f","Homo sapiens","SERINE PROTEASE HEPSIN","PF00089(Trypsin)",6,"HIS H  57;ASP H 189;ALA H 190;VAL H 213;TRP H 215;GLY H 226","CR9 H 256 (-3.9A);CR9 H 256 (-2.4A);CR9 H 256 (-2.9A);CR9 H 256 (-4.3A);None;CR9 H 256 (-3.0A)","0.36A","4hfpD-1o5fH:34.8","4hfpD-1o5fH:39.64"],["4HFP_D_15UD402_1","1pq5","Fusarium oxysporum","TRYPSIN","PF00089(Trypsin)",5,"HIS A  56;ASP A 189;VAL A 210;TRP A 212;GLY A 223","ARG A 703 (-4.3A);ARG A 703 (-2.0A);ARG A 703 (-4.5A);None;ARG A 703 (-2.6A)","0.33A","4hfpD-1pq5A:32.2","4hfpD-1pq5A:34.48"],["4HFP_D_15UD402_1","1q3x","Homo sapiens","MANNAN-BINDING LECTIN SERINE PROTEASE 2","PF00084(Sushi);PF00089(Trypsin)",5,"HIS A 483;ASP A 627;VAL A 653;TRP A 655;GLY A 667","None; NA A 800 ( 4.6A);GOL A 701 (-4.9A);None;GOL A 701 ( 4.0A)","0.23A","4hfpD-1q3xA:34.5","4hfpD-1q3xA:28.65"],["4HFP_D_15UD402_1","1umb","Thermus thermophilus","2-OXO ACID DEHYDROGENASE ALPHA SUBUNIT","PF00676(E1_dh)",5,"HIS A  98;LEU A  51;ILE A 322;ASP A 295;ALA A  70","None","1.02A","4hfpD-1umbA:undetectable","4hfpD-1umbA:21.74"],["4HFP_D_15UD402_1","1vkm","Thermotoga maritima","CONSERVED HYPOTHETICAL PROTEIN TM1464","PF04227(Indigoidine_A)",5,"HIS A  23;ALA A  99;GLU A  17;ALA A  94;VAL A  78","None;None;UNL A 600 (-2.9A);None;None","1.12A","4hfpD-1vkmA:undetectable","4hfpD-1vkmA:21.14"],["4HFP_D_15UD402_1","1w8o","Micromonospora viridifaciens","BACTERIAL SIALIDASE","PF00754(F5_F8_type_C);PF10633(NPCBM_assoc);PF13088(BNR_2)",5,"TRP A 357;LEU A 401;ALA A 375;ALA A 317;GLY A 382","None","1.08A","4hfpD-1w8oA:undetectable","4hfpD-1w8oA:19.16"],["4HFP_D_15UD402_1","1wky","Bacillus sp. JAMB-602","ENDO-BETA-1,4-MANNANASE","PF00150(Cellulase)",5,"TRP A 282;ASP A  88;GLU A 117;ALA A  61;GLY A  90","None","1.03A","4hfpD-1wkyA:undetectable","4hfpD-1wkyA:18.86"],["4HFP_D_15UD402_1","1woi","Deinococcus radiodurans","AGMATINASE","PF00491(Arginase)",5,"LEU A 127;ASP A  82;ALA A  83;ALA A 103;VAL A 107","None","1.14A","4hfpD-1woiA:undetectable","4hfpD-1woiA:19.38"],["4HFP_D_15UD402_1","1ym0","Eisenia fetida","FIBRINOTIC ENZYME COMPONENT B","PF00089(Trypsin)",6,"HIS A  57;LEU A  99;ASP A 189;VAL A 213;TRP A 215;GLY A 226","None","0.55A","4hfpD-1ym0A:35.6","4hfpD-1ym0A:33.58"],["4HFP_D_15UD402_1","1zlr","Homo sapiens","COAGULATION FACTOR XI","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;ALA A 190;TRP A 215;GLY A 226","368 A 901 (-4.0A);368 A 901 (-2.8A);368 A 901 (-3.7A);None;368 A 901 (-3.5A)","0.22A","4hfpD-1zlrA:34.6","4hfpD-1zlrA:36.64"],["4HFP_D_15UD402_1","2ayi","Thermus thermophilus","AMINOPEPTIDASE T","PF02073(Peptidase_M29)",5,"HIS A 345;ILE A 280;ALA A 318;VAL A 317;TRP A 379"," ZN A 501 (-3.9A);None; ZN A 501 ( 4.7A);None;None","1.11A","4hfpD-2ayiA:undetectable","4hfpD-2ayiA:20.76"],["4HFP_D_15UD402_1","2dkd","Candida albicans","PHOSPHOACETYLGLUCOSAMINE MUTASE","PF00408(PGM_PMM_IV);PF02878(PGM_PMM_I)",5,"HIS A 176;LEU A 175;ILE A 137;ALA A  27;GLY A  74","None","1.06A","4hfpD-2dkdA:undetectable","4hfpD-2dkdA:19.46"],["4HFP_D_15UD402_1","2eek","Gadus morhua","TRYPSIN-1","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","None;BEN A 301 (-2.7A);None;None;BEN A 301 (-3.2A)","0.29A","4hfpD-2eekA:33.0","4hfpD-2eekA:37.98"],["4HFP_D_15UD402_1","2ei8","Homo sapiens","COAGULATION FACTOR X, HEAVY CHAIN","PF00089(Trypsin)",6,"HIS A  57;ASP A 189;ALA A 190;VAL A 213;TRP A 215;GLY A 226","None;DT8 A 700 (-3.5A);DT8 A 700 (-3.6A);DT8 A 700 ( 4.1A);DT8 A 700 (-3.9A);DT8 A 700 (-3.5A)","0.42A","4hfpD-2ei8A:35.1","4hfpD-2ei8A:40.38"],["4HFP_D_15UD402_1","2f91","Astacus leptodactylus","HEPATOPANCREAS TRYPSIN","PF00089(Trypsin)",6,"HIS A  57;LEU A  99;ASP A 189;VAL A 213;TRP A 215;GLY A 227","None","0.35A","4hfpD-2f91A:34.3","4hfpD-2f91A:36.60"],["4HFP_D_15UD402_1","2og7","Streptomyces coelicolor","ASPARAGINE OXYGENASE","PF02668(TauD)",5,"LEU A 130;ALA A  35;GLU A  46;ALA A  48;GLY A  37","None","1.09A","4hfpD-2og7A:undetectable","4hfpD-2og7A:21.94"],["4HFP_D_15UD402_1","2ojh","Agrobacterium fabrum","UNCHARACTERIZED PROTEIN ATU1656\/AGR_C_3050","PF07676(PD40)",5,"HIS A  88;TRP A 131;LEU A  62;ALA A 285;ALA A  44","None","1.12A","4hfpD-2ojhA:undetectable","4hfpD-2ojhA:23.17"],["4HFP_D_15UD402_1","2oq5","Homo sapiens","TRANSMEMBRANE PROTEASE, SERINE 11E","PF00089(Trypsin)",6,"HIS A  57;ASP A 189;ALA A 190;VAL A 213;TRP A 215;GLY A 226","None;BEN A 245 (-3.0A);BEN A 245 (-3.9A);None;None;BEN A 245 (-3.4A)","0.28A","4hfpD-2oq5A:34.5","4hfpD-2oq5A:36.92"],["4HFP_D_15UD402_1","2pkq","Spinacia oleracea","GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE B","PF00044(Gp_dh_N);PF02672(CP12);PF02800(Gp_dh_C)",5,"ILE O  91;ALA O 120;ALA O 122;VAL O 100;GLY O  95","None;NDP O 363 ( 3.7A);None;None;NDP O 363 (-4.8A)","1.13A","4hfpD-2pkqO:undetectable","4hfpD-2pkqO:20.37"],["4HFP_D_15UD402_1","2pks","Homo sapiens","THROMBIN HEAVY CHAIN FRAGMENT","PF00089(Trypsin)",7,"ILE C 209;ASP C 229;ALA C 230;GLU C 232;VAL C 255;TRP C 257;GLY C 268","G44 C 101 (-3.9A);G44 C 101 (-2.6A);G44 C 101 (-3.8A);None;None;G44 C 101 (-4.1A);G44 C 101 (-3.0A)","0.65A","4hfpD-2pksC:15.6","4hfpD-2pksC:99.02"],["4HFP_D_15UD402_1","2po4","Escherichia virus N4","VIRION RNA POLYMERASE","no annotation",5,"LEU A 816;ILE A 882;ASP A 929;ALA A 568;GLY A 926","None","1.12A","4hfpD-2po4A:undetectable","4hfpD-2po4A:12.44"],["4HFP_D_15UD402_1","2psy","Homo sapiens","KALLIKREIN-5","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","None","0.45A","4hfpD-2psyA:14.9","4hfpD-2psyA:34.48"],["4HFP_D_15UD402_1","2qko","Rhodococcus jostii","POSSIBLE TRANSCRIPTIONAL REGULATOR, TETR FAMILY PROTEIN","PF00440(TetR_N)",5,"LEU A 109;ALA A  31;ALA A  15;VAL A  18;GLY A  26","None","0.97A","4hfpD-2qkoA:undetectable","4hfpD-2qkoA:21.05"],["4HFP_D_15UD402_1","2qy0","Homo sapiens","COMPLEMENT C1R SUBCOMPONENT","PF00089(Trypsin)",6,"HIS B 485;ASP B 631;ALA B 632;VAL B 657;TRP B 659;GLY B 668","None","0.32A","4hfpD-2qy0B:32.8","4hfpD-2qy0B:37.78"],["4HFP_D_15UD402_1","2r0l","Homo sapiens","HEPATOCYTE GROWTH FACTOR ACTIVATOR","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;ALA A 190;TRP A 215;GLY A 226","None","0.27A","4hfpD-2r0lA:34.5","4hfpD-2r0lA:34.70"],["4HFP_D_15UD402_1","2r2w","Homo sapiens","PLASMINOGEN ACTIVATOR, UROKINASE","PF00089(Trypsin)",5,"HIS U  57;ASP U 189;VAL U 213;TRP U 215;GLY U 226","4PG U 300 (-3.9A);4PG U 300 (-2.8A);None;None;4PG U 300 (-3.2A)","0.42A","4hfpD-2r2wU:35.0","4hfpD-2r2wU:31.75"],["4HFP_D_15UD402_1","2vpw","Thermus thermophilus","THIOSULFATE REDUCTASE","PF00384(Molybdopterin);PF01568(Molydop_binding);PF04879(Molybdop_Fe4S4)",5,"HIS A 697;ILE A 417;ASP A 466;ALA A 632;GLY A 439","MGD A1765 (-3.5A);None;MGD A1765 (-2.8A);MGD A1765 (-2.9A);MGD A1765 (-3.1A)","1.08A","4hfpD-2vpwA:undetectable","4hfpD-2vpwA:15.91"],["4HFP_D_15UD402_1","2whl","Salipaludibacillus agaradhaerens","BETA-MANNANASE","PF00150(Cellulase)",5,"TRP A 251;ASP A  57;GLU A  86;ALA A  30;GLY A  59","MAN A1301 (-4.5A);None;None;None;None","1.02A","4hfpD-2whlA:undetectable","4hfpD-2whlA:21.09"],["4HFP_D_15UD402_1","2zec","Homo sapiens","TRYPTASE BETA 2","PF00089(Trypsin)",5,"HIS A  59;ASP A 203;VAL A 227;TRP A 229;GLY A 240","None;11N A   1 (-2.6A);None;None;11N A   1 (-3.6A)","0.37A","4hfpD-2zecA:33.1","4hfpD-2zecA:35.32"],["4HFP_D_15UD402_1","3a75","Bacillus subtilis","GAMMA-GLUTAMYLTRANSPEPTIDASE LARGE CHAIN","PF01019(G_glu_transpept)",5,"LEU A  64;ALA A 157;ALA A  74;VAL A  75;GLY A 162","None","1.12A","4hfpD-3a75A:undetectable","4hfpD-3a75A:19.13"],["4HFP_D_15UD402_1","3beu","Streptomyces griseus","TRYPSIN","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","SO4 A 246 ( 3.8A);BEN A 247 (-3.0A);None;None;BEN A 247 (-3.5A)","0.22A","4hfpD-3beuA:31.3","4hfpD-3beuA:33.72"],["4HFP_D_15UD402_1","3bkn","Mycolicibacterium smegmatis","BACTERIOFERRITIN","PF00210(Ferritin)",5,"HIS A  28;TRP A  35;LEU A  27;GLU A  85;ALA A  89","None","1.16A","4hfpD-3bknA:undetectable","4hfpD-3bknA:24.18"],["4HFP_D_15UD402_1","3c4q","Corynebacterium glutamicum","PREDICTED GLYCOSYLTRANSFERASES","PF00534(Glycos_transf_1);PF13439(Glyco_transf_4)",5,"ILE A 261;ALA A 322;GLU A 316;ALA A 334;VAL A 332","None;None;UDP A 600 (-3.2A);None;None","1.09A","4hfpD-3c4qA:undetectable","4hfpD-3c4qA:20.28"],["4HFP_D_15UD402_1","3dme","Bordetella pertussis","CONSERVED EXPORTED PROTEIN","PF01266(DAO)",5,"LEU A 201;ALA A  12;ALA A  33;VAL A  32;GLY A  16","None;None;None;None;FAD A 500 (-4.6A)","0.88A","4hfpD-3dmeA:undetectable","4hfpD-3dmeA:21.58"],["4HFP_D_15UD402_1","3dmy","Escherichia coli","PROTEIN FDRA","PF00549(Ligase_CoA);PF02629(CoA_binding)",5,"LEU A 120;ILE A 224;ALA A 528;GLU A 524;GLY A 182","None","1.14A","4hfpD-3dmyA:undetectable","4hfpD-3dmyA:18.28"],["4HFP_D_15UD402_1","3f6u","Homo sapiens","VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN","PF00089(Trypsin)",6,"ASP H 189;ALA H 190;GLU H 192;VAL H 213;TRP H 215;GLY H 226","0G6 H   1 (-2.8A);0G6 H   1 (-3.4A);0G6 H   1 ( 4.0A);None;0G6 H   1 (-4.1A);0G6 H   1 ( 3.9A)","0.74A","4hfpD-3f6uH:35.4","4hfpD-3f6uH:39.85"],["4HFP_D_15UD402_1","3f6u","Homo sapiens","VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN","PF00089(Trypsin)",6,"HIS H  57;ASP H 189;ALA H 190;VAL H 213;TRP H 215;GLY H 226","0G6 H   1 (-3.2A);0G6 H   1 (-2.8A);0G6 H   1 (-3.4A);None;0G6 H   1 (-4.1A);0G6 H   1 ( 3.9A)","0.38A","4hfpD-3f6uH:35.4","4hfpD-3f6uH:39.85"],["4HFP_D_15UD402_1","3fcp","Klebsiella pneumoniae","L-ALA-D\/L-GLU EPIMERASE, A MUCONATE LACTONIZING ENZYME","PF02746(MR_MLE_N);PF13378(MR_MLE_C)",5,"LEU A  35;ASP A 115;ALA A 112;ALA A 108;VAL A  38","None","1.15A","4hfpD-3fcpA:undetectable","4hfpD-3fcpA:20.67"],["4HFP_D_15UD402_1","3gov","Homo sapiens","MASP-1","PF00089(Trypsin)",6,"HIS B 490;ASP B 640;ALA B 641;VAL B 666;TRP B 668;GLY B 679","None","0.30A","4hfpD-3govB:36.2","4hfpD-3govB:36.20"],["4HFP_D_15UD402_1","3gvy","Rhodobacter sphaeroides","BACTERIOFERRITIN","PF00210(Ferritin)",5,"HIS A  28;TRP A  35;LEU A  27;GLU A  85;ALA A  89","None","0.97A","4hfpD-3gvyA:undetectable","4hfpD-3gvyA:21.84"],["4HFP_D_15UD402_1","3gym","Homo sapiens","PROSTASIN","PF00089(Trypsin)",6,"HIS A  57;ASP A 189;ALA A 190;VAL A 213;TRP A 215;GLY A 226","None","0.40A","4hfpD-3gymA:33.8","4hfpD-3gymA:36.20"],["4HFP_D_15UD402_1","3h7a","Rhodopseudomonas palustris","SHORT CHAIN DEHYDROGENASE","PF00106(adh_short)",5,"ASP A  62;ALA A  63;GLU A 110;ALA A 112;VAL A  89","ASP A  62 ( 0.6A);ALA A  63 ( 0.0A);GLU A 110 ( 0.6A);ALA A 112 ( 0.0A);VAL A  89 ( 0.6A)","1.01A","4hfpD-3h7aA:undetectable","4hfpD-3h7aA:20.07"],["4HFP_D_15UD402_1","3hwr","Cupriavidus pinatubonensis","2-DEHYDROPANTOATE 2-REDUCTASE","PF02558(ApbA);PF08546(ApbA_C)",5,"LEU A  70;ILE A   5;ALA A 107;ALA A 119;VAL A 118","None","0.99A","4hfpD-3hwrA:undetectable","4hfpD-3hwrA:20.62"],["4HFP_D_15UD402_1","3icc","Bacillus anthracis","PUTATIVE 3-OXOACYL-(ACYL CARRIER PROTEIN) REDUCTASE","PF13561(adh_short_C2)",5,"TYR A  73;ILE A 140;ALA A  21;ALA A  32;VAL A  31","TYR A  73 ( 1.3A);ILE A 140 ( 0.7A);ALA A  21 ( 0.0A);ALA A  32 ( 0.0A);VAL A  31 ( 0.6A)","1.05A","4hfpD-3iccA:undetectable","4hfpD-3iccA:22.60"],["4HFP_D_15UD402_1","3jug","Bacillus sp. N16-5","BETA-MANNANASE","PF00150(Cellulase)",5,"TRP A 282;ASP A  88;GLU A 117;ALA A  61;GLY A  90","None","1.02A","4hfpD-3jugA:undetectable","4hfpD-3jugA:20.40"],["4HFP_D_15UD402_1","3kx6","Babesia bovis","FRUCTOSE-BISPHOSPHATE ALDOLASE","PF00274(Glycolytic)",5,"LEU A 221;GLU A  15;ALA A  17;VAL A 182;GLY A 180","PEG A 401 ( 4.6A);None;None;None;None","1.05A","4hfpD-3kx6A:undetectable","4hfpD-3kx6A:21.39"],["4HFP_D_15UD402_1","3kzz","Homo sapiens","SNAP-TAG","PF01035(DNA_binding_1);PF02870(Methyltransf_1N)",5,"LEU A 168;GLU A 159;ALA A 145;VAL A 148;GLY A 156","None;OBG A 181 (-3.7A);OBG A 181 (-3.4A);OBG A 181 (-4.3A);None","1.14A","4hfpD-3kzzA:undetectable","4hfpD-3kzzA:23.37"],["4HFP_D_15UD402_1","3nxp","Homo sapiens","PRETHROMBIN-1","PF00051(Kringle);PF00089(Trypsin);PF09396(Thrombin_light)",7,"HIS A 457;TYR A 460;TRP A 460;LEU A 499;ILE A 574;VAL A 613;GLY A 626","None","0.73A","4hfpD-3nxpA:29.6","4hfpD-3nxpA:99.61"],["4HFP_D_15UD402_1","3omn","Rhodobacter sphaeroides","CYTOCHROME C OXIDASE, AA3 TYPE, SUBUNIT I","PF00115(COX1)",5,"TRP A 439;LEU A  34;ILE A 515;ALA A 428;VAL A 111","None;DMU A   7 (-4.3A);DMU A   7 ( 4.4A);None;HEA A   1 (-4.5A)","1.05A","4hfpD-3omnA:undetectable","4hfpD-3omnA:17.21"],["4HFP_D_15UD402_1","3ppc","Candida albicans","5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE","PF01717(Meth_synt_2);PF08267(Meth_synt_1)",6,"HIS A 667;LEU A 671;ILE A 654;ALA A 589;ALA A 637;GLY A 593","None","1.31A","4hfpD-3ppcA:undetectable","4hfpD-3ppcA:17.11"],["4HFP_D_15UD402_1","3r3g","Homo sapiens","THROMBIN HEAVY CHAIN","PF00089(Trypsin)",9,"HIS B  57;TYR B  60;LEU B  99;ILE B 174;ALA B 190;GLU B 192;VAL B 213;TRP B 215;GLY B 226","None","0.80A","4hfpD-3r3gB:43.1","4hfpD-3r3gB:97.30"],["4HFP_D_15UD402_1","3r3g","Homo sapiens","THROMBIN HEAVY CHAIN","PF00089(Trypsin)",10,"HIS B  57;TYR B  60;TRP B  60;LEU B  99;ILE B 174;ASP B 189;ALA B 190;VAL B 213;TRP B 215;GLY B 226","None","0.57A","4hfpD-3r3gB:43.1","4hfpD-3r3gB:97.30"],["4HFP_D_15UD402_1","3tx8","Corynebacterium glutamicum","SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE","PF01546(Peptidase_M20);PF07687(M20_dimer)",5,"LEU A  22;ILE A 356;ALA A  75;ALA A 132;GLY A 164","None","0.93A","4hfpD-3tx8A:undetectable","4hfpD-3tx8A:20.26"],["4HFP_D_15UD402_1","3ze7","Desulfovibrio vulgaris","PERIPLASMIC [NIFESE] HYDROGENASE, LARGE SUBUNIT, SELENOCYSTEINE-CONTAINING","PF00374(NiFeSe_Hases)",5,"ILE B 104;ASP B  91;ALA B  96;VAL B 404;GLY B 193","None","1.14A","4hfpD-3ze7B:undetectable","4hfpD-3ze7B:20.46"],["4HFP_D_15UD402_1","4bxw","Pseudonaja textilis","FACTOR XA","PF00089(Trypsin);PF14670(FXa_inhibition)",5,"HIS A 211;ASP A 356;ALA A 357;VAL A 380;GLY A 393","0GJ A1411 (-2.8A);0GJ A1411 (-2.7A);0GJ A1411 (-3.4A);None;0GJ A1411 (-3.3A)","0.27A","4hfpD-4bxwA:33.1","4hfpD-4bxwA:25.00"],["4HFP_D_15UD402_1","4dmm","Synechococcus elongatus","3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE","PF13561(adh_short_C2)",5,"LEU A  87;ILE A 140;ALA A  25;ALA A  36;VAL A  35","None","1.12A","4hfpD-4dmmA:undetectable","4hfpD-4dmmA:20.34"],["4HFP_D_15UD402_1","4ej6","Sinorhizobium meliloti","PUTATIVE ZINC-BINDING DEHYDROGENASE","PF00107(ADH_zinc_N);PF08240(ADH_N)",5,"LEU A  43;ILE A 324;GLU A 143;ALA A 107;GLY A 115","None","1.14A","4hfpD-4ej6A:undetectable","4hfpD-4ej6A:19.89"],["4HFP_D_15UD402_1","4fxg","Homo sapiens","MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN","PF00089(Trypsin)",6,"HIS H 483;ASP H 627;ALA H 633;VAL H 653;TRP H 655;GLY H 667","None","0.54A","4hfpD-4fxgH:35.0","4hfpD-4fxgH:35.61"],["4HFP_D_15UD402_1","4hzh","Homo sapiens","PROTHROMBIN","PF00051(Kringle);PF00089(Trypsin);PF09396(Thrombin_light)",6,"HIS A 363;TYR A 367;LEU A 416;ILE A 499;VAL A 545;GLY A 558","None","0.86A","4hfpD-4hzhA:29.9","4hfpD-4hzhA:100.00"],["4HFP_D_15UD402_1","4hzh","Homo sapiens","PROTHROMBIN","PF00051(Kringle);PF00089(Trypsin);PF09396(Thrombin_light)",7,"HIS A 363;TYR A 367;TRP A 370;LEU A 416;ALA A 525;VAL A 545;GLY A 558","None","0.79A","4hfpD-4hzhA:29.9","4hfpD-4hzhA:100.00"],["4HFP_D_15UD402_1","4ilk","Escherichia coli","STARVATION SENSING PROTEIN RSPB","PF00107(ADH_zinc_N);PF08240(ADH_N)",5,"LEU A 165;ILE A 241;ALA A 207;VAL A 177;GLY A 173","None;NAI A 401 ( 4.8A);None;None;None","1.14A","4hfpD-4ilkA:undetectable","4hfpD-4ilkA:21.74"],["4HFP_D_15UD402_1","4iw4","Homo sapiens","MANNAN-BINDING LECTIN SERINE PROTEASE 3","PF00089(Trypsin)",5,"HIS E 478;ASP E 639;VAL E 665;TRP E 667;GLY E 680","None","0.59A","4hfpD-4iw4E:32.9","4hfpD-4iw4E:34.83"],["4HFP_D_15UD402_1","4j9t","Micromonospora viridifaciens","DESIGNED UNNATURAL AMINO ACID DEPENDENT METALLOPROTEIN","PF13088(BNR_2)",5,"TRP A 357;LEU A 401;ALA A 375;ALA A 317;GLY A 382","None","1.06A","4hfpD-4j9tA:undetectable","4hfpD-4j9tA:21.58"],["4HFP_D_15UD402_1","4kem","Azospirillum lipoferum","MANDELATE RACEMASE\/MUCONATE LACTONIZING ENZYME","PF13378(MR_MLE_C)",5,"LEU A 387;ILE A   6;ALA A  57;ALA A  11;GLY A  59","None","1.03A","4hfpD-4kemA:undetectable","4hfpD-4kemA:20.00"],["4HFP_D_15UD402_1","4n2x","Methylobacterium sp. CPA1","DL-2-HALOACID DEHALOGENASE","PF10778(DehI)",5,"ILE A 152;ALA A 233;ALA A 126;VAL A 237;GLY A  71","None","0.91A","4hfpD-4n2xA:undetectable","4hfpD-4n2xA:24.24"],["4HFP_D_15UD402_1","4oso","Streptomyces cyanogenus","REDUCTASE HOMOLOG","PF13561(adh_short_C2)",5,"LEU A  91;ILE A 142;ALA A  23;ALA A  34;VAL A  33","None","1.11A","4hfpD-4osoA:undetectable","4hfpD-4osoA:19.66"],["4HFP_D_15UD402_1","4r0i","Homo sapiens","SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;VAL A 213;TRP A 215;GLY A 226","3KM A 900 ( 4.4A);3KM A 900 (-2.9A);None;None;3KM A 900 (-3.2A)","0.36A","4hfpD-4r0iA:36.0","4hfpD-4r0iA:35.11"],["4HFP_D_15UD402_1","4wwy","Homo sapiens","TRYPSIN-1","PF00089(Trypsin)",6,"HIS A  57;LEU A  99;ASP A 189;VAL A 213;TRP A 215;GLY A 226","None","0.62A","4hfpD-4wwyA:33.8","4hfpD-4wwyA:36.05"],["4HFP_D_15UD402_1","4wyr","Clostridium acetobutylicum","ACETYL-COA ACETYLTRANSFERASE","PF00108(Thiolase_N);PF02803(Thiolase_C)",5,"LEU A 389;ALA A 254;ALA A   9;VAL A 359;GLY A 354","None","1.03A","4hfpD-4wyrA:undetectable","4hfpD-4wyrA:20.10"],["4HFP_D_15UD402_1","4ylq","Homo sapiens","COAGULATION FACTOR VII","PF00089(Trypsin)",5,"HIS H  57;ASP H 189;VAL H 213;TRP H 215;GLY H 226","0Z7 H 501 (-2.6A);0Z7 H 501 (-2.3A);0Z7 H 501 ( 4.7A);TMA H 508 ( 3.9A);0Z7 H 501 (-3.0A)","0.26A","4hfpD-4ylqH:34.4","4hfpD-4ylqH:35.36"],["4HFP_D_15UD402_1","5brr","Homo sapiens","TISSUE-TYPE PLASMINOGEN ACTIVATOR","PF00089(Trypsin)",6,"HIS E  57;ASP E 189;ALA E 190;ALA E 195;TRP E 215;GLY E 226","None","0.46A","4hfpD-5brrE:34.9","4hfpD-5brrE:32.74"],["4HFP_D_15UD402_1","5f8z","Homo sapiens","PLASMA KALLIKREIN LIGHT CHAIN","PF00089(Trypsin)",5,"HIS A  57;ASP A 189;ALA A 190;TRP A 215;GLY A 226","None","0.22A","4hfpD-5f8zA:34.6","4hfpD-5f8zA:39.33"],["4HFP_D_15UD402_1","5gl6","Mycolicibacterium smegmatis","RIBOSOME MATURATION FACTOR RIMP","PF02576(DUF150);PF17384(DUF150_C)",5,"LEU A 121;ILE A 153;ALA A 144;VAL A 136;GLY A 126","None","1.16A","4hfpD-5gl6A:undetectable","4hfpD-5gl6A:19.17"],["4HFP_D_15UD402_1","5m60","Chaetomium thermophilum","BETA-1,3-GLUCANASE","PF12708(Pectate_lyase_3)",5,"TYR A 591;LEU A 586;ALA A 643;VAL A 646;GLY A 621","None","0.94A","4hfpD-5m60A:undetectable","4hfpD-5m60A:15.31"],["4HFP_D_15UD402_1","5o32","Homo sapiens","COMPLEMENT FACTOR I","PF00089(Trypsin)",5,"ASP I 519;ALA I 520;VAL I 544;TRP I 546;GLY I 557","None","0.83A","4hfpD-5o32I:31.2","4hfpD-5o32I:32.73"],["4HFP_D_15UD402_1","5oy0","Synechocystis sp. PCC 6803","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","no annotation",5,"LEU b 476;ASP b 272;ALA b 488;TRP b 494;GLY b 259","CLA b1836 (-4.3A);None;CLA b1837 ( 4.1A);CLA b1836 ( 4.1A);CLA b1820 ( 4.0A)","1.14A","4hfpD-5oy0b:undetectable","4hfpD-5oy0b:12.60"],["4HFP_D_15UD402_1","5to3","Homo sapiens","PROTHROMBIN,THROMBOMODULIN","PF00089(Trypsin);PF09064(Tme5_EGF_like)",8,"HIS B  58;TYR B  62;LEU B 111;ILE B 194;ASP B 214;ALA B 215;VAL B 240;GLY B 253","0G6 B 501 (-2.5A);0G6 B 501 (-3.7A);0G6 B 501 ( 3.8A);None;0G6 B 501 (-2.9A);0G6 B 501 (-3.4A);None;0G6 B 501 (-3.6A)","0.40A","4hfpD-5to3B:44.4","4hfpD-5to3B:88.28"],["4HFP_D_15UD402_1","5to3","Homo sapiens","PROTHROMBIN,THROMBOMODULIN","PF00089(Trypsin);PF09064(Tme5_EGF_like)",6,"TYR B  62;LEU B 111;ILE B 194;ALA B 215;GLU B 217;VAL B 240","0G6 B 501 (-3.7A);0G6 B 501 ( 3.8A);None;0G6 B 501 (-3.4A);0G6 B 501 (-3.8A);None","1.37A","4hfpD-5to3B:44.4","4hfpD-5to3B:88.28"],["4HFP_D_15UD402_1","5to3","Homo sapiens","PROTHROMBIN,THROMBOMODULIN","PF00089(Trypsin);PF09064(Tme5_EGF_like)",8,"TYR B  62;TRP B  65;LEU B 111;ILE B 194;ASP B 214;ALA B 215;VAL B 240;GLY B 253","0G6 B 501 (-3.7A);0G6 B 501 (-4.8A);0G6 B 501 ( 3.8A);None;0G6 B 501 (-2.9A);0G6 B 501 (-3.4A);None;0G6 B 501 (-3.6A)","0.52A","4hfpD-5to3B:44.4","4hfpD-5to3B:88.28"],["4HFP_D_15UD402_1","5u63","Haemophilus influenzae","THIOREDOXIN REDUCTASE","PF07992(Pyr_redox_2)",5,"TYR A 192;LEU A 202;ALA A 242;ALA A 162;VAL A 151","None","0.95A","4hfpD-5u63A:undetectable","4hfpD-5u63A:22.22"],["4HFP_D_15UD402_1","5ubm","Homo sapiens","COMPLEMENT C1S SUBCOMPONENT","no annotation",5,"HIS A 475;ASP A 626;VAL A 653;TRP A 655;GLY A 663","None","0.48A","4hfpD-5ubmA:31.7","4hfpD-5ubmA:35.16"],["4HFP_D_15UD402_1","5uff","Petromyzon marinus","RBC36","no annotation",5,"LEU A 170;ILE A 140;ALA A 215;ALA A 201;VAL A 194","None","1.15A","4hfpD-5uffA:undetectable","4hfpD-5uffA:17.92"],["4HFP_D_15UD402_1","5ysm","Amycolatopsis mediterranei","CYTOCHROME P450","no annotation",5,"TRP A 342;GLU A  63;ALA A  65;VAL A  59;GLY A  43","None","1.16A","4hfpD-5ysmA:undetectable","4hfpD-5ysmA:14.23"],["4HFP_D_15UD402_1","6b74","Homo sapiens","COAGULATION FACTOR XII","no annotation",5,"HIS B  57;ASP B 189;ALA B 190;TRP B 215;GLY B 226","SO4 B 304 (-3.8A);BEN B 301 (-2.7A);BEN B 301 (-4.1A);None;BEN B 301 (-3.1A)","0.44A","4hfpD-6b74B:34.3","4hfpD-6b74B:16.87"]]