SIMILAR PATTERNS OF AMINO ACIDS FOR 4HBF_A_DXCA75_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 ILE B1705
LEU B1709
PHE B1870
GLY B1735
 None
 0.91A 4hbfA-1a9xB:
0.0		 4hbfA-1a9xB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 LEU A 255
PHE A 266
MET A 289
GLY A 191
 None
 0.95A 4hbfA-1cjaA:
0.0		 4hbfA-1cjaA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.80A 4hbfA-1j5sA:
0.0		 4hbfA-1j5sA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  99
LEU A 101
PHE A  58
GLY A  57
 None
 1.03A 4hbfA-1jhdA:
0.0		 4hbfA-1jhdA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		4 ILE A 248
LEU A 222
PHE A 179
GLY A 236
 None
 0.84A 4hbfA-1jjfA:
0.0		 4hbfA-1jjfA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ILE A 673
LEU A 582
LYS A 663
GLY A 585
 None
 1.01A 4hbfA-1kb0A:
0.0		 4hbfA-1kb0A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 ILE A  51
LEU A  39
PHE A  34
GLY A 416
 None
 0.89A 4hbfA-1kfwA:
0.0		 4hbfA-1kfwA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		4 ILE A 220
LEU A 223
PHE A 117
GLY A  89
 None
 1.04A 4hbfA-1konA:
0.0		 4hbfA-1konA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ILE A 169
LEU A 119
MET A 105
GLY A  62
 None
 1.06A 4hbfA-1m2wA:
0.0		 4hbfA-1m2wA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 281
LEU A 127
LYS A 117
GLY A 116
 None
 1.03A 4hbfA-1mnsA:
undetectable		 4hbfA-1mnsA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE A 347
LEU A 345
LYS A 333
PHE A 335
 None
None
CL  A 737 (-2.8A)
None
 1.07A 4hbfA-1moxA:
undetectable		 4hbfA-1moxA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ILE A 357
LEU A 268
MET A 418
GLY A 416
 None
 1.04A 4hbfA-1pw4A:
undetectable		 4hbfA-1pw4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 ILE A 244
LEU A 127
MET A 143
GLY A 144
 None
 1.07A 4hbfA-1qgoA:
undetectable		 4hbfA-1qgoA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		4 ILE A  33
LEU A  36
PHE A 111
GLY A 427
 None
 0.94A 4hbfA-1qleA:
undetectable		 4hbfA-1qleA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu4 ORNITHINE
DECARBOXYLASE

(Trypanosoma
brucei) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 212
PHE A 219
MET A 229
GLY A 193
 None
 1.06A 4hbfA-1qu4A:
undetectable		 4hbfA-1qu4A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 ILE B 326
LEU B 329
PHE B 193
GLY B 198
 None
 1.06A 4hbfA-1y8qB:
undetectable		 4hbfA-1y8qB:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE

(Brucella
melitensis) 		PF00682
(HMGL-like) 		4 ILE A 217
LEU A 221
PHE A 262
GLY A 261
 None
 1.07A 4hbfA-1ydnA:
undetectable		 4hbfA-1ydnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 ILE A 516
LEU A 372
PHE A 380
GLY A 512
 None
 1.02A 4hbfA-1yi7A:
undetectable		 4hbfA-1yi7A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmg KIAA1228 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		4 ILE A  37
LEU A 111
LYS A  68
GLY A 101
 None
 0.97A 4hbfA-2dmgA:
undetectable		 4hbfA-2dmgA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		4 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.75A 4hbfA-2fgcA:
undetectable		 4hbfA-2fgcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		4 ILE A  31
LEU A  20
PHE A  66
GLY A  91
 None
 0.84A 4hbfA-2g6tA:
undetectable		 4hbfA-2g6tA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  21
LEU A  22
PHE A 302
GLY A  73
 None
 0.88A 4hbfA-2g76A:
undetectable		 4hbfA-2g76A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE A  13
LEU A  17
PHE A  46
GLY A  68
 None
None
GOL  A 610 (-4.9A)
None
 0.96A 4hbfA-2hr7A:
undetectable		 4hbfA-2hr7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 ILE A  24
LEU A  27
PHE A 239
GLY A   8
 None
 0.98A 4hbfA-2i9eA:
undetectable		 4hbfA-2i9eA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		4 ILE A  56
LEU A 156
LYS A 169
GLY A 168
 None
 1.05A 4hbfA-2j0aA:
undetectable		 4hbfA-2j0aA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		4 ILE A 153
LEU A  69
LYS A 250
GLY A 249
 None
 1.07A 4hbfA-2odfA:
undetectable		 4hbfA-2odfA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ILE A 739
LEU A 735
PHE A 762
GLY A 755
 None
 1.02A 4hbfA-2olsA:
undetectable		 4hbfA-2olsA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Archaeoglobus
fulgidus) 		PF00005
(ABC_tran) 		4 ILE A  72
LEU A  57
MET A   1
GLY A  23
 None
 1.01A 4hbfA-2onkA:
undetectable		 4hbfA-2onkA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 LEU A  65
MET A 360
LYS A  20
GLY A  19
 None
 1.05A 4hbfA-2qs8A:
undetectable		 4hbfA-2qs8A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		4 ILE A 443
PHE A 488
LYS A 455
GLY A 454
 None
 1.06A 4hbfA-2wozA:
undetectable		 4hbfA-2wozA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.10A 4hbfA-2xn6A:
undetectable		 4hbfA-2xn6A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 268
LEU A 272
PHE A 233
MET A 244
 None
 1.02A 4hbfA-2y7jA:
undetectable		 4hbfA-2y7jA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 0.90A 4hbfA-3b0hA:
undetectable		 4hbfA-3b0hA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 320
LEU A 163
LYS A 153
GLY A 152
 None
 0.99A 4hbfA-3bjsA:
undetectable		 4hbfA-3bjsA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 LEU A 163
PHE A 400
LYS A 405
GLY A 404
 None
 1.00A 4hbfA-3cmgA:
undetectable		 4hbfA-3cmgA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF02522
(Antibiotic_NAT) 		4 ILE A 143
LEU A 165
LYS A  28
GLY A  29
 None
 1.01A 4hbfA-3e4fA:
undetectable		 4hbfA-3e4fA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 ILE A 253
LEU A 306
PHE A 295
GLY A  44
 None
 0.96A 4hbfA-3ez1A:
undetectable		 4hbfA-3ez1A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs5 UNCHARACTERIZED
PROTEIN YGR203W

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 ILE A  48
LEU A  17
PHE A  33
GLY A  24
 None
 1.06A 4hbfA-3fs5A:
undetectable		 4hbfA-3fs5A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		4 ILE A 219
LEU A 188
PHE A 247
GLY A 169
 None
 0.84A 4hbfA-3g85A:
undetectable		 4hbfA-3g85A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpk PPIC-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00639
(Rotamase) 		4 ILE A 234
LEU A 238
PHE A 244
GLY A 213
 None
 1.07A 4hbfA-3gpkA:
undetectable		 4hbfA-3gpkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		4 ILE A 296
LEU A 295
LYS A 224
GLY A 223
 None
 1.03A 4hbfA-3lomA:
undetectable		 4hbfA-3lomA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 824
LEU A 827
PHE A 602
GLY A 606
 None
None
A3C  A 911 ( 4.8A)
A3C  A 911 (-3.8A)
 0.91A 4hbfA-3p5pA:
undetectable		 4hbfA-3p5pA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 ILE A 239
LEU A 330
LYS A 235
PHE A 332
 None
 0.93A 4hbfA-3puaA:
undetectable		 4hbfA-3puaA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb8 A654L PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF00583
(Acetyltransf_1) 		4 ILE A 133
LEU A 129
PHE A 157
GLY A 146
 None
 0.92A 4hbfA-3qb8A:
undetectable		 4hbfA-3qb8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2

(Burkholderia
pseudomallei) 		PF00793
(DAHP_synth_1) 		4 ILE A  23
LEU A  26
LYS A  83
PHE A  79
 None
 1.03A 4hbfA-3tmqA:
undetectable		 4hbfA-3tmqA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 LEU A 219
LYS A 211
PHE A 228
GLY A 287
 None
 0.57A 4hbfA-3u4vA:
undetectable		 4hbfA-3u4vA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		4 ILE A 132
LEU A 129
PHE A 143
GLY A 145
 None
 0.91A 4hbfA-3w04A:
undetectable		 4hbfA-3w04A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		4 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 0.95A 4hbfA-3w1hA:
undetectable		 4hbfA-3w1hA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		4 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 2.9A)
None
 1.05A 4hbfA-3w1jA:
undetectable		 4hbfA-3w1jA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2i NADH-CYTOCHROME B5
REDUCTASE 3

(Sus scrofa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A 162
LEU A 193
PHE A 179
GLY A 152
 None
None
None
NAD  A 302 (-3.3A)
 0.85A 4hbfA-3w2iA:
undetectable		 4hbfA-3w2iA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 LEU A 325
PHE A 501
MET A 447
GLY A 373
 None
 0.87A 4hbfA-4av6A:
undetectable		 4hbfA-4av6A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 ILE A 353
LEU A 276
LYS A 385
GLY A 384
 None
 0.90A 4hbfA-4bbwA:
undetectable		 4hbfA-4bbwA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 ILE A 128
LEU A 130
PHE A  95
GLY A  39
 None
 0.79A 4hbfA-4df9A:
undetectable		 4hbfA-4df9A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 ILE A  89
LEU A  56
MET A  34
GLY A 227
 None
 0.89A 4hbfA-4dg8A:
undetectable		 4hbfA-4dg8A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  99
LEU A 101
PHE A  58
GLY A  57
 None
 1.04A 4hbfA-4dnxA:
undetectable		 4hbfA-4dnxA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 AP-1 COMPLEX SUBUNIT
MU-1

(Mus musculus) 		no annotation 4 ILE M 253
LEU M 214
LYS M 199
GLY M 196
 None
 0.76A 4hbfA-4en2M:
undetectable		 4hbfA-4en2M:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 ILE A 219
LEU A 217
PHE A 268
GLY A 270
 None
 0.98A 4hbfA-4f1hA:
undetectable		 4hbfA-4f1hA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 460
LEU A 464
LYS A 413
GLY A 414
 None
 0.97A 4hbfA-4f4cA:
undetectable		 4hbfA-4f4cA:
4.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hc3 PPCA

(Geobacter
sulfurreducens) 		no annotation 7 ILE A   4
LEU A   6
LYS A  37
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.20A 4hbfA-4hc3A:
undetectable		 4hbfA-4hc3A:
98.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 ILE A  34
LEU A  38
LYS A 348
GLY A 347
 None
 0.82A 4hbfA-4hcxA:
undetectable		 4hbfA-4hcxA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA

(Thermotoga
maritima) 		no annotation 4 ILE D1058
PHE D1152
LYS D 999
GLY D1001
 None
 0.97A 4hbfA-4hluD:
undetectable		 4hbfA-4hluD:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 ILE A 330
LEU A 327
PHE A 292
GLY A 321
 None
 0.96A 4hbfA-4jn6A:
undetectable		 4hbfA-4jn6A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.91A 4hbfA-4jypA:
undetectable		 4hbfA-4jypA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laf NAD(P)H
DEHYDROGENASE
(QUINONE)

(Pseudomonas sp.
WBC-3) 		PF03358
(FMN_red) 		4 ILE A 145
LEU A 138
PHE A 134
GLY A  81
 None
 1.05A 4hbfA-4lafA:
undetectable		 4hbfA-4lafA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE

(Trypanosoma
cruzi) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A  41
PHE A  43
MET A 113
LYS A 110
 None
 1.04A 4hbfA-4llrA:
undetectable		 4hbfA-4llrA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 316
LEU A 313
PHE A 152
GLY A 250
 None
 0.85A 4hbfA-4o38A:
undetectable		 4hbfA-4o38A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF01636
(APH) 		4 LEU A 299
LYS A 334
PHE A 338
GLY A 271
 None
None
None
SCN  A 409 ( 4.7A)
 1.06A 4hbfA-4pdyA:
undetectable		 4hbfA-4pdyA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A  77
LEU A 116
PHE A 112
GLY A  73
 None
None
None
GOL  A 413 ( 4.2A)
 1.01A 4hbfA-4q3nA:
undetectable		 4hbfA-4q3nA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ILE A 370
PHE A 408
LYS A 387
GLY A 386
 None
 1.01A 4hbfA-4r16A:
undetectable		 4hbfA-4r16A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ILE A 322
LEU A 345
LYS A 330
GLY A 331
 None
None
3YN  A 503 (-2.9A)
None
 1.06A 4hbfA-4rvhA:
undetectable		 4hbfA-4rvhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ILE A 118
LEU A 110
PHE A 142
GLY A 102
 None
 1.07A 4hbfA-4tnbA:
undetectable		 4hbfA-4tnbA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891

(Streptococcus
agalactiae) 		PF13561
(adh_short_C2) 		4 ILE A 250
LEU A 242
LYS A 171
GLY A 192
 None
 0.81A 4hbfA-4u8gA:
undetectable		 4hbfA-4u8gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ILE A 545
LEU A 520
LYS A 490
GLY A 489
 None
 0.85A 4hbfA-4y9lA:
undetectable		 4hbfA-4y9lA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 ILE A 744
LEU A 717
LYS A 626
GLY A 627
 ILE  A 744 ( 0.7A)
LEU  A 717 ( 0.6A)
LYS  A 626 ( 0.0A)
GLY  A 627 ( 0.0A)
 1.05A 4hbfA-4zkeA:
undetectable		 4hbfA-4zkeA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE E  13
LEU E  17
PHE E  46
GLY E  68
 None
 1.05A 4hbfA-4zxbE:
undetectable		 4hbfA-4zxbE:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		4 ILE A 219
LEU A  43
MET A  38
GLY A  25
 None
 1.06A 4hbfA-5btbA:
undetectable		 4hbfA-5btbA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c93 HISTIDINE KINASE

(Lactobacillus
plantarum) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 ILE A 459
LEU A 607
LYS A 503
MET A 586
 None
None
SO4  A 704 ( 3.8A)
None
 0.97A 4hbfA-5c93A:
undetectable		 4hbfA-5c93A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.88A 4hbfA-5cbkA:
undetectable		 4hbfA-5cbkA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d27 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 361
LEU A 298
LYS A 382
GLY A 276
 None
 0.84A 4hbfA-5d27A:
undetectable		 4hbfA-5d27A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.91A 4hbfA-5dnwA:
undetectable		 4hbfA-5dnwA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6v SUMO-CONJUGATING
ENZYME UBC9

(Homo sapiens) 		PF00179
(UQ_con) 		4 ILE A 116
LEU A 120
PHE A  58
GLY A  56
 None
 1.05A 4hbfA-5f6vA:
undetectable		 4hbfA-5f6vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 361
LEU A 298
LYS A 382
GLY A 276
 None
 0.83A 4hbfA-5fi0A:
undetectable		 4hbfA-5fi0A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 ILE A 294
LEU A 282
PHE A 324
GLY A  75
 None
 1.01A 4hbfA-5gmxA:
undetectable		 4hbfA-5gmxA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 4 LEU A 130
LYS A 438
MET A  55
LYS A  32
 None
 0.99A 4hbfA-5gt5A:
undetectable		 4hbfA-5gt5A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm9 MAMO PROTEASE DOMAIN

(Magnetospirillum
magneticum) 		PF13365
(Trypsin_2) 		4 ILE A 216
LEU A 108
MET A 111
GLY A  65
 None
 0.98A 4hbfA-5hm9A:
undetectable		 4hbfA-5hm9A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 ILE A 825
LEU A 828
PHE A 728
GLY A 730
 None
 1.08A 4hbfA-5hp6A:
undetectable		 4hbfA-5hp6A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S9

(Pyrococcus
abyssi) 		PF00380
(Ribosomal_S9) 		4 ILE K  45
LEU K  49
LYS K  23
GLY K  24
 None
None
G  21097 ( 3.7A)
None
 0.74A 4hbfA-5jb3K:
undetectable		 4hbfA-5jb3K:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy5 THIOREDOXIN

(Cryptococcus
neoformans) 		PF00085
(Thioredoxin) 		4 ILE A  95
LEU A  99
PHE A  52
GLY A  45
 None
 0.97A 4hbfA-5jy5A:
undetectable		 4hbfA-5jy5A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		4 ILE A 176
LEU A 180
PHE A  87
GLY A  31
 None
None
None
STE  A 502 ( 3.9A)
 0.93A 4hbfA-5k53A:
undetectable		 4hbfA-5k53A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE E  13
LEU E  17
PHE E  46
GLY E  68
 None
 1.00A 4hbfA-5kqvE:
undetectable		 4hbfA-5kqvE:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 ILE A 497
LEU A 625
MET A 585
GLY A 584
 None
 0.93A 4hbfA-5ksdA:
undetectable		 4hbfA-5ksdA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 ILE A 486
LEU A 490
PHE A 504
GLY A 555
 None
 0.83A 4hbfA-5me3A:
undetectable		 4hbfA-5me3A:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 ILE A 278
LEU A 275
LYS A 725
GLY A 724
 None
 0.96A 4hbfA-5mz9A:
undetectable		 4hbfA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc7 VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF00004
(AAA) 		4 ILE A 599
LEU A 596
PHE A 627
GLY A 609
 None
 1.04A 4hbfA-5vc7A:
undetectable		 4hbfA-5vc7A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhu FERREDOXIN--NADP
REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ILE A  84
LEU A  86
LYS A  45
GLY A  44
 None
None
FAD  A1000 (-2.8A)
FAD  A1000 (-3.3A)
 0.92A 4hbfA-5xhuA:
undetectable		 4hbfA-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		4 ILE T 107
LEU T 111
LYS T 125
GLY T 126
 None
None
G  21177 ( 4.2A)
G  21306 ( 4.3A)
 0.94A 4hbfA-5xyiT:
undetectable		 4hbfA-5xyiT:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6j NUCLEOPROTEIN

(Tomato spotted
wilt
orthotospovirus) 		PF01533
(Tospo_nucleocap) 		4 ILE A 100
LEU A  96
PHE A  74
GLY A  75
 None
 0.97A 4hbfA-5y6jA:
undetectable		 4hbfA-5y6jA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 ILE A  26
LEU A  39
PHE A  89
GLY A  88
 None
 0.92A 4hbfA-5ze4A:
undetectable		 4hbfA-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bca A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		no annotation 4 ILE A2204
LEU A2227
PHE A2271
MET A2214
 None
 1.03A 4hbfA-6bcaA:
undetectable		 4hbfA-6bcaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 ILE A 244
LEU A 248
PHE A 210
GLY A 275
 None
 0.90A 4hbfA-6frvA:
undetectable		 4hbfA-6frvA:
undetectable