SIMILAR PATTERNS OF AMINO ACIDS FOR 4HB8_A_DXCA75_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 ILE A 239
LEU A 227
LYS A 219
GLY A 399
 None
None
3PG  A 423 ( 2.6A)
None
 0.80A 4hb8A-13pkA:
undetectable		 4hb8A-13pkA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  32
LEU A  52
PHE A  87
LYS A  46
GLY A  47
 None
 1.33A 4hb8A-1airA:
undetectable		 4hb8A-1airA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		5 ILE A 245
LEU A 201
LYS A 221
ILE A 224
GLY A 187
 None
None
SO4  A 283 ( 4.2A)
None
None
 1.30A 4hb8A-1ajzA:
undetectable		 4hb8A-1ajzA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		4 ILE A  52
LEU A  33
ILE A 212
GLY A 140
 None
 0.85A 4hb8A-1azzA:
undetectable		 4hb8A-1azzA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 257
LEU A  51
ILE A 397
GLY A  44
 None
 0.83A 4hb8A-1bdgA:
undetectable		 4hb8A-1bdgA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 ILE A 107
LEU A 126
ILE A 122
GLY A  65
 1BH  A 300 ( 4.9A)
1BH  A 300 (-4.0A)
None
None
 0.79A 4hb8A-1bh6A:
undetectable		 4hb8A-1bh6A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		4 LEU A 367
LYS A  78
ILE A  80
GLY A 350
 None
DFP  A 401 ( 4.2A)
None
DFP  A 401 (-3.3A)
 0.83A 4hb8A-1ci9A:
undetectable		 4hb8A-1ci9A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE B  93
LEU B 434
LYS B  83
GLY B 123
 None
 0.78A 4hb8A-1e9yB:
undetectable		 4hb8A-1e9yB:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ILE A 242
LYS A 220
ILE A 259
MET A 283
GLY A 263
 None
None
None
None
SO4  A 600 (-3.4A)
 1.37A 4hb8A-1eepA:
undetectable		 4hb8A-1eepA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 ILE A 364
LEU A 368
ILE A 163
GLY A 172
 None
 0.60A 4hb8A-1eljA:
undetectable		 4hb8A-1eljA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 ILE A 314
ILE A 385
PHE A 361
GLY A 339
 None
 0.68A 4hb8A-1eyyA:
undetectable		 4hb8A-1eyyA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft9 CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR

(Rhodospirillum
rubrum) 		PF13545
(HTH_Crp_2) 		4 ILE A 139
LEU A 184
ILE A 203
GLY A 199
 None
 0.76A 4hb8A-1ft9A:
undetectable		 4hb8A-1ft9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 ILE B 517
LEU B 491
ILE B 425
GLY B 442
 None
 0.80A 4hb8A-1gh6B:
undetectable		 4hb8A-1gh6B:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1o CYTOCHROME C-552

(Acidithiobacillus
ferrooxidans) 		PF00034
(Cytochrom_C) 		5 ILE A 144
LEU A 180
PHE A 107
MET A 120
GLY A 124
 HEM  A1184 ( 4.4A)
None
None
None
None
 1.44A 4hb8A-1h1oA:
undetectable		 4hb8A-1h1oA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ILE A 426
LEU A 404
ILE A 421
GLY A  73
 None
 0.85A 4hb8A-1h54A:
undetectable		 4hb8A-1h54A:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ILE A 767
LEU A 633
ILE A 676
MET A 673
GLY A 672
 None
 1.48A 4hb8A-1i8qA:
undetectable		 4hb8A-1i8qA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihn HYPOTHETICAL PROTEIN
MTH938

(Methanothermobacter
thermautotrophicus) 		PF04430
(DUF498) 		4 ILE A  73
LEU A  65
ILE A 117
GLY A  37
 None
 0.77A 4hb8A-1ihnA:
undetectable		 4hb8A-1ihnA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A  46
LEU A  49
ILE A 370
GLY A 100
 None
 0.81A 4hb8A-1j3uA:
undetectable		 4hb8A-1j3uA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		4 ILE A 256
ILE A 210
PHE A 212
GLY A 214
 None
None
None
UDP  A 353 (-3.2A)
 0.80A 4hb8A-1jiuA:
undetectable		 4hb8A-1jiuA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 230
LEU A 226
ILE A 125
GLY A 189
 None
 0.80A 4hb8A-1jscA:
undetectable		 4hb8A-1jscA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 ILE A  51
LEU A  39
PHE A  34
GLY A 416
 None
 0.76A 4hb8A-1kfwA:
undetectable		 4hb8A-1kfwA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 288
LEU A  16
LYS A 189
GLY A 168
 None
 0.84A 4hb8A-1kkhA:
undetectable		 4hb8A-1kkhA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr4 PROTEIN TM1056, CUTA

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 ILE A  86
LEU A  75
LYS A  62
ILE A   8
PHE A  61
 None
 1.36A 4hb8A-1kr4A:
undetectable		 4hb8A-1kr4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 ILE A 347
LEU A 345
LYS A 333
ILE A 370
PHE A 335
 None
None
CL  A 737 (-2.8A)
None
None
 1.45A 4hb8A-1moxA:
undetectable		 4hb8A-1moxA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ILE A 230
LEU A 187
ILE A 197
GLY A 442
 None
 0.80A 4hb8A-1mqqA:
undetectable		 4hb8A-1mqqA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5j PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 ILE A  80
LEU A  69
LYS A  56
ILE A   2
PHE A  55
 None
 1.30A 4hb8A-1o5jA:
undetectable		 4hb8A-1o5jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38) 		4 ILE A 117
ILE A 195
PHE A 217
GLY A 215
 None
 0.75A 4hb8A-1o7dA:
undetectable		 4hb8A-1o7dA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		4 ILE A 151
LEU A 129
ILE A 112
GLY A 134
 None
None
None
NAI  A 301 (-3.1A)
 0.80A 4hb8A-1o9bA:
undetectable		 4hb8A-1o9bA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ILE A 352
LEU A 354
PHE A 332
GLY A 422
 None
 0.59A 4hb8A-1q5aA:
undetectable		 4hb8A-1q5aA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 ILE A 130
LEU A 121
ILE A 109
GLY A  33
 None
 0.85A 4hb8A-1q8fA:
undetectable		 4hb8A-1q8fA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 309
LEU A 314
ILE A 116
PHE A 274
GLY A 273
 None
 1.22A 4hb8A-1rblA:
undetectable		 4hb8A-1rblA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 723
LEU A 767
ILE A 351
GLY A 314
 None
 0.84A 4hb8A-1rrhA:
undetectable		 4hb8A-1rrhA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 ILE A 272
LEU A 314
ILE A 360
GLY A 263
 None
 0.81A 4hb8A-1rtkA:
undetectable		 4hb8A-1rtkA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3n HYPOTHETICAL PROTEIN
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		4 ILE A  16
LEU A  13
ILE A  43
PHE A  41
 None
 0.85A 4hb8A-1s3nA:
undetectable		 4hb8A-1s3nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 ILE B 110
LEU B 135
LYS B  12
PHE B 134
MET B  78
 None
 1.38A 4hb8A-1spgB:
undetectable		 4hb8A-1spgB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II

(Sus scrofa) 		PF00431
(CUB) 		4 ILE B  79
LEU B  49
LYS B  91
ILE B  90
 None
 0.82A 4hb8A-1sppB:
undetectable		 4hb8A-1sppB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 ILE C  40
ILE C 127
PHE C 125
GLY C 123
 None
 0.85A 4hb8A-1sr4C:
undetectable		 4hb8A-1sr4C:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 ILE A 197
LEU A 132
ILE A 175
GLY A 146
 None
 0.82A 4hb8A-1suwA:
undetectable		 4hb8A-1suwA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 ILE A  85
LEU A  51
ILE A  57
LYS A  23
GLY A  22
 None
 1.45A 4hb8A-1sxrA:
undetectable		 4hb8A-1sxrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		4 ILE A  87
LEU A  83
ILE A 123
GLY A  74
 None
None
None
SAM  A1501 ( 4.6A)
 0.84A 4hb8A-1tv8A:
undetectable		 4hb8A-1tv8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ILE A  23
LEU A  76
ILE A 278
GLY A  30
 None
None
None
GLU  A1313 ( 4.0A)
 0.78A 4hb8A-1us4A:
undetectable		 4hb8A-1us4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw7 NSP9

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08710
(nsp9) 		4 LEU A  88
ILE A  91
PHE A  90
GLY A 100
 None
 0.84A 4hb8A-1uw7A:
undetectable		 4hb8A-1uw7A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 ILE A 226
LEU A   7
ILE A 182
GLY A  12
 None
 0.84A 4hb8A-1vbjA:
undetectable		 4hb8A-1vbjA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcz RNASE NGR3

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		4 ILE A 147
LEU A 125
ILE A 199
PHE A 201
 None
 0.83A 4hb8A-1vczA:
undetectable		 4hb8A-1vczA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A  18
ILE A  61
PHE A  82
GLY A 301
 None
 0.67A 4hb8A-1vkzA:
undetectable		 4hb8A-1vkzA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		4 ILE A  54
LEU A 340
ILE A 326
GLY A 346
 None
 0.79A 4hb8A-1vtkA:
undetectable		 4hb8A-1vtkA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 245
 None
 1.19A 4hb8A-1w27A:
undetectable		 4hb8A-1w27A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 246
 None
 1.29A 4hb8A-1w27A:
undetectable		 4hb8A-1w27A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 110
LEU A 103
ILE A 117
GLY A 121
 None
 0.84A 4hb8A-1w93A:
undetectable		 4hb8A-1w93A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wym TRANSGELIN-2

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  58
LEU A  61
ILE A  26
GLY A 126
 None
 0.71A 4hb8A-1wymA:
undetectable		 4hb8A-1wymA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 ILE A 189
LEU A 175
ILE A 199
GLY A 157
 None
 0.85A 4hb8A-1xknA:
undetectable		 4hb8A-1xknA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 ILE A 143
LEU A 131
ILE A 162
GLY A  77
 None
 0.83A 4hb8A-1xp3A:
undetectable		 4hb8A-1xp3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 ILE A 264
LEU A 223
LYS A  10
ILE A   9
PHE A 230
 None
 1.31A 4hb8A-1ydoA:
undetectable		 4hb8A-1ydoA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 ILE A 197
LEU A 132
ILE A 175
GLY A 146
 None
 0.79A 4hb8A-1z0uA:
undetectable		 4hb8A-1z0uA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  96
LEU A  92
ILE A 196
MET A 115
 None
 0.77A 4hb8A-1zltA:
undetectable		 4hb8A-1zltA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		4 ILE C 317
LEU C  21
ILE C  41
GLY C 119
 None
 0.85A 4hb8A-2af4C:
undetectable		 4hb8A-2af4C:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 ILE A 261
LYS A 274
ILE A 272
GLY A 292
 None
 0.84A 4hb8A-2apoA:
undetectable		 4hb8A-2apoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		5 ILE A 383
LEU A 385
ILE A 395
PHE A 390
GLY A 414
 None
 1.38A 4hb8A-2bmfA:
undetectable		 4hb8A-2bmfA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE

(Thermotoga
maritima) 		PF00696
(AA_kinase) 		4 LYS A  27
ILE A  26
PHE A  28
GLY A  30
 NLG  A1284 (-3.4A)
None
None
NLG  A1284 (-2.7A)
 0.84A 4hb8A-2btyA:
undetectable		 4hb8A-2btyA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A 916
LEU A1153
ILE A1167
GLY A1126
 None
None
None
EDO  A2187 (-3.5A)
 0.83A 4hb8A-2bzlA:
undetectable		 4hb8A-2bzlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 ILE A 266
LEU A 123
MET A 241
LYS A 237
GLY A 239
 None
 1.35A 4hb8A-2ch6A:
undetectable		 4hb8A-2ch6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxx PROBABLE GTP-BINDING
PROTEIN ENGB

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1) 		4 ILE A 163
LEU A  17
ILE A 126
GLY A   8
 None
 0.85A 4hb8A-2cxxA:
undetectable		 4hb8A-2cxxA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		5 ILE A 270
LEU A 351
ILE A 297
MET A  53
GLY A  49
 None
 1.17A 4hb8A-2cycA:
undetectable		 4hb8A-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 4 ILE B 272
LEU B 248
ILE B 276
GLY B 142
 None
 0.80A 4hb8A-2d4aB:
undetectable		 4hb8A-2d4aB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		4 ILE X 100
LEU X 171
ILE X 139
GLY X 147
 None
 0.84A 4hb8A-2dchX:
undetectable		 4hb8A-2dchX:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		4 LEU A  73
LYS A   5
ILE A   6
PHE A   4
 None
 0.83A 4hb8A-2dd7A:
undetectable		 4hb8A-2dd7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmg KIAA1228 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		4 ILE A  37
LEU A 111
LYS A  68
GLY A 101
 None
 0.74A 4hb8A-2dmgA:
undetectable		 4hb8A-2dmgA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		4 ILE A 300
LEU A 372
ILE A 304
GLY A 326
 None
 0.72A 4hb8A-2dr1A:
undetectable		 4hb8A-2dr1A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 ILE A 999
LEU A1030
ILE A 939
PHE A1037
GLY A 911
 None
 1.20A 4hb8A-2ec5A:
undetectable		 4hb8A-2ec5A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A 267
LEU A 265
ILE A 150
GLY A 160
 None
 0.81A 4hb8A-2f43A:
undetectable		 4hb8A-2f43A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2

(Pseudomonas
syringae) 		PF05721
(PhyH) 		4 ILE A  91
LEU A   7
ILE A  84
PHE A  24
 None
 0.82A 4hb8A-2fctA:
undetectable		 4hb8A-2fctA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		4 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.74A 4hb8A-2fgcA:
undetectable		 4hb8A-2fgcA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1d 30S RIBOSOMAL
PROTEIN S24E

(Thermoplasma
acidophilum) 		PF01282
(Ribosomal_S24e) 		4 LEU A   3
LYS A  70
ILE A  71
GLY A  67
 None
 0.82A 4hb8A-2g1dA:
undetectable		 4hb8A-2g1dA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		4 ILE A  31
LEU A  20
PHE A  66
GLY A  91
 None
 0.80A 4hb8A-2g6tA:
undetectable		 4hb8A-2g6tA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		4 ILE A 100
ILE A 135
LYS A  84
GLY A  85
 None
 0.84A 4hb8A-2h6rA:
undetectable		 4hb8A-2h6rA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 ILE X 152
LEU X 161
LYS X 225
PHE X 210
GLY X 208
 None
 1.02A 4hb8A-2hczX:
undetectable		 4hb8A-2hczX:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ILE B 214
LEU B 292
ILE B 281
GLY B 257
 None
 0.85A 4hb8A-2hdnB:
undetectable		 4hb8A-2hdnB:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx1 PREDICTED SUGAR
PHOSPHATASES OF THE
HAD SUPERFAMILY

(Cytophaga
hutchinsonii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ILE A 161
LEU A 156
ILE A 199
PHE A 198
 None
 0.86A 4hb8A-2hx1A:
undetectable		 4hb8A-2hx1A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 ILE A 314
LEU A 311
ILE A  74
PHE A  24
GLY A  78
 None
None
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.6A)
 1.14A 4hb8A-2i9kA:
undetectable		 4hb8A-2i9kA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jmr FIMF

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 ILE A 170
ILE A 104
MET A 133
GLY A  93
 None
 0.72A 4hb8A-2jmrA:
undetectable		 4hb8A-2jmrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		4 ILE A  47
LEU A   5
ILE A  82
GLY A  51
 None
 0.83A 4hb8A-2lxnA:
undetectable		 4hb8A-2lxnA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqm PROTEIN HNRNPL

(Rattus
norvegicus) 		PF00076
(RRM_1) 		4 ILE A 253
LEU A 260
ILE A 223
PHE A 194
 None
 0.82A 4hb8A-2mqmA:
undetectable		 4hb8A-2mqmA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o74 OHCU DECARBOXYLASE

(Danio rerio) 		PF09349
(OHCU_decarbox) 		4 ILE A  63
LEU A  55
ILE A  48
PHE A  51
 None
 0.82A 4hb8A-2o74A:
undetectable		 4hb8A-2o74A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 405
LEU A 399
ILE A 352
GLY A 444
 None
 0.83A 4hb8A-2oajA:
undetectable		 4hb8A-2oajA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		5 ILE A 153
LEU A  69
ILE A 169
LYS A 250
GLY A 249
 None
 1.26A 4hb8A-2odfA:
undetectable		 4hb8A-2odfA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohd PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Sulfurisphaera
tokodaii) 		PF01967
(MoaC) 		4 ILE A 138
LEU A 112
ILE A  89
GLY A  85
 None
 0.85A 4hb8A-2ohdA:
undetectable		 4hb8A-2ohdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ILE A 253
ILE A 292
PHE A 290
GLY A 548
 None
 0.82A 4hb8A-2olsA:
undetectable		 4hb8A-2olsA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  14
LEU A 325
ILE A  34
GLY A 300
 None
 0.68A 4hb8A-2ovlA:
undetectable		 4hb8A-2ovlA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 514
LEU A 511
ILE A 593
GLY A 626
 None
 0.83A 4hb8A-2p6rA:
undetectable		 4hb8A-2p6rA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peg HEMOGLOBIN SUBUNIT
BETA

(Trematomus
bernacchii) 		PF00042
(Globin) 		5 ILE B 110
LEU B 134
PHE B 133
MET B  78
GLY B  74
 None
 1.38A 4hb8A-2pegB:
undetectable		 4hb8A-2pegB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		5 ILE A 234
LEU A 201
ILE A 217
PHE A 188
GLY A 208
 None
 1.34A 4hb8A-2pfkA:
undetectable		 4hb8A-2pfkA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 ILE A 226
LEU A  38
LYS A 234
ILE A 233
 None
 0.71A 4hb8A-2ph1A:
undetectable		 4hb8A-2ph1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		4 ILE A  10
LEU A  80
ILE A  96
PHE A  94
 None
 0.69A 4hb8A-2pjqA:
undetectable		 4hb8A-2pjqA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ILE X 143
LYS X 187
ILE X 178
GLY X 184
 None
 0.83A 4hb8A-2pmoX:
undetectable		 4hb8A-2pmoX:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qck FLAVIN REDUCTASE
DOMAIN PROTEIN

(Arthrobacter
sp. FB24) 		PF01613
(Flavin_Reduct) 		4 ILE A  25
LEU A  84
ILE A 109
GLY A  97
 None
 0.77A 4hb8A-2qckA:
undetectable		 4hb8A-2qckA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 ILE A 160
LEU A 185
ILE A 268
PHE A 233
GLY A 231
 None
 1.25A 4hb8A-2qe6A:
undetectable		 4hb8A-2qe6A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgg 16S RRNA-PROCESSING
PROTEIN RIMM

(Acinetobacter
calcoaceticus) 		PF01782
(RimM)
PF05239
(PRC) 		4 ILE A  47
LEU A  17
LYS A  59
GLY A  25
 None
 0.73A 4hb8A-2qggA:
undetectable		 4hb8A-2qggA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh9 UPF0215 PROTEIN
AF_1433

(Archaeoglobus
fulgidus) 		PF01949
(DUF99) 		4 ILE A  80
LEU A  67
LYS A  48
ILE A  50
 None
 0.84A 4hb8A-2qh9A:
undetectable		 4hb8A-2qh9A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 ILE A 402
LEU A 444
PHE A 348
GLY A 106
 None
None
None
CL  A   1 ( 3.8A)
 0.82A 4hb8A-2r9hA:
undetectable		 4hb8A-2r9hA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A 168
LEU A 317
ILE A 151
GLY A 161
 None
 0.82A 4hb8A-2r9vA:
undetectable		 4hb8A-2r9vA:
9.47