SIMILAR PATTERNS OF AMINO ACIDS FOR 4HB6_A_DXCA75

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 ILE A 239
LEU A 227
LYS A 219
GLY A 399
 None
None
3PG  A 423 ( 2.6A)
None
 0.89A 4hb6A-13pkA:
undetectable		 4hb6A-13pkA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		4 ILE A   9
LEU A   8
ILE A  34
GLY A  28
 None
 0.83A 4hb6A-1a9nA:
undetectable		 4hb6A-1a9nA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 257
LEU A 261
ILE A 306
GLY A 178
 None
 0.86A 4hb6A-1cliA:
undetectable		 4hb6A-1cliA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqi PROTEIN
(SUCCINYL-COA
SYNTHETASE BETA
CHAIN)

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 ILE B 180
LEU B 184
PHE B  12
GLY B 214
 None
 0.85A 4hb6A-1cqiB:
undetectable		 4hb6A-1cqiB:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 ILE A 364
LEU A 368
ILE A 163
GLY A 172
 None
 0.74A 4hb6A-1eljA:
undetectable		 4hb6A-1eljA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 ILE A 314
ILE A 385
PHE A 361
GLY A 339
 None
 0.84A 4hb6A-1eyyA:
undetectable		 4hb6A-1eyyA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 103
LEU A 105
ILE A 129
GLY A 380
 None
 0.84A 4hb6A-1fnoA:
undetectable		 4hb6A-1fnoA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 ILE A 304
LEU A 262
PHE A 217
GLY A 297
 None
 0.83A 4hb6A-1fp9A:
undetectable		 4hb6A-1fp9A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		4 ILE A 221
LEU A 223
PHE A 194
GLY A 196
 None
 0.85A 4hb6A-1g0vA:
undetectable		 4hb6A-1g0vA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ILE A 426
LEU A 404
ILE A 421
GLY A  73
 None
 0.89A 4hb6A-1h54A:
undetectable		 4hb6A-1h54A:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		4 ILE A 184
LEU A 188
ILE A 144
GLY A  10
 None
 0.88A 4hb6A-1hyqA:
undetectable		 4hb6A-1hyqA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 LEU A 331
ILE A 250
MET A 431
GLY A 334
 None
 0.85A 4hb6A-1itxA:
undetectable		 4hb6A-1itxA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		4 ILE A  22
LEU A   5
ILE A 191
GLY A 160
 None
 0.85A 4hb6A-1iu8A:
undetectable		 4hb6A-1iu8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 LEU A 279
ILE A 289
PHE A 291
GLY A 296
 None
 0.86A 4hb6A-1j1wA:
undetectable		 4hb6A-1j1wA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		4 ILE H  58
LEU H  55
ILE H  79
GLY H 117
 None
 0.88A 4hb6A-1j2qH:
undetectable		 4hb6A-1j2qH:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A  46
LEU A  49
ILE A 370
GLY A 100
 None
 0.85A 4hb6A-1j3uA:
undetectable		 4hb6A-1j3uA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 LEU A 289
PHE A 327
LYS A 278
GLY A 277
 None
 0.78A 4hb6A-1j5sA:
undetectable		 4hb6A-1j5sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		4 ILE A 256
ILE A 210
PHE A 212
GLY A 214
 None
None
None
UDP  A 353 (-3.2A)
 0.90A 4hb6A-1jiuA:
undetectable		 4hb6A-1jiuA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 ILE A  58
LEU A  54
ILE A  80
GLY A 215
 None
 0.88A 4hb6A-1k1xA:
undetectable		 4hb6A-1k1xA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 178
LEU A 180
MET A  98
GLY A  64
 None
 0.81A 4hb6A-1kfiA:
undetectable		 4hb6A-1kfiA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 ILE A  51
LEU A  39
PHE A  34
GLY A 416
 None
 0.86A 4hb6A-1kfwA:
undetectable		 4hb6A-1kfwA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5j PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 ILE A  80
LEU A  69
LYS A  56
ILE A   2
PHE A  55
 None
 1.45A 4hb6A-1o5jA:
undetectable		 4hb6A-1o5jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38) 		4 ILE A 117
ILE A 195
PHE A 217
GLY A 215
 None
 0.83A 4hb6A-1o7dA:
undetectable		 4hb6A-1o7dA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ILE A 352
LEU A 354
PHE A 332
GLY A 422
 None
 0.52A 4hb6A-1q5aA:
undetectable		 4hb6A-1q5aA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		4 ILE A  49
LEU A  53
ILE A 146
GLY A 136
 None
 0.89A 4hb6A-1r4vA:
undetectable		 4hb6A-1r4vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		4 ILE A 216
LEU A 301
ILE A 347
GLY A 338
 None
 0.89A 4hb6A-1r55A:
undetectable		 4hb6A-1r55A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 ILE P 131
LEU P 197
ILE P 225
GLY P 190
 None
 0.88A 4hb6A-1r6zP:
undetectable		 4hb6A-1r6zP:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 309
LEU A 314
ILE A 116
PHE A 274
GLY A 273
 None
 1.19A 4hb6A-1rblA:
undetectable		 4hb6A-1rblA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 ILE B 110
LEU B 135
LYS B  12
PHE B 134
MET B  78
 None
 1.48A 4hb6A-1spgB:
undetectable		 4hb6A-1spgB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		4 ILE B 296
LEU B   3
ILE B 234
GLY B 267
 None
 0.89A 4hb6A-1ta3B:
undetectable		 4hb6A-1ta3B:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		4 ILE A  87
LEU A  83
ILE A 123
GLY A  74
 None
None
None
SAM  A1501 ( 4.6A)
 0.76A 4hb6A-1tv8A:
undetectable		 4hb6A-1tv8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 ILE A 140
ILE A  89
PHE A 117
GLY A 115
 None
 0.86A 4hb6A-1v6mA:
undetectable		 4hb6A-1v6mA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhz ADP COMPOUNDS
HYDROLASE NUDE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 ILE A  55
LEU A  60
ILE A  52
PHE A  77
 None
 0.89A 4hb6A-1vhzA:
undetectable		 4hb6A-1vhzA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A  18
ILE A  61
PHE A  82
GLY A 301
 None
 0.81A 4hb6A-1vkzA:
undetectable		 4hb6A-1vkzA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wub CONSERVED
HYPOTHETICAL PROTEIN
TT1927B

(Thermus
thermophilus) 		PF04264
(YceI) 		4 ILE A  80
LEU A  28
ILE A 137
PHE A  14
 None
None
None
OTP  A1001 (-4.2A)
 0.89A 4hb6A-1wubA:
undetectable		 4hb6A-1wubA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wym TRANSGELIN-2

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  58
LEU A  61
ILE A  26
GLY A 126
 None
 0.88A 4hb6A-1wymA:
undetectable		 4hb6A-1wymA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 ILE A 264
LEU A 223
LYS A  10
ILE A   9
PHE A 230
 None
 1.37A 4hb6A-1ydoA:
undetectable		 4hb6A-1ydoA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 ILE A  59
LEU A  63
ILE A 104
GLY A 232
 None
 0.81A 4hb6A-1ygpA:
undetectable		 4hb6A-1ygpA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 ILE A  59
LEU A  99
ILE A 104
GLY A 113
 None
 0.90A 4hb6A-1ygpA:
undetectable		 4hb6A-1ygpA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 124
LEU A 150
ILE A 128
GLY A 106
 None
 0.87A 4hb6A-1z1eA:
undetectable		 4hb6A-1z1eA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		4 ILE A 236
LEU A 240
PHE A 156
GLY A 110
 None
 0.81A 4hb6A-1zchA:
undetectable		 4hb6A-1zchA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  96
LEU A  92
ILE A 196
MET A 115
 None
 0.66A 4hb6A-1zltA:
undetectable		 4hb6A-1zltA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		4 ILE A 625
LEU A 683
ILE A 500
GLY A 630
 None
 0.85A 4hb6A-1zvdA:
undetectable		 4hb6A-1zvdA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A 157
LEU A 161
ILE A 211
GLY A 169
 None
 0.81A 4hb6A-1zybA:
undetectable		 4hb6A-1zybA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 ILE A  86
LEU A  48
ILE A 115
GLY A  45
 None
 0.88A 4hb6A-2a9vA:
undetectable		 4hb6A-2a9vA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 0.85A 4hb6A-2akjA:
undetectable		 4hb6A-2akjA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		4 ILE A  13
LEU A  19
ILE A  77
GLY A  51
 None
 0.88A 4hb6A-2akoA:
undetectable		 4hb6A-2akoA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 ILE A 261
LYS A 274
ILE A 272
GLY A 292
 None
 0.89A 4hb6A-2apoA:
undetectable		 4hb6A-2apoA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		5 ILE A 383
LEU A 385
ILE A 395
PHE A 390
GLY A 414
 None
 1.40A 4hb6A-2bmfA:
undetectable		 4hb6A-2bmfA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE

(Thermotoga
maritima) 		PF00696
(AA_kinase) 		4 LYS A  27
ILE A  26
PHE A  28
GLY A  30
 NLG  A1284 (-3.4A)
None
None
NLG  A1284 (-2.7A)
 0.86A 4hb6A-2btyA:
undetectable		 4hb6A-2btyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN

(Mus musculus) 		PF04564
(U-box)
PF12895
(ANAPC3) 		4 LEU A 276
LYS A 235
ILE A 236
GLY A 250
 None
 0.85A 4hb6A-2c2lA:
undetectable		 4hb6A-2c2lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 ILE A 266
LEU A 123
MET A 241
LYS A 237
GLY A 239
 None
 1.49A 4hb6A-2ch6A:
undetectable		 4hb6A-2ch6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 ILE A 270
LEU A 351
MET A  53
GLY A  49
 None
 0.89A 4hb6A-2cycA:
undetectable		 4hb6A-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		4 LEU A  73
LYS A   5
ILE A   6
PHE A   4
 None
 0.86A 4hb6A-2dd7A:
undetectable		 4hb6A-2dd7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		4 ILE A 449
LEU A 451
ILE A 486
GLY A 370
 None
None
GOL  A 602 ( 4.8A)
None
 0.81A 4hb6A-2e0pA:
undetectable		 4hb6A-2e0pA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 ILE A 999
LEU A1030
ILE A 939
PHE A1037
GLY A 911
 None
 1.21A 4hb6A-2ec5A:
undetectable		 4hb6A-2ec5A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A 267
LEU A 265
ILE A 150
GLY A 160
 None
 0.90A 4hb6A-2f43A:
undetectable		 4hb6A-2f43A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2

(Pseudomonas
syringae) 		PF05721
(PhyH) 		4 ILE A  91
LEU A   7
ILE A  84
PHE A  24
 None
 0.85A 4hb6A-2fctA:
undetectable		 4hb6A-2fctA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		4 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.76A 4hb6A-2fgcA:
undetectable		 4hb6A-2fgcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanopyrus
kandleri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ILE A  25
ILE A  77
PHE A 158
LYS A 123
GLY A 121
 None
None
None
MFN  A 600 (-4.0A)
None
 1.41A 4hb6A-2fhkA:
undetectable		 4hb6A-2fhkA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fim TUBBY RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		4 LEU A 256
ILE A 477
PHE A 475
GLY A 286
 None
 0.86A 4hb6A-2fimA:
undetectable		 4hb6A-2fimA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		4 ILE A 277
LEU A 334
ILE A 462
GLY A 353
 None
 0.83A 4hb6A-2fv5A:
undetectable		 4hb6A-2fv5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvg ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 ILE A  89
LEU A  90
LYS A 163
PHE A 149
GLY A  65
 None
None
None
EDO  A 341 (-4.7A)
None
 1.45A 4hb6A-2fvgA:
undetectable		 4hb6A-2fvgA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1d 30S RIBOSOMAL
PROTEIN S24E

(Thermoplasma
acidophilum) 		PF01282
(Ribosomal_S24e) 		4 LEU A   3
LYS A  70
ILE A  71
GLY A  67
 None
 0.80A 4hb6A-2g1dA:
undetectable		 4hb6A-2g1dA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		4 ILE A  31
LEU A  20
PHE A  66
GLY A  91
 None
 0.82A 4hb6A-2g6tA:
undetectable		 4hb6A-2g6tA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  21
LEU A  22
PHE A 302
GLY A  73
 None
 0.89A 4hb6A-2g76A:
undetectable		 4hb6A-2g76A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		4 ILE A  58
LEU A  30
ILE A  66
LYS A  12
 None
 0.89A 4hb6A-2gcuA:
undetectable		 4hb6A-2gcuA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6

(Homo sapiens) 		PF00025
(Arf) 		4 LEU A 126
ILE A  94
PHE A 128
GLY A 169
 None
 0.82A 4hb6A-2h57A:
undetectable		 4hb6A-2h57A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		4 ILE A 100
ILE A 135
LYS A  84
GLY A  85
 None
 0.82A 4hb6A-2h6rA:
undetectable		 4hb6A-2h6rA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 ILE A 167
LEU A  68
ILE A  29
LYS A  90
GLY A  91
 None
 1.45A 4hb6A-2i7tA:
undetectable		 4hb6A-2i7tA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 ILE A 333
LEU A 329
ILE A  66
GLY A 368
 None
 0.74A 4hb6A-2i9uA:
undetectable		 4hb6A-2i9uA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ift PUTATIVE METHYLASE
HI0767

(Haemophilus
influenzae) 		PF03602
(Cons_hypoth95) 		4 LEU A  96
ILE A 109
PHE A  81
GLY A  68
 None
 0.85A 4hb6A-2iftA:
undetectable		 4hb6A-2iftA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		4 ILE A  46
LEU A  53
PHE A  74
GLY A  82
 None
 0.90A 4hb6A-2igwA:
undetectable		 4hb6A-2igwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4e INOSINE TRIPHOSPHATE
PYROPHOSPHATASE

(Homo sapiens) 		PF01725
(Ham1p_like) 		4 ILE A 140
LEU A 104
ILE A  88
GLY A  81
 None
None
ITT  A1001 ( 4.8A)
None
 0.79A 4hb6A-2j4eA:
undetectable		 4hb6A-2j4eA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 ILE A 386
ILE A 311
PHE A 409
GLY A 391
 None
 0.79A 4hb6A-2j6lA:
undetectable		 4hb6A-2j6lA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jmr FIMF

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 ILE A 170
ILE A 104
MET A 133
GLY A  93
 None
 0.89A 4hb6A-2jmrA:
undetectable		 4hb6A-2jmrA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2joi HYPOTHETICAL PROTEIN
TA0095

(Thermoplasma
acidophilum) 		no annotation 4 ILE A  69
LEU A 103
ILE A  64
GLY A  47
 None
 0.89A 4hb6A-2joiA:
undetectable		 4hb6A-2joiA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2juo GA-BINDING PROTEIN
ALPHA CHAIN

(Mus musculus) 		PF11620
(GABP-alpha) 		4 ILE A 113
LEU A  94
ILE A  73
GLY A  49
 None
 0.86A 4hb6A-2juoA:
undetectable		 4hb6A-2juoA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 ILE A 125
LYS A 307
PHE A 306
GLY A 116
 None
 0.84A 4hb6A-2nrjA:
undetectable		 4hb6A-2nrjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o74 OHCU DECARBOXYLASE

(Danio rerio) 		PF09349
(OHCU_decarbox) 		4 ILE A  63
LEU A  55
ILE A  48
PHE A  51
 None
 0.78A 4hb6A-2o74A:
undetectable		 4hb6A-2o74A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 405
LEU A 399
ILE A 352
GLY A 444
 None
 0.85A 4hb6A-2oajA:
undetectable		 4hb6A-2oajA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 408
LEU A 351
ILE A 411
GLY A 444
 None
 0.89A 4hb6A-2oajA:
undetectable		 4hb6A-2oajA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		5 ILE A 153
LEU A  69
ILE A 169
LYS A 250
GLY A 249
 None
 1.50A 4hb6A-2odfA:
undetectable		 4hb6A-2odfA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ILE A 253
ILE A 292
PHE A 290
GLY A 548
 None
 0.79A 4hb6A-2olsA:
undetectable		 4hb6A-2olsA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		4 ILE A 219
LEU A 222
ILE A 149
GLY A 202
 None
 0.87A 4hb6A-2p4zA:
undetectable		 4hb6A-2p4zA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 514
LEU A 511
ILE A 593
GLY A 626
 None
 0.82A 4hb6A-2p6rA:
undetectable		 4hb6A-2p6rA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		4 ILE A  10
LEU A  80
ILE A  96
PHE A  94
 None
 0.82A 4hb6A-2pjqA:
undetectable		 4hb6A-2pjqA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkp HOMOACONITASE SMALL
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00694
(Aconitase_C) 		4 ILE A  79
LEU A 100
ILE A  83
GLY A  62
 None
 0.81A 4hb6A-2pkpA:
undetectable		 4hb6A-2pkpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 ILE A   3
LEU A  17
MET A  98
LYS A  96
 None
 0.86A 4hb6A-2q42A:
undetectable		 4hb6A-2q42A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgg 16S RRNA-PROCESSING
PROTEIN RIMM

(Acinetobacter
calcoaceticus) 		PF01782
(RimM)
PF05239
(PRC) 		4 ILE A  47
LEU A  17
LYS A  59
GLY A  25
 None
 0.89A 4hb6A-2qggA:
undetectable		 4hb6A-2qggA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 LEU A 519
ILE A 572
PHE A 573
GLY A 494
 None
 0.85A 4hb6A-2qq8A:
undetectable		 4hb6A-2qq8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6

(Homo sapiens) 		PF00071
(Ras) 		4 ILE B 155
LEU B 122
LYS B 106
GLY B  20
 None
 0.84A 4hb6A-2rexB:
undetectable		 4hb6A-2rexB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 295
LEU A 136
ILE A   5
GLY A  11
 None
 0.75A 4hb6A-2rgwA:
undetectable		 4hb6A-2rgwA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ILE G1053
LYS G1064
ILE G 807
GLY G 826
 None
 0.86A 4hb6A-2uv8G:
undetectable		 4hb6A-2uv8G:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ILE A 397
LEU A 409
ILE A 350
GLY A 381
 None
 0.90A 4hb6A-2v0jA:
undetectable		 4hb6A-2v0jA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep) 		4 ILE A 105
LEU A 117
LYS A 149
GLY A 130
 None
 0.89A 4hb6A-2vheA:
undetectable		 4hb6A-2vheA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ILE M 532
LEU M 525
LYS M 567
GLY M 560
 None
 0.86A 4hb6A-2w4gM:
undetectable		 4hb6A-2w4gM:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjz IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Thermotoga
maritima) 		PF00117
(GATase) 		4 ILE B  48
LEU B  46
ILE B  67
PHE B  69
 None
 0.84A 4hb6A-2wjzB:
undetectable		 4hb6A-2wjzB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ILE A 118
LYS A 145
ILE A 146
GLY A  89
 None
 0.88A 4hb6A-2wnxA:
undetectable		 4hb6A-2wnxA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		4 ILE A  45
LEU A  47
ILE A 135
GLY A 106
 None
None
OTP  A1174 (-4.8A)
None
 0.86A 4hb6A-2x32A:
undetectable		 4hb6A-2x32A:
9.84