SIMILAR PATTERNS OF AMINO ACIDS FOR 4GRK_A_KTRA713_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ad0 | ANTIBODY A5B7 (HEAVYCHAIN) (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | THR B 82GLY B 16VAL B 12PRO B 14 | None | 0.84A | 4grkA-1ad0B:undetectable | 4grkA-1ad0B:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bfo | CAMPATH-1G ANTIBODY (Rattus rattus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR B 87GLY B 16VAL B 12PRO B 14 | None | 0.81A | 4grkA-1bfoB:undetectable | 4grkA-1bfoB:20.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1biy | LACTOFERRIN (Bubalus bubalis) |
PF00405(Transferrin) | 5 | THR A 430GLY A 432VAL A 591PRO A 593TYR A 660 | None | 0.37A | 4grkA-1biyA:55.3 | 4grkA-1biyA:91.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cfz | HYDROGENASE 2MATURATION PROTEASE (Escherichiacoli) |
PF01750(HycI) | 4 | THR A 133GLY A 72VAL A 119PRO A 121 | None | 1.08A | 4grkA-1cfzA:0.6 | 4grkA-1cfzA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fl5 | ANTIBODY GERMLINEPRECURSOR TOANTIBODY 28B4 (Homo sapiens) |
no annotation | 4 | THR H 822GLY H 16VAL H 12PRO H 14 | None | 0.90A | 4grkA-1fl5H:0.0 | 4grkA-1fl5H:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jgu | ANTIBODY HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR H 82GLY H 16VAL H 12PRO H 14 | None | 0.95A | 4grkA-1jguH:undetectable | 4grkA-1jguH:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jhd | SULFATEADENYLYLTRANSFERASE (Sulfur-oxidizingendosymbiont ofRiftiapachyptila) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 4 | THR A 179GLY A 50PRO A 12TYR A 16 | None | 1.05A | 4grkA-1jhdA:0.0 | 4grkA-1jhdA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwg | BETA-GALACTOSIDASE (Thermusthermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | GLY A 486VAL A 464PRO A 462TYR A 412 | None | 0.97A | 4grkA-1kwgA:0.0 | 4grkA-1kwgA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mam | IGG2B-KAPPA YST9.1FAB (HEAVY CHAIN) (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR H 87GLY H 16VAL H 12PRO H 14 | None | 0.85A | 4grkA-1mamH:undetectable | 4grkA-1mamH:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n94 | PROTEINFARNESYLTRANSFERASEBETA SUBUNIT (Rattusnorvegicus) |
PF00432(Prenyltrans) | 4 | THR B 153GLY B 141PRO B 148TYR B 180 | None | 0.86A | 4grkA-1n94B:undetectable | 4grkA-1n94B:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n9b | BETA-LACTAMASE SHV-2 (Klebsiellapneumoniae) |
PF13354(Beta-lactamase2) | 4 | THR A 149GLY A 147VAL A 142PRO A 145 | None | 1.18A | 4grkA-1n9bA:undetectable | 4grkA-1n9bA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocx | MALTOSEO-ACETYLTRANSFERASE (Escherichiacoli) |
PF12464(Mac)PF14602(Hexapep_2) | 4 | THR A 149GLY A 151VAL A 154PRO A 167 | None | 1.17A | 4grkA-1ocxA:undetectable | 4grkA-1ocxA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pv5 | HYPOTHETICAL PROTEINYWQG (Bacillussubtilis) |
PF09234(DUF1963) | 4 | THR A 168VAL A 153PRO A 155TYR A 183 | None | 1.08A | 4grkA-1pv5A:undetectable | 4grkA-1pv5A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qsa | PROTEIN (SOLUBLELYTICTRANSGLYCOSYLASESLT70) (Escherichiacoli) |
PF01464(SLT)PF14718(SLT_L) | 4 | GLY A 493VAL A 485PRO A 483TYR A 453 | None | 1.16A | 4grkA-1qsaA:undetectable | 4grkA-1qsaA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rvk | ISOMERASE/LACTONIZING ENZYME (Agrobacteriumfabrum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | THR A 172VAL A 177PRO A 181TYR A 211 | None | 1.14A | 4grkA-1rvkA:undetectable | 4grkA-1rvkA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkc | HB8 TT1367 PROTEIN (Thermusthermophilus) |
PF01812(5-FTHF_cyc-lig) | 4 | GLY A 140VAL A 142PRO A 109TYR A 127 | NoneNoneNoneSO4 A 200 (-4.9A) | 1.04A | 4grkA-1wkcA:undetectable | 4grkA-1wkcA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woi | AGMATINASE (Deinococcusradiodurans) |
PF00491(Arginase) | 4 | THR A 178GLY A 180VAL A 207PRO A 203 | None | 1.16A | 4grkA-1woiA:undetectable | 4grkA-1woiA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wue | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | THR A1106GLY A1269VAL A1267PRO A1265 | None | 1.14A | 4grkA-1wueA:undetectable | 4grkA-1wueA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wvh | TENSIN (Gallus gallus) |
PF08416(PTB) | 4 | THR A1656GLY A1654VAL A1675PRO A1671 | None | 1.15A | 4grkA-1wvhA:undetectable | 4grkA-1wvhA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wz1 | IG HEAVY CHAIN (Mus musculus) |
PF07686(V-set) | 4 | THR H 87GLY H 16VAL H 12PRO H 14 | None | 0.89A | 4grkA-1wz1H:undetectable | 4grkA-1wz1H:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z0v | PUTATIVE PROTEASE LAHOMOLOG TYPE (Archaeoglobusfulgidus) |
PF05362(Lon_C) | 4 | GLY A 431VAL A 429PRO A 444TYR A 502 | None | 1.11A | 4grkA-1z0vA:undetectable | 4grkA-1z0vA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z1n | SIXTEEN HEMECYTOCHROME (Desulfovibriogigas) |
PF02085(Cytochrom_CIII)PF14522(Cytochrome_C7) | 4 | THR X 120GLY X 116VAL X 114PRO X 11 | None | 1.05A | 4grkA-1z1nX:undetectable | 4grkA-1z1nX:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cjl | SECRETED CHITINASE (Streptomycescoelicolor) |
PF00182(Glyco_hydro_19) | 4 | THR A 144GLY A 106VAL A 75TYR A 116 | None | 1.16A | 4grkA-2cjlA:undetectable | 4grkA-2cjlA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4e | 5-CARBOXYMETHYL-2-HYDROXYMUCONATESEMIALDEHYDEDEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 4 | THR A 246GLY A 167VAL A 242TYR A 495 | None | 1.08A | 4grkA-2d4eA:1.3 | 4grkA-2d4eA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzk | TRAP-T FAMILYSORBITOL/MANNITOLTRANSPORTER,PERIPLASMIC BINDINGPROTEIN, SMOM (Rhodobactersphaeroides) |
PF03480(DctP) | 4 | GLY A 150VAL A 245PRO A 149TYR A 128 | None | 1.12A | 4grkA-2hzkA:4.9 | 4grkA-2hzkA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzk | TRAP-T FAMILYSORBITOL/MANNITOLTRANSPORTER,PERIPLASMIC BINDINGPROTEIN, SMOM (Rhodobactersphaeroides) |
PF03480(DctP) | 4 | GLY A 151VAL A 245PRO A 149TYR A 128 | None | 1.15A | 4grkA-2hzkA:4.9 | 4grkA-2hzkA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inr | DNA TOPOISOMERASE 4SUBUNIT A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV) | 4 | THR A 169GLY A 167PRO A 180TYR A 326 | None | 1.08A | 4grkA-2inrA:undetectable | 4grkA-2inrA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iya | OLEANDOMYCINGLYCOSYLTRANSFERASE (Streptomycesantibioticus) |
PF00201(UDPGT) | 4 | GLY A 408VAL A 235PRO A 237TYR A 239 | None | 1.08A | 4grkA-2iyaA:undetectable | 4grkA-2iyaA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ot3 | RAS-RELATED PROTEINRAB-21 (Homo sapiens) |
PF00071(Ras) | 4 | THR B 75GLY B 26VAL B 98TYR B 89 | None | 1.12A | 4grkA-2ot3B:undetectable | 4grkA-2ot3B:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4o | HYPOTHETICAL PROTEIN (Nostocpunctiforme) |
no annotation | 4 | THR A 275GLY A 277VAL A 287PRO A 289 | None | 1.18A | 4grkA-2p4oA:undetectable | 4grkA-2p4oA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pxj | JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATIONPROTEIN 3A (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN) | 4 | GLY A 216VAL A 211PRO A 213TYR A 299 | None | 1.08A | 4grkA-2pxjA:undetectable | 4grkA-2pxjA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uud | NQ10-1.12 ANTI-PHOXANTIBODY (Mus musculus) |
PF07686(V-set) | 4 | THR H 82GLY H 16VAL H 12PRO H 14 | None | 1.17A | 4grkA-2uudH:undetectable | 4grkA-2uudH:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vc2 | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF13517(VCBS) | 4 | THR A 176GLY A 179VAL A 200PRO A 199 | None | 1.17A | 4grkA-2vc2A:undetectable | 4grkA-2vc2A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vkp | BTB/POZDOMAIN-CONTAININGPROTEIN 6 (Homo sapiens) |
PF00651(BTB) | 4 | THR A 20GLY A 15VAL A 57PRO A 55 | None | 1.11A | 4grkA-2vkpA:undetectable | 4grkA-2vkpA:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w35 | ENDONUCLEASE V (Thermotogamaritima) |
PF04493(Endonuclease_5) | 4 | THR A 134GLY A 136VAL A 181PRO A 183 | None | 1.11A | 4grkA-2w35A:undetectable | 4grkA-2w35A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wb7 | PT26-6P (Thermococcussp. 26-2) |
no annotation | 4 | GLY A 204VAL A 185PRO A 203TYR A 439 | None | 1.03A | 4grkA-2wb7A:undetectable | 4grkA-2wb7A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xts | CYTOCHROME (Paracoccuspantotrophus) |
PF13442(Cytochrome_CBB3) | 4 | THR B 160GLY B 49VAL B 45PRO B 47 | None | 1.07A | 4grkA-2xtsB:undetectable | 4grkA-2xtsB:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzw | ABC TRANSPORTER,SOLUTE-BINDINGPROTEIN (Thermusthermophilus) |
PF03480(DctP) | 4 | THR A 40VAL A 69PRO A 71TYR A 49 | None | 1.05A | 4grkA-2zzwA:3.2 | 4grkA-2zzwA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjx | PROTEIN OF UNKNOWNFUNCTION WITH ACUPIN-LIKE FOLD (Cupriaviduspinatubonensis) |
no annotation | 4 | THR A 58GLY A 56PRO A 106TYR A 78 | None | 0.82A | 4grkA-3cjxA:undetectable | 4grkA-3cjxA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clv | RAB5 PROTEIN,PUTATIVE (Plasmodiumfalciparum) |
PF00071(Ras)PF08477(Roc) | 4 | THR A 100GLY A 14VAL A 123TYR A 114 | None | 1.13A | 4grkA-3clvA:undetectable | 4grkA-3clvA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d37 | TAIL PROTEIN, 43 KDA (Neisseriameningitidis) |
no annotation | 4 | THR A 342GLY A 177VAL A 175PRO A 166 | None | 1.03A | 4grkA-3d37A:undetectable | 4grkA-3d37A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3duu | IG-LIKE PROTEIN (Mus musculus) |
PF07686(V-set) | 4 | THR B 82GLY B 16VAL B 12PRO B 14 | None | 0.91A | 4grkA-3duuB:undetectable | 4grkA-3duuB:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0j | DNA POLYMERASESUBUNIT DELTA-2 (Homo sapiens) |
PF04042(DNA_pol_E_B) | 4 | THR A 344GLY A 405VAL A 428TYR A 402 | None | 1.03A | 4grkA-3e0jA:undetectable | 4grkA-3e0jA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7s | LONG-CHAIN-FATTY-ACID--COA LIGASE(FADD-1) (Archaeoglobusfulgidus) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | THR A 125GLY A 79VAL A 103PRO A 102 | None | 1.08A | 4grkA-3g7sA:0.7 | 4grkA-3g7sA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i50 | MURINE HEAVY CHAIN(IGG3) OF E53MONOCLONAL ANTIBODYFAB (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR H 82GLY H 16VAL H 12PRO H 14 | None | 1.00A | 4grkA-3i50H:undetectable | 4grkA-3i50H:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2w | BETAINE-ALDEHYDEDEHYDROGENASE (Pseudoalteromonasatlantica) |
PF00171(Aldedh) | 4 | THR A 230GLY A 152VAL A 178TYR A 476 | None | 1.08A | 4grkA-3k2wA:undetectable | 4grkA-3k2wA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzr | 2-DEHYDRO-3-DEOXYPHOSPHOGLUCONATEALDOLASE (Aliivibriofischeri) |
PF07071(KDGP_aldolase) | 4 | THR A 122GLY A 124VAL A 144PRO A 143 | None | 1.16A | 4grkA-3nzrA:undetectable | 4grkA-3nzrA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooq | AMIDOHYDROLASE (Thermotogamaritima) |
PF01979(Amidohydro_1) | 4 | GLY A 127VAL A 91PRO A 89TYR A 182 | None | 1.19A | 4grkA-3ooqA:undetectable | 4grkA-3ooqA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3q | ALKALINE PHOSPHATASE (Sphingomonassp. BSAR-1) |
PF01663(Phosphodiest) | 4 | THR A 311GLY A 246VAL A 238PRO A 237 | None | 0.96A | 4grkA-3q3qA:0.8 | 4grkA-3q3qA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sb4 | HYPOTHETICAL LEUCINERICH REPEAT PROTEIN (Bacteroidesthetaiotaomicron) |
PF13306(LRR_5) | 4 | THR A 283GLY A 285VAL A 288PRO A 262 | None | 1.11A | 4grkA-3sb4A:undetectable | 4grkA-3sb4A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3srt | MALTOSEO-ACETYLTRANSFERASE (Clostridioidesdifficile) |
PF12464(Mac)PF14602(Hexapep_2) | 4 | THR A 149GLY A 151VAL A 154PRO A 167 | None | 1.09A | 4grkA-3srtA:undetectable | 4grkA-3srtA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttl | POLYAMINE TRANSPORTPROTEIN (Pseudomonasaeruginosa) |
PF13416(SBP_bac_8) | 4 | THR A 64GLY A 67VAL A 70TYR A 32 | None | 1.10A | 4grkA-3ttlA:4.1 | 4grkA-3ttlA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3e | COTYLEDONEOUSYIELDIN-LIKE PROTEIN (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 4 | THR A 152GLY A 114VAL A 88TYR A 124 | None | 1.16A | 4grkA-3w3eA:undetectable | 4grkA-3w3eA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvr | PGM1 (Streptomycescirratus) |
no annotation | 4 | THR A 357GLY A 354VAL A 351PRO A 353 | None | 1.15A | 4grkA-3wvrA:undetectable | 4grkA-3wvrA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0d | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT 1CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT 3 (Homo sapiens) |
PF04054(Not1)PF04153(NOT2_3_5) | 4 | GLY A2033VAL A2035PRO A2032TYR C 613 | None | 1.07A | 4grkA-4c0dA:undetectable | 4grkA-4c0dA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1g | FIBER PROTEIN (Snakeatadenovirus A) |
no annotation | 4 | THR A 282GLY A 280VAL A 334PRO A 332 | None | 1.12A | 4grkA-4d1gA:undetectable | 4grkA-4d1gA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnx | SULFATEADENYLYLTRANSFERASE (Allochromatiumvinosum) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 4 | THR A 179GLY A 50PRO A 12TYR A 16 | None | 1.05A | 4grkA-4dnxA:undetectable | 4grkA-4dnxA:22.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fim | LACTOTRANSFERRIN (Bos taurus) |
PF00405(Transferrin) | 5 | THR A 430GLY A 432VAL A 591PRO A 593TYR A 660 | NoneCEL A 711 (-3.7A)NoneCEL A 711 (-4.3A)CEL A 711 (-4.4A) | 0.15A | 4grkA-4fimA:60.7 | 4grkA-4fimA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gi5 | QUINONE REDUCTASE (Klebsiellapneumoniae) |
PF02525(Flavodoxin_2) | 4 | GLY A 140VAL A 143PRO A 184TYR A 183 | NoneNoneNoneUNL A 302 (-4.2A) | 1.19A | 4grkA-4gi5A:undetectable | 4grkA-4gi5A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | THR A 309GLY A 297VAL A 316PRO A 314 | None | 1.04A | 4grkA-4h7uA:undetectable | 4grkA-4h7uA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hlz | FAB C179 HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR G 82GLY G 16VAL G 12PRO G 14 | None | 0.80A | 4grkA-4hlzG:undetectable | 4grkA-4hlzG:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | GLY A 313VAL A 60PRO A 709TYR A 696 | None | 0.92A | 4grkA-4iigA:undetectable | 4grkA-4iigA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kro | CETUXIMAB HEAVYCHAIN (Homo sapiens;Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR D 113GLY D 10VAL D 12PRO D 9 | None | 1.13A | 4grkA-4kroD:undetectable | 4grkA-4kroD:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m98 | PILIN GLYCOSYLATIONPROTEIN (Neisseriagonorrhoeae) |
PF00132(Hexapep) | 4 | THR A 372GLY A 374VAL A 377PRO A 390 | None | 1.15A | 4grkA-4m98A:undetectable | 4grkA-4m98A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhm | ARGINASE (Trypanosomabrucei) |
PF00491(Arginase) | 4 | THR A 304GLY A 258VAL A 219PRO A 218 | None | 1.18A | 4grkA-4rhmA:undetectable | 4grkA-4rhmA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4umi | FIBER PROTEIN (Snakeatadenovirus A) |
no annotation | 4 | THR A 282GLY A 280VAL A 334PRO A 332 | None | 1.14A | 4grkA-4umiA:undetectable | 4grkA-4umiA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr5 | NEPRILYSIN (Oryctolaguscuniculus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | THR A 171GLY A 166VAL A 164PRO A 162 | None | 1.17A | 4grkA-4zr5A:undetectable | 4grkA-4zr5A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c8s | GUANINE-N7METHYLTRANSFERASE (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF06471(NSP11) | 4 | THR B 437VAL B 398PRO B 393TYR B 370 | None | 1.18A | 4grkA-5c8sB:undetectable | 4grkA-5c8sB:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxd | PUTATIVEBETA-GLUCANASE (Mycobacteroidesabscessus) |
PF00722(Glyco_hydro_16) | 4 | THR A 158GLY A 156VAL A 173PRO A 172 | None | 0.99A | 4grkA-5dxdA:undetectable | 4grkA-5dxdA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3e | LARGE EXOPROTEININVOLVED IN HEMEUTILIZATION ORADHESION (Yersiniakristensenii) |
no annotation | 4 | THR B 199GLY B 242VAL B 255PRO B 240 | None | 1.12A | 4grkA-5e3eB:undetectable | 4grkA-5e3eB:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9a | BETA-GALACTOSIDASE (Rahnella sp. R3) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | THR A 501GLY A 217VAL A 215TYR A 179 | None | 1.18A | 4grkA-5e9aA:undetectable | 4grkA-5e9aA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewy | PUTATIVEADP-RIBOSYLTRANSFERASE SCABIN (Streptomycesscabiei) |
no annotation | 4 | GLY A 165VAL A 57PRO A 114TYR A 106 | None | 1.15A | 4grkA-5ewyA:undetectable | 4grkA-5ewyA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyi | NON-STRUCTURALPROTEIN 11 (Porcinereproductiveand respiratorysyndrome virus) |
no annotation | 4 | THR A 105GLY A 66VAL A 82PRO A 80 | None | 1.06A | 4grkA-5eyiA:undetectable | 4grkA-5eyiA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9s | SERINE--PYRUVATEAMINOTRANSFERASE (Homo sapiens) |
PF00266(Aminotran_5) | 4 | THR A 154GLY A 109VAL A 113TYR A 204 | PLP A 401 ( 4.4A)NoneNoneNone | 1.16A | 4grkA-5f9sA:undetectable | 4grkA-5f9sA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | GLY A 314VAL A 60PRO A 712TYR A 699 | EDO A1870 ( 3.7A)NoneNoneNone | 0.87A | 4grkA-5fjiA:undetectable | 4grkA-5fjiA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | GLY A 314VAL A 61PRO A 710TYR A 697 | NoneNoneNAG A1001 ( 4.9A)None | 0.86A | 4grkA-5fjjA:undetectable | 4grkA-5fjjA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ik2 | ATP SYNTHASE EPSILONCHAINATP SYNTHASE GAMMACHAIN (Caldalkalibacillusthermarum) |
PF00231(ATP-synt)PF02823(ATP-synt_DE_N) | 4 | THR G 38VAL H 9PRO H 11TYR G 227 | None | 0.76A | 4grkA-5ik2G:undetectable | 4grkA-5ik2G:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j55 | CAROTENOID OXYGENASE (Novosphingobiumaromaticivorans) |
PF03055(RPE65) | 4 | THR A 118GLY A 63VAL A 43PRO A 45 | NoneNoneNoneV55 A 503 ( 4.8A) | 1.08A | 4grkA-5j55A:undetectable | 4grkA-5j55A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ju6 | BETA-GLUCOSIDASE (Rasamsoniaemersonii) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | GLY A 310VAL A 60PRO A 704TYR A 691 | None | 0.88A | 4grkA-5ju6A:undetectable | 4grkA-5ju6A:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1b | 3-OCTAPRENYL-4-HYDROXYBENZOATECARBOXY-LYASE (Escherichiacoli) |
PF01977(UbiD) | 4 | THR A 160GLY A 162VAL A 219TYR A 317 | None | 1.17A | 4grkA-5m1bA:undetectable | 4grkA-5m1bA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m9f | ORF68 (Staphylococcusvirus K) |
no annotation | 4 | GLY A 286VAL A 284PRO A 288TYR A 311 | None | 1.11A | 4grkA-5m9fA:undetectable | 4grkA-5m9fA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n2p | TRYPTOPHAN SYNTHASEALPHA CHAIN (Sulfolobussolfataricus) |
no annotation | 4 | THR A 9GLY A 11VAL A 15PRO A 13 | None | 1.16A | 4grkA-5n2pA:undetectable | 4grkA-5n2pA:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 4 | THR A 299GLY A 287VAL A 306PRO A 304 | None | 0.99A | 4grkA-5oc1A:undetectable | 4grkA-5oc1A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oup | PERFORIN-LIKEPROTEIN 1 (Toxoplasmagondii) |
no annotation | 4 | GLY A 738VAL A 758PRO A 762TYR A 468 | None | 1.05A | 4grkA-5oupA:undetectable | 4grkA-5oupA:12.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ov6 | PORPHOBILINOGENDEAMINASE (Bacillusmegaterium) |
PF01379(Porphobil_deam)PF03900(Porphobil_deamC) | 4 | THR A 260GLY A 247VAL A 195PRO A 193 | None | 0.99A | 4grkA-5ov6A:6.5 | 4grkA-5ov6A:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyn | DEHYDRATASE,ILVD/EDD FAMILY (Caulobactervibrioides) |
no annotation | 4 | GLY A 457VAL A 549PRO A 459TYR A 560 | None | 1.18A | 4grkA-5oynA:undetectable | 4grkA-5oynA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5szj | RAS-RELATED PROTEINRAB-10 (Homo sapiens) |
PF00071(Ras) | 4 | THR A 65GLY A 16VAL A 88TYR A 79 | None | 1.19A | 4grkA-5szjA:undetectable | 4grkA-5szjA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tx7 | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASE FAMILYPROTEIN (Desulfovibriovulgaris) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | THR A 10GLY A 8VAL A 29PRO A 31 | None | 0.84A | 4grkA-5tx7A:undetectable | 4grkA-5tx7A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3l | DH511.2 FAB HEAVYCHAIN (Homo sapiens) |
no annotation | 4 | THR H 82GLY H 16VAL H 12PRO H 14 | None | 1.03A | 4grkA-5u3lH:undetectable | 4grkA-5u3lH:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8z | CAROTENOID OXYGENASE1 (Neurosporacrassa) |
PF03055(RPE65) | 4 | THR A 148GLY A 95VAL A 75PRO A 77 | None | 0.99A | 4grkA-5u8zA:undetectable | 4grkA-5u8zA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uvq | SCABIN (Streptomycesscabiei) |
no annotation | 4 | GLY A 165VAL A 57PRO A 114TYR A 106 | None | 1.11A | 4grkA-5uvqA:undetectable | 4grkA-5uvqA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2d | DIOXYGENASE (Pseudomonasbrassicacearum) |
no annotation | 4 | THR A 119GLY A 65VAL A 45PRO A 47 | None | 0.95A | 4grkA-5v2dA:undetectable | 4grkA-5v2dA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vgj | VRC38.01 FAB HEAVYCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | THR H 82GLY H 16VAL H 12PRO H 14 | None | 1.02A | 4grkA-5vgjH:undetectable | 4grkA-5vgjH:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xap | PROTEIN TRANSLOCASESUBUNIT SECD (Deinococcusradiodurans) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 4 | THR A 596GLY A 592VAL A 587PRO A 505 | None | 1.15A | 4grkA-5xapA:undetectable | 4grkA-5xapA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | THR B 447GLY B 159VAL B 115PRO B 114 | None | 1.15A | 4grkA-5xogB:undetectable | 4grkA-5xogB:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xon | RNA POLYMERASE IISUBUNIT (Komagataellaphaffii) |
PF00575(S1)PF03876(SHS2_Rpb7-N) | 4 | THR G 112GLY G 98VAL G 94PRO G 96 | None | 1.05A | 4grkA-5xonG:undetectable | 4grkA-5xonG:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINES4 (Toxoplasmagondii) |
PF00467(KOW)PF00900(Ribosomal_S4e)PF01479(S4)PF08071(RS4NT)PF16121(40S_S4_C) | 4 | GLY E 132VAL E 130PRO E 137TYR E 149 | U 2 252 ( 4.5A) A 2 251 ( 4.8A)NoneNone | 0.70A | 4grkA-5xxuE:undetectable | 4grkA-5xxuE:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zj5 | - (-) |
no annotation | 4 | GLY A 169VAL A 61PRO A 118TYR A 110 | NoneNoneNoneNAI A 301 (-4.4A) | 1.09A | 4grkA-5zj5A:undetectable | 4grkA-5zj5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 4 | THR A 538GLY A 523VAL A 519PRO A 521 | None | 1.01A | 4grkA-6en4A:undetectable | 4grkA-6en4A:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f0x | MAD2L1-BINDINGPROTEIN (Homo sapiens) |
no annotation | 4 | THR P 145VAL P 150PRO P 148TYR P 260 | None | 1.18A | 4grkA-6f0xP:undetectable | 4grkA-6f0xP:12.84 |