SIMILAR PATTERNS OF AMINO ACIDS FOR 4GQP_H_B40H1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mm3 MI2-BETA(CHROMODOMAI
N
HELICASE-DNA-BINDING
PROTEIN 4) AND
TRANSCRIPTION FACTOR
WSTF

(Homo sapiens) 		PF00628
(PHD) 		5 SER A  30
TYR A  31
PHE A  11
GLU A  10
HIS A   8
 None
 1.48A 4gqpH-1mm3A:
undetectable		 4gqpH-1mm3A:
10.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR H  33
TYR H  47
TYR H  50
TYR L  34
TYR L  36
 None
 0.83A 4gqpH-3go1H:
21.1		 4gqpH-3go1H:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		5 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.33A 4gqpH-4dddA:
0.0		 4gqpH-4dddA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy6 PGT123 HEAVY CHAIN
PGT123 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.18A 4gqpH-4jy6B:
17.0		 4gqpH-4jy6B:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		6 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.67A 4gqpH-4laqH:
17.2		 4gqpH-4laqH:
99.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 SER H  93
PHE H  95
TYR L  34
HIS L  89
TRP L  91
 None
1WE  L 300 ( 4.1A)
1WE  L 300 ( 4.8A)
1WE  L 300 (-4.2A)
1WE  L 300 (-4.1A)
 1.08A 4gqpH-4larH:
25.1		 4gqpH-4larH:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		11 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
TYR L  34
TYR L  36
HIS L  89
TRP L  91
PHE L  96
 1WE  L 300 (-3.9A)
1WE  L 300 (-3.6A)
None
1WE  L 300 ( 4.5A)
1WE  L 300 ( 4.1A)
1WE  L 300 (-3.7A)
1WE  L 300 ( 4.8A)
None
1WE  L 300 (-4.2A)
1WE  L 300 (-4.1A)
1WE  L 300 ( 4.7A)
 0.21A 4gqpH-4larH:
25.1		 4gqpH-4larH:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		8 TYR H  50
SER H  35
GLU H 101
TYR L  34
TYR L  36
HIS L  89
TRP L  91
PHE L  96
 1WE  L 300 ( 4.5A)
1WE  L 300 (-3.6A)
1WE  L 300 (-3.7A)
1WE  L 300 ( 4.8A)
None
1WE  L 300 (-4.2A)
1WE  L 300 (-4.1A)
1WE  L 300 ( 4.7A)
 1.25A 4gqpH-4larH:
25.1		 4gqpH-4larH:
99.15