SIMILAR PATTERNS OF AMINO ACIDS FOR 4GN6_A_TYLA621_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1d7w	MYELOPEROXIDASE (Homo sapiens)	PF03098 (An_peroxidase)	4	HIS A 95 ARG C 239 GLU C 242 PHE C 366	CYN A1844 (-4.1A) HEM A 605 (-4.3A) HEM A 605 (-2.1A) None	0.45A	4gn6A-1d7wA: undetectable	4gn6A-1d7wA: 38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1d7w	MYELOPEROXIDASE (Homo sapiens)	PF03098 (An_peroxidase)	4	HIS A 95 ARG C 239 GLU C 242 PHE C 407	CYN A1844 (-4.1A) HEM A 605 (-4.3A) HEM A 605 (-2.1A) HEM A 605 (-4.5A)	1.10A	4gn6A-1d7wA: undetectable	4gn6A-1d7wA: 38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2gjm	LACTOPEROXIDASE (Bubalus bubalis)	PF03098 (An_peroxidase)	4	HIS A 95 ARG A 239 GLU A 242 PHE A 366	SCN A1502 ( 4.8A) HEM A 605 (-4.7A) HEM A 605 ( 2.2A) None	0.39A	4gn6A-2gjmA: 65.0	4gn6A-2gjmA: 99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6erc	PEROXINECTIN A (Dictyostelium discoideum)	no annotation	4	HIS A 101 ARG A 233 GLU A 236 PHE A 352	None HEM A 604 (-3.1A) HEM A 604 (-2.2A) None	0.93A	4gn6A-6ercA: 39.6	4gn6A-6ercA: 9.17