SIMILAR PATTERNS OF AMINO ACIDS FOR 4GKH_L_KANL301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ASP 1 268
ASN 1  66
GLU 1  32
ASP 1  38
GLU 1  39
 None
 1.30A 4gkhK-1gt91:
0.0
4gkhL-1gt91:
0.0		 4gkhK-1gt91:
24.04
4gkhL-1gt91:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		5 ASP A 157
ASP A 159
ASP A 190
ASP A 261
GLU A 262
 KAN  A1300 (-3.7A)
KAN  A1300 (-3.2A)
KAN  A1300 ( 2.8A)
KAN  A1300 (-3.8A)
KAN  A1300 (-3.1A)
 0.32A 4gkhK-1nd4A:
30.8
4gkhL-1nd4A:
31.4		 4gkhK-1nd4A:
33.94
4gkhL-1nd4A:
33.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		5 ASP A 157
ASP A 159
GLU A 230
ASP A 261
GLU A 262
 KAN  A1300 (-3.7A)
KAN  A1300 (-3.2A)
KAN  A1300 (-4.1A)
KAN  A1300 (-3.8A)
KAN  A1300 (-3.1A)
 0.96A 4gkhK-1nd4A:
30.8
4gkhL-1nd4A:
31.4		 4gkhK-1nd4A:
33.94
4gkhL-1nd4A:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 HIS A 538
ASP A 443
ASP A 203
ASP A 571
GLU A 182
 None
3CU  A1001 (-2.7A)
GOL  A3001 (-2.6A)
3CU  A1001 ( 4.8A)
None
 1.35A 4gkhK-3cttA:
0.2
4gkhL-3cttA:
1.5		 4gkhK-3cttA:
15.32
4gkhL-3cttA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 HIS A 567
ASP A 472
ASP A 231
ASP A 600
GLU A 210
 None
TRS  A6001 (-3.2A)
None
None
None
 1.38A 4gkhK-3lppA:
0.8
4gkhL-3lppA:
0.9		 4gkhK-3lppA:
16.67
4gkhL-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 HIS A1522
ASP A1420
ASP A1157
ASP A1555
GLU A1136
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
None
None
 1.30A 4gkhK-3topA:
0.0
4gkhL-3topA:
0.0		 4gkhK-3topA:
14.57
4gkhL-3topA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 SER A1297
HIS A1329
ASP A1343
ASP A1485
ASN A1447
 None
 1.33A 4gkhK-4guaA:
0.0
4gkhL-4guaA:
0.6		 4gkhK-4guaA:
19.58
4gkhL-4guaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		5 SER A 231
HIS A 230
ASN A 208
GLU A 207
GLU A 235
 None
None
GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
 1.30A 4gkhK-4ovrA:
0.0
4gkhL-4ovrA:
0.0		 4gkhK-4ovrA:
23.39
4gkhL-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 HIS A 612
ASP A 518
ASP A 282
ASP A 645
GLU A 262
 None
ACR  A1015 (-3.1A)
ACR  A1015 (-2.6A)
None
None
 1.41A 4gkhK-5nn8A:
1.9
4gkhL-5nn8A:
0.7		 4gkhK-5nn8A:
14.51
4gkhL-5nn8A:
14.51