SIMILAR PATTERNS OF AMINO ACIDS FOR 4GKH_J_KANJ301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A   3
ASP A 495
ASP A 546
GLU A 545
 None
 1.34A 4gkhJ-1dedA:
0.0		 4gkhJ-1dedA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee1 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
subtilis) 		PF02540
(NAD_synthase) 		4 ASP A  50
ASP A 158
ASP A 232
GLU A 162
 ATP  A5000 (-3.5A)
None
None
ATP  A5000 ( 4.4A)
 1.35A 4gkhJ-1ee1A:
0.0		 4gkhJ-1ee1A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ASP 1 268
ASN 1  66
ASP 1  38
GLU 1  39
 None
 1.34A 4gkhJ-1gt91:
0.0		 4gkhJ-1gt91:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 ASP A 152
ASP A 146
ASN A 124
ASP A 200
 None
CA  A 700 (-3.2A)
CA  A 700 (-3.0A)
None
 1.22A 4gkhJ-1h3gA:
undetectable		 4gkhJ-1h3gA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ASP A 228
ASP A 596
ASP A 443
GLU A 255
 None
MLZ  A 513 ( 4.9A)
None
None
 1.17A 4gkhJ-1iv8A:
0.0		 4gkhJ-1iv8A:
16.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		5 ASP A 157
ASP A 159
ASP A 190
ASP A 261
GLU A 262
 KAN  A1300 (-3.7A)
KAN  A1300 (-3.2A)
KAN  A1300 ( 2.8A)
KAN  A1300 (-3.8A)
KAN  A1300 (-3.1A)
 0.34A 4gkhJ-1nd4A:
31.4		 4gkhJ-1nd4A:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 4 ASP A 151
ASP A 261
ASN A 197
GLU A 241
 None
 1.27A 4gkhJ-1nluA:
0.0		 4gkhJ-1nluA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		4 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.14A 4gkhJ-1nnhA:
1.8		 4gkhJ-1nnhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 ASP A 183
ASP A 232
ASP A 128
GLU A 186
 S2C  A 551 (-2.8A)
MN  A 500 (-3.1A)
MN  A 501 ( 2.6A)
S2C  A 551 ( 4.2A)
 1.32A 4gkhJ-1p8rA:
undetectable		 4gkhJ-1p8rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.24A 4gkhJ-1r4nB:
undetectable		 4gkhJ-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ASP A 457
ASN A 255
ASP A 227
GLU A 228
 None
 1.12A 4gkhJ-1t1eA:
undetectable		 4gkhJ-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 130
ASP A  51
ASP A 214
ASN A  14
 GLA  A1501 (-2.5A)
GLA  A1501 (-2.9A)
None
None
 1.34A 4gkhJ-1uasA:
2.1		 4gkhJ-1uasA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASP A 874
ASP A 870
ASP A 890
ASN A 882
 None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
 1.22A 4gkhJ-1ux6A:
undetectable		 4gkhJ-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASP A 874
ASP A 870
ASP A 890
ASP A 879
 None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2004 ( 3.1A)
 1.33A 4gkhJ-1ux6A:
undetectable		 4gkhJ-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASP A 933
ASP A 868
ASN A 855
ASP A 874
 None
CA  A2007 ( 2.7A)
None
None
 1.18A 4gkhJ-1ux6A:
undetectable		 4gkhJ-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Escherichia
coli) 		PF02540
(NAD_synthase) 		4 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.12A 4gkhJ-1wxfA:
undetectable		 4gkhJ-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
 1.30A 4gkhJ-1xkhA:
undetectable		 4gkhJ-1xkhA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ASP A 147
ASN A  36
ASP A 202
GLU A 219
 MN  A 502 (-2.6A)
None
None
None
 1.22A 4gkhJ-2eb0A:
undetectable		 4gkhJ-2eb0A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb1 ENDORIBONUCLEASE
DICER

(Homo sapiens) 		PF00636
(Ribonuclease_3) 		4 ASP A 152
ASN A  84
ASP A  51
GLU A  47
 MG  A 502 (-3.1A)
None
MG  A 505 (-2.8A)
MG  A 502 (-3.1A)
 1.10A 4gkhJ-2eb1A:
undetectable		 4gkhJ-2eb1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ASP A  14
ASP A  43
ASP A 542
ASN A  46
 None
None
PO4  A 912 ( 2.9A)
None
 1.34A 4gkhJ-2hnhA:
undetectable		 4gkhJ-2hnhA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 ASP A 771
ASP A 652
ASN A 660
ASP A 658
 None
 1.34A 4gkhJ-2j7nA:
undetectable		 4gkhJ-2j7nA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans) 		PF01070
(FMN_dh) 		4 ASP A  24
ASP A  55
ASN A  21
GLU A  27
 None
 1.22A 4gkhJ-2nliA:
undetectable		 4gkhJ-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 ASP B2252
ASP B2146
ASN B2087
ASP B2081
 None
MG  B 101 ( 3.1A)
ATP  B 103 (-3.6A)
ATP  B 103 (-3.8A)
 1.34A 4gkhJ-2nvuB:
undetectable		 4gkhJ-2nvuB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 ASP A 803
ASP A 187
ASP A 203
ASN A 184
 None
PO4  A   3 (-4.0A)
None
PO4  A   3 (-3.4A)
 1.20A 4gkhJ-2o5pA:
undetectable		 4gkhJ-2o5pA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 ASP A  35
ASP A 590
ASP A  28
GLU A  25
 None
 1.28A 4gkhJ-2o8rA:
undetectable		 4gkhJ-2o8rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Shigella
flexneri) 		PF03009
(GDPD) 		4 ASP A  41
ASP A 235
ASN A  22
GLU A 114
 PO4  A 301 (-3.8A)
None
None
PO4  A 301 (-3.4A)
 1.21A 4gkhJ-2otdA:
undetectable		 4gkhJ-2otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		4 ASP A 108
ASP A  93
ASP A 101
GLU A  80
 CA  A 302 (-3.3A)
CA  A 303 (-2.1A)
CA  A 303 (-2.9A)
CA  A 302 (-2.2A)
 1.27A 4gkhJ-2porA:
undetectable		 4gkhJ-2porA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		4 ASP A  51
ASP A 159
ASP A 233
GLU A 163
 APC  A3001 (-3.7A)
None
None
APC  A3001 ( 4.6A)
 1.11A 4gkhJ-2pz8A:
undetectable		 4gkhJ-2pz8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 738
ASP A 734
ASP A 754
ASN A 746
 None
CA  A  26 ( 2.8A)
CA  A  23 ( 2.3A)
CA  A  26 (-2.7A)
 1.17A 4gkhJ-2rhpA:
undetectable		 4gkhJ-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 738
ASP A 734
ASP A 754
ASP A 743
 None
CA  A  26 ( 2.8A)
CA  A  23 ( 2.3A)
CA  A  24 ( 3.3A)
 1.34A 4gkhJ-2rhpA:
undetectable		 4gkhJ-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 894
ASP A 890
ASP A 910
ASN A 902
 None
CA  A   7 ( 2.5A)
CA  A1175 ( 2.5A)
CA  A1176 (-3.1A)
 1.20A 4gkhJ-2rhpA:
undetectable		 4gkhJ-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 894
ASP A 890
ASP A 910
ASP A 899
 None
CA  A   7 ( 2.5A)
CA  A1175 ( 2.5A)
CA  A1174 ( 3.1A)
 1.29A 4gkhJ-2rhpA:
undetectable		 4gkhJ-2rhpA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ASP A  75
ASP A 252
ASN A  77
ASP A 150
 None
 1.32A 4gkhJ-2v5dA:
undetectable		 4gkhJ-2v5dA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASP A 139
ASN A 132
ASP A 209
GLU A 210
 None
 1.24A 4gkhJ-2vdaA:
undetectable		 4gkhJ-2vdaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 432
ASP A  71
ASN A 245
GLU A  75
 None
 1.03A 4gkhJ-2wbaA:
undetectable		 4gkhJ-2wbaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 ASP J 335
ASP J 942
ASP J 988
GLU J 337
 None
 1.35A 4gkhJ-2wp8J:
undetectable		 4gkhJ-2wp8J:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 ASP A  56
ASP A  30
ASP A  86
ASN A  79
 None
 1.00A 4gkhJ-2xheA:
undetectable		 4gkhJ-2xheA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		4 ASP A  28
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.29A 4gkhJ-2xryA:
undetectable		 4gkhJ-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		4 ASP A 116
ASP A 142
ASP A 412
ASN A 145
 None
None
FAD  A1463 ( 4.2A)
None
 1.34A 4gkhJ-2xryA:
undetectable		 4gkhJ-2xryA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ASP A 582
ASN A 348
ASP A 587
GLU A 585
 None
 1.22A 4gkhJ-2xvgA:
undetectable		 4gkhJ-2xvgA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 ASP A 129
ASP A  51
ASP A 238
ASN A  14
 TRS  A 841 (-4.0A)
TRS  A 841 (-3.3A)
None
None
 1.25A 4gkhJ-3a5vA:
undetectable		 4gkhJ-3a5vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4b ENDORIBONUCLEASE
DICER

(Mus musculus) 		PF00636
(Ribonuclease_3) 		4 ASP A1794
ASN A1726
ASP A1693
GLU A1689
 None
 1.25A 4gkhJ-3c4bA:
undetectable		 4gkhJ-3c4bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 ASP A 285
ASP A  19
ASP A 183
ASP A  52
 None
None
IMD  A 437 ( 3.8A)
IMD  A 437 (-3.3A)
 1.24A 4gkhJ-3cc1A:
undetectable		 4gkhJ-3cc1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ASP A1207
ASP A1013
ASN A1090
ASP A1091
 None
 1.32A 4gkhJ-3ecqA:
undetectable		 4gkhJ-3ecqA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 ASP A  33
ASP B 482
ASP B 500
GLU B 472
 None
 1.13A 4gkhJ-3egwA:
undetectable		 4gkhJ-3egwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASP A 466
ASP A 462
ASP A 482
ASN A 474
 None
CA  A 819 ( 2.8A)
CA  A 823 ( 2.8A)
CA  A 820 (-2.9A)
 1.14A 4gkhJ-3fbyA:
undetectable		 4gkhJ-3fbyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		4 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.91A 4gkhJ-3h4xA:
undetectable		 4gkhJ-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 ASP A   8
ASN A 383
ASP A 388
GLU A 392
 None
 1.09A 4gkhJ-3h7nA:
undetectable		 4gkhJ-3h7nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Salmonella
enterica) 		PF02540
(NAD_synthase) 		4 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 SO4  A 276 (-4.9A)
None
None
None
 1.06A 4gkhJ-3hmqA:
undetectable		 4gkhJ-3hmqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ASP A3461
ASP A3286
ASN A3358
ASP A3363
 None
 1.19A 4gkhJ-3hwcA:
undetectable		 4gkhJ-3hwcA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ASP A 263
ASP A 302
ASN A 317
GLU A 230
 None
 1.31A 4gkhJ-3i12A:
undetectable		 4gkhJ-3i12A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 ASP A  36
ASP A  50
ASP A 231
ASP A  16
 FE  A 250 (-2.6A)
EDO  A 256 (-3.0A)
None
EDO  A 256 (-3.5A)
 1.13A 4gkhJ-3ks5A:
undetectable		 4gkhJ-3ks5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 ASP A  51
ASP A 295
ASN A  32
GLU A 148
 MG  A 313 (-2.6A)
None
None
MG  A 313 (-2.9A)
 1.23A 4gkhJ-3l12A:
undetectable		 4gkhJ-3l12A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		4 ASP A  61
ASP A 244
ASN A  42
GLU A 123
 MG  A 301 (-2.5A)
None
None
MG  A 301 ( 2.8A)
 1.20A 4gkhJ-3no3A:
undetectable		 4gkhJ-3no3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.13A 4gkhJ-3p8tA:
1.9		 4gkhJ-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445

(Oleispira
antarctica) 		PF03009
(GDPD) 		4 ASP A  43
ASP A 237
ASN A  24
GLU A 116
 MG  A 310 ( 2.6A)
None
None
G3P  A 301 ( 2.3A)
 1.23A 4gkhJ-3qvqA:
undetectable		 4gkhJ-3qvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s83 GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		4 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.15A 4gkhJ-3s83A:
undetectable		 4gkhJ-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		4 ASP A 274
ASP A 323
ASP A 220
GLU A 277
 FB6  A 414 (-2.9A)
MN  A 412 (-2.8A)
FB6  A 414 ( 2.6A)
FB6  A 414 ( 4.0A)
 1.26A 4gkhJ-3sl1A:
undetectable		 4gkhJ-3sl1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 ASP A  47
ASP A 167
ASP A 430
ASN A 170
 None
None
FAD  A 801 ( 4.2A)
None
 1.33A 4gkhJ-3umvA:
undetectable		 4gkhJ-3umvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.26A 4gkhJ-3v4yA:
undetectable		 4gkhJ-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		4 ASP A 433
ASP A 422
ASN A 690
ASP A 686
 None
 1.26A 4gkhJ-3v8vA:
undetectable		 4gkhJ-3v8vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.90A 4gkhJ-3wjoA:
undetectable		 4gkhJ-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 257
ASP A 269
ASP A 287
ASN A 280
 MG  A1767 (-2.5A)
MG  A1768 ( 3.9A)
2PN  A1773 (-3.9A)
MG  A1768 ( 4.9A)
 1.14A 4gkhJ-4a01A:
undetectable		 4gkhJ-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 691
ASP A 727
ASP A 269
ASP A 257
 MG  A1771 ( 2.7A)
MG  A1769 ( 2.5A)
MG  A1768 ( 3.9A)
MG  A1767 (-2.5A)
 0.85A 4gkhJ-4a01A:
undetectable		 4gkhJ-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 723
ASP A 257
ASP A 287
GLU A 268
 MG  A1769 ( 3.9A)
MG  A1767 (-2.5A)
2PN  A1773 (-3.9A)
2PN  A1773 (-3.7A)
 1.28A 4gkhJ-4a01A:
undetectable		 4gkhJ-4a01A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnm TROPHOBLAST
GLYCOPROTEIN

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ASP A 240
ASP A 292
ASN A 268
ASP A 267
 None
 1.29A 4gkhJ-4cnmA:
undetectable		 4gkhJ-4cnmA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ASP A 287
ASP A 396
ASN A 253
ASP A 392
 None
 1.13A 4gkhJ-4cotA:
undetectable		 4gkhJ-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ASP A 186
ASP A 363
ASP A  85
GLU A  35
 None
None
MN  A1373 (-2.7A)
MN  A1372 ( 2.6A)
 1.25A 4gkhJ-4czpA:
undetectable		 4gkhJ-4czpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		4 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.24A 4gkhJ-4e2oA:
2.9		 4gkhJ-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 150
ASP A 152
ASN A 289
ASP A 260
 None
 1.12A 4gkhJ-4f7kA:
undetectable		 4gkhJ-4f7kA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		4 ASP A 153
ASP A 184
ASP A 264
GLU A 265
 None
 0.47A 4gkhJ-4h05A:
29.6		 4gkhJ-4h05A:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		4 ASP A 183
ASP A 232
ASP A 128
GLU A 186
 X8A  A 901 (-3.0A)
MN  A 902 (-3.0A)
MN  A 903 ( 2.6A)
X8A  A 901 ( 4.3A)
 1.31A 4gkhJ-4hxqA:
undetectable		 4gkhJ-4hxqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		4 ASP A 194
ASP A 243
ASP A 141
GLU A 197
 S2C  A 405 (-2.4A)
MN  A 402 (-2.8A)
MN  A 401 ( 2.5A)
S2C  A 405 ( 4.2A)
 1.31A 4gkhJ-4iu4A:
undetectable		 4gkhJ-4iu4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		4 ASP A 202
ASP A 251
ASP A 147
GLU A 205
 38I  A 406 (-3.1A)
MN  A 402 (-2.8A)
38I  A 406 ( 2.5A)
38I  A 406 ( 4.0A)
 1.29A 4gkhJ-4ixuA:
undetectable		 4gkhJ-4ixuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A  59
ASP A  53
ASN A  32
ASP A 117
 EDO  A 726 ( 4.9A)
CA  A 701 (-3.3A)
CA  A 701 (-3.2A)
GOL  A 717 (-2.9A)
 1.19A 4gkhJ-4jclA:
2.7		 4gkhJ-4jclA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-1A
SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00804
(Syntaxin)
PF00995
(Sec1) 		4 ASP A 282
ASP A  49
ASP B 231
GLU B 228
 None
 1.24A 4gkhJ-4jeuA:
undetectable		 4gkhJ-4jeuA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ASP A3183
ASP A3225
ASN A3256
GLU A3143
 None
 1.17A 4gkhJ-4kc5A:
undetectable		 4gkhJ-4kc5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.19A 4gkhJ-4nzjA:
undetectable		 4gkhJ-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		4 ASP A  59
ASP A 167
ASP A 241
GLU A 171
 SO4  A 301 (-4.2A)
None
None
None
 1.20A 4gkhJ-4q16A:
undetectable		 4gkhJ-4q16A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 ASP A 188
ASP A 220
ASN A 345
ASP A 224
 None
None
NO3  A 407 (-3.1A)
None
 1.29A 4gkhJ-4rkcA:
undetectable		 4gkhJ-4rkcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ASP A  88
ASP A 109
ASN A 102
ASP A  30
 None
 0.91A 4gkhJ-4uxvA:
undetectable		 4gkhJ-4uxvA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pseudomonas
aeruginosa) 		PF02540
(NAD_synthase) 		4 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.06A 4gkhJ-4xfdA:
undetectable		 4gkhJ-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 ASP A  75
ASP A 252
ASN A  77
ASP A 150
 None
CD  A 708 (-2.6A)
None
CD  A 708 (-3.6A)
 1.28A 4gkhJ-4zxlA:
undetectable		 4gkhJ-4zxlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ASP A1207
ASP A1013
ASN A1090
ASP A1091
 CA  A2422 (-2.2A)
None
CA  A2422 (-3.2A)
None
 1.25A 4gkhJ-5a55A:
undetectable		 4gkhJ-5a55A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 ASP A  92
ASP A 272
ASP A 268
GLU A  93
 None
 1.29A 4gkhJ-5ah1A:
undetectable		 4gkhJ-5ah1A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwa TYPE-2 RESTRICTION
ENZYME AGEI

(Thalassobius
gelatinovorus) 		no annotation 4 ASP A  18
ASP A  65
ASP A 208
ASN A 211
 None
 1.35A 4gkhJ-5dwaA:
undetectable		 4gkhJ-5dwaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		4 ASP A 238
ASP A 144
ASP A 111
ASN A 146
 None
 1.35A 4gkhJ-5ewtA:
undetectable		 4gkhJ-5ewtA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 1.00A 4gkhJ-5iryA:
undetectable		 4gkhJ-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3w CPUTA1

(Curtobacterium
pusillum) 		PF01063
(Aminotran_4) 		4 ASP A 227
ASP A 202
ASP A 161
GLU A 164
 None
 1.27A 4gkhJ-5k3wA:
undetectable		 4gkhJ-5k3wA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 382
ASP A  36
ASN A   9
GLU A  12
 None
 1.32A 4gkhJ-5ks8A:
undetectable		 4gkhJ-5ks8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 312
ASP A 318
ASP A 338
GLU A 342
 None
 1.35A 4gkhJ-5kxjA:
undetectable		 4gkhJ-5kxjA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ASP B 515
ASN B 329
ASP B 579
GLU B 581
 None
 1.32A 4gkhJ-5m45B:
undetectable		 4gkhJ-5m45B:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ASP A 416
ASP A 419
ASP A 331
GLU A 330
 CA  A 610 (-3.4A)
CA  A 611 ( 2.2A)
None
CA  A 611 ( 2.1A)
 1.34A 4gkhJ-5sznA:
undetectable		 4gkhJ-5sznA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.13A 4gkhJ-5ucmA:
3.4		 4gkhJ-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 ASP A 561
ASP A 322
ASP A 371
ASP A 330
 DJN  A 702 (-2.9A)
CA  A 703 (-2.1A)
DJN  A 702 (-3.1A)
DJN  A 702 (-2.6A)
 1.18A 4gkhJ-5wzrA:
undetectable		 4gkhJ-5wzrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 ASP A1810
ASN A1742
ASP A1709
GLU A1705
 None
 0.94A 4gkhJ-5zalA:
undetectable		 4gkhJ-5zalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Enterococcus
faecalis) 		no annotation 4 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.13A 4gkhJ-6c8qA:
undetectable		 4gkhJ-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 4 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.20A 4gkhJ-6ceyA:
18.1		 4gkhJ-6ceyA:
16.61