SIMILAR PATTERNS OF AMINO ACIDS FOR 4GH8_A_MTXA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		3 LYS A 302
ILE A 353
THR A 394
 None
 0.87A 4gh8A-1b3qA:
undetectable		 4gh8A-1b3qA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1z SAP SH2 DOMAIN

(Homo sapiens) 		PF00017
(SH2) 		3 LYS A1089
ILE A1096
THR A1068
 None
 0.81A 4gh8A-1d1zA:
undetectable		 4gh8A-1d1zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dex RHAMNOGALACTURONAN
ACETYLESTERASE

(Aspergillus
aculeatus) 		PF13472
(Lipase_GDSL_2) 		3 LYS A 220
ILE A 129
THR A   1
 None
 0.65A 4gh8A-1dexA:
0.9		 4gh8A-1dexA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 LYS A  10
ILE A 302
THR A 127
 None
 0.88A 4gh8A-1dkrA:
2.4		 4gh8A-1dkrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 LYS A  63
ILE A  70
THR A 195
 None
 0.88A 4gh8A-1dlcA:
0.0		 4gh8A-1dlcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LYS C   1
ILE C  27
THR C  61
 None
 0.87A 4gh8A-1ea9C:
undetectable		 4gh8A-1ea9C:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 LYS A 121
ILE A  31
THR A 129
 None
 0.75A 4gh8A-1f7uA:
undetectable		 4gh8A-1f7uA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A 408
ILE A  73
THR A 118
 None
 0.75A 4gh8A-1ff9A:
1.7		 4gh8A-1ff9A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw1 GLUTATHIONE
TRANSFERASE ZETA

(Homo sapiens) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		3 LYS A 177
ILE A 135
THR A 181
 None
 0.84A 4gh8A-1fw1A:
undetectable		 4gh8A-1fw1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 LYS A 329
ILE A 280
THR A 272
 None
 0.85A 4gh8A-1g1aA:
undetectable		 4gh8A-1g1aA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1k SCAFFOLDING PROTEIN

([Clostridium]
cellulolyticum) 		PF00963
(Cohesin) 		3 LYS A 101
ILE A  98
THR A 111
 None
 0.86A 4gh8A-1g1kA:
undetectable		 4gh8A-1g1kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00355
(Rieske) 		3 LYS B  74
ILE B  94
THR B  67
 None
 0.82A 4gh8A-1g8kB:
undetectable		 4gh8A-1g8kB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A 136
ILE A 113
THR A 102
 None
 0.63A 4gh8A-1guzA:
undetectable		 4gh8A-1guzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LYS A 136
ILE A 113
THR A 102
 None
 0.82A 4gh8A-1gv0A:
undetectable		 4gh8A-1gv0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		3 LYS A 246
ILE A 291
THR A 295
 None
 0.81A 4gh8A-1hjoA:
undetectable		 4gh8A-1hjoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		3 LYS A 164
ILE A 232
THR A 264
 None
 0.82A 4gh8A-1hkhA:
undetectable		 4gh8A-1hkhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		3 LYS A 246
ILE A 241
THR A 105
 None
 0.81A 4gh8A-1hnoA:
undetectable		 4gh8A-1hnoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		3 LYS A 237
ILE A 283
THR A 278
 None
 0.82A 4gh8A-1ia5A:
undetectable		 4gh8A-1ia5A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		3 LYS A 109
ILE A 117
THR A 122
 None
 0.87A 4gh8A-1j0aA:
undetectable		 4gh8A-1j0aA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		3 LYS A 259
ILE A 143
THR A 267
 None
None
UDP  A 353 ( 4.6A)
 0.81A 4gh8A-1jiuA:
2.0		 4gh8A-1jiuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		3 LYS A 113
ILE A 143
THR A 139
 None
 0.78A 4gh8A-1l0qA:
undetectable		 4gh8A-1l0qA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		3 LYS A  64
ILE A 283
THR A 275
 None
 0.83A 4gh8A-1l2qA:
undetectable		 4gh8A-1l2qA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		3 LYS A 481
ILE A 462
THR A 359
 None
 0.86A 4gh8A-1lnsA:
undetectable		 4gh8A-1lnsA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvm CATALYTIC DOMAIN OF
THE NUCLEAR
INCLUSION PROTEIN A
(NIA)

(Tobacco etch
virus) 		PF00863
(Peptidase_C4) 		3 LYS A 141
ILE A 109
THR A 146
 None
 0.85A 4gh8A-1lvmA:
undetectable		 4gh8A-1lvmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk7 TALIN

(Gallus gallus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 LYS B 343
ILE B 348
THR B 307
 None
 0.68A 4gh8A-1mk7B:
undetectable		 4gh8A-1mk7B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 LYS A 245
ILE A 212
THR A 265
 None
 0.88A 4gh8A-1nhcA:
undetectable		 4gh8A-1nhcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		3 LYS A  32
ILE A  86
THR A 132
 None
 0.83A 4gh8A-1o20A:
undetectable		 4gh8A-1o20A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2

(Mus musculus) 		PF09258
(Glyco_transf_64) 		3 LYS A 182
ILE A 297
THR A 254
 None
 0.87A 4gh8A-1omxA:
undetectable		 4gh8A-1omxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 LYS A 146
ILE A  96
THR A 108
 None
 0.84A 4gh8A-1pgpA:
2.5		 4gh8A-1pgpA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 LYS A 103
ILE A 115
THR A  49
 None
 0.83A 4gh8A-1qh5A:
undetectable		 4gh8A-1qh5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 LYS A 352
ILE A 405
THR A 400
 None
 0.76A 4gh8A-1qu2A:
undetectable		 4gh8A-1qu2A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		3 LYS A  68
ILE A 294
THR A   7
 None
 0.86A 4gh8A-1sh2A:
undetectable		 4gh8A-1sh2A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		3 LYS A 154
ILE A  19
THR A 159
 None
 0.78A 4gh8A-1t0iA:
2.6		 4gh8A-1t0iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0y TUBULIN FOLDING
COFACTOR B

(Caenorhabditis
elegans) 		PF14560
(Ubiquitin_2) 		3 LYS A  34
ILE A  48
THR A  14
 None
 0.86A 4gh8A-1t0yA:
undetectable		 4gh8A-1t0yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		3 LYS A 397
ILE A 429
THR A 416
 None
 0.83A 4gh8A-1t90A:
undetectable		 4gh8A-1t90A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LYS C  48
ILE C  53
THR C  86
 None
 0.85A 4gh8A-1u6gC:
undetectable		 4gh8A-1u6gC:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LYS C 577
ILE C 581
THR C 624
 None
 0.87A 4gh8A-1u6gC:
undetectable		 4gh8A-1u6gC:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwx ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS K  72
ILE K  31
THR K  54
 None
 0.86A 4gh8A-1uwxK:
undetectable		 4gh8A-1uwxK:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 LYS A 372
ILE A 361
THR A 357
 None
 0.78A 4gh8A-1uwyA:
undetectable		 4gh8A-1uwyA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1viw ALPHA-AMYLASE-INHIBI
TOR

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		3 LYS B 203
ILE B  51
THR B  56
 None
 0.70A 4gh8A-1viwB:
undetectable		 4gh8A-1viwB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 LYS A 226
ILE A 197
THR A 189
 None
 0.80A 4gh8A-1vljA:
undetectable		 4gh8A-1vljA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LYS A  86
ILE A  56
THR A  35
 None
 0.82A 4gh8A-1vrpA:
undetectable		 4gh8A-1vrpA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 LYS A 469
ILE A 411
THR A 491
 None
 0.85A 4gh8A-1w6sA:
undetectable		 4gh8A-1w6sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 LYS A 248
ILE A 322
THR A 288
 None
 0.77A 4gh8A-1wn1A:
undetectable		 4gh8A-1wn1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		3 LYS A 139
ILE A 146
THR A  16
 None
 0.74A 4gh8A-1xq1A:
2.5		 4gh8A-1xq1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF12840
(HTH_20) 		3 LYS A  63
ILE A  34
THR A  81
 None
 0.69A 4gh8A-1y0uA:
undetectable		 4gh8A-1y0uA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9k IAA
ACETYLTRANSFERASE

(Bacillus cereus) 		PF00583
(Acetyltransf_1) 		3 LYS A  79
ILE A  65
THR A  87
 None
 0.83A 4gh8A-1y9kA:
undetectable		 4gh8A-1y9kA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		3 LYS A  81
ILE A  85
THR A  49
 None
 0.86A 4gh8A-1z34A:
undetectable		 4gh8A-1z34A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6m CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13462
(Thioredoxin_4) 		3 LYS A  10
ILE A 151
THR A  15
 None
 0.73A 4gh8A-1z6mA:
undetectable		 4gh8A-1z6mA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		3 LYS A  32
ILE A  96
THR A 115
 SO4  A3484 (-3.1A)
None
None
 0.38A 4gh8A-1zdrA:
24.6		 4gh8A-1zdrA:
39.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhv HYPOTHETICAL PROTEIN
ATU0741

(Agrobacterium
fabrum) 		PF13840
(ACT_7) 		3 LYS A   8
ILE A   5
THR A 115
 None
 0.73A 4gh8A-1zhvA:
undetectable		 4gh8A-1zhvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		3 LYS A 196
ILE A 264
THR A 166
 None
 0.55A 4gh8A-2aqwA:
undetectable		 4gh8A-2aqwA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 LYS A 404
ILE A  72
THR A 117
 None
 0.81A 4gh8A-2axqA:
undetectable		 4gh8A-2axqA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 LYS A 529
ILE A 464
THR A 572
 None
 0.88A 4gh8A-2b8eA:
undetectable		 4gh8A-2b8eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		3 LYS B 211
ILE A 449
THR B 217
 None
 0.80A 4gh8A-2b9sB:
undetectable		 4gh8A-2b9sB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ba0 ARCHAEAL EXOSOME RNA
BINDING PROTEIN RRP4

(Archaeoglobus
fulgidus) 		PF00575
(S1)
PF14382
(ECR1_N)
PF15985
(KH_6) 		3 LYS A   2
ILE A  34
THR A  22
 None
 0.86A 4gh8A-2ba0A:
undetectable		 4gh8A-2ba0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		3 LYS A 204
ILE A 182
THR A  29
 None
 0.80A 4gh8A-2bufA:
undetectable		 4gh8A-2bufA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		3 LYS A 292
ILE A 306
THR A 246
 None
 0.86A 4gh8A-2c0hA:
undetectable		 4gh8A-2c0hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 LYS A 228
ILE A 240
THR A 308
 None
 0.74A 4gh8A-2cn3A:
undetectable		 4gh8A-2cn3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cz4 HYPOTHETICAL PROTEIN
TTHA0516

(Thermus
thermophilus) 		no annotation 3 LYS A  19
ILE A  56
THR A  60
 None
None
ACT  A 303 (-4.4A)
 0.87A 4gh8A-2cz4A:
undetectable		 4gh8A-2cz4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2da0 130-KDA
PHOSPHATIDYLINOSITOL
4,5-BIPHOSPHATE-DEPE
NDENT ARF1
GTPASE-ACTIVATING
PROTEIN

(Homo sapiens) 		PF00169
(PH) 		3 LYS A  19
ILE A  41
THR A  45
 None
 0.82A 4gh8A-2da0A:
undetectable		 4gh8A-2da0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		3 LYS A 166
ILE A  15
THR A 140
 None
 0.78A 4gh8A-2e5fA:
undetectable		 4gh8A-2e5fA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 LYS A 202
ILE A 198
THR A 176
 None
 0.68A 4gh8A-2ep5A:
undetectable		 4gh8A-2ep5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		3 LYS A 303
ILE A 324
THR A 332
 None
 0.79A 4gh8A-2fnaA:
undetectable		 4gh8A-2fnaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 LYS A 397
ILE A 509
THR A 524
 None
 0.87A 4gh8A-2fuqA:
undetectable		 4gh8A-2fuqA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 LYS A 341
ILE A  42
THR A  31
 None
 0.88A 4gh8A-2gp6A:
undetectable		 4gh8A-2gp6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		3 LYS A 224
ILE A 292
THR A 194
 None
 0.60A 4gh8A-2guuA:
undetectable		 4gh8A-2guuA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6

(Homo sapiens) 		PF00025
(Arf) 		3 LYS A  85
ILE A  90
THR A  66
 None
 0.88A 4gh8A-2h57A:
1.7		 4gh8A-2h57A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		3 LYS A 462
ILE A 407
THR A 237
 None
 0.86A 4gh8A-2hmfA:
undetectable		 4gh8A-2hmfA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		3 LYS A 127
ILE A  98
THR A  62
 None
 0.76A 4gh8A-2hpwA:
undetectable		 4gh8A-2hpwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A 755
ILE A 752
THR A 439
 None
 0.81A 4gh8A-2iujA:
undetectable		 4gh8A-2iujA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A 767
ILE A 764
THR A 451
 None
 0.86A 4gh8A-2iukA:
undetectable		 4gh8A-2iukA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		3 LYS A 131
ILE A 311
THR A 348
 None
 0.76A 4gh8A-2iv0A:
1.9		 4gh8A-2iv0A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		3 LYS A  64
ILE A 221
THR A 233
 None
 0.87A 4gh8A-2iw0A:
undetectable		 4gh8A-2iw0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		3 LYS A  76
ILE A 183
THR A  84
 None
 0.72A 4gh8A-2ixoA:
undetectable		 4gh8A-2ixoA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3c CRYSTALLIN, GAMMA M7

(Danio rerio) 		PF00030
(Crystall) 		3 LYS A  90
ILE A 168
THR A 172
 None
 0.78A 4gh8A-2m3cA:
undetectable		 4gh8A-2m3cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ncg RGA1E

(Aegilops
tauschii) 		no annotation 3 LYS A  41
ILE A   8
THR A 106
 None
 0.86A 4gh8A-2ncgA:
undetectable		 4gh8A-2ncgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu BROMODOMAIN-CONTAINI
NG PROTEIN 4
REGULATORY PROTEIN
E2

(Alphapapillomavirus
9;
Homo sapiens) 		PF00508
(PPV_E2_N)
PF17105
(BRD4_CDT) 		3 LYS B1343
ILE A  73
THR A  81
 None
 0.81A 4gh8A-2nnuB:
undetectable		 4gh8A-2nnuB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 430
ILE A 404
THR A 309
 None
 0.61A 4gh8A-2nt2A:
undetectable		 4gh8A-2nt2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 LYS A 399
ILE A 389
THR A 369
 None
 0.71A 4gh8A-2ou2A:
undetectable		 4gh8A-2ou2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 LYS A 125
ILE A 145
THR A 149
 None
 0.80A 4gh8A-2p0uA:
undetectable		 4gh8A-2p0uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		3 LYS A  96
ILE A  45
THR A  49
 None
 0.84A 4gh8A-2p4zA:
undetectable		 4gh8A-2p4zA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		3 LYS A 413
ILE A 320
THR A 268
 None
 0.87A 4gh8A-2qqhA:
undetectable		 4gh8A-2qqhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raq CONSERVED PROTEIN
MTH889

(Methanothermobacter
thermautotrophicus) 		PF02680
(DUF211) 		3 LYS A  52
ILE A  69
THR A  48
 None
 0.85A 4gh8A-2raqA:
undetectable		 4gh8A-2raqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 LYS A 246
ILE A 291
THR A 295
 None
 0.76A 4gh8A-2v7zA:
undetectable		 4gh8A-2v7zA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		3 LYS A 216
ILE A 189
THR A 199
 None
 0.86A 4gh8A-2varA:
0.8		 4gh8A-2varA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25

(Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25) 		3 LYS A 115
ILE A  96
THR A 104
 None
 0.82A 4gh8A-2ve7A:
undetectable		 4gh8A-2ve7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		3 LYS A 320
ILE A 253
THR A 343
 None
 0.73A 4gh8A-2vhlA:
undetectable		 4gh8A-2vhlA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		3 LYS A 109
ILE A 126
THR A 156
 None
 0.82A 4gh8A-2vrnA:
undetectable		 4gh8A-2vrnA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vs0 VIRULENCE FACTOR
ESXA

(Staphylococcus
aureus) 		PF06013
(WXG100) 		3 LYS A  61
ILE A  25
THR A  33
 None
 0.78A 4gh8A-2vs0A:
undetectable		 4gh8A-2vs0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		3 LYS A 534
ILE A 510
THR A 477
 None
 0.70A 4gh8A-2wkpA:
undetectable		 4gh8A-2wkpA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 LYS A  80
ILE A 249
THR A 138
 None
 0.77A 4gh8A-2wzsA:
undetectable		 4gh8A-2wzsA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		3 LYS A 434
ILE A 468
THR A 445
 None
 0.87A 4gh8A-2xa7A:
undetectable		 4gh8A-2xa7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		3 LYS A 193
ILE A 261
THR A 163
 None
None
OMP  A 500 ( 4.2A)
 0.65A 4gh8A-2za1A:
undetectable		 4gh8A-2za1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		3 LYS A 615
ILE A 515
THR A 495
 None
 0.82A 4gh8A-2zj8A:
undetectable		 4gh8A-2zj8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		3 LYS A 163
ILE A 194
THR A  32
 None
 0.87A 4gh8A-2ztsA:
undetectable		 4gh8A-2ztsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 601
ILE A 696
THR A 729
 None
 0.87A 4gh8A-3b2tA:
undetectable		 4gh8A-3b2tA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b73 PHIH1 REPRESSOR-LIKE
PROTEIN

(Haloarcula
marismortui) 		no annotation 3 LYS A  49
ILE A  15
THR A  67
 None
 0.69A 4gh8A-3b73A:
undetectable		 4gh8A-3b73A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdd REGULATORY PROTEIN
MARR

(Streptococcus
suis) 		PF01047
(MarR) 		3 LYS A  66
ILE A  35
THR A  91
 None
 0.74A 4gh8A-3bddA:
undetectable		 4gh8A-3bddA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		3 LYS A 140
ILE A 125
THR A 220
 None
 0.84A 4gh8A-3bl6A:
undetectable		 4gh8A-3bl6A:
21.21