SIMILAR PATTERNS OF AMINO ACIDS FOR 4GC9_A_SAMA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		3 GLU A 186
ASP A 255
ASP A  24
 None
 0.79A 4gc9A-1bhwA:
undetectable		 4gc9A-1bhwA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		3 GLU A  29
ASP A  31
ASP A  50
 None
 0.44A 4gc9A-1dctA:
6.2		 4gc9A-1dctA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1frd HETEROCYST [2FE-2S]
FERREDOXIN

(Nostoc sp. PCC
7120) 		PF00111
(Fer2) 		3 GLU A  32
ASP A  28
ASP A  21
 None
 0.78A 4gc9A-1frdA:
undetectable		 4gc9A-1frdA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		3 GLU A  71
ASP A  73
ASP A  89
 NEA  A 500 (-2.8A)
None
NEA  A 500 (-3.4A)
 0.33A 4gc9A-1g38A:
10.8		 4gc9A-1g38A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		3 GLU A 110
ASP A 109
ASP A 104
 None
 0.76A 4gc9A-1jr7A:
undetectable		 4gc9A-1jr7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 104
ASP A 106
ASP A 141
 None
 0.20A 4gc9A-1mjfA:
9.8		 4gc9A-1mjfA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 GLU A 528
ASP A 521
ASP A 100
 None
 0.75A 4gc9A-1mroA:
undetectable		 4gc9A-1mroA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1c SKELETAL MUSCLE
MYOSIN II REGULATORY
LIGHT CHAIN

(Gallus gallus) 		PF13833
(EF-hand_8) 		3 GLU B  49
ASP B  45
ASP B  35
 None
 0.63A 4gc9A-1o1cB:
undetectable		 4gc9A-1o1cB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 GLU A 120
ASP A  73
ASP C 447
 None
None
TRS  A   2 (-3.6A)
 0.67A 4gc9A-1o7dA:
undetectable		 4gc9A-1o7dA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 GLU A 281
ASP A 336
ASP A 333
 None
 0.78A 4gc9A-1odoA:
undetectable		 4gc9A-1odoA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		3 GLU A 293
ASP A 347
ASP A 344
 None
 0.73A 4gc9A-1q5dA:
undetectable		 4gc9A-1q5dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr5 PHOSPHOCARRIER
PROTEIN HPR

(Staphylococcus
carnosus) 		PF00381
(PTS-HPr) 		3 GLU A  70
ASP A  66
ASP A  30
 None
 0.78A 4gc9A-1qr5A:
undetectable		 4gc9A-1qr5A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 GLU A 280
ASP A 335
ASP A 332
 None
 0.75A 4gc9A-1s1fA:
undetectable		 4gc9A-1s1fA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		3 GLU A  58
ASP A  62
ASP A 118
 None
 0.79A 4gc9A-1sjjA:
undetectable		 4gc9A-1sjjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhm PROTEIN YEBR

(Escherichia
coli) 		PF13185
(GAF_2) 		3 GLU A 125
ASP A 143
ASP A 108
 MES  A 194 (-3.2A)
MES  A 194 (-4.0A)
None
 0.67A 4gc9A-1vhmA:
undetectable		 4gc9A-1vhmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		3 GLU A  79
ASP A  81
ASP A 105
 SAH  A1001 (-2.8A)
None
SAH  A1001 (-3.2A)
 0.39A 4gc9A-1wy7A:
13.1		 4gc9A-1wy7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 151
ASP A 153
ASP A 182
 None
 0.46A 4gc9A-1xj5A:
10.1		 4gc9A-1xj5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 GLU A 122
ASP A 124
ASP A 150
 None
 0.41A 4gc9A-1yb2A:
10.1		 4gc9A-1yb2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zak ADENYLATE KINASE

(Zea mays) 		PF00406
(ADK) 		3 GLU A 120
ASP A 119
ASP A 194
 None
 0.63A 4gc9A-1zakA:
undetectable		 4gc9A-1zakA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 GLU A 153
ASP A 155
ASP A  53
 None
 0.76A 4gc9A-1zl6A:
undetectable		 4gc9A-1zl6A:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		3 GLU A  85
ASP A  87
ASP A 113
 SAM  A4000 (-2.8A)
None
SAM  A4000 (-3.8A)
 0.53A 4gc9A-1zq9A:
25.3		 4gc9A-1zq9A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bud MALES-ABSENT ON THE
FIRST PROTEIN

(Drosophila
melanogaster) 		PF11717
(Tudor-knot) 		3 GLU A 377
ASP A 374
ASP A 434
 None
 0.77A 4gc9A-2budA:
undetectable		 4gc9A-2budA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 GLU A  33
ASP A  29
ASP A  51
 None
 0.74A 4gc9A-2bvmA:
undetectable		 4gc9A-2bvmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 GLU A  98
ASP A 101
ASP A 236
 None
HXD  A 900 (-3.1A)
None
 0.79A 4gc9A-2ddhA:
undetectable		 4gc9A-2ddhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdo HYPOTHETICAL PROTEIN
AF2331

(Archaeoglobus
fulgidus) 		no annotation 3 GLU B  52
ASP B  33
ASP B  30
 None
 0.63A 4gc9A-2fdoB:
undetectable		 4gc9A-2fdoB:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		3 GLU A  85
ASP A  87
ASP A 113
 None
None
ZN  A 306 ( 4.7A)
 0.58A 4gc9A-2gpyA:
9.8		 4gc9A-2gpyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 GLU A 272
ASP A 271
ASP A 275
 None
 0.73A 4gc9A-2i6uA:
undetectable		 4gc9A-2i6uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 GLU A  40
ASP A  42
ASP A  60
 SAH  A 328 (-2.8A)
None
SAH  A 328 (-3.6A)
 0.25A 4gc9A-2i9kA:
6.0		 4gc9A-2i9kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 GLU A 280
ASP A 333
ASP A 330
 None
 0.75A 4gc9A-2jjpA:
undetectable		 4gc9A-2jjpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv5 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF10052
(DUF2288) 		3 GLU A  47
ASP A  44
ASP A  40
 None
 0.58A 4gc9A-2lv5A:
undetectable		 4gc9A-2lv5A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oys HYPOTHETICAL PROTEIN
SP1951

(Streptococcus
pneumoniae) 		PF03358
(FMN_red) 		3 GLU A  55
ASP A  52
ASP A  62
 None
 0.78A 4gc9A-2oysA:
undetectable		 4gc9A-2oysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 147
ASP A 149
ASP A 178
 S4M  A 501 (-2.7A)
None
S4M  A 501 (-3.3A)
 0.33A 4gc9A-2pt6A:
9.8		 4gc9A-2pt6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		3 GLU A 103
ASP A 100
ASP A 105
 None
 0.80A 4gc9A-2wsbA:
5.2		 4gc9A-2wsbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 GLU B 261
ASP B 314
ASP B 311
 None
 0.67A 4gc9A-2yjnB:
undetectable		 4gc9A-2yjnB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 GLU A  46
ASP A 109
ASP A  74
 None
 0.67A 4gc9A-2ylkA:
undetectable		 4gc9A-2ylkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		3 GLU A 293
ASP A 346
ASP A 343
 None
 0.75A 4gc9A-2z3tA:
undetectable		 4gc9A-2z3tA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 107
ASP A 109
ASP A 144
 None
 0.20A 4gc9A-2zsuA:
10.2		 4gc9A-2zsuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		3 GLU A 262
ASP A 264
ASP A 288
 SAH  A 376 (-2.7A)
None
SAH  A 376 (-4.1A)
 0.33A 4gc9A-2zwvA:
8.1		 4gc9A-2zwvA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1w IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		3 GLU A  83
ASP A  82
ASP A  88
 None
 0.80A 4gc9A-3a1wA:
undetectable		 4gc9A-3a1wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 220
ASP A 222
ASP A 255
 MTA  A 401 (-2.5A)
None
MTA  A 401 (-3.6A)
 0.36A 4gc9A-3c6mA:
8.7		 4gc9A-3c6mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		3 GLU A 160
ASP A 159
ASP A 163
 None
 0.75A 4gc9A-3d6kA:
undetectable		 4gc9A-3d6kA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		3 GLU A  97
ASP A  96
ASP A  91
 None
 0.80A 4gc9A-3f6tA:
undetectable		 4gc9A-3f6tA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		3 GLU A  87
ASP A  86
ASP A  62
 None
 0.52A 4gc9A-3fkqA:
undetectable		 4gc9A-3fkqA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		3 GLU A  75
ASP A  77
ASP A  99
 None
 0.28A 4gc9A-3futA:
23.7		 4gc9A-3futA:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		3 GLU A  59
ASP A  61
ASP A  84
 None
 0.27A 4gc9A-3fydA:
26.0		 4gc9A-3fydA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 GLU A 336
ASP A 335
ASP A 330
 None
 0.73A 4gc9A-3g4fA:
undetectable		 4gc9A-3g4fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		3 GLU A  29
ASP A  31
ASP A  51
 None
 0.48A 4gc9A-3g7uA:
7.2		 4gc9A-3g7uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 3 GLU A 117
ASP A 119
ASP A 144
 FMT  A 315 (-3.6A)
None
None
 0.63A 4gc9A-3gjyA:
8.7		 4gc9A-3gjyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		3 GLU A  59
ASP A  61
ASP A  84
 SAM  A 300 (-2.8A)
None
SAM  A 300 (-3.7A)
 0.28A 4gc9A-3gryA:
25.9		 4gc9A-3gryA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtn ADAPTER PROTEIN MECA
2

(Bacillus
subtilis) 		PF05389
(MecA) 		3 GLU A  42
ASP A  43
ASP A   2
 IOD  A  95 (-4.9A)
None
None
 0.73A 4gc9A-3jtnA:
undetectable		 4gc9A-3jtnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		3 GLU A 155
ASP A 157
ASP A 183
 None
 0.34A 4gc9A-3k6rA:
10.6		 4gc9A-3k6rA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		3 GLU A 344
ASP A 397
ASP A 394
 None
 0.53A 4gc9A-3mzsA:
undetectable		 4gc9A-3mzsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		3 GLU A 187
ASP A 189
ASP A 254
 None
 0.68A 4gc9A-3na6A:
undetectable		 4gc9A-3na6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159

(Methanocaldococcus
jannaschii) 		PF01995
(DUF128) 		3 GLU A 361
ASP A 360
ASP A 355
 None
 0.74A 4gc9A-3nekA:
undetectable		 4gc9A-3nekA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 GLU B  98
ASP B  89
ASP A 107
 CA  B 538 (-3.0A)
None
None
 0.77A 4gc9A-3ojyB:
undetectable		 4gc9A-3ojyB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		3 GLU A 344
ASP A 285
ASP A 297
 None
 0.65A 4gc9A-3pt1A:
4.3		 4gc9A-3pt1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		3 GLU A 295
ASP A 348
ASP A 345
 None
 0.79A 4gc9A-3r9bA:
undetectable		 4gc9A-3r9bA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Aquifex
aeolicus) 		PF00398
(RrnaAD) 		3 GLU B  60
ASP B  62
ASP B  83
 None
 0.64A 4gc9A-3r9xB:
23.1		 4gc9A-3r9xB:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 124
ASP A 126
ASP A 155
 DSH  A 303 (-2.6A)
None
DSH  A 303 (-3.5A)
 0.36A 4gc9A-3rw9A:
9.6		 4gc9A-3rw9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 GLU A 547
ASP A 540
ASP A 108
 None
 0.76A 4gc9A-3sqgA:
undetectable		 4gc9A-3sqgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		3 GLU A  83
ASP A  82
ASP A   4
 None
 0.74A 4gc9A-3tc2A:
undetectable		 4gc9A-3tc2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		3 GLU A  61
ASP A  63
ASP A  86
 None
 0.34A 4gc9A-3tqsA:
26.7		 4gc9A-3tqsA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		3 GLU A 575
ASP A 574
ASP A 567
 None
 0.74A 4gc9A-3txaA:
2.0		 4gc9A-3txaA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		3 GLU A  71
ASP A  73
ASP A  94
 None
 0.48A 4gc9A-3uzuA:
25.2		 4gc9A-3uzuA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		3 GLU A 118
ASP A  96
ASP A  86
 None
None
GD  A 202 (-3.3A)
 0.60A 4gc9A-3vdzA:
undetectable		 4gc9A-3vdzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 3 GLU A 446
ASP A 448
ASP A 479
 None
 0.79A 4gc9A-3w36A:
undetectable		 4gc9A-3w36A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 GLU A 173
ASP A 178
ASP A 181
 None
 0.79A 4gc9A-3wt0A:
undetectable		 4gc9A-3wt0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2

(Homo sapiens) 		PF10250
(O-FucT) 		3 GLU A 416
ASP A 305
ASP A 414
 None
 0.64A 4gc9A-4ap5A:
undetectable		 4gc9A-4ap5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		3 GLU A 234
ASP A 230
ASP A 225
 None
 0.73A 4gc9A-4asyA:
undetectable		 4gc9A-4asyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		3 GLU A  36
ASP A  35
ASP A 240
 None
 0.78A 4gc9A-4e2oA:
undetectable		 4gc9A-4e2oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		3 GLU A 430
ASP A 483
ASP A 480
 None
 0.69A 4gc9A-4ep6A:
undetectable		 4gc9A-4ep6A:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		3 GLU A  85
ASP A  87
ASP A 111
 ACT  A 402 (-2.9A)
None
None
 0.15A 4gc9A-4gc5A:
47.1		 4gc9A-4gc5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		3 GLU A 148
ASP A 144
ASP A 293
 None
 0.62A 4gc9A-4injA:
undetectable		 4gc9A-4injA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		3 GLU A 261
ASP A 263
ASP A 283
 AGS  A 502 (-2.4A)
None
AGS  A 502 (-2.9A)
 0.26A 4gc9A-4j9vA:
6.8		 4gc9A-4j9vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		3 GLU A 505
ASP A 504
ASP A 513
 None
 0.63A 4gc9A-4jc8A:
2.7		 4gc9A-4jc8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN

(Marinobacter
hydrocarbonoclasticus) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		3 GLU A  39
ASP A  34
ASP A   5
 None
 0.55A 4gc9A-4n0vA:
undetectable		 4gc9A-4n0vA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		3 GLU A 141
ASP A 137
ASP A 102
 None
 0.67A 4gc9A-4r9oA:
undetectable		 4gc9A-4r9oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 GLU A 341
ASP A 106
ASP A 258
 None
 0.79A 4gc9A-4rf7A:
undetectable		 4gc9A-4rf7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 GLU A 280
ASP A 333
ASP A 330
 None
 0.79A 4gc9A-4ubsA:
undetectable		 4gc9A-4ubsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLU A 147
ASP A 149
ASP A 178
 MTA  A 401 (-2.7A)
None
MTA  A 401 (-3.2A)
 0.34A 4gc9A-4uoeA:
9.9		 4gc9A-4uoeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 GLU A 592
ASP A 352
ASP A 462
 None
 0.78A 4gc9A-4wgkA:
undetectable		 4gc9A-4wgkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 3 GLU A  87
ASP A  89
ASP A 132
 CA  A 402 (-2.9A)
None
None
 0.60A 4gc9A-4wmyA:
undetectable		 4gc9A-4wmyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		3 GLU A 187
ASP A   3
ASP A 326
 None
 0.69A 4gc9A-4x8iA:
undetectable		 4gc9A-4x8iA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus) 		PF00067
(p450) 		3 GLU A 283
ASP A 338
ASP A 335
 None
 0.79A 4gc9A-4xe3A:
undetectable		 4gc9A-4xe3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 GLU A 154
ASP A 156
ASP A  54
 None
 0.59A 4gc9A-4zktA:
undetectable		 4gc9A-4zktA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE

(Salinibacter
ruber) 		PF13847
(Methyltransf_31) 		3 GLU A  53
ASP A  55
ASP A  81
 SAH  A 201 (-2.8A)
None
SAH  A 201 (-3.6A)
 0.48A 4gc9A-5bxyA:
11.7		 4gc9A-5bxyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		3 GLU A  80
ASP A  79
ASP A  29
 None
 0.76A 4gc9A-5c1bA:
undetectable		 4gc9A-5c1bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		3 GLU A 269
ASP A 268
ASP A 266
 None
 0.79A 4gc9A-5d3mA:
undetectable		 4gc9A-5d3mA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 GLU A 234
ASP A 230
ASP A 225
 None
 0.72A 4gc9A-5ifyA:
undetectable		 4gc9A-5ifyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 GLU A 613
ASP A 615
ASP A 580
 None
 0.59A 4gc9A-5mswA:
2.1		 4gc9A-5mswA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		3 GLU A 112
ASP A  93
ASP A  72
 None
None
GAL  A 301 (-2.7A)
 0.79A 4gc9A-5muaA:
undetectable		 4gc9A-5muaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 GLU A 530
ASP A 523
ASP A 103
 None
 0.79A 4gc9A-5n28A:
undetectable		 4gc9A-5n28A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7c HIPPOCALCIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 GLU A  84
ASP A  81
ASP A  73
 None
 0.69A 4gc9A-5t7cA:
undetectable		 4gc9A-5t7cA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6u CYTOCHROME P450

(Rhodopseudomonas
palustris) 		no annotation 3 GLU A 287
ASP A 340
ASP A 337
 None
 0.76A 4gc9A-5u6uA:
undetectable		 4gc9A-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		3 GLU A 524
ASP A 526
ASP A 551
 SAH  A 705 (-2.7A)
None
SAH  A 705 (-3.4A)
 0.27A 4gc9A-5wcjA:
10.0		 4gc9A-5wcjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 GLU A 222
ASP A 207
ASP A 240
 None
None
ZN  A 502 ( 2.1A)
 0.62A 4gc9A-5xevA:
undetectable		 4gc9A-5xevA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 6

(Homo sapiens) 		PF05347
(Complex1_LYR) 		3 GLU E  27
ASP E  24
ASP E  80
 None
 0.70A 4gc9A-5xtdE:
undetectable		 4gc9A-5xtdE:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 3 GLU A 426
ASP A 432
ASP A 418
 None
 0.68A 4gc9A-5z0uA:
undetectable		 4gc9A-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 3 GLU A  36
ASP A  32
ASP A  38
 None
 0.78A 4gc9A-6b9rA:
undetectable		 4gc9A-6b9rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqo SINGLE-STRANDED
DNA-BINDING PROTEIN
RIM1, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A  87
ASP A 112
ASP A  89
 None
 0.77A 4gc9A-6cqoA:
undetectable		 4gc9A-6cqoA:
undetectable