SIMILAR PATTERNS OF AMINO ACIDS FOR 4GBO_B_CUB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 HIS A 291
ALA A 393
GLN A 352
TYR A 353
 None
 1.28A 4gboB-1itxA:
undetectable		 4gboB-1itxA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc4 METHYLMALONYL-COA
EPIMERASE

(Propionibacterium
freudenreichii) 		PF13669
(Glyoxalase_4) 		4 HIS A  91
ALA A  93
HIS A  12
GLN A  65
 None
None
SO4  A 203 ( 4.8A)
SO4  A 203 (-2.6A)
 0.99A 4gboB-1jc4A:
undetectable		 4gboB-1jc4A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 HIS A 110
ALA A 111
GLN A 178
TYR A 126
 None
 1.25A 4gboB-1o94A:
undetectable		 4gboB-1o94A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP3)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 ALA 3 194
HIS 3 191
GLN 3 188
TYR 3 121
 None
 1.32A 4gboB-1qgc3:
undetectable		 4gboB-1qgc3:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.40A 4gboB-2a3lA:
undetectable		 4gboB-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4p HYPOTHETICAL PROTEIN
TM1010

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		4 HIS A  52
ALA A 117
HIS A  54
GLN A  58
 UNL  A 136 (-3.3A)
UNL  A 136 ( 4.9A)
UNL  A 136 (-3.7A)
UNL  A 136 (-3.2A)
 1.12A 4gboB-2f4pA:
undetectable		 4gboB-2f4pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq9 MLL6688 PROTEIN

(Mesorhizobium
loti) 		PF12900
(Pyridox_ox_2) 		4 HIS A  44
HIS A  95
GLN A  98
TYR A  46
 None
 1.22A 4gboB-2hq9A:
undetectable		 4gboB-2hq9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		4 HIS A 108
ALA A 112
HIS A 165
TYR A 362
 None
 1.50A 4gboB-2ibpA:
undetectable		 4gboB-2ibpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		4 HIS A 239
ALA A 236
HIS A 232
TYR A 213
 None
 1.15A 4gboB-2rfgA:
undetectable		 4gboB-2rfgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0o FCH DOMAIN ONLY
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		4 HIS A 209
HIS A 112
GLN A 108
TYR A 104
 None
 1.36A 4gboB-2v0oA:
undetectable		 4gboB-2v0oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  89
GLN A 174
TYR A 176
 NI  A1231 (-3.2A)
NI  A1231 (-3.2A)
NI  A1231 ( 4.7A)
NI  A1231 (-4.7A)
 1.00A 4gboB-2vtcA:
8.5		 4gboB-2vtcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 HIS A 400
ALA A 401
GLN A 410
TYR A 407
 None
None
None
EPE  A1100 (-4.1A)
 1.47A 4gboB-2ww8A:
undetectable		 4gboB-2ww8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		4 ALA A 743
HIS A 529
GLN A 546
TYR A 553
 None
 1.48A 4gboB-2yhgA:
undetectable		 4gboB-2yhgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		4 HIS A  44
ALA A  47
HIS A 134
GLN A 165
 None
 1.44A 4gboB-3bt5A:
undetectable		 4gboB-3bt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		4 ALA A 187
HIS A 157
GLN A 281
TYR A 263
 GOL  A   1 ( 4.1A)
GOL  A   1 ( 4.7A)
GOL  A   1 (-3.3A)
None
 1.13A 4gboB-3e61A:
undetectable		 4gboB-3e61A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum) 		PF02645
(DegV) 		4 HIS A 141
ALA A 214
GLN A 185
TYR A 139
 None
 1.07A 4gboB-3eglA:
undetectable		 4gboB-3eglA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eja PROTEIN GH61E

(Thielavia
terrestris) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 142
GLN A 151
TYR A 153
 MG  A 701 (-3.2A)
SO4  A4851 (-3.9A)
SO4  A4851 (-3.2A)
None
 0.97A 4gboB-3ejaA:
8.5		 4gboB-3ejaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 HIS A  28
ALA A  94
HIS A 228
TYR A 174
 None
CL  A 268 (-3.5A)
None
CL  A 268 ( 4.8A)
 1.41A 4gboB-3flbA:
undetectable		 4gboB-3flbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A  32
ALA A  30
HIS A  41
TYR A  60
 None
 1.18A 4gboB-3g8dA:
undetectable		 4gboB-3g8dA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ira CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03190
(Thioredox_DsbH) 		4 HIS A  54
ALA A  57
HIS A  16
GLN A  15
 None
 1.47A 4gboB-3iraA:
undetectable		 4gboB-3iraA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		4 ALA A 687
HIS A 591
GLN A 589
TYR A 588
 None
 1.36A 4gboB-3l6yA:
undetectable		 4gboB-3l6yA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 HIS B1205
ALA B1202
HIS B1102
GLN B1099
 None
 1.37A 4gboB-3myrB:
undetectable		 4gboB-3myrB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 ALA A 274
HIS A 259
GLN A 255
TYR A 254
 None
 1.22A 4gboB-3nibA:
undetectable		 4gboB-3nibA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 ALA A  37
HIS A  66
GLN A  72
TYR A  89
 None
 1.46A 4gboB-3vnkA:
undetectable		 4gboB-3vnkA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D

(Phanerochaete
chrysosporium) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 149
GLN A 158
TYR A 160
 CU  A 221 ( 3.0A)
GOL  A 222 (-4.2A)
GOL  A 222 (-3.0A)
CU  A 221 (-4.9A)
 0.90A 4gboB-4b5qA:
8.4		 4gboB-4b5qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 HIS A   1
ALA A  80
HIS A  83
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-3.1A)
CU  A 300 (-4.3A)
None
 1.03A 4gboB-4d7uA:
7.9		 4gboB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 155
GLN A 164
TYR A 166
 CU  A 300 (-3.0A)
None
CU  A 300 (-4.3A)
None
 1.00A 4gboB-4d7uA:
7.9		 4gboB-4d7uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 HIS A 439
ALA A 442
HIS A 446
GLN A 458
 None
 1.43A 4gboB-4fixA:
undetectable		 4gboB-4fixA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS H 525
ALA H 484
HIS H 483
TYR H 523
 None
 1.43A 4gboB-4fxgH:
undetectable		 4gboB-4fxgH:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		5 HIS A  37
ALA A 142
HIS A 144
GLN A 211
TYR A 213
 CU  A 301 (-2.9A)
CU  A 301 ( 3.9A)
CU  A 301 (-3.4A)
CU  A 301 ( 4.7A)
None
 0.51A 4gboB-4gboA:
37.5		 4gboB-4gboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 HIS A  37
HIS A 208
GLN A 211
TYR A 213
 CU  A 301 (-2.9A)
None
CU  A 301 ( 4.7A)
None
 0.75A 4gboB-4gboA:
37.5		 4gboB-4gboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r LIGHT CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA L  50
HIS L  32
GLN L  66
TYR L  71
 None
 1.50A 4gboB-4i3rL:
3.0		 4gboB-4i3rL:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A  32
ALA A  30
HIS A  41
TYR A  60
 None
 1.18A 4gboB-4mv3A:
undetectable		 4gboB-4mv3A:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oy8 PUTATIVE SECRETED
CELLULOSE-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		4 ALA A 148
HIS A 150
GLN A 217
TYR A 219
 ACT  A 311 ( 3.1A)
ZN  A 305 ( 3.2A)
None
None
 0.59A 4gboB-4oy8A:
35.3		 4gboB-4oy8A:
69.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oy8 PUTATIVE SECRETED
CELLULOSE-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		4 HIS A  43
ALA A 148
HIS A 150
TYR A 219
 ZN  A 305 ( 3.1A)
ACT  A 311 ( 3.1A)
ZN  A 305 ( 3.2A)
None
 0.90A 4gboB-4oy8A:
35.3		 4gboB-4oy8A:
69.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  81
GLN A 162
TYR A 164
 CU  A1226 ( 3.0A)
CU  A1226 ( 3.3A)
SO4  A1227 ( 3.3A)
None
 0.85A 4gboB-5fohA:
8.6		 4gboB-5fohA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 153
GLN A 162
TYR A 164
 CU  A1226 ( 3.0A)
SO4  A1227 (-4.1A)
SO4  A1227 ( 3.3A)
None
 1.03A 4gboB-5fohA:
8.6		 4gboB-5fohA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
US15

(Kluyveromyces
lactis) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		4 ALA N  57
HIS N  58
GLN N  36
TYR N  40
 None
 1.17A 4gboB-5it9N:
undetectable		 4gboB-5it9N:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 4 HIS A   1
ALA A  89
HIS A  91
TYR A 184
 CU1  A 303 (-3.0A)
CU1  A 303 ( 4.0A)
CU1  A 303 (-3.2A)
CU1  A 303 (-4.9A)
 0.83A 4gboB-5mszA:
13.9		 4gboB-5mszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		4 ALA A  75
HIS A  78
GLN A 162
TYR A 164
 BGC  A 305 (-3.6A)
CU  A 301 ( 3.2A)
CL  A 309 (-3.3A)
HIC  A   1 (-3.9A)
 1.06A 4gboB-5n05A:
7.8		 4gboB-5n05A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 4 HIS A   1
HIS A  80
GLN A 165
TYR A 167
 CU  A 303 (-3.2A)
CU  A 303 ( 3.3A)
GOL  A 309 (-3.3A)
None
 0.82A 4gboB-5nnsA:
8.2		 4gboB-5nnsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 4 HIS A   1
HIS A 159
GLN A 165
TYR A 167
 CU  A 303 (-3.2A)
GOL  A 309 (-4.2A)
GOL  A 309 (-3.3A)
None
 0.95A 4gboB-5nnsA:
8.2		 4gboB-5nnsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no7 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Trametes
cinnabarina) 		no annotation 4 HIS A   1
HIS A  99
GLN A 174
TYR A 176
 None
 0.69A 4gboB-5no7A:
6.5		 4gboB-5no7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 5 HIS A  37
ALA A 142
HIS A 144
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
CU  A 301 ( 3.9A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.2A)
None
 0.56A 4gboB-5opfA:
34.0		 4gboB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 HIS A  37
HIS A 216
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
None
CU  A 301 ( 4.2A)
None
 0.78A 4gboB-5opfA:
34.0		 4gboB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A  84
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
CU  A 308 (-3.1A)
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.91A 4gboB-5tkfA:
8.5		 4gboB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 HIS A   1
HIS A 157
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
None
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.96A 4gboB-5tkfA:
8.5		 4gboB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 4 HIS A 602
ALA A 603
HIS A 492
TYR A1241
 None
 1.19A 4gboB-5wtkA:
undetectable		 4gboB-5wtkA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 HIS A1122
HIS A 908
GLN A 904
TYR A 928
 C  B  38 ( 3.6A)
A  B  40 ( 4.1A)
C  B  38 ( 3.8A)
None
 0.97A 4gboB-5xwyA:
undetectable		 4gboB-5xwyA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z97 LACTONASE FOR
PROTEIN

(Rhinocladiella
mackenziei) 		no annotation 4 HIS A 128
ALA A 105
HIS A 243
TYR A 246
 None
ZER  A 301 (-3.0A)
ZER  A 301 (-4.0A)
None
 1.48A 4gboB-5z97A:
undetectable		 4gboB-5z97A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 HIS A1213
ALA A1189
HIS A1257
TYR A1220
 None
 1.37A 4gboB-6apxA:
undetectable		 4gboB-6apxA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 HIS A  81
ALA A 147
HIS A  80
GLN A  84
 None
 1.08A 4gboB-6c54A:
undetectable		 4gboB-6c54A:
undetectable