SIMILAR PATTERNS OF AMINO ACIDS FOR 4G5J_A_0WMA1102

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		4 HIS A  48
ILE A 137
TYR A 134
PRO A  82
 None
 1.14A 4g5jA-1d02A:
undetectable		 4g5jA-1d02A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PHE A 170
ILE A  27
PRO A 172
HIS A  36
 None
 1.06A 4g5jA-1kijA:
0.0		 4g5jA-1kijA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 ILE A 471
TYR A 451
PRO A 489
HIS A 494
 None
 1.10A 4g5jA-1ttuA:
0.0		 4g5jA-1ttuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF07859
(Abhydrolase_3) 		4 TYR A  73
HIS A  36
ILE A  35
HIS A 109
 None
 1.12A 4g5jA-1vkhA:
undetectable		 4g5jA-1vkhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3c ZINC FINGER PROTEIN
292

(Homo sapiens) 		no annotation 4 PHE A  60
TYR A  49
PRO A  58
HIS A  32
 None
ZN  A 201 ( 4.8A)
None
None
 1.03A 4g5jA-1x3cA:
undetectable		 4g5jA-1x3cA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 HIS A   7
ILE A  33
PRO A  38
HIS A  69
 None
None
None
ZN  A 301 (-3.4A)
 1.19A 4g5jA-1xp3A:
undetectable		 4g5jA-1xp3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		4 HIS A  29
ILE A 130
PRO A  85
HIS A 124
 ZN  A 174 ( 3.5A)
None
None
None
 1.21A 4g5jA-1y13A:
undetectable		 4g5jA-1y13A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yws PROTEIN YBL071W-A

(Saccharomyces
cerevisiae) 		PF05207
(zf-CSL) 		4 PHE A  14
TYR A  66
ILE A  72
PRO A  16
 None
 1.19A 4g5jA-1ywsA:
undetectable		 4g5jA-1ywsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 TYR A 602
HIS A 606
ILE A 608
PRO A 559
 None
 1.02A 4g5jA-1zcjA:
0.0		 4g5jA-1zcjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gc1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Pyrococcus
furiosus) 		PF06560
(GPI) 		4 PHE A 148
TYR A  99
TYR A 152
HIS A 158
 None
S6P  A 502 (-4.8A)
S6P  A 502 ( 3.9A)
S6P  A 502 (-4.2A)
 1.17A 4g5jA-2gc1A:
undetectable		 4g5jA-2gc1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		4 TYR A 147
ILE A  18
PRO A 104
HIS A  12
 None
None
None
ZN  A1234 ( 3.1A)
 1.08A 4g5jA-2ixdA:
undetectable		 4g5jA-2ixdA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1

(Mesorhizobium
loti) 		PF00885
(DMRL_synthase) 		4 HIS A  22
ILE A  25
PRO A 117
HIS A 126
 INI  A 201 ( 4.9A)
None
None
None
 1.04A 4g5jA-2obxA:
undetectable		 4g5jA-2obxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		4 TYR A  70
HIS A  74
ILE A 113
TYR A 116
 None
 1.14A 4g5jA-2p8eA:
undetectable		 4g5jA-2p8eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 PHE A 221
HIS A 167
ILE A 166
PRO A 192
 None
 1.18A 4g5jA-2pbfA:
undetectable		 4g5jA-2pbfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		4 PHE A  54
TYR A  56
HIS A 283
ILE A 287
 None
GOL  A 336 (-4.5A)
None
None
 1.00A 4g5jA-2q0xA:
undetectable		 4g5jA-2q0xA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 807
HIS A 811
ILE A 815
PRO A 854
 None
 0.54A 4g5jA-2r4bA:
35.2		 4g5jA-2r4bA:
73.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 TYR A 929
HIS A 869
ILE A 871
PRO A 927
 None
 0.98A 4g5jA-2vsqA:
0.7		 4g5jA-2vsqA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 PHE A 215
ILE A 198
PRO A 177
HIS A 192
 None
 1.15A 4g5jA-2vwsA:
undetectable		 4g5jA-2vwsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		4 TYR A 183
ILE A  76
TYR A 117
PRO A 182
 None
 1.00A 4g5jA-2w1vA:
undetectable		 4g5jA-2w1vA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		4 TYR A 216
ILE A 257
TYR A 222
PRO A 214
 None
 1.12A 4g5jA-2wamA:
undetectable		 4g5jA-2wamA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 TYR A 602
HIS A 606
ILE A 608
PRO A 559
 None
 1.01A 4g5jA-2x58A:
undetectable		 4g5jA-2x58A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 PHE A 105
ILE A 329
PRO A 177
HIS A 441
 None
 1.10A 4g5jA-2xu0A:
undetectable		 4g5jA-2xu0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 PHE A 105
ILE A 329
PRO A 177
HIS A 441
 None
 1.11A 4g5jA-2yk0A:
undetectable		 4g5jA-2yk0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PHE A 392
TYR A 302
HIS A  56
ILE A  58
 None
 0.98A 4g5jA-2yp2A:
undetectable		 4g5jA-2yp2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 TYR A  73
HIS A  77
ILE A  74
PRO A 126
 None
 1.16A 4g5jA-2z6vA:
undetectable		 4g5jA-2z6vA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpo INTERLEUKIN-13
RECEPTOR ALPHA-1
CHAIN

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 PHE C 183
TYR C 158
ILE C 213
PRO C 148
 PHE  C 183 ( 1.3A)
TYR  C 158 ( 1.3A)
ILE  C 213 ( 0.6A)
PRO  C 148 ( 1.1A)
 0.78A 4g5jA-3bpoC:
undetectable		 4g5jA-3bpoC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 TYR A 270
HIS A 269
ILE A 291
PRO A 289
 None
 1.13A 4g5jA-3e74A:
undetectable		 4g5jA-3e74A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs3 NUCLEOSOME ASSEMBLY
PROTEIN 1, PUTATIVE

(Plasmodium
falciparum) 		PF00956
(NAP) 		4 PHE A 157
TYR A 127
ILE A  94
PRO A 156
 None
 1.03A 4g5jA-3fs3A:
undetectable		 4g5jA-3fs3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 PHE A 461
TYR A 459
TYR A 440
HIS A 395
 None
 1.17A 4g5jA-3gecA:
undetectable		 4g5jA-3gecA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1s SUPEROXIDE DISMUTASE

(Francisella
tularensis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  10
ILE A  24
TYR A  28
HIS A  32
 None
 1.20A 4g5jA-3h1sA:
undetectable		 4g5jA-3h1sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y UL16

(Homo sapiens) 		PF00252
(Ribosomal_L16) 		4 PHE N 128
ILE N 131
TYR N  96
PRO N 153
 None
None
A  A2110 ( 4.5A)
None
 1.11A 4g5jA-3j7yN:
undetectable		 4g5jA-3j7yN:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr1 PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Histophilus
somni) 		PF03881
(Fructosamin_kin) 		4 PHE A 107
ILE A 243
TYR A 240
HIS A 115
 None
 1.08A 4g5jA-3jr1A:
5.6		 4g5jA-3jr1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khy PROPIONATE KINASE

(Francisella
tularensis) 		PF00871
(Acetate_kinase) 		4 PHE A 303
TYR A 307
ILE A 216
HIS A 146
 None
 1.18A 4g5jA-3khyA:
undetectable		 4g5jA-3khyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 PHE B 282
TYR B  96
TYR B 335
PRO B  94
 None
 0.86A 4g5jA-3l4gB:
undetectable		 4g5jA-3l4gB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F

(Staphylococcus
epidermidis) 		PF04464
(Glyphos_transf) 		4 HIS A 420
ILE A 355
TYR A 383
HIS A 715
 None
None
CL  A 744 ( 4.8A)
None
 0.92A 4g5jA-3l7iA:
undetectable		 4g5jA-3l7iA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln7 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Pasteurella
multocida) 		PF02655
(ATP-grasp_3)
PF04262
(Glu_cys_ligase) 		4 ILE A 443
TYR A  53
PRO A  68
HIS A 448
 None
 1.14A 4g5jA-3ln7A:
undetectable		 4g5jA-3ln7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 444
TYR A 529
ILE A 511
PRO A 442
 None
 1.14A 4g5jA-3lppA:
undetectable		 4g5jA-3lppA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 PHE A 771
TYR A 777
HIS A 781
ILE A 785
TYR A 789
PRO A 824
 None
 0.48A 4g5jA-3lzbA:
33.2		 4g5jA-3lzbA:
86.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A 269
HIS A 303
ILE A 310
HIS A 170
 None
CL  A 503 (-4.1A)
None
None
 1.21A 4g5jA-3n0qA:
undetectable		 4g5jA-3n0qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 TYR A 126
ILE A 163
PRO A 204
HIS A 165
 None
 1.08A 4g5jA-3q98A:
undetectable		 4g5jA-3q98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13201
(PCMD) 		4 PHE A 326
TYR A 328
ILE A 335
PRO A 246
 None
 0.86A 4g5jA-3s30A:
undetectable		 4g5jA-3s30A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		4 TYR B 156
ILE B  64
PRO B 155
HIS B  59
 None
 1.17A 4g5jA-3vsjB:
undetectable		 4g5jA-3vsjB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 PHE A 131
TYR A 334
ILE A 208
HIS A 282
 None
 1.13A 4g5jA-3w08A:
undetectable		 4g5jA-3w08A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 PHE A 441
TYR A 527
ILE A 508
PRO A 439
 None
 1.19A 4g5jA-3welA:
undetectable		 4g5jA-3welA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PHE A 392
TYR A 302
HIS A  56
ILE A  58
 None
 0.87A 4g5jA-3wheA:
undetectable		 4g5jA-3wheA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		4 PHE A 160
HIS A 223
ILE A 287
TYR A  31
 None
 1.04A 4g5jA-3wx7A:
undetectable		 4g5jA-3wx7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 HIS A 912
ILE A 915
PRO A 862
HIS A 857
 None
 1.19A 4g5jA-3zhrA:
undetectable		 4g5jA-3zhrA:
15.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 921
TYR A 927
TYR A1008
HIS A1004
 None
 1.20A 4g5jA-4agdA:
23.5		 4g5jA-4agdA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ato TOXN

(Bacillus
thuringiensis) 		PF13958
(ToxN_toxin) 		4 TYR A  16
ILE A  88
PRO A  91
HIS A  49
 None
 1.10A 4g5jA-4atoA:
undetectable		 4g5jA-4atoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 PHE A 252
TYR A 159
ILE A  71
PRO A 175
 None
 1.16A 4g5jA-4c4aA:
undetectable		 4g5jA-4c4aA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 PHE A 362
ILE A 117
PRO A 450
HIS A 447
 None
 1.13A 4g5jA-4cmrA:
undetectable		 4g5jA-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 TYR A 318
HIS A 322
ILE A 326
PRO A 181
 None
 0.78A 4g5jA-4euoA:
undetectable		 4g5jA-4euoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27

(Homo sapiens) 		no annotation 4 TYR D 225
HIS D 163
ILE D 196
TYR D 147
 None
 1.12A 4g5jA-4f9zD:
undetectable		 4g5jA-4f9zD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl4 TBC1 DOMAIN FAMILY
MEMBER 20

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 PHE A 299
TYR A 252
TYR A 191
PRO A 304
 None
 1.09A 4g5jA-4hl4A:
undetectable		 4g5jA-4hl4A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 PHE B 172
ILE B 148
TYR B 157
PRO B 176
 None
 1.06A 4g5jA-4i0wB:
undetectable		 4g5jA-4i0wB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A  53
ILE A  43
PRO A   9
HIS A  47
 None
 1.13A 4g5jA-4ilkA:
undetectable		 4g5jA-4ilkA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bombyx mori) 		PF00731
(AIRC)
PF01259
(SAICAR_synt) 		4 PHE A 133
ILE A 160
TYR A 155
PRO A  98
 None
 1.13A 4g5jA-4ja0A:
undetectable		 4g5jA-4ja0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		4 HIS A 446
ILE A 445
TYR A 468
HIS A 447
 PG4  A 617 ( 3.6A)
None
None
None
 1.20A 4g5jA-4jrfA:
undetectable		 4g5jA-4jrfA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A3125
ILE A3296
TYR A3066
HIS A3153
 None
 0.94A 4g5jA-4kc5A:
undetectable		 4g5jA-4kc5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE D  38
TYR D  40
TYR G  39
HIS G  37
 None
 1.01A 4g5jA-4lhuD:
undetectable		 4g5jA-4lhuD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT

(Homo sapiens) 		PF01896
(DNA_primase_S) 		4 PHE A  21
TYR A  16
ILE A 353
PRO A  22
 None
 1.13A 4g5jA-4likA:
undetectable		 4g5jA-4likA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 PHE A 215
TYR A 208
HIS A 173
ILE A 177
 None
 1.04A 4g5jA-4n7tA:
undetectable		 4g5jA-4n7tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		4 PHE A 250
TYR A 172
ILE A 201
PRO A 170
 PHE  A 250 ( 1.3A)
TYR  A 172 ( 1.3A)
ILE  A 201 ( 0.7A)
PRO  A 170 ( 1.1A)
 0.98A 4g5jA-4nonA:
undetectable		 4g5jA-4nonA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A 184
TYR A 176
HIS A 411
HIS A 378
 None
None
None
C8E  A 702 ( 2.6A)
 1.08A 4g5jA-4nreA:
undetectable		 4g5jA-4nreA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 TYR A 478
ILE A 512
TYR A 493
PRO A 488
 None
 1.10A 4g5jA-4oe1A:
undetectable		 4g5jA-4oe1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 HIS A 337
ILE A 335
PRO A 304
HIS A 340
 None
 1.17A 4g5jA-4ohtA:
undetectable		 4g5jA-4ohtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Saccharomyces
cerevisiae) 		PF00078
(RVT_1) 		4 HIS A  51
ILE A 159
TYR A 156
PRO A 191
 None
None
None
G  C   3 ( 4.2A)
 1.19A 4g5jA-4ol8A:
undetectable		 4g5jA-4ol8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 TYR B 538
ILE B 503
TYR B 536
HIS B 501
 None
 1.19A 4g5jA-4plbB:
undetectable		 4g5jA-4plbB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4png LD04004P

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 PHE A 108
HIS A  69
ILE A  72
PRO A  14
 GSF  A2001 (-3.8A)
GSF  A2001 (-3.9A)
None
GSF  A2001 (-4.6A)
 1.18A 4g5jA-4pngA:
undetectable		 4g5jA-4pngA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leptospira
interrogans) 		PF00156
(Pribosyltran) 		4 PHE A 117
ILE A  39
PRO A 121
HIS A  95
 None
 1.08A 4g5jA-4qriA:
undetectable		 4g5jA-4qriA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 HIS A 149
ILE A 151
TYR A 162
PRO A  73
 None
 1.18A 4g5jA-4tmuA:
undetectable		 4g5jA-4tmuA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01040
(UbiA) 		4 TYR A 137
ILE A  67
TYR A  71
PRO A 142
 None
 1.13A 4g5jA-4tq5A:
undetectable		 4g5jA-4tq5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		4 TYR A 230
HIS A 234
ILE A 236
PRO A 205
 None
 1.15A 4g5jA-4x81A:
undetectable		 4g5jA-4x81A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes) 		PF05721
(PhyH) 		4 TYR A 214
TYR A 109
PRO A 106
HIS A  88
 None
 1.17A 4g5jA-4xaaA:
undetectable		 4g5jA-4xaaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 TYR B 538
ILE B 503
TYR B 536
HIS B 501
 None
 1.19A 4g5jA-5cdoB:
undetectable		 4g5jA-5cdoB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 ILE C 290
TYR C 270
PRO C 305
HIS C 310
 None
 1.18A 4g5jA-5eg6C:
undetectable		 4g5jA-5eg6C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1m PHOSPHORYLATED
PROTEIN PHOSPHATASE

(Staphylococcus
aureus) 		PF13672
(PP2C_2) 		4 PHE A 237
ILE A 126
TYR A 188
HIS A 218
 None
 1.12A 4g5jA-5f1mA:
undetectable		 4g5jA-5f1mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 4 PHE B 333
ILE B  97
TYR B  95
HIS B 344
 None
 1.19A 4g5jA-5fbhB:
undetectable		 4g5jA-5fbhB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE C 121
TYR C 274
PRO C 272
HIS C 128
 None
 1.15A 4g5jA-5fqdC:
21.0		 4g5jA-5fqdC:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		4 PHE A 349
ILE A 142
TYR A 374
PRO A 164
 None
 1.16A 4g5jA-5g5zA:
undetectable		 4g5jA-5g5zA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy6 RIBONUCLEASE T1

(Hericium
erinaceus) 		PF00545
(Ribonuclease) 		4 TYR A  32
HIS A  34
PRO A  67
HIS A  86
 None
ZN  A 201 (-3.1A)
None
None
 0.80A 4g5jA-5gy6A:
undetectable		 4g5jA-5gy6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 PHE A  14
TYR A  15
ILE A 231
PRO A 225
 None
 1.12A 4g5jA-5gyzA:
undetectable		 4g5jA-5gyzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PHE A 261
TYR A 253
ILE A 161
PRO A 234
 None
 1.15A 4g5jA-5ho9A:
undetectable		 4g5jA-5ho9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 PHE A 261
TYR A 253
ILE A 161
PRO A 234
 None
 1.16A 4g5jA-5hp6A:
undetectable		 4g5jA-5hp6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		4 PHE A 407
TYR A 232
ILE A 239
PRO A 403
 None
 0.91A 4g5jA-5i6zA:
undetectable		 4g5jA-5i6zA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 HIS A 421
ILE A 423
TYR A 313
PRO A 371
 None
 1.16A 4g5jA-5i85A:
undetectable		 4g5jA-5i85A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 PHE A 795
TYR A 801
HIS A 805
ILE A 809
TYR A 813
PRO A 848
 None
 0.50A 4g5jA-5j9zA:
38.0		 4g5jA-5j9zA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 TYR L 132
HIS L 136
ILE L 138
PRO L  76
 None
 0.80A 4g5jA-5jfcL:
undetectable		 4g5jA-5jfcL:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngw OPGH99A

(Ochrovirga
pacifica) 		no annotation 4 PHE A 229
ILE A 281
TYR A 280
HIS A 238
 None
 1.18A 4g5jA-5ngwA:
undetectable		 4g5jA-5ngwA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 PHE A 490
TYR A 575
ILE A 557
PRO A 488
 None
 1.17A 4g5jA-5nn8A:
undetectable		 4g5jA-5nn8A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no7 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Trametes
cinnabarina) 		no annotation 4 ILE A   2
TYR A 176
PRO A  28
HIS A 166
 None
 1.19A 4g5jA-5no7A:
undetectable		 4g5jA-5no7A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 PHE A 919
ILE A 984
TYR A 981
PRO A 806
 None
 1.21A 4g5jA-5t8vA:
undetectable		 4g5jA-5t8vA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		5 PHE A  77
TYR A   7
HIS A  24
ILE A  34
PRO A  74
 None
 0.63A 4g5jA-5u7wA:
undetectable		 4g5jA-5u7wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 PHE F 335
TYR F 234
ILE F 247
PRO F 351
 None
 1.15A 4g5jA-5u7xF:
undetectable		 4g5jA-5u7xF:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg2 INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Tetranychus
urticae) 		no annotation 4 PHE U 159
ILE U 109
PRO U 160
HIS U 169
 None
None
None
FE  U 301 (-3.5A)
 1.07A 4g5jA-5vg2U:
undetectable		 4g5jA-5vg2U:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 TYR A 132
HIS A 136
ILE A 138
PRO A  76
 None
 0.75A 4g5jA-5vj7A:
undetectable		 4g5jA-5vj7A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
LUMINAL EXTRINSIC
PROTEIN TN, PSBTN

(Pisum sativum) 		no annotation 4 PHE B 355
HIS B 343
ILE B 284
PRO U  15
 None
 0.97A 4g5jA-5xnmB:
undetectable		 4g5jA-5xnmB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20

(Homo sapiens) 		no annotation 4 ILE A  37
TYR A  38
PRO A  31
HIS A 131
 CME  A  52 ( 3.6A)
None
None
None
 1.06A 4g5jA-6cwxA:
undetectable		 4g5jA-6cwxA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 489
ILE A 403
PRO A 435
HIS A 495
 None
None
None
CU  A 601 (-3.1A)
 0.71A 4g5jA-6evgA:
undetectable		 4g5jA-6evgA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 4 HIS A 886
ILE A 883
TYR A1068
PRO A 816
 CD  A1101 (-3.3A)
None
None
None
 1.10A 4g5jA-6fj4A:
undetectable		 4g5jA-6fj4A:
13.98