SIMILAR PATTERNS OF AMINO ACIDS FOR 4G2Z_A_ID8A711_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 PRO A 251
TYR A 319
GLY A 321
 None
 0.38A 4g2zA-1biyA:
55.2		 4g2zA-1biyA:
91.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 PRO A 593
TYR A 660
GLY A 662
 None
 0.27A 4g2zA-1biyA:
55.2		 4g2zA-1biyA:
91.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PRO A 687
TYR A 127
GLY A 694
 None
ADP  A 998 (-4.4A)
None
 0.71A 4g2zA-1br2A:
undetectable		 4g2zA-1br2A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 PRO B 749
TYR B 644
GLY B 571
 None
 0.68A 4g2zA-1ffvB:
undetectable		 4g2zA-1ffvB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		3 PRO B  79
TYR B 109
GLY B  56
 None
 0.67A 4g2zA-1gydB:
undetectable		 4g2zA-1gydB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 PRO A 321
TYR A 125
GLY A 120
 None
DTL  A9010 (-4.5A)
None
 0.70A 4g2zA-1h17A:
undetectable		 4g2zA-1h17A:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		3 PRO A 251
TYR A 318
GLY A 320
 None
 0.43A 4g2zA-1h76A:
43.6		 4g2zA-1h76A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		3 PRO A 592
TYR A 658
GLY A 660
 None
 0.30A 4g2zA-1h76A:
43.6		 4g2zA-1h76A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 PRO A 251
TYR A 319
GLY A 321
 None
 0.59A 4g2zA-1i6qA:
27.2		 4g2zA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 PRO A 593
TYR A 660
GLY A 662
 None
 0.36A 4g2zA-1i6qA:
27.2		 4g2zA-1i6qA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		3 PRO A 275
TYR A 265
GLY A 268
 None
 0.56A 4g2zA-1iugA:
undetectable		 4g2zA-1iugA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		3 PRO A 247
TYR A 314
GLY A 316
 None
 0.41A 4g2zA-1jnfA:
50.3		 4g2zA-1jnfA:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		3 PRO A 580
TYR A 647
GLY A 649
 None
 0.38A 4g2zA-1jnfA:
50.3		 4g2zA-1jnfA:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 PRO A 870
TYR A 326
GLY A 321
 None
 0.75A 4g2zA-1kqfA:
undetectable		 4g2zA-1kqfA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 PRO B 755
TYR B 650
GLY B 577
 None
 0.70A 4g2zA-1n60B:
undetectable		 4g2zA-1n60B:
17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 251
TYR A 319
GLY A 321
 None
 0.47A 4g2zA-1n76A:
52.9		 4g2zA-1n76A:
68.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 595
TYR A 662
GLY A 664
 None
 0.38A 4g2zA-1n76A:
52.9		 4g2zA-1n76A:
68.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 PRO A 379
TYR A  45
GLY A  40
 None
None
NAG  A 603 (-4.5A)
 0.67A 4g2zA-1p49A:
undetectable		 4g2zA-1p49A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		3 PRO A 321
TYR A 369
GLY A 367
 None
 0.72A 4g2zA-1p9bA:
undetectable		 4g2zA-1p9bA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 101
TYR A  72
GLY A  67
 None
 0.75A 4g2zA-1qgdA:
undetectable		 4g2zA-1qgdA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 PRO A 251
TYR A 319
GLY A 321
 None
 0.32A 4g2zA-1qjmA:
53.3		 4g2zA-1qjmA:
45.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 PRO A 593
TYR A 660
GLY A 662
 None
 0.40A 4g2zA-1qjmA:
53.3		 4g2zA-1qjmA:
45.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 101
TYR A  72
GLY A  67
 None
 0.68A 4g2zA-1r9jA:
undetectable		 4g2zA-1r9jA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		3 PRO A  31
TYR A 161
GLY A 164
 None
 0.71A 4g2zA-1rc9A:
undetectable		 4g2zA-1rc9A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rie RIESKE IRON-SULFUR
PROTEIN

(Bos taurus) 		PF00355
(Rieske) 		3 PRO A 183
TYR A 185
GLY A 196
 None
 0.75A 4g2zA-1rieA:
undetectable		 4g2zA-1rieA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 247
TYR A 314
GLY A 316
 None
 0.49A 4g2zA-1ryoA:
42.1		 4g2zA-1ryoA:
42.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO E 580
TYR E 647
GLY E 649
 None
 0.38A 4g2zA-1suvE:
50.1		 4g2zA-1suvE:
58.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 PRO A 151
TYR A 125
GLY A 128
 None
 0.71A 4g2zA-1uliA:
undetectable		 4g2zA-1uliA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 PRO A 157
TYR A 146
GLY A 148
 None
 0.63A 4g2zA-1up2A:
undetectable		 4g2zA-1up2A:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vfd LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 251
TYR A 319
GLY A 321
 None
 0.39A 4g2zA-1vfdA:
39.4		 4g2zA-1vfdA:
41.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjg PUTATIVE LIPASE FROM
THE G-D-S-L FAMILY

(Nostoc sp. PCC
7120) 		PF13472
(Lipase_GDSL_2) 		3 PRO A 183
TYR A 188
GLY A 186
 None
 0.74A 4g2zA-1vjgA:
undetectable		 4g2zA-1vjgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvr TRIFLIN

(Protobothrops
flavoviridis) 		PF00188
(CAP)
PF08562
(Crisp) 		3 PRO A  31
TYR A 161
GLY A 164
 None
 0.72A 4g2zA-1wvrA:
undetectable		 4g2zA-1wvrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		3 PRO B  95
TYR B 321
GLY A 266
 None
 0.56A 4g2zA-1wytB:
undetectable		 4g2zA-1wytB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		3 PRO A 124
TYR A 130
GLY A 211
 None
 0.74A 4g2zA-1ym0A:
undetectable		 4g2zA-1ym0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 PRO A  46
TYR A 150
GLY A 148
 None
 0.74A 4g2zA-2e4uA:
undetectable		 4g2zA-2e4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 105
TYR A  76
GLY A  71
 None
 0.70A 4g2zA-2e6kA:
undetectable		 4g2zA-2e6kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epf PSEUDECIN

(Pseudechis
porphyriacus) 		PF00188
(CAP)
PF08562
(Crisp) 		3 PRO A  22
TYR A 150
GLY A 153
 None
 0.75A 4g2zA-2epfA:
undetectable		 4g2zA-2epfA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 583
TYR A 650
GLY A 652
 None
 0.51A 4g2zA-2hauA:
26.9		 4g2zA-2hauA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		3 PRO A 174
TYR A 189
GLY A 187
 None
 0.68A 4g2zA-2jbwA:
undetectable		 4g2zA-2jbwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 PRO A 550
TYR A 531
GLY A 527
 None
 0.73A 4g2zA-2owoA:
undetectable		 4g2zA-2owoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbj PROSTAGLANDIN E
SYNTHASE 2

(Macaca
fascicularis) 		PF13417
(GST_N_3) 		3 PRO A 134
TYR A 107
GLY A 268
 HEM  A 476 (-4.1A)
HEM  A 476 (-4.0A)
None
 0.71A 4g2zA-2pbjA:
undetectable		 4g2zA-2pbjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		3 PRO A 179
TYR A 177
GLY A 248
 None
 0.72A 4g2zA-2pbzA:
undetectable		 4g2zA-2pbzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PRO M 677
TYR M 129
GLY M 684
 None
 0.66A 4g2zA-2w4gM:
undetectable		 4g2zA-2w4gM:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we9 MOBA-RELATED PROTEIN

(Mycobacterium
tuberculosis) 		PF12804
(NTP_transf_3) 		3 PRO A 107
TYR A  28
GLY A  35
 None
 0.72A 4g2zA-2we9A:
undetectable		 4g2zA-2we9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 PRO A 334
TYR A 291
GLY A 295
 None
 0.73A 4g2zA-2wmhA:
undetectable		 4g2zA-2wmhA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		3 PRO A  69
TYR A 142
GLY A 140
 None
 0.75A 4g2zA-3ailA:
undetectable		 4g2zA-3ailA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx5 CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		3 PRO E 203
TYR E 205
GLY E 215
 None
 0.75A 4g2zA-3cx5E:
undetectable		 4g2zA-3cx5E:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Moraxella sp.) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 PRO A 312
TYR A 102
GLY A 389
 None
 0.75A 4g2zA-3fn4A:
undetectable		 4g2zA-3fn4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1i CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Gallus gallus) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		3 PRO E 183
TYR E 185
GLY E 196
 None
 0.69A 4g2zA-3h1iE:
undetectable		 4g2zA-3h1iE:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		3 PRO A 675
TYR A 126
GLY A 682
 None
 0.75A 4g2zA-3i5gA:
undetectable		 4g2zA-3i5gA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		3 PRO A  65
TYR A  75
GLY A  71
 None
 0.56A 4g2zA-3lcrA:
undetectable		 4g2zA-3lcrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqa HEAVY CHAIN OF ANTI
HIV FAB FROM HUMAN
21C ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 111
TYR H 102
GLY H 100
 None
 0.75A 4g2zA-3lqaH:
undetectable		 4g2zA-3lqaH:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 103
TYR A  74
GLY A  69
 None
 0.71A 4g2zA-3m49A:
undetectable		 4g2zA-3m49A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 PRO A 586
TYR A 652
GLY A 654
 None
 0.23A 4g2zA-3mc2A:
38.8		 4g2zA-3mc2A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2r GLIOMA
PATHOGENESIS-RELATED
PROTEIN 1

(Homo sapiens) 		PF00188
(CAP) 		3 PRO A  50
TYR A 186
GLY A 189
 None
 0.71A 4g2zA-3q2rA:
undetectable		 4g2zA-3q2rA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 PRO A 104
TYR A 128
GLY A 120
 None
 0.74A 4g2zA-3q41A:
undetectable		 4g2zA-3q41A:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3skp SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 583
TYR A 650
GLY A 652
 None
None
SO4  A 683 (-3.4A)
 0.44A 4g2zA-3skpA:
25.7		 4g2zA-3skpA:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		3 PRO A 387
TYR A 376
GLY A 297
 None
 0.69A 4g2zA-3sluA:
undetectable		 4g2zA-3sluA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr3 MICROCIN IMMUNITY
PROTEIN MCCF

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		3 PRO A 224
TYR A 122
GLY A 120
 None
 0.70A 4g2zA-3sr3A:
undetectable		 4g2zA-3sr3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 PRO A 306
TYR A 255
GLY A 254
 None
 0.73A 4g2zA-3sxpA:
undetectable		 4g2zA-3sxpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 PRO A 503
TYR A 584
GLY A 511
 None
 0.55A 4g2zA-3ttsA:
undetectable		 4g2zA-3ttsA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 121
TYR A  92
GLY A  87
 None
 0.72A 4g2zA-3uk1A:
undetectable		 4g2zA-3uk1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PRO A 184
TYR A 173
GLY A 180
 None
 0.75A 4g2zA-3x1bA:
undetectable		 4g2zA-3x1bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		3 PRO B 451
TYR B 313
GLY B  49
 None
 0.72A 4g2zA-3ze7B:
undetectable		 4g2zA-3ze7B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zib RAP2A SMA2265

(Serratia
marcescens) 		PF16695
(Tai4) 		3 PRO A  30
TYR A  69
GLY A  67
 None
 0.72A 4g2zA-3zibA:
undetectable		 4g2zA-3zibA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PRO A 728
TYR A 226
GLY A 229
 None
 0.65A 4g2zA-4aipA:
undetectable		 4g2zA-4aipA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 PRO A 248
TYR A 213
GLY A 216
 None
 0.59A 4g2zA-4bc5A:
undetectable		 4g2zA-4bc5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 PRO A 593
TYR A  55
GLY A 600
 None
AOV  A1001 ( 4.5A)
None
 0.66A 4g2zA-4byfA:
undetectable		 4g2zA-4byfA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 104
TYR A  75
GLY A  70
 None
 0.72A 4g2zA-4c7vA:
undetectable		 4g2zA-4c7vA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 PRO A 743
TYR A 700
GLY A 704
 None
 0.60A 4g2zA-4d72A:
undetectable		 4g2zA-4d72A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PRO A 675
TYR A 128
GLY A 682
 None
ANP  A 801 ( 4.6A)
None
 0.72A 4g2zA-4db1A:
undetectable		 4g2zA-4db1A:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 PRO A 593
TYR A 660
GLY A 662
 CEL  A 711 (-4.3A)
CEL  A 711 (-4.4A)
CEL  A 711 (-3.3A)
 0.04A 4g2zA-4fimA:
61.4		 4g2zA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		3 PRO A 133
TYR A 137
GLY A 121
 None
 0.70A 4g2zA-4gsoA:
undetectable		 4g2zA-4gsoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 PRO A  73
TYR A  17
GLY A 337
 None
 0.74A 4g2zA-4j5tA:
undetectable		 4g2zA-4j5tA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PRO A 406
TYR A 199
GLY A 281
 NA  A 707 (-4.4A)
None
None
 0.65A 4g2zA-4l37A:
undetectable		 4g2zA-4l37A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		3 PRO A  76
TYR A 189
GLY A 193
 None
 0.75A 4g2zA-4m9dA:
undetectable		 4g2zA-4m9dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		3 PRO A 393
TYR A 433
GLY A 377
 None
 0.73A 4g2zA-4p05A:
undetectable		 4g2zA-4p05A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		3 PRO A 403
TYR A 331
GLY A 334
 None
 0.72A 4g2zA-4p1cA:
undetectable		 4g2zA-4p1cA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 PRO A 675
TYR A 128
GLY A 682
 None
 0.58A 4g2zA-4p7hA:
undetectable		 4g2zA-4p7hA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 PRO A 521
TYR A 603
GLY A 529
 None
 0.48A 4g2zA-4uozA:
undetectable		 4g2zA-4uozA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 PRO A 517
TYR A 599
GLY A 525
 None
None
POL  A 707 (-3.7A)
 0.68A 4g2zA-4uzsA:
undetectable		 4g2zA-4uzsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 101
TYR A  72
GLY A  67
 None
 0.75A 4g2zA-4xeuA:
undetectable		 4g2zA-4xeuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		3 PRO A 180
TYR A 156
GLY A 154
 None
 0.72A 4g2zA-4xkqA:
5.0		 4g2zA-4xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		3 PRO A 127
TYR A 105
GLY A 100
 None
 0.74A 4g2zA-4xydA:
undetectable		 4g2zA-4xydA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bow INTERLEUKIN-1 FAMILY
MEMBER 10

(Homo sapiens) 		PF00340
(IL1) 		3 PRO A 125
TYR A  14
GLY A  30
 None
None
EDO  A 205 ( 3.8A)
 0.71A 4g2zA-5bowA:
undetectable		 4g2zA-5bowA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		3 PRO A  34
TYR A  58
GLY A 256
 None
 0.58A 4g2zA-5bp8A:
undetectable		 4g2zA-5bp8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 PRO A  39
TYR A 144
GLY A 142
 CL  A 602 ( 4.0A)
None
CL  A 602 ( 4.1A)
 0.73A 4g2zA-5cniA:
undetectable		 4g2zA-5cniA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		3 PRO A 703
TYR A 735
GLY A 778
 None
 0.72A 4g2zA-5e4sA:
undetectable		 4g2zA-5e4sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhi GLUTATHIONE
S-TRANSFERASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 PRO A 215
TYR A 119
GLY A 115
 None
 0.71A 4g2zA-5fhiA:
undetectable		 4g2zA-5fhiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1k TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 PRO A 157
TYR A 197
GLY A 240
 None
 0.67A 4g2zA-5j1kA:
undetectable		 4g2zA-5j1kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 PRO B 157
TYR B 197
GLY B 240
 None
 0.71A 4g2zA-5j1lB:
undetectable		 4g2zA-5j1lB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgj UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF01209
(Ubie_methyltran) 		3 PRO A 116
TYR A 120
GLY A 118
 None
 0.67A 4g2zA-5jgjA:
undetectable		 4g2zA-5jgjA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		3 PRO B 202
TYR B  12
GLY B 315
 None
 0.58A 4g2zA-5kinB:
undetectable		 4g2zA-5kinB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 PRO A  39
TYR A 144
GLY A 142
 None
 0.71A 4g2zA-5kznA:
undetectable		 4g2zA-5kznA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 3 PRO A 113
TYR A  97
GLY A 109
 None
 0.63A 4g2zA-5m22A:
undetectable		 4g2zA-5m22A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 PRO A1610
TYR A1688
GLY A1691
 None
 0.66A 4g2zA-5m59A:
undetectable		 4g2zA-5m59A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 153
TYR A 123
GLY A 118
 None
 0.68A 4g2zA-5nd5A:
undetectable		 4g2zA-5nd5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o64 REACTION CENTER
PROTEIN H CHAIN

(Blastochloris
viridis) 		PF03967
(PRCH)
PF05239
(PRC) 		3 PRO H 114
TYR H 248
GLY H 245
 None
 0.70A 4g2zA-5o64H:
undetectable		 4g2zA-5o64H:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okd CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Bos taurus) 		no annotation 3 PRO E 183
TYR E 185
GLY E 196
 None
 0.74A 4g2zA-5okdE:
undetectable		 4g2zA-5okdE:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus) 		no annotation 3 PRO A 319
TYR A 370
GLY A 372
 None
 0.59A 4g2zA-5or7A:
undetectable		 4g2zA-5or7A:
15.33