SIMILAR PATTERNS OF AMINO ACIDS FOR 4G24_A_ACAA1004_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ALA A  17
LEU A  21
VAL A  22
GLU A  51
 None
 1.02A 4g24A-1c4oA:
undetectable		 4g24A-1c4oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 ALA A  40
ASN A  36
VAL A  35
ASP A 238
 None
None
None
RET  A 999 (-4.4A)
 1.02A 4g24A-1e12A:
0.8		 4g24A-1e12A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A  76
LEU A  94
VAL A  95
ASP A  35
 None
 0.90A 4g24A-1f8wA:
undetectable		 4g24A-1f8wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ALA A 379
LEU A 356
VAL A 355
GLU A 405
 None
 0.99A 4g24A-1gg4A:
undetectable		 4g24A-1gg4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 374
LEU A 378
VAL A 379
GLU A 207
 None
 0.70A 4g24A-1hrdA:
0.0		 4g24A-1hrdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		4 ALA A  65
LEU A  69
VAL A  70
ASP A  60
 None
 1.00A 4g24A-1hxhA:
2.0		 4g24A-1hxhA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ist CYCLOPHILIN A

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase) 		4 ALA A  31
ASN A  24
LEU A  22
ASP A  25
 None
 0.96A 4g24A-1istA:
undetectable		 4g24A-1istA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 ALA A 604
ASN A 603
LEU A 600
VAL A 599
 None
CL  A2004 (-4.1A)
None
SO4  A 734 ( 4.8A)
 1.04A 4g24A-1itkA:
0.0		 4g24A-1itkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 ALA A  53
LEU A  10
VAL A   9
ASP A   4
 None
 0.94A 4g24A-1jdiA:
undetectable		 4g24A-1jdiA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 LEU A   4
VAL A   5
ASP A  57
GLU A  56
 None
 0.90A 4g24A-1qd1A:
undetectable		 4g24A-1qd1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 ALA A 534
VAL A 548
ASP A 568
GLU A 567
 None
 0.80A 4g24A-1qjmA:
undetectable		 4g24A-1qjmA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ASN A 171
LEU A 170
ASP A 176
GLU A 177
 None
 0.90A 4g24A-1ryyA:
undetectable		 4g24A-1ryyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te2 2-DEOXYGLUCOSE-6-P
PHOSPHATASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 ALA A 158
LEU A 155
VAL A 153
GLU A 172
 None
None
None
PGA  A 711 ( 4.4A)
 0.91A 4g24A-1te2A:
2.3		 4g24A-1te2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 ALA A 382
ASN A 541
LEU A 542
VAL A 540
 None
 1.08A 4g24A-1thgA:
undetectable		 4g24A-1thgA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 234
VAL A 231
ASP A 237
GLU A 254
 LEU  A 234 ( 0.6A)
VAL  A 231 ( 0.6A)
ASP  A 237 ( 0.5A)
GLU  A 254 ( 0.6A)
 0.83A 4g24A-1wqaA:
undetectable		 4g24A-1wqaA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 ALA A 173
LEU A 132
ASP A 126
GLU A 125
 None
 1.00A 4g24A-1xt8A:
undetectable		 4g24A-1xt8A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtd EUKARYOTIC
INITIATION FACTOR 5A

(Leishmania
mexicana) 		PF01287
(eIF-5a) 		4 ALA A 171
ASN A 170
LEU A 153
VAL A 152
 None
 1.06A 4g24A-1xtdA:
undetectable		 4g24A-1xtdA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ALA A 487
ASN A 486
LEU A 483
VAL A 482
 None
 1.00A 4g24A-1y1uA:
1.5		 4g24A-1y1uA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		4 ALA A 325
LEU A 270
VAL A 269
GLU A 321
 None
 0.86A 4g24A-1yhtA:
undetectable		 4g24A-1yhtA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 ALA A 159
VAL A 142
ASP A 145
GLU A 144
 None
 0.95A 4g24A-1za4A:
undetectable		 4g24A-1za4A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayx SENSOR KINASE
PROTEIN RCSC

(Escherichia
coli) 		PF00072
(Response_reg)
PF09456
(RcsC) 		4 ALA A 716
ASN A 715
ASP A 750
GLU A 751
 None
 1.02A 4g24A-2ayxA:
undetectable		 4g24A-2ayxA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 ALA A 259
LEU A 263
VAL A 264
GLU A  28
 None
 0.87A 4g24A-2fjkA:
undetectable		 4g24A-2fjkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h89 SUCCINATE
DEHYDROGENASE
CYTOCHROME B, LARGE
SUBUNIT

(Gallus gallus) 		PF01127
(Sdh_cyt) 		4 ALA C  87
LEU C  91
VAL C  92
GLU C 140
 None
 0.77A 4g24A-2h89C:
undetectable		 4g24A-2h89C:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 ALA A 442
ASN A 443
VAL A 447
ASP A 545
 None
GOL  A 708 (-3.3A)
GOL  A 708 (-3.9A)
MN  A 702 ( 2.6A)
 0.91A 4g24A-2i0kA:
undetectable		 4g24A-2i0kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 ALA A  92
ASN A  93
LEU A  96
VAL A  97
 None
 0.75A 4g24A-2id3A:
undetectable		 4g24A-2id3A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ALA A 188
ASN A 225
VAL A 223
GLU A 435
 None
 0.97A 4g24A-2j2mA:
1.9		 4g24A-2j2mA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		4 ALA A 125
ASN A 126
LEU A 107
VAL A 108
 None
 0.99A 4g24A-2o6wA:
undetectable		 4g24A-2o6wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		4 ALA A 135
ASN A 136
LEU A 117
GLU A 158
 None
 1.08A 4g24A-2o6wA:
undetectable		 4g24A-2o6wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyy HEXAMERIC CYTOCHROME

(Ruegeria
pomeroyi) 		PF11534
(HTHP) 		4 ASN A  68
LEU A   6
VAL A   7
GLU A  13
 None
 1.00A 4g24A-2oyyA:
undetectable		 4g24A-2oyyA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A 129
VAL A 221
ASP A 190
GLU A 189
 None
 0.89A 4g24A-2wngA:
undetectable		 4g24A-2wngA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 ALA A1343
ASN A1342
LEU A1351
GLU A1354
 None
 1.03A 4g24A-3aehA:
undetectable		 4g24A-3aehA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asf MAGNETOSOME PROTEIN
MAMA

(Magnetospirillum
gryphiswaldense) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		4 ALA A 133
LEU A 137
VAL A 138
GLU A 166
 None
None
None
SO4  A  24 (-3.8A)
 0.86A 4g24A-3asfA:
5.7		 4g24A-3asfA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		4 ALA A 146
LEU A 150
VAL A 151
GLU A 124
 None
 0.94A 4g24A-3bwhA:
undetectable		 4g24A-3bwhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		4 ALA K 100
ASN K  99
LEU K 101
GLU K 177
 None
 1.04A 4g24A-3ci0K:
undetectable		 4g24A-3ci0K:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		4 ALA X 110
ASN X 111
LEU X  92
VAL X  93
 None
 0.84A 4g24A-3du1X:
undetectable		 4g24A-3du1X:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		4 ASN X 111
LEU X  92
VAL X  93
ASP X 136
 None
 0.90A 4g24A-3du1X:
undetectable		 4g24A-3du1X:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 357
LEU A 413
VAL A 414
GLU A 264
 None
 0.99A 4g24A-3e60A:
undetectable		 4g24A-3e60A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		4 ALA X 252
ASN X 254
LEU X 257
ASP X 112
 None
 0.72A 4g24A-3eatX:
undetectable		 4g24A-3eatX:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF01661
(Macro) 		4 ALA A 124
ASN A 123
LEU A 122
VAL A 121
 None
 0.92A 4g24A-3ew5A:
undetectable		 4g24A-3ew5A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 229
LEU A 233
VAL A 234
GLU A 269
 COW  A 350 (-3.6A)
None
None
None
 1.00A 4g24A-3h77A:
undetectable		 4g24A-3h77A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie4 GRAM-NEGATIVE
BINDING PROTEIN 3

(Drosophila
melanogaster) 		PF15886
(CBM39) 		4 LEU A  28
VAL A  80
ASP A  22
GLU A  23
 None
 0.98A 4g24A-3ie4A:
undetectable		 4g24A-3ie4A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		4 ALA A 271
ASN A 270
LEU A 267
VAL A 266
 None
 1.01A 4g24A-3iv7A:
undetectable		 4g24A-3iv7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0l RIBOSOMAL PROTEIN
S14

(Oryctolagus
cuniculus) 		PF00411
(Ribosomal_S11) 		4 ALA K  92
LEU K  93
VAL K  30
GLU K 130
 None
 1.05A 4g24A-3j0lK:
undetectable		 4g24A-3j0lK:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 ALA A 198
LEU A 246
VAL A 247
ASP A 233
 None
 1.00A 4g24A-3k5zA:
2.7		 4g24A-3k5zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ALA A 286
ASN A 284
LEU A 285
VAL A 175
 None
 0.95A 4g24A-3mi6A:
undetectable		 4g24A-3mi6A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 350
LEU A 406
VAL A 407
GLU A 256
 None
 0.97A 4g24A-3o04A:
undetectable		 4g24A-3o04A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 ALA A 108
ASN A 107
LEU A 106
VAL A 105
 None
 0.96A 4g24A-3o82A:
undetectable		 4g24A-3o82A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 344
LEU A 400
VAL A 401
GLU A 257
 None
 1.01A 4g24A-3oytA:
undetectable		 4g24A-3oytA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 4 ALA A 791
ASN A 792
VAL A 800
GLU A 764
 None
 0.90A 4g24A-3p06A:
undetectable		 4g24A-3p06A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rob UNCHARACTERIZED
CONSERVED PROTEIN

(Planctopirus
limnophila) 		PF14534
(DUF4440) 		4 ALA A 130
ASN A 131
LEU A 132
VAL A 133
 None
GOL  A 137 (-3.4A)
None
None
 0.81A 4g24A-3robA:
undetectable		 4g24A-3robA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		4 ASN A 238
LEU A 237
VAL A 236
GLU A 155
 GOL  A 278 ( 4.1A)
None
None
GOL  A 278 (-3.4A)
 0.98A 4g24A-3rq0A:
undetectable		 4g24A-3rq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 103
LEU A  62
VAL A  63
ASP A  68
 None
 1.06A 4g24A-3toyA:
undetectable		 4g24A-3toyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 104
LEU A  63
VAL A  64
ASP A  69
 None
 1.02A 4g24A-3ugvA:
undetectable		 4g24A-3ugvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ALA A 199
ASN A 200
LEU A 203
VAL A 204
 None
 0.87A 4g24A-4a01A:
undetectable		 4g24A-4a01A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beg PHOSPHATIDYLETHANOLA
MINE BINDING PROTEIN

(Mycobacterium
tuberculosis) 		PF01161
(PBP) 		4 ALA A  81
LEU A 109
VAL A 110
ASP A 112
 None
 0.96A 4g24A-4begA:
undetectable		 4g24A-4begA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crq ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 147
LEU A 148
VAL A 172
ASP A 169
 None
 0.89A 4g24A-4crqA:
undetectable		 4g24A-4crqA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 ALA A  78
ASN A  77
ASP A  67
GLU A  68
 None
 0.92A 4g24A-4dqdA:
2.3		 4g24A-4dqdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A  25
ASN A  26
LEU A  27
VAL A  28
 None
 0.83A 4g24A-4ewpA:
undetectable		 4g24A-4ewpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07738
(Sad1_UNC) 		4 ALA A 556
LEU A 615
VAL A 689
GLU A 691
 None
 1.02A 4g24A-4fi9A:
undetectable		 4g24A-4fi9A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		5 ALA A 401
ASN A 402
LEU A 405
VAL A 406
ASP A 493
 None
 0.07A 4g24A-4g25A:
51.5		 4g24A-4g25A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		5 ALA A 425
ASN A 424
LEU A 423
VAL A 422
GLU A 398
 None
 1.25A 4g24A-4h3sA:
undetectable		 4g24A-4h3sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ALA A 224
LEU A  28
VAL A  29
GLU A  36
 None
 0.89A 4g24A-4h7uA:
undetectable		 4g24A-4h7uA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 ALA A 237
ASN A 236
LEU A 233
GLU A  99
 None
 0.80A 4g24A-4itxA:
undetectable		 4g24A-4itxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 351
LEU A 407
VAL A 408
GLU A 257
 None
 1.00A 4g24A-4jb6A:
undetectable		 4g24A-4jb6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN

(Paraburkholderia
graminis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ALA A 111
LEU A 115
VAL A 116
GLU A 174
 None
 0.93A 4g24A-4kdxA:
3.3		 4g24A-4kdxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A 302
LEU A 305
ASP A 240
GLU A 237
 None
None
COS  A 402 (-2.9A)
COS  A 402 (-4.5A)
 0.88A 4g24A-4l1fA:
undetectable		 4g24A-4l1fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		4 ALA A 259
ASN A 258
LEU A 255
VAL A 254
 None
 1.05A 4g24A-4mtnA:
undetectable		 4g24A-4mtnA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 LEU A 152
VAL A 153
ASP A 166
GLU A 165
 None
None
CA  A 702 ( 3.2A)
None
 1.06A 4g24A-4n2cA:
undetectable		 4g24A-4n2cA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 103
ASN A  72
LEU A  73
VAL A  74
ASP A 110
 None
 1.36A 4g24A-4oogA:
undetectable		 4g24A-4oogA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ALA A 223
ASN A 199
LEU A  65
VAL A  64
 None
 1.02A 4g24A-4ovdA:
undetectable		 4g24A-4ovdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 ALA A 176
ASN A 175
LEU A 172
VAL A 171
 None
 0.90A 4g24A-4pxnA:
undetectable		 4g24A-4pxnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reg UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01905
(DevR) 		4 ALA A 116
ASN A  75
LEU A  76
VAL A  74
 None
 1.08A 4g24A-4regA:
undetectable		 4g24A-4regA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ALA A4182
ASN A4181
LEU A4183
ASP A4177
 None
 1.06A 4g24A-4rh7A:
undetectable		 4g24A-4rh7A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ALA A 122
LEU A 124
VAL A 125
GLU A 266
 None
 1.06A 4g24A-4rncA:
undetectable		 4g24A-4rncA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		4 ALA A 185
LEU A 194
VAL A 193
ASP A 190
 None
 0.97A 4g24A-4tu3A:
undetectable		 4g24A-4tu3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE

(Staphylococcus
aureus) 		PF03328
(HpcH_HpaI) 		4 ALA A 213
LEU A 214
ASP A 220
GLU A 217
 None
 1.02A 4g24A-4tv6A:
undetectable		 4g24A-4tv6A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfh POTASSIUM CHANNEL
SUBFAMILY K MEMBER 4

(Homo sapiens) 		PF07885
(Ion_trans_2) 		4 ALA A 256
LEU A 260
VAL A 261
GLU A 221
 None
 1.06A 4g24A-4wfhA:
undetectable		 4g24A-4wfhA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 340
LEU A 396
VAL A 397
GLU A 254
 None
 1.00A 4g24A-4xoxA:
undetectable		 4g24A-4xoxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE

(Blastochloris
viridis) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ALA A 104
ASN A 107
LEU A  79
VAL A  76
 None
 1.04A 4g24A-4xqeA:
undetectable		 4g24A-4xqeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 ALA B 150
ASN B 151
LEU B 120
GLU B 288
 None
UPG  B 403 (-3.9A)
None
UPG  B 403 (-3.5A)
 0.87A 4g24A-4xsrB:
undetectable		 4g24A-4xsrB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		4 ALA A  90
ASN A  91
LEU A  72
GLU A  94
 None
 0.87A 4g24A-4yeiA:
undetectable		 4g24A-4yeiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwj DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A  17
LEU A  26
ASP A  32
GLU A  31
 None
 1.07A 4g24A-5cwjA:
6.8		 4g24A-5cwjA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 ALA A 345
ASN A 346
LEU A 349
ASP A 440
 None
 0.35A 4g24A-5dizA:
34.8		 4g24A-5dizA:
46.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		4 ALA A 687
LEU A 691
VAL A 692
GLU A 699
 None
 1.07A 4g24A-5fbuA:
undetectable		 4g24A-5fbuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		4 ALA A 310
ASN A 309
LEU A 308
GLU A 400
 None
 1.00A 4g24A-5ghsA:
undetectable		 4g24A-5ghsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 ASN A 870
LEU A 872
ASP A 830
GLU A 866
 None
 0.93A 4g24A-5h64A:
undetectable		 4g24A-5h64A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iet BACTERIAL PROTEASOME
ACTIVATOR

(Mycobacterium
tuberculosis) 		no annotation 4 ALA B 118
LEU B 122
VAL B 123
GLU B  59
 None
None
MPD  B 205 ( 3.9A)
None
 1.03A 4g24A-5ietB:
undetectable		 4g24A-5ietB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ALA A 194
ASN A 195
LEU A 196
VAL A 197
 None
 0.90A 4g24A-5jd5A:
undetectable		 4g24A-5jd5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC

(Mycobacterium
tuberculosis) 		PF01547
(SBP_bac_1) 		4 ALA A 213
LEU A 252
VAL A 253
ASP A 259
 None
 1.05A 4g24A-5k2yA:
undetectable		 4g24A-5k2yA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfj BACTERIAL PROTEASOME
ACTIVATOR

(Mycobacterium
tuberculosis) 		PF10759
(DUF2587) 		4 ALA A 118
LEU A 122
VAL A 123
GLU A  59
 None
 1.04A 4g24A-5lfjA:
undetectable		 4g24A-5lfjA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		4 ALA A 667
LEU A 767
VAL A 768
ASP A 775
 None
 1.04A 4g24A-5loiA:
5.1		 4g24A-5loiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loz EPSIN-1

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 ALA A  26
ASN A  25
LEU A  22
VAL A  21
 None
 0.88A 4g24A-5lozA:
2.7		 4g24A-5lozA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ALA A 253
ASN A 252
LEU A 251
VAL A 250
 None
 1.05A 4g24A-5mewA:
undetectable		 4g24A-5mewA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A 185
ASN A 184
LEU A 219
ASP A 182
 None
 1.01A 4g24A-5necA:
undetectable		 4g24A-5necA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 ALA A  77
ASN A  76
VAL A  72
ASP A 399
 None
 1.02A 4g24A-5o1mA:
undetectable		 4g24A-5o1mA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9l PARALOG OF
ACCUMULATION AND
REPLICATION OF
CHLOROPLASTS 6
(PARC6)

(Arabidopsis
thaliana) 		no annotation 4 ALA A 788
ASN A 787
LEU A 779
VAL A 780
 None
 1.01A 4g24A-5u9lA:
undetectable		 4g24A-5u9lA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 ALA A 644
LEU A 662
VAL A 659
ASP A 699
 None
 0.91A 4g24A-5wblA:
3.8		 4g24A-5wblA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 4 ALA A  34
ASN A  27
LEU A  25
ASP A  28
 None
 1.03A 4g24A-5ybaA:
undetectable		 4g24A-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica) 		no annotation 4 ALA B  35
ASN B  36
LEU B  39
VAL B  40
 None
 0.79A 4g24A-6ch3B:
2.6		 4g24A-6ch3B:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ALA A 568
ASN A 567
LEU A 601
VAL A 600
 None
GOL  A 905 (-3.0A)
None
None
 0.80A 4g24A-6eksA:
undetectable		 4g24A-6eksA:
21.64