SIMILAR PATTERNS OF AMINO ACIDS FOR 4G1B_B_ECNB403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a79 TRNA ENDONUCLEASE

(Methanocaldococcus
jannaschii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 ILE A  10
ALA A  32
LEU A  30
LEU A  53
TYR A  52
 None
 1.15A 4g1bB-1a79A:
0.0		 4g1bB-1a79A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  50
PHE A  19
ALA A  87
LEU A  90
THR A  89
 None
 1.12A 4g1bB-1bucA:
2.4		 4g1bB-1bucA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		5 ILE A 134
THR A 135
PHE A 138
TYR A 139
ALA A  56
 None
 0.95A 4g1bB-1cf5A:
0.0		 4g1bB-1cf5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 THR A  92
ALA A  94
LEU A  93
THR A  78
VAL A  79
 None
 1.06A 4g1bB-1dabA:
0.0		 4g1bB-1dabA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcz TRANSCARBOXYLASE
1.3S SUBUNIT

(Propionibacterium
freudenreichii) 		PF00364
(Biotin_lipoyl) 		6 THR A  92
ALA A  87
LEU A  85
THR A  64
VAL A 113
LEU A  83
 None
 1.47A 4g1bB-1dczA:
undetectable		 4g1bB-1dczA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 ILE A 242
ALA A 202
LEU A 201
VAL A 197
LEU A 238
 None
 1.07A 4g1bB-1dk5A:
undetectable		 4g1bB-1dk5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm1 PROTEIN TYROSINE
PHOSPHATASE

(Mus musculus) 		PF00595
(PDZ) 		5 ILE A  27
ALA A  81
LEU A  85
THR A  84
LEU A  94
 None
 1.14A 4g1bB-1gm1A:
undetectable		 4g1bB-1gm1A:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 THR A  25
PHE A  28
TYR A  29
LEU A 102
TYR A 124
 None
None
None
None
HEM  A1398 ( 4.9A)
 0.45A 4g1bB-1gvhA:
44.1		 4g1bB-1gvhA:
36.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkf NK CELL ACTIVATING
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		5 ILE A  65
THR A  64
PHE A  63
VAL A  20
TYR A  89
 None
 1.13A 4g1bB-1hkfA:
undetectable		 4g1bB-1hkfA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 ILE A  67
PHE A  21
ALA A  18
LEU A  19
VAL A  14
 None
 1.12A 4g1bB-1imjA:
4.4		 4g1bB-1imjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 ILE A 134
ALA A 102
LEU A 101
THR A  98
LEU A 332
 None
 1.08A 4g1bB-1kk0A:
3.6		 4g1bB-1kk0A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 ILE A 372
THR A 368
ALA A 398
LEU A 399
THR A 402
 None
 1.15A 4g1bB-1rq1A:
undetectable		 4g1bB-1rq1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		6 PHE A 822
ALA A 612
LEU A 613
THR A 615
VAL A 617
LEU A 818
 None
 1.34A 4g1bB-1urjA:
undetectable		 4g1bB-1urjA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 ILE A  54
ALA A 182
LEU A 181
VAL A 176
LEU A  56
 None
 1.11A 4g1bB-1x3lA:
4.8		 4g1bB-1x3lA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 ILE A 434
GLN A 441
LEU A 443
VAL A 454
LEU A 524
 None
 0.95A 4g1bB-1xhbA:
undetectable		 4g1bB-1xhbA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		5 THR A 309
PHE A 342
LEU A 252
VAL A 256
LEU A 366
 None
 1.15A 4g1bB-1xmxA:
6.2		 4g1bB-1xmxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 ALA A 112
LEU A 113
THR A 116
VAL A 117
LEU A  72
 None
None
None
None
HEM  A 160 (-4.5A)
 1.08A 4g1bB-1yhuA:
13.1		 4g1bB-1yhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 ALA A 112
LEU A 113
THR A 116
VAL A 117
TYR A  20
 None
 0.84A 4g1bB-1yhuA:
13.1		 4g1bB-1yhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 ILE A  53
ALA A  20
LEU A  19
THR A  31
VAL A  32
 None
 0.89A 4g1bB-1z9dA:
2.5		 4g1bB-1z9dA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		5 ILE A  77
ALA A 232
LEU A 233
LEU A  73
TYR A 305
 None
 1.07A 4g1bB-2aazA:
undetectable		 4g1bB-2aazA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 306
ALA A 296
LEU A 295
VAL A 291
LEU A 278
 None
 1.11A 4g1bB-2e5vA:
2.9		 4g1bB-2e5vA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		5 THR G 129
ALA G 131
LEU G 130
THR G 115
VAL G 116
 None
 1.05A 4g1bB-2iouG:
undetectable		 4g1bB-2iouG:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		5 ILE A 906
ALA A 873
LEU A 872
VAL A 868
LEU A 895
 None
 1.03A 4g1bB-2iusA:
undetectable		 4g1bB-2iusA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 209
THR A 210
VAL A 128
LEU A 106
TYR A 152
 None
 1.11A 4g1bB-2jamA:
undetectable		 4g1bB-2jamA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		5 ILE A 121
THR A 118
LEU A  34
VAL A  63
LEU A  90
 None
 1.14A 4g1bB-2npnA:
2.1		 4g1bB-2npnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ALA A 379
LEU A 377
VAL A 384
LEU A 302
TYR A 245
 None
 1.09A 4g1bB-2okxA:
undetectable		 4g1bB-2okxA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q79 REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00511
(PPV_E2_C) 		5 ILE A 350
LEU A 289
THR A 332
VAL A 287
TYR A 310
 None
 1.14A 4g1bB-2q79A:
undetectable		 4g1bB-2q79A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ILE B 147
ALA B 114
LEU B 113
VAL B 109
LEU B 168
 None
 1.07A 4g1bB-2qbyB:
undetectable		 4g1bB-2qbyB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae) 		PF00089
(Trypsin) 		5 PHE A 176
GLN A 137
ALA A 122
LEU A 135
VAL A 132
 None
 1.13A 4g1bB-2sfaA:
undetectable		 4g1bB-2sfaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		5 ILE A 272
ALA A 252
LEU A 254
THR A 250
VAL A 249
 None
 1.12A 4g1bB-2we5A:
undetectable		 4g1bB-2we5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		6 PHE A  27
TYR A  28
GLN A  52
ALA A  55
LEU A 101
TYR A 123
 None
CYN  A 151 (-4.7A)
HEM  A 150 ( 3.6A)
HEM  A 150 (-4.2A)
None
None
 0.94A 4g1bB-2wy4A:
20.7		 4g1bB-2wy4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		5 PHE A  27
TYR A  28
LEU A  23
LEU A 101
TYR A 123
 None
CYN  A 151 (-4.7A)
None
None
None
 1.12A 4g1bB-2wy4A:
20.7		 4g1bB-2wy4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		5 THR A  24
PHE A  27
TYR A  28
GLN A  52
TYR A 123
 None
None
CYN  A 151 (-4.7A)
HEM  A 150 ( 3.6A)
None
 0.80A 4g1bB-2wy4A:
20.7		 4g1bB-2wy4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 GLN A 125
ALA A 120
LEU A 121
VAL A 171
LEU A 157
 None
 1.15A 4g1bB-2z00A:
undetectable		 4g1bB-2z00A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ILE A 119
ALA A  54
LEU A  55
THR A  58
VAL A  59
 None
 0.94A 4g1bB-3cemA:
3.4		 4g1bB-3cemA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Rhodobacter
sphaeroides) 		PF01323
(DSBA) 		5 ILE A 147
ALA A 151
LEU A 152
THR A 155
VAL A 156
 None
 1.01A 4g1bB-3fz5A:
undetectable		 4g1bB-3fz5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3c CHROMOBOX PROTEIN
HOMOLOG 5

(Homo sapiens) 		PF01393
(Chromo_shadow) 		5 ILE A  65
PHE A  69
TYR A  70
ALA A  55
VAL A  53
 NA  A  76 (-4.7A)
None
None
None
None
 1.12A 4g1bB-3i3cA:
undetectable		 4g1bB-3i3cA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		5 ILE B 416
ALA B 395
LEU B 397
VAL A 305
LEU B 418
 None
 1.06A 4g1bB-3kydB:
6.2		 4g1bB-3kydB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 ILE A 241
THR A 238
PHE A 242
VAL A 168
LEU A 245
 None
 1.14A 4g1bB-3n9xA:
undetectable		 4g1bB-3n9xA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A 246
THR A 243
PHE A 247
LEU A 140
VAL A 170
LEU A 250
 None
 1.19A 4g1bB-3nieA:
2.2		 4g1bB-3nieA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 6 ILE B  24
PHE B  28
TYR B  29
LEU B  57
LEU B 102
TYR B 126
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
ECN  B 411 (-4.1A)
ECN  B 411 (-3.2A)
HEM  B 404 ( 3.9A)
 0.83A 4g1bB-3ozvB:
46.3		 4g1bB-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 5 ILE B  24
PHE B  28
TYR B  29
LEU B  57
VAL B  61
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
 0.93A 4g1bB-3ozvB:
46.3		 4g1bB-3ozvB:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phu RNA-DIRECTED RNA
POLYMERASE L

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02338
(OTU) 		5 ILE A  31
PHE A  29
LEU A 145
THR A 120
VAL A 121
 None
 0.97A 4g1bB-3phuA:
undetectable		 4g1bB-3phuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pse RNA POLYMERASE

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02338
(OTU) 		5 ILE A  31
PHE A  29
LEU A 145
THR A 120
VAL A 121
 None
 0.99A 4g1bB-3pseA:
undetectable		 4g1bB-3pseA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 ILE A 379
THR A 378
ALA A 369
LEU A 375
THR A 371
 None
 1.15A 4g1bB-3q3qA:
undetectable		 4g1bB-3q3qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A 173
GLN A 168
LEU A 169
VAL A 132
LEU A 159
 None
None
None
FAD  A 401 (-4.1A)
None
 1.08A 4g1bB-3qj4A:
4.4		 4g1bB-3qj4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Campylobacter
jejuni) 		PF00290
(Trp_syntA) 		5 ILE A 114
ALA A  80
LEU A  79
VAL A  75
TYR A 100
 None
 1.11A 4g1bB-3thaA:
undetectable		 4g1bB-3thaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm9 BACTERIAL HEMOGLOBIN

(Vitreoscilla
stercoraria) 		PF00042
(Globin) 		5 ILE A  24
THR A  25
PHE A  28
LEU A 102
TYR A 126
 None
None
None
None
HEM  A 201 (-3.5A)
 0.65A 4g1bB-3tm9A:
19.9		 4g1bB-3tm9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm9 BACTERIAL HEMOGLOBIN

(Vitreoscilla
stercoraria) 		PF00042
(Globin) 		5 ILE A  24
THR A  25
THR A  60
LEU A 102
TYR A 126
 None
None
HEM  A 201 (-2.5A)
None
HEM  A 201 (-3.5A)
 0.91A 4g1bB-3tm9A:
19.9		 4g1bB-3tm9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 ILE A  24
PHE A  28
GLN A  50
LEU A  99
TYR A 123
 None
None
HEM  A 201 ( 3.3A)
None
HEM  A 201 (-4.4A)
 0.88A 4g1bB-3ubcA:
18.8		 4g1bB-3ubcA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 ILE A  24
PHE A  28
TYR A  29
GLN A  50
TYR A 123
 None
None
None
HEM  A 201 ( 3.3A)
HEM  A 201 (-4.4A)
 0.95A 4g1bB-3ubcA:
18.8		 4g1bB-3ubcA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		5 ALA A 110
LEU A 111
THR A 114
VAL A 115
TYR A  18
 None
 0.87A 4g1bB-3wctA:
13.3		 4g1bB-3wctA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 318
GLN A 324
ALA A 323
LEU A 322
LEU A 302
 None
 1.15A 4g1bB-3zo9A:
undetectable		 4g1bB-3zo9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		6 ILE A 354
GLN A 362
ALA A 361
LEU A 364
THR A 333
VAL A 334
 None
 1.35A 4g1bB-4cjaA:
undetectable		 4g1bB-4cjaA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		5 ILE A  59
PHE A 371
ALA A  87
LEU A  61
LEU A 360
 None
 1.11A 4g1bB-4d1iA:
undetectable		 4g1bB-4d1iA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 ILE A 333
TYR A 165
LEU A 329
THR A 179
VAL A 182
 None
 1.05A 4g1bB-4gmfA:
5.8		 4g1bB-4gmfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ILE A 283
THR A 280
ALA A 314
LEU A 315
THR A 317
VAL A 319
 None
 1.48A 4g1bB-4i3gA:
4.0		 4g1bB-4i3gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 ILE A 213
ALA A 210
LEU A 211
VAL A 172
LEU A 197
 None
 1.07A 4g1bB-4i8qA:
undetectable		 4g1bB-4i8qA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 182
TYR A 145
THR A 100
LEU A 184
TYR A 107
 None
 1.12A 4g1bB-4iv6A:
undetectable		 4g1bB-4iv6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 ILE A  19
THR A  20
PHE A  63
LEU A  91
LEU A  22
 None
 1.02A 4g1bB-4jpkA:
undetectable		 4g1bB-4jpkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 ILE A 658
LEU A 662
THR A 706
VAL A 703
LEU A 681
 None
 1.07A 4g1bB-4k6jA:
2.5		 4g1bB-4k6jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 5 ILE A  84
THR A  85
ALA A  87
LEU A  86
VAL A  91
 None
 0.99A 4g1bB-4l3aA:
undetectable		 4g1bB-4l3aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		5 THR A 285
PHE A 304
LEU A 270
VAL A 155
LEU A 394
 None
 1.08A 4g1bB-4lejA:
undetectable		 4g1bB-4lejA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		5 ILE A 126
LEU A 154
THR A 156
VAL A 157
LEU A 209
 None
 1.01A 4g1bB-4lh7A:
3.5		 4g1bB-4lh7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 780
LEU A 839
THR A 751
VAL A 767
LEU A 774
 None
 1.14A 4g1bB-4ncnA:
2.5		 4g1bB-4ncnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A  53
ALA A  11
LEU A  12
THR A  15
VAL A  16
 None
 1.07A 4g1bB-4o5mA:
3.6		 4g1bB-4o5mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqz PUTATIVE
OXIDOREDUCTASE YFJR

(Streptomyces
aurantiacus) 		PF03446
(NAD_binding_2) 		6 ILE A  63
TYR A  26
GLN A   3
LEU A  61
VAL A  87
LEU A 148
 None
 1.40A 4g1bB-4oqzA:
2.2		 4g1bB-4oqzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow4 BETA-TERFOIL
DESIGNED BY FOLDING
NUCLEUS SYMMETRIC
EXPANSION
('PHIFOIL')

(synthetic
construct) 		PF00167
(FGF) 		5 ILE A  56
GLN A  63
LEU A  65
VAL A  73
LEU A  23
 None
 1.11A 4g1bB-4ow4A:
undetectable		 4g1bB-4ow4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox3 PUTATIVE
CARBOXYPEPTIDASE
YODJ

(Bacillus
subtilis) 		PF02557
(VanY) 		5 ILE A 225
TYR A 228
ALA A 190
THR A 187
LEU A 263
 None
 1.14A 4g1bB-4ox3A:
undetectable		 4g1bB-4ox3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 ILE A1538
TYR A1565
LEU A1555
VAL A1552
LEU A1586
 None
 1.14A 4g1bB-4r04A:
2.7		 4g1bB-4r04A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 5 ILE B 780
LEU B 839
THR B 751
VAL B 767
LEU B 774
 None
 1.13A 4g1bB-4tmzB:
2.6		 4g1bB-4tmzB:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tt6 ATPASE FAMILY AAA
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 ILE A1056
ALA A1080
LEU A1081
THR A1084
LEU A1031
 None
 1.15A 4g1bB-4tt6A:
2.8		 4g1bB-4tt6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 FRACTALKINE
G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus;
Homo sapiens) 		PF00001
(7tm_1)
PF00048
(IL8) 		5 THR A 108
PHE A 111
TYR A 112
THR B   6
TYR A  40
 PCA  B   1 ( 3.8A)
None
None
None
None
 1.06A 4g1bB-4xt1A:
undetectable		 4g1bB-4xt1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B  85
GLN B 110
ALA B  51
LEU B  50
VAL B  48
 None
 1.12A 4g1bB-5a8rB:
undetectable		 4g1bB-5a8rB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 502
ALA A 521
LEU A 525
THR A 524
LEU A 498
 None
 1.13A 4g1bB-5bymA:
undetectable		 4g1bB-5bymA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3o THYMINE DIOXYGENASE

(Neurospora
crassa) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 ILE A 220
THR A 221
ALA A 290
LEU A 222
TYR A  47
 None
 1.11A 4g1bB-5c3oA:
undetectable		 4g1bB-5c3oA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 ILE A 422
THR A 421
ALA A 393
LEU A  50
LEU A 341
 MG  A1005 (-4.9A)
MG  A1005 (-4.5A)
None
None
None
 1.07A 4g1bB-5d8gA:
undetectable		 4g1bB-5d8gA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2

(Homo sapiens) 		PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C)
PF03153
(TFIIA) 		5 ILE D  44
GLN D  50
ALA D  49
LEU D  48
LEU B  13
 None
 1.06A 4g1bB-5furD:
4.1		 4g1bB-5furD:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 ILE A 168
GLN A 120
LEU A 116
THR A 112
VAL A  96
 None
 1.13A 4g1bB-5gmxA:
undetectable		 4g1bB-5gmxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		5 THR A 272
ALA A 316
LEU A 317
THR A 319
LEU A 266
 None
 0.91A 4g1bB-5hh9A:
5.2		 4g1bB-5hh9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu4 CYSTEINE PROTEASE

(Listeria
monocytogenes) 		PF04203
(Sortase) 		5 ILE A 112
ALA A  54
LEU A  53
THR A  38
VAL A  24
 None
 1.14A 4g1bB-5hu4A:
undetectable		 4g1bB-5hu4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ILE A 148
ALA A 141
LEU A 140
VAL A 136
LEU A 161
 None
 0.87A 4g1bB-5j3pA:
undetectable		 4g1bB-5j3pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ILE A 291
ALA A 274
LEU A 273
VAL A 269
LEU A 301
 None
 1.12A 4g1bB-5jryA:
5.0		 4g1bB-5jryA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l73 NEUROPILIN-1

(Homo sapiens) 		PF00629
(MAM) 		5 ALA A 719
LEU A 770
VAL A 713
LEU A 740
TYR A 742
 None
 1.15A 4g1bB-5l73A:
undetectable		 4g1bB-5l73A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		5 ILE A 161
PHE A 162
ALA A 208
LEU A 207
LEU A 165
 None
 0.92A 4g1bB-5m8hA:
undetectable		 4g1bB-5m8hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ILE A 102
ALA A 154
LEU A 153
VAL A 149
LEU A 130
 None
 1.14A 4g1bB-5n9uA:
undetectable		 4g1bB-5n9uA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlt CVAA9A

(Collariella
virescens) 		no annotation 5 ILE A  87
GLN A 146
LEU A 144
VAL A 175
LEU A 133
 None
 1.10A 4g1bB-5nltA:
undetectable		 4g1bB-5nltA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpt AMYLOID-LIKE PROTEIN
2

(Homo sapiens) 		no annotation 5 ILE A 561
ALA A 492
LEU A 493
VAL A 497
LEU A 544
 None
 1.04A 4g1bB-5tptA:
5.3		 4g1bB-5tptA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 5 ILE A  52
LEU A 189
THR A 202
VAL A 187
TYR A 207
 None
 1.11A 4g1bB-5u81A:
undetectable		 4g1bB-5u81A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 ILE A 317
LEU A 348
THR A 350
VAL A 352
LEU A 321
 None
 1.01A 4g1bB-5vhaA:
undetectable		 4g1bB-5vhaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 ILE A 417
THR A 416
ALA A 388
LEU A  48
LEU A 335
 None
 1.03A 4g1bB-5w19A:
undetectable		 4g1bB-5w19A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 0.93A 4g1bB-5ydjA:
undetectable		 4g1bB-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 ILE A 307
LEU A  69
VAL A  68
LEU A 357
TYR A  62
 HEM  A 501 (-4.4A)
None
None
None
None
 1.07A 4g1bB-5ysmA:
undetectable		 4g1bB-5ysmA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbl CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		no annotation 5 ILE A 111
ALA A  30
LEU A  34
THR A  33
LEU A 182
 None
 1.03A 4g1bB-5zblA:
3.7		 4g1bB-5zblA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 1.02A 4g1bB-6arxA:
undetectable		 4g1bB-6arxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b23 MAJOR HEAD PROTEIN

(Staphylococcus
virus 80alpha) 		no annotation 5 ILE A  47
THR A  44
LEU A  39
THR A  38
LEU A 291
 None
 1.15A 4g1bB-6b23A:
undetectable		 4g1bB-6b23A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0p PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 5 ILE A  71
GLN A 141
ALA A 174
VAL A 182
LEU A 125
 None
 1.12A 4g1bB-6d0pA:
undetectable		 4g1bB-6d0pA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 5 ILE A 244
ALA A 264
LEU A 265
VAL A 180
LEU A 233
 None
 1.02A 4g1bB-6dawA:
undetectable		 4g1bB-6dawA:
10.97