SIMILAR PATTERNS OF AMINO ACIDS FOR 4G19_D_ACTD302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 TYR A 160
PHE A 147
ARG A 143
 None
 1.16A 4g19D-1cptA:
0.0		 4g19D-1cptA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 TYR M 189
PHE M 261
ARG M 259
 None
None
SO4  M 926 ( 2.9A)
 1.12A 4g19D-1dwaM:
0.0		 4g19D-1dwaM:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h31 DIHEME CYTOCHROME C

(Rhodovulum
sulfidophilum) 		no annotation 3 TYR A 167
PHE A  28
ARG A 248
 None
 1.23A 4g19D-1h31A:
undetectable		 4g19D-1h31A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		3 TYR A 296
PHE A  52
ARG A 303
 None
 1.03A 4g19D-1ihpA:
0.0		 4g19D-1ihpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 TYR A 478
PHE A 252
ARG A 180
 TBU  A 501 ( 4.9A)
None
None
 0.88A 4g19D-1kq0A:
undetectable		 4g19D-1kq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 TYR A  67
PHE A 146
ARG A 112
 None
 1.14A 4g19D-1mwoA:
0.0		 4g19D-1mwoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 TYR A 207
PHE A 280
ARG A 203
 None
None
SO4  A 906 (-3.0A)
 1.11A 4g19D-1o99A:
0.0		 4g19D-1o99A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		3 TYR A 146
PHE A  33
ARG A 222
 None
 0.97A 4g19D-1odiA:
0.1		 4g19D-1odiA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 TYR A 807
PHE A 550
ARG A 883
 None
 1.03A 4g19D-1p2zA:
0.0		 4g19D-1p2zA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvx PROTEIN
(ENDO-1,4-BETA-XYLAN
ASE)

(Byssochlamys
spectabilis) 		PF00457
(Glyco_hydro_11) 		3 TYR A 115
PHE A  62
ARG A 141
 None
 1.08A 4g19D-1pvxA:
undetectable		 4g19D-1pvxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 3 TYR A 353
PHE A 144
ARG A 349
 HEM  A 999 (-3.8A)
HEM  A 999 (-4.5A)
HEM  A 999 (-3.4A)
 1.22A 4g19D-1u5uA:
undetectable		 4g19D-1u5uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A1153
PHE A1323
ARG A1322
 None
 1.19A 4g19D-1wufA:
undetectable		 4g19D-1wufA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyn ENDO-1,4-BETA-XYLANA
SE I

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 TYR A 102
PHE A  50
ARG A 128
 None
 1.00A 4g19D-1xynA:
undetectable		 4g19D-1xynA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		3 TYR A 115
PHE A  62
ARG A 141
 None
 1.09A 4g19D-1ynaA:
undetectable		 4g19D-1ynaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE

(Escherichia
coli) 		PF01636
(APH) 		3 TYR A 276
PHE A   6
ARG A 283
 None
 1.08A 4g19D-1zylA:
undetectable		 4g19D-1zylA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 TYR A 478
PHE A 252
ARG A 180
 None
 0.82A 4g19D-2aduA:
undetectable		 4g19D-2aduA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		PF10604
(Polyketide_cyc2) 		3 TYR A  77
PHE A  53
ARG A  51
 None
 1.15A 4g19D-2le1A:
undetectable		 4g19D-2le1A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 TYR A 412
PHE A  68
ARG A 390
 None
 1.06A 4g19D-2p3eA:
undetectable		 4g19D-2p3eA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		3 TYR A 284
PHE A 391
ARG A 229
 None
 1.20A 4g19D-2w45A:
undetectable		 4g19D-2w45A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wau ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 TYR A2558
PHE A2609
ARG A2523
 None
 1.23A 4g19D-2wauA:
undetectable		 4g19D-2wauA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Escherichia
coli) 		PF01370
(Epimerase) 		3 TYR A 272
PHE A 211
ARG A 209
 ADP  A 401 (-4.3A)
None
ADP  A 401 (-2.7A)
 1.05A 4g19D-2x86A:
undetectable		 4g19D-2x86A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 TYR A 407
PHE A 316
ARG A 312
 None
 1.16A 4g19D-3cghA:
undetectable		 4g19D-3cghA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY

(Acinetobacter
sp. ADP1) 		no annotation 3 TYR A  34
PHE A 117
ARG A  54
 SO4  A 177 ( 4.5A)
SO4  A 177 (-4.6A)
SO4  A 177 (-3.7A)
 1.16A 4g19D-3d3oA:
undetectable		 4g19D-3d3oA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 TYR A 353
PHE A 144
ARG A 349
 HEM  A1100 (-4.2A)
HEM  A1100 ( 4.7A)
HEM  A1100 (-3.3A)
 1.22A 4g19D-3dy5A:
undetectable		 4g19D-3dy5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 TYR A 416
PHE A 389
ARG A 423
 None
 1.12A 4g19D-3e2sA:
undetectable		 4g19D-3e2sA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh MUKE

(Escherichia
coli) 		PF04288
(MukE) 		3 TYR C  70
PHE C  32
ARG C  40
 None
 1.08A 4g19D-3euhC:
undetectable		 4g19D-3euhC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ey5 ACETYLTRANSFERASE-LI
KE, GNAT FAMILY

(Bacteroides
thetaiotaomicron) 		PF00583
(Acetyltransf_1) 		3 TYR A 139
PHE A  47
ARG A  32
 None
 1.06A 4g19D-3ey5A:
undetectable		 4g19D-3ey5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		3 TYR A 358
PHE A 131
ARG A  59
 None
 0.90A 4g19D-3fmqA:
undetectable		 4g19D-3fmqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im0 VAL-1

(Paramecium
bursaria
Chlorella virus
CVK2) 		no annotation 3 TYR A 128
PHE A 220
ARG A 116
 BDP  A 301 (-4.6A)
BDP  A 301 (-4.6A)
BDP  A 301 (-2.6A)
 1.23A 4g19D-3im0A:
undetectable		 4g19D-3im0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im0 VAL-1

(Paramecium
bursaria
Chlorella virus
CVK2) 		no annotation 3 TYR A 130
PHE A 220
ARG A 116
 BDP  A 301 (-4.5A)
BDP  A 301 (-4.6A)
BDP  A 301 (-2.6A)
 1.21A 4g19D-3im0A:
undetectable		 4g19D-3im0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 236
PHE A  76
ARG A 163
 None
 1.10A 4g19D-3ip3A:
undetectable		 4g19D-3ip3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		3 TYR A 274
PHE A  60
ARG A  62
 None
 1.08A 4g19D-3kgbA:
undetectable		 4g19D-3kgbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		3 TYR A 103
PHE A  89
ARG A 361
 None
None
HEM  A 488 (-3.3A)
 1.17A 4g19D-3kswA:
undetectable		 4g19D-3kswA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 3 TYR B 213
PHE B 186
ARG B 215
 None
 1.14A 4g19D-3nwaB:
undetectable		 4g19D-3nwaB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		3 TYR A 491
PHE A 704
ARG A 536
 None
AMP  A 900 (-3.3A)
AMP  A 900 (-4.3A)
 1.22A 4g19D-3ty9A:
undetectable		 4g19D-3ty9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 TYR A 141
PHE A  82
ARG A 166
 None
 1.14A 4g19D-3wp5A:
undetectable		 4g19D-3wp5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 TYR A1232
PHE A 916
ARG A 153
 None
 1.19A 4g19D-3zyvA:
undetectable		 4g19D-3zyvA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		3 TYR A 255
PHE A 244
ARG A 242
 None
 1.23A 4g19D-4azwA:
undetectable		 4g19D-4azwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		3 TYR A 213
PHE A 186
ARG A 215
 None
 0.99A 4g19D-4bomA:
undetectable		 4g19D-4bomA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		3 TYR A1982
PHE A1840
ARG A2028
 None
 1.24A 4g19D-4by6A:
undetectable		 4g19D-4by6A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		3 TYR B 348
PHE B 421
ARG B 352
 None
 1.21A 4g19D-4cakB:
undetectable		 4g19D-4cakB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e10 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		3 TYR A 369
PHE A 265
ARG A 254
 None
 0.93A 4g19D-4e10A:
undetectable		 4g19D-4e10A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		3 TYR A 292
PHE A 215
ARG A 213
 None
 1.01A 4g19D-4ej0A:
undetectable		 4g19D-4ej0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f41 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		3 TYR A 369
PHE A 265
ARG A 254
 None
 0.97A 4g19D-4f41A:
undetectable		 4g19D-4f41A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		3 TYR A 187
PHE A 146
ARG A 184
 None
 1.11A 4g19D-4fwmA:
undetectable		 4g19D-4fwmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 TYR A 546
PHE A 376
ARG A 380
 None
 1.21A 4g19D-4fyeA:
undetectable		 4g19D-4fyeA:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 TYR A  46
PHE A 130
ARG A 153
 GSH  A 302 ( 4.7A)
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.09A 4g19D-4g19A:
43.7		 4g19D-4g19A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 TYR A 609
PHE A 517
ARG A 600
 None
 1.24A 4g19D-4g56A:
undetectable		 4g19D-4g56A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 TYR A 115
PHE A  62
ARG A 141
 None
 1.05A 4g19D-4hk9A:
undetectable		 4g19D-4hk9A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		3 TYR B 338
PHE B  57
ARG B  55
 None
 1.23A 4g19D-4hxeB:
undetectable		 4g19D-4hxeB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1q BRIDGING INTEGRATOR
2

(Homo sapiens) 		PF03114
(BAR) 		3 TYR A 221
PHE A  67
ARG A 217
 None
 0.93A 4g19D-4i1qA:
undetectable		 4g19D-4i1qA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		3 TYR A 263
PHE A  49
ARG A 305
 NO2  A 501 (-4.6A)
NO2  A 501 (-4.8A)
NO2  A 501 (-3.8A)
 1.21A 4g19D-4jreA:
undetectable		 4g19D-4jreA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lmw GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 TYR A  46
PHE A 130
ARG A 153
 FMT  A 301 ( 4.9A)
None
FMT  A 305 ( 4.0A)
 0.89A 4g19D-4lmwA:
38.5		 4g19D-4lmwA:
59.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nw4 LIPOPROTEIN S-LAYER
PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		3 TYR A 148
PHE A  99
ARG A 123
 SO4  A 402 (-4.4A)
SO4  A 402 (-4.0A)
SO4  A 402 (-2.9A)
 1.19A 4g19D-4nw4A:
undetectable		 4g19D-4nw4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 TYR A 416
PHE A 389
ARG A 423
 None
 1.12A 4g19D-4o8aA:
undetectable		 4g19D-4o8aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		3 TYR A  84
PHE A  67
ARG A  91
 None
 1.16A 4g19D-4ojzA:
undetectable		 4g19D-4ojzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pii N-GLYCOSYLASE/DNA
LYASE

(Pyrococcus
furiosus) 		PF09171
(AGOG) 		3 TYR A 167
PHE A  27
ARG A 158
 None
 1.24A 4g19D-4piiA:
undetectable		 4g19D-4piiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		3 TYR A  63
PHE A 142
ARG A 180
 None
 1.23A 4g19D-4pxdA:
undetectable		 4g19D-4pxdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		3 TYR A 541
PHE A  80
ARG A  61
 None
 0.98A 4g19D-4ql6A:
undetectable		 4g19D-4ql6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		3 TYR A  37
PHE A 107
ARG A  34
 None
 1.23A 4g19D-4us4A:
undetectable		 4g19D-4us4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN UL2M, MRPL2

(Sus scrofa) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		3 TYR D 104
PHE D 109
ARG D 136
 A  A 857 ( 3.8A)
None
G  A 858 ( 3.3A)
 1.24A 4g19D-4v19D:
undetectable		 4g19D-4v19D:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 3 TYR A 320
PHE A 286
ARG A 342
 None
 1.15A 4g19D-4wseA:
undetectable		 4g19D-4wseA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		3 TYR A 169
PHE A1285
ARG A1276
 None
 1.09A 4g19D-4xajA:
undetectable		 4g19D-4xajA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN

(Roseobacter
denitrificans;
Roseobacter
denitrificans) 		PF00115
(COX1)
PF00034
(Cytochrom_C) 		3 TYR A 416
PHE A 405
ARG B 114
 None
 1.16A 4g19D-4xydA:
undetectable		 4g19D-4xydA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01

(Homo sapiens) 		no annotation 3 TYR H 176
PHE H 108
ARG H 110
 None
 1.20A 4g19D-4ydjH:
undetectable		 4g19D-4ydjH:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		3 TYR A  19
PHE A 158
ARG A 135
 None
 1.00A 4g19D-4zd6A:
undetectable		 4g19D-4zd6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apm VP3

(Parechovirus A) 		no annotation 3 TYR B 196
PHE B 246
ARG B 139
 None
 1.15A 4g19D-5apmB:
undetectable		 4g19D-5apmB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 TYR A1249
PHE A1506
ARG A1362
 None
 1.18A 4g19D-5b2oA:
undetectable		 4g19D-5b2oA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		3 TYR A 183
PHE A 121
ARG A 246
 None
 0.95A 4g19D-5bptA:
undetectable		 4g19D-5bptA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmo HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Neisseria
meningitidis) 		PF01648
(ACPS) 		3 TYR A  48
PHE A  89
ARG A  52
 None
 1.21A 4g19D-5cmoA:
undetectable		 4g19D-5cmoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 TYR A 944
PHE A1025
ARG A 985
 None
 0.87A 4g19D-5eawA:
undetectable		 4g19D-5eawA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		3 TYR A 304
PHE A 274
ARG A 272
 None
 1.04A 4g19D-5evjA:
undetectable		 4g19D-5evjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 TYR A 532
PHE A 500
ARG A 529
 None
 1.02A 4g19D-5ez3A:
undetectable		 4g19D-5ez3A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		3 TYR G  69
PHE G  33
ARG G  83
 None
 0.90A 4g19D-5fq8G:
undetectable		 4g19D-5fq8G:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 3 TYR A 140
PHE A 235
ARG A 128
 None
 1.24A 4g19D-5gmtA:
undetectable		 4g19D-5gmtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 3 TYR A 142
PHE A 235
ARG A 128
 None
 1.16A 4g19D-5gmtA:
undetectable		 4g19D-5gmtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 156
PHE A  74
ARG A  97
 None
 1.01A 4g19D-5gsbA:
undetectable		 4g19D-5gsbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		3 TYR A 181
PHE A 106
ARG A 207
 None
 0.99A 4g19D-5gv1A:
undetectable		 4g19D-5gv1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		3 TYR A 181
PHE A 106
ARG A 207
 None
 0.96A 4g19D-5gygA:
undetectable		 4g19D-5gygA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 190
PHE A 206
ARG A 224
 None
 1.23A 4g19D-5hesA:
undetectable		 4g19D-5hesA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgq LYSINE--TRNA LIGASE

(Loa loa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 TYR A 159
PHE A 176
ARG A 162
 None
 1.21A 4g19D-5hgqA:
undetectable		 4g19D-5hgqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 TYR A1504
PHE A1418
ARG A1336
 None
 1.15A 4g19D-5i6gA:
undetectable		 4g19D-5i6gA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 TYR A1504
PHE A1418
ARG A1336
 None
 1.16A 4g19D-5i6hA:
undetectable		 4g19D-5i6hA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 TYR A1504
PHE A1418
ARG A1336
 None
 1.18A 4g19D-5i6iA:
undetectable		 4g19D-5i6iA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhx SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Drosophila
melanogaster) 		PF00659
(POLO_box) 		3 TYR A 685
PHE A 721
ARG A 726
 None
 1.22A 4g19D-5lhxA:
undetectable		 4g19D-5lhxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP3

(Parechovirus A) 		no annotation 3 TYR B 193
PHE B 243
ARG B 136
 None
 1.02A 4g19D-5mjvB:
undetectable		 4g19D-5mjvB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 3 TYR A 260
PHE A 107
ARG A 171
 None
 1.03A 4g19D-5mrjA:
undetectable		 4g19D-5mrjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 3 TYR A 208
PHE A 303
ARG A 203
 None
 1.04A 4g19D-5nfnA:
undetectable		 4g19D-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxx RNA POLYMERASE SIGMA
FACTOR

(Bartonella
quintana) 		no annotation 3 TYR A  70
PHE A  22
ARG A  66
 None
 1.19A 4g19D-5uxxA:
undetectable		 4g19D-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 3 TYR A 183
PHE A 310
ARG A 104
 None
 1.17A 4g19D-5v2dA:
undetectable		 4g19D-5v2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A 213
PHE A 229
ARG A 247
 None
 1.07A 4g19D-5w5jA:
undetectable		 4g19D-5w5jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 3 TYR A 207
PHE A 223
ARG A 241
 None
 1.21A 4g19D-5wnmA:
undetectable		 4g19D-5wnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpw AMPHIOXUS IGVJ-C2

(Branchiostoma
floridae) 		no annotation 3 TYR A  22
PHE A  56
ARG A  60
 None
 1.15A 4g19D-5xpwA:
undetectable		 4g19D-5xpwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys6 PRV GLYCOPROTEN B

(Suid
alphaherpesvirus
1) 		no annotation 3 TYR A 224
PHE A 197
ARG A 226
 None
 1.21A 4g19D-5ys6A:
undetectable		 4g19D-5ys6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 3 TYR A 706
PHE A 221
ARG A 288
 None
 1.21A 4g19D-5z96A:
undetectable		 4g19D-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z96 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 4

(Mus musculus) 		no annotation 3 TYR A 706
PHE A 300
ARG A 288
 None
 1.07A 4g19D-5z96A:
undetectable		 4g19D-5z96A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 3 TYR A 562
PHE A 623
ARG A 619
 None
 1.17A 4g19D-6a91A:
undetectable		 4g19D-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k CYTOCHROME C FAMILY
PROTEIN
FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT

(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		no annotation
no annotation
no annotation 		3 TYR A  40
PHE E  42
ARG B  76
 None
 1.02A 4g19D-6f0kA:
undetectable		 4g19D-6f0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 884
PHE A1389
ARG A 887
 None
 1.22A 4g19D-6f42A:
undetectable		 4g19D-6f42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A

(Danio rerio) 		no annotation 3 TYR A 705
PHE A 300
ARG A 288
 None
 1.17A 4g19D-6g1kA:
undetectable		 4g19D-6g1kA:
undetectable