SIMILAR PATTERNS OF AMINO ACIDS FOR 4G19_B_ACTB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASN A 399
TYR A 450
PHE A 579
ARG A 550
 None
 1.47A 4g19B-1z68A:
0.0		 4g19B-1z68A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 ASN A 133
TYR A 288
TRP A 188
ARG A 582
 None
 1.06A 4g19B-3ayxA:
0.0		 4g19B-3ayxA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 ASN A  24
TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.20A 4g19B-4g19A:
43.3		 4g19B-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ASN A  24
TYR A  46
TRP A 122
ARG A 154
 None
FLC  A 300 (-3.7A)
None
FLC  A 300 (-3.1A)
 0.88A 4g19B-4lmvA:
40.7		 4g19B-4lmvA:
73.91