SIMILAR PATTERNS OF AMINO ACIDS FOR 4G19_A_ACTA304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		4 ILE A  12
LEU A   6
LYS A   5
ASN A  49
 None
 1.11A 4g19A-1cleA:
0.0		 4g19A-1cleA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		4 ALA A 102
ILE A  73
LEU A  80
ASN A  37
 None
 1.17A 4g19A-1g0vA:
undetectable		 4g19A-1g0vA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu1 3-DEHYDROQUINATE
DEHYDRATASE

(Streptomyces
coelicolor) 		PF01220
(DHquinase_II) 		4 ALA A  81
ILE A 107
LEU A  20
ASN A  79
 FA1  A 201 (-3.7A)
FA1  A 201 (-3.8A)
GOL  A 202 (-4.3A)
FA1  A 201 (-3.0A)
 1.17A 4g19A-1gu1A:
0.7		 4g19A-1gu1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ALA A  95
ILE A  85
LEU A  68
LYS A  93
 None
 1.19A 4g19A-1ik6A:
0.0		 4g19A-1ik6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		4 ALA A  79
ILE A 100
LEU A 145
ASN A 140
 None
 1.22A 4g19A-1iu8A:
0.7		 4g19A-1iu8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		4 ALA A 177
ILE A 202
LYS A 228
ASN A 179
 None
 1.17A 4g19A-1k5cA:
undetectable		 4g19A-1k5cA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A  58
LEU A 201
LYS A 202
ASN A  73
 None
 1.19A 4g19A-1kijA:
0.0		 4g19A-1kijA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb1 MLU1-BOX BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF04383
(KilA-N) 		4 ILE A  39
LEU A  40
LYS A  41
ASN A  35
 None
 1.07A 4g19A-1mb1A:
undetectable		 4g19A-1mb1A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 SMAD 3

(Homo sapiens) 		PF03166
(MH2) 		4 ILE A 341
LEU A 339
LYS A 340
ASN A 318
 None
 1.01A 4g19A-1mk2A:
0.0		 4g19A-1mk2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ALA A 461
ILE A 387
LEU A 351
LYS A 350
 None
 1.19A 4g19A-1nylA:
undetectable		 4g19A-1nylA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 ALA A 127
ILE A 141
LEU A 116
LYS A 142
 None
 1.20A 4g19A-1pk8A:
undetectable		 4g19A-1pk8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 ALA A 357
ILE A 300
LEU A 262
ASN A 299
 None
None
HEM  A 440 ( 4.5A)
None
 1.08A 4g19A-1q5dA:
undetectable		 4g19A-1q5dA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 ALA A1554
ILE A1465
LEU A1470
ASN A1447
 None
 1.11A 4g19A-1qhmA:
undetectable		 4g19A-1qhmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyj CELLULOSOMAL
SCAFFOLDIN

(Pseudobacteroides
cellulosolvens) 		PF00963
(Cohesin) 		4 ILE A  23
LEU A  21
LYS A 113
ASN A  24
 None
 0.97A 4g19A-1tyjA:
undetectable		 4g19A-1tyjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		4 ILE A 146
LEU A 117
LYS A 113
ASN A 151
 None
None
ADP  A2001 (-2.7A)
None
 0.95A 4g19A-1z5aA:
undetectable		 4g19A-1z5aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 ALA A  82
ILE A 103
LEU A 148
ASN A 143
 None
 1.18A 4g19A-1z8wA:
undetectable		 4g19A-1z8wA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		4 ALA A   7
ILE A 192
LEU A 222
ASN A  73
 None
 0.97A 4g19A-1zosA:
undetectable		 4g19A-1zosA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 ALA I  86
ILE I 219
LEU I  81
ASN I 144
 None
 1.07A 4g19A-2b4xI:
undetectable		 4g19A-2b4xI:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 ALA A  52
ILE A  77
LEU A  71
ASN A 271
 None
 1.13A 4g19A-2fncA:
undetectable		 4g19A-2fncA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 ALA A  52
ILE A  77
LEU A  71
ASN A 271
 None
 1.17A 4g19A-2ghbA:
undetectable		 4g19A-2ghbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs0 RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF08567
(PH_TFIIH) 		4 ALA A  50
ILE A 100
LEU A 104
LYS A 101
 None
 1.11A 4g19A-2gs0A:
undetectable		 4g19A-2gs0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ALA A 160
ILE A  67
LEU A  69
ASN A 131
 None
 1.22A 4g19A-2i4nA:
undetectable		 4g19A-2i4nA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkq MYOTILIN

(Homo sapiens) 		PF07679
(I-set) 		4 ALA A  96
ILE A  42
LYS A  13
ASN A  94
 None
 1.15A 4g19A-2kkqA:
undetectable		 4g19A-2kkqA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knr UNCHARACTERIZED
PROTEIN ATC0905

(Agrobacterium
fabrum) 		PF07372
(DUF1491) 		4 ALA A  75
ILE A 106
LEU A 112
ASN A  48
 None
 1.12A 4g19A-2knrA:
undetectable		 4g19A-2knrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		4 ALA A  69
ILE A  51
LEU A  52
LYS A  53
 None
None
None
IMP  A3036 ( 4.6A)
 1.22A 4g19A-2pyuA:
undetectable		 4g19A-2pyuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A 172
LEU A 169
LYS A 168
ASN A 247
 None
 1.11A 4g19A-2vawA:
undetectable		 4g19A-2vawA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 ALA A  50
ILE A  45
LEU A  24
ASN A  52
 None
 1.15A 4g19A-2vwsA:
undetectable		 4g19A-2vwsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfw ARC

(Rhodococcus
erythropolis) 		PF16450
(Prot_ATP_ID_OB) 		4 ALA A 128
ILE A 131
LEU A 106
ASN A 126
 None
 1.20A 4g19A-2wfwA:
undetectable		 4g19A-2wfwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 ALA A 260
ILE A 263
LEU A 267
ASN A 155
 None
 1.02A 4g19A-2x24A:
undetectable		 4g19A-2x24A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		4 ILE A 186
LEU A 151
LYS A 154
ASN A 156
 None
 0.97A 4g19A-2x7xA:
undetectable		 4g19A-2x7xA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd7 CORE HISTONE
MACRO-H2A.2

(Homo sapiens) 		PF01661
(Macro) 		4 ALA A 336
ILE A 294
LEU A 298
LYS A 295
 None
 1.13A 4g19A-2xd7A:
undetectable		 4g19A-2xd7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn3 PUTATIVE INNER
MEMBRANE PROTEIN

(Salmonella
enterica) 		PF12245
(Big_3_2) 		4 ALA A5242
ILE A5158
LEU A5156
ASN A5244
 None
 1.19A 4g19A-2yn3A:
undetectable		 4g19A-2yn3A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		4 ALA A 172
ILE A 178
LEU A 227
LYS A 226
 None
 1.15A 4g19A-3alfA:
undetectable		 4g19A-3alfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 ALA A 148
ILE A 128
LEU A 151
ASN A 146
 None
 1.18A 4g19A-3cv3A:
undetectable		 4g19A-3cv3A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ALA A 402
ILE A 407
LEU A 409
ASN A 434
 None
 1.21A 4g19A-3e0lA:
undetectable		 4g19A-3e0lA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 328
LEU A 330
LYS A 329
ASN A 368
 None
None
PRO  A   1 (-2.8A)
None
 1.08A 4g19A-3e2sA:
undetectable		 4g19A-3e2sA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 ALA A1828
ILE A1938
LEU A1942
ASN A1830
 None
 1.22A 4g19A-3ff6A:
undetectable		 4g19A-3ff6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 ALA A1935
ILE A1938
LEU A1942
ASN A1830
 None
 0.98A 4g19A-3ff6A:
undetectable		 4g19A-3ff6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 222
ILE A 184
LEU A 160
LYS A 159
 None
 1.07A 4g19A-3gd5A:
undetectable		 4g19A-3gd5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ALA A 272
ILE A 282
LEU A 305
ASN A 279
 None
 1.07A 4g19A-3i12A:
undetectable		 4g19A-3i12A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 ALA A  21
ILE A   3
LEU A 157
LYS A   1
 None
None
None
SO4  A 437 (-4.3A)
 1.23A 4g19A-3ie1A:
undetectable		 4g19A-3ie1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 282
LEU A 283
LYS A 284
ASN A 278
 None
 0.86A 4g19A-3igoA:
undetectable		 4g19A-3igoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		4 ILE A 394
LEU A 466
LYS A 467
ASN A 418
 None
 1.21A 4g19A-3kk7A:
undetectable		 4g19A-3kk7A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ALA A  16
LEU A  11
LYS A  13
ASN A 166
 None
 1.18A 4g19A-3l8qA:
undetectable		 4g19A-3l8qA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ALA A  29
ILE A  37
LEU A  11
ASN A  39
 None
 1.03A 4g19A-3mmpA:
undetectable		 4g19A-3mmpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtr NEURAL CELL ADHESION
MOLECULE 1

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 ALA A 405
LEU A 408
LYS A 407
ASN A 483
 None
 1.14A 4g19A-3mtrA:
undetectable		 4g19A-3mtrA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 ALA A 122
ILE A 128
LEU A 132
LYS A 129
 None
 0.91A 4g19A-3npkA:
undetectable		 4g19A-3npkA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae) 		PF16782
(SIL1) 		4 ILE C 244
LEU C 248
LYS C 245
ASN C 276
 None
 1.11A 4g19A-3qmlC:
2.8		 4g19A-3qmlC:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 ALA A  75
ILE A  65
LEU A 110
ASN A  64
 None
 1.13A 4g19A-3se5A:
undetectable		 4g19A-3se5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ALA A 505
ILE A 593
LEU A 493
ASN A 590
 None
 1.10A 4g19A-3u1kA:
undetectable		 4g19A-3u1kA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 ALA A 597
ILE A 535
LEU A 539
ASN A 632
 None
 0.89A 4g19A-3uelA:
undetectable		 4g19A-3uelA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		4 ALA A 393
ILE A 432
LEU A 396
ASN A 424
 None
 0.89A 4g19A-3zm8A:
undetectable		 4g19A-3zm8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ALA A 465
ILE A 410
LEU A 474
ASN A 462
 None
 1.19A 4g19A-3zo9A:
undetectable		 4g19A-3zo9A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 ALA A 181
ILE A 212
LEU A 208
LYS A 211
 None
 1.11A 4g19A-4a6uA:
undetectable		 4g19A-4a6uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 ALA A1861
ILE A1864
LEU A1868
ASN A1756
 None
 1.00A 4g19A-4asiA:
undetectable		 4g19A-4asiA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		4 ALA A 401
ILE A 346
LEU A 343
LYS A 342
 None
 1.23A 4g19A-4binA:
undetectable		 4g19A-4binA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 ALA A 481
ILE A 401
LEU A 405
LYS A 402
 None
 1.04A 4g19A-4conA:
undetectable		 4g19A-4conA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 361
ILE A  91
LEU A  68
ASN A  88
 None
 1.13A 4g19A-4czpA:
undetectable		 4g19A-4czpA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		4 ILE A 149
LEU A 134
LYS A 135
ASN A 145
 None
 1.12A 4g19A-4drsA:
undetectable		 4g19A-4drsA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		4 ALA A 196
ILE A 226
LEU A 200
ASN A 230
 None
None
EDO  A 310 (-4.2A)
None
 1.15A 4g19A-4f40A:
undetectable		 4g19A-4f40A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ALA A 214
ILE A 218
LEU A 425
ASN A 212
 None
 0.95A 4g19A-4f7kA:
undetectable		 4g19A-4f7kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fah GENTISATE
1,2-DIOXYGENASE

(Pseudaminobacter
salicylatoxidans) 		PF07883
(Cupin_2) 		4 ALA A 227
ILE A 230
LEU A 153
ASN A 268
 None
 1.10A 4g19A-4fahA:
undetectable		 4g19A-4fahA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 ALA A 594
ILE A 532
LEU A 536
ASN A 629
 None
 0.92A 4g19A-4fc2A:
undetectable		 4g19A-4fc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 ALA A 224
ILE A 244
LEU A 222
LYS A 221
 SO4  A 512 (-3.2A)
None
None
SO4  A 512 (-3.2A)
 1.22A 4g19A-4fd0A:
undetectable		 4g19A-4fd0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 ALA A  30
ILE A  38
LEU A  12
ASN A  40
 None
 1.20A 4g19A-4fwtA:
undetectable		 4g19A-4fwtA:
11.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 ALA A   2
ILE A   5
LEU A  37
LYS A  38
ASN A  80
 ACT  A 304 (-3.1A)
None
ACT  A 304 (-4.2A)
None
ACT  A 304 ( 4.6A)
 0.05A 4g19A-4g19A:
45.4		 4g19A-4g19A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 ALA A 445
ILE A 362
LEU A 251
ASN A 446
 None
AMP  A 602 (-4.3A)
None
None
 1.18A 4g19A-4gvlA:
undetectable		 4g19A-4gvlA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 ALA A 445
ILE A 362
LEU A 251
ASN A 446
 None
PO4  A 608 (-3.8A)
None
None
 1.15A 4g19A-4gx0A:
undetectable		 4g19A-4gx0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 ALA A 196
ILE A 131
LEU A 261
ASN A 197
 None
None
None
MG  A 405 ( 4.8A)
 1.23A 4g19A-4i0nA:
undetectable		 4g19A-4i0nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF13417
(GST_N_3) 		4 ALA A 202
ILE A 189
LEU A 192
ASN A 170
 None
 0.95A 4g19A-4ielA:
13.2		 4g19A-4ielA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 ALA A  86
ILE A 136
LEU A 177
ASN A 106
 None
 0.85A 4g19A-4iqfA:
undetectable		 4g19A-4iqfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjm EXTRACELLULAR
MATRIX-BINDING
PROTEIN EBH

(Staphylococcus
aureus) 		PF07554
(FIVAR) 		4 ALA A  92
LEU A 103
LYS A 100
ASN A 127
 None
 1.13A 4g19A-4kjmA:
undetectable		 4g19A-4kjmA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lmw GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ILE A   6
LEU A  37
LYS A  38
ASN A  80
 FMT  A 308 ( 4.7A)
FMT  A 308 ( 4.4A)
FMT  A 308 ( 4.1A)
FMT  A 308 ( 4.8A)
 0.51A 4g19A-4lmwA:
38.6		 4g19A-4lmwA:
59.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ALA A 473
ILE A 418
LEU A 482
ASN A 470
 None
 1.18A 4g19A-4lxfA:
undetectable		 4g19A-4lxfA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A  62
ILE A  58
LEU A 125
ASN A 128
 None
 1.16A 4g19A-4mmoA:
undetectable		 4g19A-4mmoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mso SERINE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
cenocepacia) 		PF00464
(SHMT) 		4 ALA A 385
ILE A 326
LEU A 321
LYS A 324
 None
 1.20A 4g19A-4msoA:
undetectable		 4g19A-4msoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ALA A 333
ILE A 335
LEU A 411
ASN A 342
 None
 1.07A 4g19A-4mt6A:
undetectable		 4g19A-4mt6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 328
LEU A 330
LYS A 329
ASN A 368
 None
None
2OP  A2002 (-2.7A)
None
 1.10A 4g19A-4o8aA:
undetectable		 4g19A-4o8aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 ALA A 375
ILE A 367
LEU A 371
LYS A 368
 None
 1.10A 4g19A-4pzvA:
undetectable		 4g19A-4pzvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 ALA A  56
ILE A   8
LEU A  12
LYS A   9
 None
 1.12A 4g19A-4r3uA:
undetectable		 4g19A-4r3uA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ILE A 187
LEU A 152
LYS A 155
ASN A 157
 None
None
CL  A 425 (-3.5A)
CL  A 425 (-3.7A)
 0.95A 4g19A-4rs3A:
undetectable		 4g19A-4rs3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		4 ALA A 121
ILE A 145
LEU A 107
ASN A 141
 None
 1.18A 4g19A-4u36A:
undetectable		 4g19A-4u36A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux5 TRANSCRIPTION FACTOR
MBP1

(Magnaporthe
oryzae) 		PF04383
(KilA-N) 		4 ILE A  54
LEU A  55
LYS A  56
ASN A  50
 None
 1.06A 4g19A-4ux5A:
undetectable		 4g19A-4ux5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ALA A 415
ILE A 243
LEU A 284
LYS A 285
 None
 1.20A 4g19A-4wgkA:
undetectable		 4g19A-4wgkA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 ALA A1018
ILE A1022
LEU A1046
ASN A 993
 None
 0.83A 4g19A-5a42A:
undetectable		 4g19A-5a42A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8h 50S RIBOSOMAL
PROTEIN L11

(Methanocaldococcus
jannaschii) 		PF00298
(Ribosomal_L11)
PF03946
(Ribosomal_L11_N) 		4 ALA C  85
ILE C  76
LEU C  80
LYS C  77
 G  A1173 ( 3.3A)
None
None
C  A1174 ( 4.1A)
 1.21A 4g19A-5d8hC:
undetectable		 4g19A-5d8hC:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 ILE A 157
LEU A 247
LYS A 244
ASN A 156
 None
 1.09A 4g19A-5dkuA:
undetectable		 4g19A-5dkuA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		4 ALA A  58
ILE A 313
LEU A 207
ASN A 321
 None
 1.13A 4g19A-5ernA:
undetectable		 4g19A-5ernA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 ALA A 272
ILE A 240
LEU A 236
ASN A 270
 None
 1.01A 4g19A-5gheA:
undetectable		 4g19A-5gheA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		4 ALA A 496
ILE A 458
LEU A 547
ASN A 482
 ACT  A 705 ( 3.8A)
ACT  A 705 (-3.9A)
None
ACT  A 705 (-3.1A)
 1.20A 4g19A-5iheA:
undetectable		 4g19A-5iheA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ILE A 264
LEU A 266
LYS A 265
ASN A 304
 None
None
TFB  A2003 (-2.8A)
None
 1.12A 4g19A-5kf7A:
undetectable		 4g19A-5kf7A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxb WISTERIA FLORIBUNDA
AGGLUTININ

(Wisteria
floribunda) 		PF00139
(Lectin_legB) 		4 ALA A 153
ILE A 177
LEU A 137
ASN A 173
 None
 1.18A 4g19A-5kxbA:
undetectable		 4g19A-5kxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 159
ILE B 175
LEU B 138
ASN B 174
 None
 1.21A 4g19A-5n28B:
undetectable		 4g19A-5n28B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 ILE A 774
LEU A 772
LYS A 773
ASN A 740
 None
 0.91A 4g19A-5oqrA:
2.6		 4g19A-5oqrA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 ALA A 433
ILE A 378
LEU A 442
ASN A 430
 None
 1.20A 4g19A-5x7uA:
undetectable		 4g19A-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 ALA A 459
ILE A 374
LEU A 378
LYS A 375
 None
 1.12A 4g19A-5xapA:
1.6		 4g19A-5xapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2

(Saccharomyces
cerevisiae) 		no annotation 4 ALA B 631
ILE B 503
LEU B 526
LYS B 501
 None
 1.22A 4g19A-6bzgB:
undetectable		 4g19A-6bzgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 4 ALA A 133
LEU A 225
LYS A 224
ASN A 131
 None
 0.96A 4g19A-6cjqA:
undetectable		 4g19A-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 4 ALA A 185
ILE A 250
LEU A 246
ASN A 182
 None
 1.18A 4g19A-6dfpA:
undetectable		 4g19A-6dfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 4 ALA A 293
ILE A 221
LEU A 265
ASN A 222
 None
 1.18A 4g19A-6fnuA:
undetectable		 4g19A-6fnuA:
undetectable