SIMILAR PATTERNS OF AMINO ACIDS FOR 4G19_A_ACTA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 TYR A 167
TRP A  21
PHE A  58
ARG A 151
 None
 1.45A 4g19A-3c2oA:
0.0		 4g19A-3c2oA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 ASN A  24
TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.00A 4g19A-4g19A:
45.4		 4g19A-4g19A:
100.00