SIMILAR PATTERNS OF AMINO ACIDS FOR 4G10_A_ACTA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP1)
PROTEIN (CRICKET
PARALYSIS VIRUS,
VP2)

(Cricket
paralysis
virus;
Cricket
paralysis virus) 		PF08762
(CRPV_capsid)
no annotation 		4 ILE A 190
TYR B 189
TYR B 149
PHE A 100
 None
 1.11A 4g10A-1b35A:
undetectable		 4g10A-1b35A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b97 RESTRICTION
ENDONUCLEASE ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		4 ILE A 205
TYR A 219
TYR A 215
PHE A 206
 None
 1.11A 4g10A-1b97A:
undetectable		 4g10A-1b97A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 PRO B 295
ILE B 268
TYR B1232
PHE B1210
 None
 1.00A 4g10A-1ej6B:
0.0		 4g10A-1ej6B:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		4 ILE A 138
TYR A 295
TYR A 269
PHE A 136
 None
PLP  A 342 ( 4.1A)
None
None
 1.18A 4g10A-1f2dA:
0.0		 4g10A-1f2dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ILE A 533
TYR A 432
TYR A 503
TYR A 500
 None
 1.24A 4g10A-1j0nA:
4.7		 4g10A-1j0nA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		4 TYR A 393
TYR A  20
TYR A 110
PHE A 323
 None
 0.85A 4g10A-1lrzA:
3.3		 4g10A-1lrzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 ILE A  74
TYR A 346
TYR A  85
PHE A  61
 None
 1.15A 4g10A-1oltA:
0.0		 4g10A-1oltA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PRO A 450
ILE A 454
TYR A 483
PHE A 482
 None
 1.24A 4g10A-1pd1A:
undetectable		 4g10A-1pd1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		4 PRO B 176
ILE B 112
TYR B 123
PHE B 130
 None
 1.03A 4g10A-1qdlB:
undetectable		 4g10A-1qdlB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlv TRANSCRIPTION
ANTITERMINATOR LICT

(Bacillus
subtilis) 		PF00874
(PRD) 		4 ILE A 175
TYR A 249
TYR A 254
PHE A 216
 None
 0.94A 4g10A-1tlvA:
undetectable		 4g10A-1tlvA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		4 PRO A 508
ILE A 425
TYR A 505
PHE A 427
 None
 1.23A 4g10A-1txkA:
undetectable		 4g10A-1txkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 ILE A 796
TYR A 948
TYR A 889
PHE A 949
 None
 1.19A 4g10A-1uf2A:
undetectable		 4g10A-1uf2A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whv POLY(A)-SPECIFIC
RIBONUCLEASE

(Mus musculus) 		PF08675
(RNA_bind) 		4 ILE A 469
TYR A 502
TYR A 505
PHE A 475
 None
 0.84A 4g10A-1whvA:
undetectable		 4g10A-1whvA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A 208
TYR A 158
TYR A 160
PHE A 173
 None
 1.21A 4g10A-1yaaA:
undetectable		 4g10A-1yaaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 330
ILE A 337
TYR A 292
TYR A 286
 None
 0.94A 4g10A-2ac5A:
undetectable		 4g10A-2ac5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PRO A 300
TYR A 239
TYR A 304
PHE A 276
 None
None
GOL  A 761 ( 4.9A)
None
 1.22A 4g10A-2e8yA:
undetectable		 4g10A-2e8yA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 ILE D 201
TYR D 195
TYR D 178
PHE D 168
 None
 1.09A 4g10A-2g9hD:
undetectable		 4g10A-2g9hD:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge5 TYPE II RESTRICTION
ENZYME ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		4 ILE A 205
TYR A 219
TYR A 215
PHE A 206
 None
 1.22A 4g10A-2ge5A:
undetectable		 4g10A-2ge5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 295
ILE A 302
TYR A 257
TYR A 251
 None
 0.92A 4g10A-2hw6A:
undetectable		 4g10A-2hw6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbz 15 PROTEIN
(BACTERIOPHAGE SPP1
COMPLETE NUCLEOTIDE
SEQUENCE)

(Bacillus phage
SPP1) 		PF05135
(Phage_connect_1) 		4 ILE A 121
TYR A  55
TYR A 115
PHE A 117
 None
 1.13A 4g10A-2kbzA:
undetectable		 4g10A-2kbzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxw RNA-BINDING PROTEIN
10

(Homo sapiens) 		no annotation 4 PRO A  13
TYR A  18
TYR A  43
TYR A  36
 None
 1.18A 4g10A-2mxwA:
undetectable		 4g10A-2mxwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ILE A  74
TYR A  82
TYR A 229
PHE A 244
 None
 1.21A 4g10A-2o1bA:
undetectable		 4g10A-2o1bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocz 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
pyogenes) 		PF01487
(DHquinase_I) 		4 PRO A   6
ILE A  48
TYR A  23
PHE A  52
 None
 0.89A 4g10A-2oczA:
undetectable		 4g10A-2oczA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		4 ILE A 271
TYR A 254
TYR A 304
PHE A 102
 None
 1.22A 4g10A-2oryA:
undetectable		 4g10A-2oryA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		4 ILE A  38
TYR A  92
TYR A 190
PHE A  40
 None
 1.18A 4g10A-2oyoA:
undetectable		 4g10A-2oyoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		4 PRO A  42
ILE A  12
TYR A 190
TYR A  92
 None
 1.22A 4g10A-2oyoA:
undetectable		 4g10A-2oyoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 PRO A 457
ILE A 402
TYR A 173
PHE A 398
 None
 1.11A 4g10A-2quqA:
2.7		 4g10A-2quqA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B

(Mus musculus) 		PF03643
(Vps26) 		4 ILE A 207
TYR A 183
TYR A 178
PHE A 176
 None
 1.22A 4g10A-2r51A:
undetectable		 4g10A-2r51A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ILE A 370
TYR A 358
TYR A 314
PHE A 356
 None
 0.72A 4g10A-2r6fA:
undetectable		 4g10A-2r6fA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 ILE A  66
TYR A 408
TYR A  82
PHE A  74
 None
 1.12A 4g10A-2ykyA:
undetectable		 4g10A-2ykyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 PRO A 102
ILE A  38
TYR A  46
TYR A   8
 None
 1.19A 4g10A-2yylA:
undetectable		 4g10A-2yylA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis;
Rhodococcus
erythropolis) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		4 PRO A 123
TYR B  37
TYR B  72
TYR B  76
 None
 1.18A 4g10A-2zpbA:
undetectable		 4g10A-2zpbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A  25
TYR A  60
TYR A  44
TYR A  58
 None
 1.01A 4g10A-3actA:
undetectable		 4g10A-3actA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PRO A 367
ILE A 440
TYR A 415
PHE A 428
 None
 1.18A 4g10A-3cttA:
undetectable		 4g10A-3cttA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eja PROTEIN GH61E

(Thielavia
terrestris) 		PF03443
(Glyco_hydro_61) 		4 PRO A 201
ILE A  36
TYR A  75
PHE A 175
 None
 1.14A 4g10A-3ejaA:
undetectable		 4g10A-3ejaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 PRO A  50
TYR A 259
TYR A 272
PHE A 335
 FAD  A 902 (-3.7A)
FAD  A 902 (-4.8A)
None
FAD  A 902 (-3.8A)
 1.00A 4g10A-3gsiA:
undetectable		 4g10A-3gsiA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it8 2L PROTEIN

(Tanapox virus) 		no annotation 4 ILE D  53
TYR D   5
TYR D 170
PHE D  51
 None
 1.16A 4g10A-3it8D:
undetectable		 4g10A-3it8D:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 PRO P 252
ILE P 216
TYR P 245
PHE P 197
 None
 1.13A 4g10A-3j31P:
undetectable		 4g10A-3j31P:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		4 PRO A1770
ILE A1764
TYR A1880
TYR A1804
 None
 1.18A 4g10A-3jbzA:
undetectable		 4g10A-3jbzA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 PRO A 393
ILE A 207
TYR A 387
PHE A 248
 None
 1.13A 4g10A-3k7lA:
undetectable		 4g10A-3k7lA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		4 ILE A 382
TYR A 306
TYR A 350
PHE A 383
 None
 1.12A 4g10A-3lcaA:
undetectable		 4g10A-3lcaA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		4 PRO A  89
ILE A 225
TYR A 243
PHE A  92
 None
 1.14A 4g10A-3m4uA:
undetectable		 4g10A-3m4uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA
COATOMER SUBUNIT
EPSILON

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF06957
(COPI_C)
PF04733
(Coatomer_E) 		4 PRO A 958
ILE B 163
TYR B  10
TYR B  36
 None
 1.03A 4g10A-3mv3A:
undetectable		 4g10A-3mv3A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		4 PRO A 100
ILE A 106
TYR C 109
PHE C 113
 None
 1.06A 4g10A-3napA:
undetectable		 4g10A-3napA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		4 PRO A 149
ILE A 181
TYR A 206
TYR A 258
 None
 0.91A 4g10A-3o0yA:
undetectable		 4g10A-3o0yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		4 PRO A 117
ILE A  59
TYR A  25
PHE A 109
 None
 1.16A 4g10A-3on4A:
undetectable		 4g10A-3on4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A  25
TYR A  60
TYR A  44
TYR A  58
 None
 1.09A 4g10A-3qdeA:
1.6		 4g10A-3qdeA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 ILE A1135
TYR A1181
TYR A1180
PHE A1177
 None
 1.13A 4g10A-3s51A:
4.3		 4g10A-3s51A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		4 PRO A 319
ILE A 272
TYR A 173
PHE A 307
 None
 0.72A 4g10A-3tlzA:
undetectable		 4g10A-3tlzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PRO A 147
ILE A 282
TYR A 417
PHE A 423
 None
 1.22A 4g10A-3tqpA:
undetectable		 4g10A-3tqpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 TYR A 101
TYR A  31
TYR A 105
PHE A 110
 None
 1.18A 4g10A-3uxjA:
undetectable		 4g10A-3uxjA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PRO A 242
ILE A 454
TYR A 659
PHE A 450
 None
 1.03A 4g10A-3v98A:
undetectable		 4g10A-3v98A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PRO A 307
TYR A 246
TYR A 311
PHE A 283
 None
 1.21A 4g10A-3wdjA:
undetectable		 4g10A-3wdjA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 ILE A 182
TYR A 254
TYR A 250
PHE A 220
 None
 0.79A 4g10A-3zgqA:
undetectable		 4g10A-3zgqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ILE A 140
TYR A 216
TYR A 215
PHE A 141
 None
 1.21A 4g10A-4a01A:
undetectable		 4g10A-4a01A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 PRO A 134
ILE A 140
TYR A 215
PHE A 141
 None
 1.04A 4g10A-4a01A:
undetectable		 4g10A-4a01A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 ILE A  44
TYR A  90
TYR A  95
PHE A  48
 None
 1.16A 4g10A-4bg5A:
undetectable		 4g10A-4bg5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 PRO A 569
ILE A 458
TYR A 466
PHE A 566
 None
 1.19A 4g10A-4bugA:
undetectable		 4g10A-4bugA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4w DNA MISMATCH REPAIR
PROTEIN MLH1

(Saccharomyces
cerevisiae) 		PF16413
(Mlh1_C) 		4 ILE A 514
TYR A 630
TYR A 631
PHE A 578
 None
 1.20A 4g10A-4e4wA:
undetectable		 4g10A-4e4wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eis POLYSACCHARIDE
MONOOXYGENASE-3

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 PRO B 218
ILE B  50
TYR B  89
PHE B 194
 None
 1.19A 4g10A-4eisB:
undetectable		 4g10A-4eisB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		4 PRO A 393
ILE A 386
TYR A 170
PHE A 165
 None
 1.21A 4g10A-4f6oA:
undetectable		 4g10A-4f6oA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG

(Sphingomonas
paucimobilis) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		6 PRO A  16
ILE A  39
TYR A 113
TYR A 214
TYR A 217
PHE A 235
 GSH  A 300 ( 4.4A)
None
ACT  A 301 (-4.5A)
ACT  A 301 (-4.5A)
None
ACT  A 301 ( 4.5A)
 0.01A 4g10A-4g10A:
45.6		 4g10A-4g10A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 PRO A 478
ILE A 335
TYR A  89
PHE A 336
 None
 1.06A 4g10A-4mivA:
undetectable		 4g10A-4mivA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		4 PRO A 118
ILE A 163
TYR A 151
PHE A 160
 None
 0.98A 4g10A-4ng3A:
undetectable		 4g10A-4ng3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		4 ILE A 177
TYR A 138
TYR A 143
TYR A 139
 None
 0.96A 4g10A-4on1A:
undetectable		 4g10A-4on1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p78 HICB3 ANTITOXIN

(Yersinia pestis) 		PF15919
(HicB_lk_antitox) 		4 PRO A  59
ILE A  46
TYR A   3
PHE A  42
 None
 1.12A 4g10A-4p78A:
undetectable		 4g10A-4p78A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 PRO H 459
ILE H 418
TYR H 294
PHE H 417
 None
 1.18A 4g10A-4qfkH:
undetectable		 4g10A-4qfkH:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 PRO A 335
ILE A 261
TYR A 279
PHE A 302
 None
 1.16A 4g10A-4qgkA:
undetectable		 4g10A-4qgkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 PRO A 207
ILE A  40
TYR A  79
PHE A 181
 None
 1.17A 4g10A-4qi8A:
undetectable		 4g10A-4qi8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		4 PRO A 251
ILE A 227
TYR A 266
TYR A 213
 None
 1.14A 4g10A-4r7oA:
undetectable		 4g10A-4r7oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 PRO A 442
ILE A 100
TYR A 413
PHE A 104
 None
 0.99A 4g10A-4ufcA:
1.6		 4g10A-4ufcA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE

(Populus
trichocarpa) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PRO A  50
ILE A 244
TYR A 293
TYR A 250
 None
 1.22A 4g10A-4ussA:
15.9		 4g10A-4ussA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 4 PRO A 528
TYR A 525
TYR A 522
PHE A 461
 None
 1.02A 4g10A-4xn3A:
undetectable		 4g10A-4xn3A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 PRO A 217
ILE A 257
TYR A 231
PHE A 255
 None
 1.15A 4g10A-4zxlA:
2.2		 4g10A-4zxlA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PRO A 579
ILE A 492
TYR A 565
PHE A 571
 None
 1.04A 4g10A-5aw4A:
undetectable		 4g10A-5aw4A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		4 PRO A 193
ILE A 200
TYR A 182
PHE A 168
 None
 1.24A 4g10A-5c77A:
undetectable		 4g10A-5c77A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		4 PRO A 146
ILE A 160
TYR A 141
PHE A 155
 None
 1.14A 4g10A-5cg0A:
undetectable		 4g10A-5cg0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 PRO A 283
TYR A 260
TYR A 285
TYR A 338
 None
 1.20A 4g10A-5cozA:
undetectable		 4g10A-5cozA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		4 PRO A  42
ILE A  82
TYR A  56
PHE A  80
 None
 1.07A 4g10A-5diyA:
2.3		 4g10A-5diyA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		4 PRO A 174
ILE A 243
TYR A  75
PHE A 245
 CIT  A 302 ( 4.5A)
None
NAP  A 301 (-4.3A)
None
 1.13A 4g10A-5ejhA:
undetectable		 4g10A-5ejhA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 PRO A 208
ILE A 125
TYR A 386
PHE A 117
 None
 1.24A 4g10A-5gr1A:
undetectable		 4g10A-5gr1A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 PRO A 100
TYR A 147
TYR A 261
TYR A 142
 None
 1.11A 4g10A-5gslA:
undetectable		 4g10A-5gslA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 PRO A  98
TYR A 145
TYR A 259
TYR A 140
 None
 1.03A 4g10A-5gsmA:
undetectable		 4g10A-5gsmA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		4 PRO A  75
TYR A 121
TYR A  46
TYR A  50
 None
 1.07A 4g10A-5h0kA:
undetectable		 4g10A-5h0kA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		4 TYR A 121
TYR A  46
TYR A  50
PHE A  45
 None
 1.14A 4g10A-5h0kA:
undetectable		 4g10A-5h0kA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 PRO A 180
ILE A 152
TYR A 232
PHE A 200
 None
 1.24A 4g10A-5jifA:
undetectable		 4g10A-5jifA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxt CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		no annotation 4 ILE B 502
TYR B 525
TYR B 531
PHE B 560
 None
 1.23A 4g10A-5jxtB:
undetectable		 4g10A-5jxtB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PRO A  47
ILE A 295
TYR A 346
TYR A 301
 GSH  A 401 ( 4.6A)
None
None
None
 1.22A 4g10A-5lkdA:
16.2		 4g10A-5lkdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 ILE A 742
TYR A 731
TYR A 732
PHE A 737
 None
 1.13A 4g10A-5ltaA:
undetectable		 4g10A-5ltaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfy RNA-BINDING PROTEIN
5

(Homo sapiens) 		no annotation 4 PRO A  10
TYR A  15
TYR A  40
TYR A  33
 None
 1.23A 4g10A-5mfyA:
undetectable		 4g10A-5mfyA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 PRO A 125
ILE A 147
TYR A 218
TYR A 170
 None
 1.00A 4g10A-5mqsA:
undetectable		 4g10A-5mqsA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 ILE A 103
TYR A 473
TYR A  58
TYR A 472
 None
 0.93A 4g10A-5oglA:
undetectable		 4g10A-5oglA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 31

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF05669
(Med31) 		4 PRO U  17
TYR X  57
TYR X  60
PHE U  23
 None
 1.21A 4g10A-5svaU:
undetectable		 4g10A-5svaU:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		4 ILE A 247
TYR A 445
TYR A 440
PHE A 396
 None
 1.23A 4g10A-5t6oA:
undetectable		 4g10A-5t6oA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 PRO A 216
ILE A  37
TYR A  91
PHE A 190
 None
 1.24A 4g10A-5tkfA:
undetectable		 4g10A-5tkfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 PRO A 630
ILE A 626
TYR A 473
TYR A 387
 None
None
None
EDO  A 819 ( 3.5A)
 1.23A 4g10A-5v1wA:
undetectable		 4g10A-5v1wA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 4 PRO A  74
TYR A 372
TYR A 250
PHE A 373
 None
None
PLP  A 701 (-4.1A)
EPE  A 702 (-4.5A)
 1.15A 4g10A-5verA:
undetectable		 4g10A-5verA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjm TYPE-2 ANGIOTENSIN
II RECEPTOR,SOLUBLE
CYTOCHROME
B562,TYPE-2
ANGIOTENSIN II
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 PRO A 301
TYR A 108
TYR A 104
TYR A 103
 None
 1.21A 4g10A-5xjmA:
undetectable		 4g10A-5xjmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 PRO A  88
ILE A 428
TYR A 273
TYR A 283
 FMT  A 601 ( 4.9A)
FMT  A 601 ( 4.7A)
None
None
 1.07A 4g10A-6begA:
undetectable		 4g10A-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 PRO A  81
ILE A 234
TYR A 142
PHE A 236
 None
 1.10A 4g10A-6f91A:
2.0		 4g10A-6f91A:
undetectable