SIMILAR PATTERNS OF AMINO ACIDS FOR 4G0V_D_MIXD101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		4 ARG B 479
GLY B  21
ASN B  47
GLU B 482
 None
 1.29A 4g0vB-1cp9B:
undetectable		 4g0vB-1cp9B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 GLY A 237
ASN A 241
GLN A 362
MET A 506
 None
 1.31A 4g0vB-1d4eA:
1.2		 4g0vB-1d4eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 341
GLY A 118
GLU A 182
MET A 397
 None
 1.04A 4g0vB-1e8cA:
undetectable		 4g0vB-1e8cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		4 ARG A 308
GLY A 305
ASN A 293
GLN A 515
 None
 1.15A 4g0vB-1fchA:
undetectable		 4g0vB-1fchA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		4 ARG A 163
GLY A 160
GLU A 162
GLN A 138
 None
 1.26A 4g0vB-1j5wA:
4.0		 4g0vB-1j5wA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		4 ARG A 104
ASN A  14
GLU A 102
MET A 114
 None
 0.89A 4g0vB-1j85A:
undetectable		 4g0vB-1j85A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		4 ARG B 479
GLY B  21
ASN B  47
GLU B 482
 None
 1.24A 4g0vB-1k5sB:
undetectable		 4g0vB-1k5sB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 246
ASN A 197
GLU A 221
MET A 109
 None
APG  A 361 (-3.1A)
MG  A 360 (-3.0A)
None
 1.29A 4g0vB-1mnsA:
undetectable		 4g0vB-1mnsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR

(Salmonella
enterica) 		PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		4 ARG A 283
GLY A 243
ASN A 197
GLU A 241
 None
 1.32A 4g0vB-1ojlA:
0.0		 4g0vB-1ojlA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ARG A 475
GLY A 167
GLU A 478
GLN A 142
 None
 1.24A 4g0vB-1qvrA:
2.8		 4g0vB-1qvrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ARG A  88
GLY A 174
GLN A 143
MET A 236
 FUM  A1311 (-4.0A)
None
NAD  A1310 (-3.7A)
None
 1.14A 4g0vB-1uxiA:
undetectable		 4g0vB-1uxiA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 GLY A 104
GLU A 129
GLN A 216
MET A  73
 CA  A1237 ( 4.3A)
None
None
None
 1.00A 4g0vB-1v6mA:
undetectable		 4g0vB-1v6mA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ARG A 183
GLY A 184
ASN A 105
GLU A 182
 None
FAD  A1561 (-3.3A)
FAD  A1561 (-4.0A)
FAD  A1561 (-4.1A)
 1.08A 4g0vB-1w1kA:
2.3		 4g0vB-1w1kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		4 ARG A 411
GLY A 413
ASN A 399
GLU A 407
 None
 1.25A 4g0vB-2bdeA:
5.3		 4g0vB-2bdeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		4 ARG A  45
GLY A  44
ASN A 148
MET A  99
 None
 1.22A 4g0vB-2be3A:
undetectable		 4g0vB-2be3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ARG A 316
GLY A 312
ASN A 244
GLU A 297
 ADP  A6001 (-2.8A)
None
P3S  A5001 ( 4.7A)
P3S  A5001 (-3.4A)
 1.17A 4g0vB-2d3aA:
1.9		 4g0vB-2d3aA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		4 ARG A 134
GLY A 135
ASN A  35
GLN A 230
 None
 1.26A 4g0vB-2e2nA:
undetectable		 4g0vB-2e2nA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 GLY A 238
ASN A 168
GLU A 139
GLN A  70
 OXL  A2001 ( 3.6A)
None
MG  A1001 ( 3.0A)
None
 1.03A 4g0vB-2eb5A:
undetectable		 4g0vB-2eb5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		4 GLY A 156
ASN A 198
GLU A 193
MET A  69
 None
PMP  A3413 ( 3.7A)
PMP  A3413 (-3.3A)
None
 1.28A 4g0vB-2ej0A:
undetectable		 4g0vB-2ej0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 GLY A 131
ASN A 155
GLU A 133
GLN A 108
 None
 1.27A 4g0vB-2fk7A:
undetectable		 4g0vB-2fk7A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		4 ARG A 285
GLY A 316
ASN A 298
MET A 343
 None
 1.12A 4g0vB-2fy2A:
undetectable		 4g0vB-2fy2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he9 NK-TUMOR RECOGNITION
PROTEIN

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 ARG A 114
GLY A 115
GLN A  74
MET A  72
 None
 1.21A 4g0vB-2he9A:
undetectable		 4g0vB-2he9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium) 		PF00381
(PTS-HPr)
PF13377
(Peripla_BP_3) 		4 ARG G  80
GLY G  81
GLU G  77
GLN L  24
 None
 1.05A 4g0vB-2nzuG:
2.9		 4g0vB-2nzuG:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium) 		PF00381
(PTS-HPr)
PF13377
(Peripla_BP_3) 		4 ARG L  17
GLY G  81
GLU G  77
GLN L  24
 None
 1.30A 4g0vB-2nzuL:
undetectable		 4g0vB-2nzuL:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		4 ARG A 136
GLY A 135
GLU A 108
MET A 247
 None
 1.21A 4g0vB-2o3iA:
undetectable		 4g0vB-2o3iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 GLY A  16
GLU A  15
GLN A 190
MET A 194
 None
 1.15A 4g0vB-2obnA:
undetectable		 4g0vB-2obnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 ARG A 392
GLY A 393
ASN A 363
MET A 474
 None
 1.24A 4g0vB-2qq8A:
undetectable		 4g0vB-2qq8A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 ARG A 551
GLY A 528
GLU A 344
MET A 391
 None
None
EDO  A1872 ( 4.5A)
None
 1.19A 4g0vB-2vmfA:
1.9		 4g0vB-2vmfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 ARG A 115
GLY A 116
GLN A  75
MET A  73
 None
MG  A1002 ( 4.8A)
None
None
 1.24A 4g0vB-2wfiA:
undetectable		 4g0vB-2wfiA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 ARG A 167
ASN A  79
GLU A  74
GLN A 150
 None
 1.21A 4g0vB-2xheA:
undetectable		 4g0vB-2xheA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 GLY A 433
ASN A 367
GLU A 432
MET A 456
 None
 1.15A 4g0vB-3a0fA:
undetectable		 4g0vB-3a0fA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ARG A 367
GLY A 365
ASN A 413
GLN A 712
 K  A2903 (-4.0A)
None
None
PO4  A2902 (-3.8A)
 1.21A 4g0vB-3actA:
undetectable		 4g0vB-3actA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		4 ARG A 202
GLY A 199
ASN A 133
MET A 235
 None
 1.17A 4g0vB-3bblA:
3.0		 4g0vB-3bblA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ARG A  86
GLY A  85
GLU A  77
GLN A 202
 SO4  A 301 ( 3.8A)
None
None
None
 1.12A 4g0vB-3dd6A:
undetectable		 4g0vB-3dd6A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		4 ARG A 136
GLY A  95
ASN A 172
GLU A 118
 None
 1.24A 4g0vB-3dzcA:
3.2		 4g0vB-3dzcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		4 GLY A  95
ASN A 172
GLU A 118
GLN A  39
 None
 1.21A 4g0vB-3dzcA:
3.2		 4g0vB-3dzcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ARG A 670
GLY A 668
ASN A 663
GLN A 623
 None
 1.22A 4g0vB-3ecqA:
undetectable		 4g0vB-3ecqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		4 ARG A 246
GLY A 247
ASN A  37
GLU A 245
 ZDR  A 500 (-3.7A)
None
ZDR  A 500 (-3.4A)
ZDR  A 500 (-3.0A)
 0.82A 4g0vB-3ekmA:
undetectable		 4g0vB-3ekmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		4 ARG A 246
GLY A 247
GLU A 245
GLN A  54
 ZDR  A 500 (-3.7A)
None
ZDR  A 500 (-3.0A)
None
 1.21A 4g0vB-3ekmA:
undetectable		 4g0vB-3ekmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		4 GLY A 247
ASN A 508
GLN A 382
MET A 384
 None
 1.24A 4g0vB-3fgwA:
undetectable		 4g0vB-3fgwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		4 ARG A 418
GLY A 420
GLN A 310
MET A 271
 None
 1.27A 4g0vB-3njxA:
undetectable		 4g0vB-3njxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 328
ASN A 323
GLU A 325
GLN A 334
 None
 1.13A 4g0vB-3nqpA:
undetectable		 4g0vB-3nqpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		4 ARG A  81
GLY A  82
GLU A  78
GLN S  24
 None
 1.19A 4g0vB-3oqnA:
2.7		 4g0vB-3oqnA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3a THIOSULFATE
SULFURTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00581
(Rhodanese) 		4 ARG A 251
GLY A 249
ASN A  66
GLU A 250
 None
 1.09A 4g0vB-3p3aA:
undetectable		 4g0vB-3p3aA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		4 ARG B 379
GLY B 378
ASN B  89
GLN B 142
 None
7MN  B   2 ( 3.7A)
None
None
 1.05A 4g0vB-3pr2B:
undetectable		 4g0vB-3pr2B:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ARG A 360
GLY A 358
ASN A 406
GLN A 699
 144  A 813 ( 4.8A)
None
None
PO4  A 812 ( 3.7A)
 1.03A 4g0vB-3qdeA:
undetectable		 4g0vB-3qdeA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 129
ASN A  48
GLU A  70
MET A 171
 None
 1.24A 4g0vB-3qwbA:
1.5		 4g0vB-3qwbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smv S-(-)-AZETIDINE-2-CA
RBOXYLATE HYDROLASE

(Pseudomonas sp.
AC2) 		PF13419
(HAD_2) 		4 ARG A  88
GLY A  92
GLU A  89
GLN A  55
 None
None
GOL  A 307 (-4.2A)
None
 1.31A 4g0vB-3smvA:
2.6		 4g0vB-3smvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ARG X 351
GLY X 350
ASN X  29
GLU X 354
 None
 1.05A 4g0vB-3ss7X:
undetectable		 4g0vB-3ss7X:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 GLY A 129
GLU A  91
GLN A   9
MET A 358
 None
 1.15A 4g0vB-3tm5A:
undetectable		 4g0vB-3tm5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		4 ARG A 346
GLY A 344
GLU A 349
GLN A 338
 None
 1.31A 4g0vB-3uetA:
undetectable		 4g0vB-3uetA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 ARG B 168
GLY B 164
GLU B 167
GLN B 256
 FAD  B 501 (-4.2A)
FAD  B 501 ( 4.6A)
None
None
 1.08A 4g0vB-3vrdB:
undetectable		 4g0vB-3vrdB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 GLY A 122
ASN A  38
GLU A  39
GLN A 101
 None
 1.32A 4g0vB-3wiqA:
2.1		 4g0vB-3wiqA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind)
no annotation 		4 GLY A  91
GLU A  92
GLN A 125
MET B  30
 None
 1.01A 4g0vB-3zheA:
undetectable		 4g0vB-3zheA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 335
GLY A 113
GLU A 177
MET A 391
 PO4  A 601 (-3.9A)
PO4  A 601 (-3.2A)
MG  A 503 (-2.8A)
None
 1.21A 4g0vB-4c13A:
undetectable		 4g0vB-4c13A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		4 ARG A 519
GLY A 518
GLU B 456
GLN A 528
 None
 1.21A 4g0vB-4cakA:
undetectable		 4g0vB-4cakA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ARG A 668
GLY A 671
GLU A 672
MET A 731
 None
 1.23A 4g0vB-4cekA:
undetectable		 4g0vB-4cekA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2l PROTEIN F1L

(Vaccinia virus) 		PF11099
(M11L) 		4 GLY A 153
ASN A 109
GLU A 151
MET A  64
 None
 1.22A 4g0vB-4d2lA:
undetectable		 4g0vB-4d2lA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		4 GLY A 181
ASN A 225
GLU A 220
MET A  91
 None
 1.24A 4g0vB-4dqnA:
undetectable		 4g0vB-4dqnA:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 GLY A 488
ASN A 504
GLU A 506
MET A 762
 None
 1.01A 4g0vB-4fm9A:
49.5		 4g0vB-4fm9A:
79.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 ARG A  80
GLY A  81
GLU A  84
MET A 135
 None
 1.27A 4g0vB-4fn7A:
undetectable		 4g0vB-4fn7A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		4 GLY A 370
ASN A 175
GLU A 163
GLN A 402
 None
 1.25A 4g0vB-4hyrA:
undetectable		 4g0vB-4hyrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1
ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 GLY B 175
ASN A  42
GLN A 147
MET A 179
 None
 1.28A 4g0vB-4hzuB:
undetectable		 4g0vB-4hzuB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASN A 201
GLU A 222
GLN A 181
MET A 135
 None
 1.04A 4g0vB-4i3gA:
2.8		 4g0vB-4i3gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 409
ASN A 101
GLU A 165
MET A 534
 None
 1.22A 4g0vB-4i3gA:
2.8		 4g0vB-4i3gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 215
GLY A 154
GLU A 217
GLN A 131
 None
 1.01A 4g0vB-4irnA:
2.1		 4g0vB-4irnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwx GLUN2A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 ARG A 176
GLY A 172
ASN A 193
GLU A 175
 None
1N4  A 301 (-3.5A)
None
None
 1.24A 4g0vB-4jwxA:
undetectable		 4g0vB-4jwxA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx6 TRAP-TYPE
C4-DICARBOXYLATE:H+
SYMPORT SYSTEM
SUBSTRATE-BINDING
COMPONENT DCTP

(Shewanella
oneidensis) 		PF03480
(DctP) 		4 ARG A 179
GLY A 216
GLN A 189
MET A 315
 SIN  A 401 (-2.9A)
None
None
None
 1.19A 4g0vB-4mx6A:
undetectable		 4g0vB-4mx6A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN

(Pseudomonas
aeruginosa) 		PF03480
(DctP) 		4 ARG A 171
GLY A 208
GLN A 181
MET A 307
 LMR  A 401 (-2.9A)
None
None
None
 0.86A 4g0vB-4nf0A:
undetectable		 4g0vB-4nf0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 ARG A 172
GLY A 209
GLN A 182
MET A 307
 ORO  A 403 (-2.8A)
None
None
None
 0.98A 4g0vB-4nn3A:
undetectable		 4g0vB-4nn3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npf IMMUNOGLOBULIN
G-BINDING PROTEIN A

(Staphylococcus
aureus) 		no annotation 4 GLY Y  29
ASN Y  23
GLU Y  25
GLN Y  40
 None
 1.26A 4g0vB-4npfY:
undetectable		 4g0vB-4npfY:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Shewanella
loihica) 		PF03480
(DctP) 		4 ARG A 176
GLY A 213
GLN A 186
MET A 312
 LMR  A 401 (-2.9A)
None
None
None
 0.91A 4g0vB-4o7mA:
undetectable		 4g0vB-4o7mA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 ARG A 169
GLY A 206
GLN A 179
MET A 305
 SIN  A 403 (-3.0A)
None
None
None
 0.82A 4g0vB-4o94A:
undetectable		 4g0vB-4o94A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		4 ARG A 167
GLY A 204
GLN A 177
MET A 307
 SIN  A 401 (-3.0A)
None
None
None
 0.86A 4g0vB-4ovsA:
undetectable		 4g0vB-4ovsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		4 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 UDP  A 601 (-3.8A)
UDP  A 601 ( 3.0A)
None
None
 1.20A 4g0vB-4pqgA:
3.2		 4g0vB-4pqgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 GLY B 688
ASN B 146
GLU B 691
GLN B 662
 None
 1.19A 4g0vB-4qj4B:
undetectable		 4g0vB-4qj4B:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		4 GLY A 634
ASN A 718
GLU A 685
GLN A 650
 None
 1.20A 4g0vB-4xgcA:
3.2		 4g0vB-4xgcA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 ARG B 208
GLY B  13
ASN B  97
MET B 274
 UPG  B 403 (-3.6A)
UPG  B 403 ( 4.0A)
None
None
 1.31A 4g0vB-4xsrB:
undetectable		 4g0vB-4xsrB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ARG A 279
GLY A 303
ASN A 282
GLN A 380
 NAG  A 905 ( 3.9A)
None
None
None
 1.14A 4g0vB-4z0cA:
undetectable		 4g0vB-4z0cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ARG A 670
GLY A 668
ASN A 663
GLN A 623
 None
 1.22A 4g0vB-5a55A:
undetectable		 4g0vB-5a55A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 GLY A1365
GLU A1364
GLN A1903
MET A1388
 None
 0.92A 4g0vB-5deuA:
undetectable		 4g0vB-5deuA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLY A 317
ASN A 357
GLU A 950
GLN A 678
 None
 1.18A 4g0vB-5dotA:
0.9		 4g0vB-5dotA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 ARG A 176
GLY A 143
ASN A 268
GLU A 147
 ALL  A 401 (-2.9A)
None
None
None
 1.05A 4g0vB-5dteA:
undetectable		 4g0vB-5dteA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		4 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 None
UDP  A 601 (-3.1A)
None
None
 0.87A 4g0vB-5e9uA:
2.6		 4g0vB-5e9uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ARG A 360
GLY A 161
ASN A 105
GLU A 157
 None
 1.25A 4g0vB-5f9sA:
undetectable		 4g0vB-5f9sA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ARG A 503
GLY A 504
ASN A 520
GLN A 778
 N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
N2W  A1302 ( 2.7A)
 1.05A 4g0vB-5gwjA:
52.9		 4g0vB-5gwjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		4 ARG A 187
GLY A 183
GLU A 191
GLN A  71
 None
 1.30A 4g0vB-5h5jA:
undetectable		 4g0vB-5h5jA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 GLY A 561
ASN A 396
GLU A 564
GLN A 449
 None
 1.02A 4g0vB-5hmpA:
undetectable		 4g0vB-5hmpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		4 ARG A 121
GLY A 199
GLU A 195
MET A  68
 None
 1.32A 4g0vB-5i39A:
undetectable		 4g0vB-5i39A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII
TRNA NUCLEASE CDIA

(Escherichia
coli) 		PF15605
(Ntox28)
no annotation 		4 GLY C  76
ASN B 184
GLU C  77
GLN B 136
 None
 1.11A 4g0vB-5j5vC:
undetectable		 4g0vB-5j5vC:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ARG A 336
GLY A 339
ASN A 296
GLN A 686
 None
 1.27A 4g0vB-5jxkA:
undetectable		 4g0vB-5jxkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 ARG A 118
GLY A 124
ASN A 142
GLN A 622
 None
CL  A 803 ( 4.0A)
None
None
 1.26A 4g0vB-5kqiA:
undetectable		 4g0vB-5kqiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ARG A 200
GLY A 196
GLU A 199
GLN A 283
 FAD  A 501 ( 4.8A)
FAD  A 501 ( 4.7A)
None
None
 1.20A 4g0vB-5n1tA:
undetectable		 4g0vB-5n1tA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 4 GLY A 211
ASN A 257
GLU A 215
GLN A 176
 None
 1.26A 4g0vB-5oydA:
undetectable		 4g0vB-5oydA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 ARG A 348
GLY A 320
ASN A 247
GLU A 319
 None
None
SAM  A 604 (-3.8A)
None
 1.15A 4g0vB-5v1sA:
undetectable		 4g0vB-5v1sA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		4 ARG A 185
GLY A 183
GLU A 330
GLN A 194
 None
 1.31A 4g0vB-5w8oA:
undetectable		 4g0vB-5w8oA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 ARG A 475
GLY A 510
GLN A 494
MET A 495
 None
 0.99A 4g0vB-5z0uA:
undetectable		 4g0vB-5z0uA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 ARG A1855
GLY A1730
ASN A1311
GLU A1313
 None
 1.19A 4g0vB-5zalA:
undetectable		 4g0vB-5zalA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLY H 261
ASN H 367
GLN H 231
MET H 235
 None
 1.31A 4g0vB-6chsH:
undetectable		 4g0vB-6chsH:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLY H 261
ASN H 575
GLN H 231
MET H 235
 None
 1.18A 4g0vB-6chsH:
undetectable		 4g0vB-6chsH:
8.74