SIMILAR PATTERNS OF AMINO ACIDS FOR 4G0V_A_MIXA1301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 ARG A 148
GLY A 179
ILE A 183
GLU A 149
 None
 0.91A 4g0vA-13pkA:
undetectable		 4g0vA-13pkA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		4 ILE A 107
ASN A  13
GLU A 173
GLN A 123
 GAR  A 221 (-4.2A)
GAR  A 221 (-4.1A)
GAR  A 221 (-2.6A)
None
 1.08A 4g0vA-1c3eA:
2.0		 4g0vA-1c3eA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 GLY A 237
ILE A 398
ASN A 396
MET A 506
 None
 1.06A 4g0vA-1d4eA:
undetectable		 4g0vA-1d4eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 GLY A 169
ILE A 200
GLU A 203
MET A 149
 None
 0.93A 4g0vA-1e1cA:
1.3		 4g0vA-1e1cA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 341
GLY A 118
GLU A 182
MET A 397
 None
 0.97A 4g0vA-1e8cA:
2.1		 4g0vA-1e8cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		4 ARG A 104
ASN A  14
GLU A 102
MET A 114
 None
 0.82A 4g0vA-1j85A:
undetectable		 4g0vA-1j85A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 ARG A 356
GLY A  96
ILE A  98
MET A  17
 None
 1.07A 4g0vA-1js6A:
1.3		 4g0vA-1js6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME

(Methanothermobacter
thermautotrophicus) 		PF00730
(HhH-GPD) 		4 ARG A 109
GLY A 107
ILE A 103
GLU A  68
 ACT  A3004 (-4.0A)
None
None
ZN  A1001 (-2.5A)
 0.91A 4g0vA-1keaA:
undetectable		 4g0vA-1keaA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 GLY A 199
ILE A 265
ASN A 242
GLU A 237
 None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.4A)
 1.10A 4g0vA-1kt8A:
undetectable		 4g0vA-1kt8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 444
ILE A 442
ASN A 545
GLU A 446
 None
 1.07A 4g0vA-1lw3A:
undetectable		 4g0vA-1lw3A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLY A  47
ILE A  24
ASN A  91
GLU A  93
 None
 1.04A 4g0vA-1p31A:
undetectable		 4g0vA-1p31A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		4 ARG A  92
ILE A  85
GLU A 129
GLN A  96
 None
 1.07A 4g0vA-1p9pA:
undetectable		 4g0vA-1p9pA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r71 TRANSCRIPTIONAL
REPRESSOR PROTEIN
KORB

(Escherichia
coli) 		PF08535
(KorB) 		4 ARG A 163
GLY A 162
ILE A 174
GLU A 164
 None
 1.04A 4g0vA-1r71A:
undetectable		 4g0vA-1r71A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1, RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 2

(Chlamydomonas
reinhardtii;
Spinacia
oleracea) 		PF00101
(RuBisCO_small) 		4 ARG C  78
GLY C  76
ILE C  39
ASN C 106
 None
EDO  C1136 (-3.4A)
EDO  C1136 (-4.3A)
None
 1.10A 4g0vA-1uzdC:
undetectable		 4g0vA-1uzdC:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 GLY A 406
ILE A 377
ASN A 374
MET A  91
 None
 1.12A 4g0vA-1v02A:
undetectable		 4g0vA-1v02A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6h DIVALENT CATION
TOLERANCE PROTEIN
CUTA1

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 ARG A  92
GLY A  90
ILE A  87
GLU A   2
 None
 1.12A 4g0vA-1v6hA:
undetectable		 4g0vA-1v6hA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ARG A 183
GLY A 184
ASN A 105
GLU A 182
 None
FAD  A1561 (-3.3A)
FAD  A1561 (-4.0A)
FAD  A1561 (-4.1A)
 1.03A 4g0vA-1w1kA:
undetectable		 4g0vA-1w1kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ARG B 231
GLY B 229
ILE B 226
GLU B 227
 None
 0.92A 4g0vA-1xv9B:
undetectable		 4g0vA-1xv9B:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7p HYPOTHETICAL PROTEIN
AF1403

(Archaeoglobus
fulgidus) 		PF01842
(ACT) 		4 ARG A  82
GLY A  85
ILE A 118
GLU A 116
 None
 1.10A 4g0vA-1y7pA:
2.5		 4g0vA-1y7pA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		4 ARG A 122
GLY A 124
ILE A 137
ASN A 139
 None
 0.96A 4g0vA-1zjyA:
2.1		 4g0vA-1zjyA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		4 ILE A 107
ASN A  13
GLU A 173
GLN A 123
 GRF  A1300 (-4.5A)
GRF  A1300 (-4.0A)
GRF  A1300 (-2.8A)
None
 1.12A 4g0vA-1zlyA:
2.7		 4g0vA-1zlyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		4 ARG A  45
GLY A  44
ASN A 148
MET A  99
 None
 1.12A 4g0vA-2be3A:
undetectable		 4g0vA-2be3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		4 ARG A 285
GLY A 316
ASN A 298
MET A 343
 None
 1.08A 4g0vA-2fy2A:
undetectable		 4g0vA-2fy2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		4 GLY A 476
ILE A 530
GLU A 528
GLN A 454
 None
 1.10A 4g0vA-2gp4A:
undetectable		 4g0vA-2gp4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 ARG A  82
GLY A  56
GLU A  58
GLN A  80
 None
 1.10A 4g0vA-2j5tA:
undetectable		 4g0vA-2j5tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqx CURVED DNA-BINDING
PROTEIN

(Escherichia
coli) 		PF00226
(DnaJ) 		4 ARG A  61
ILE A   9
GLU A  51
GLN A  67
 None
 1.04A 4g0vA-2kqxA:
undetectable		 4g0vA-2kqxA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmv CALMODULIN-RELATED
PROTEIN 97A

(Drosophila
melanogaster) 		PF13499
(EF-hand_7) 		4 ARG A 126
ILE A 136
ASN A 137
GLU A 140
 None
None
CA  A 150 ( 4.7A)
CA  A 150 (-2.2A)
 1.07A 4g0vA-2lmvA:
undetectable		 4g0vA-2lmvA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 352
ASN A 419
GLU A 350
GLN A 450
 None
 0.71A 4g0vA-2v7bA:
undetectable		 4g0vA-2v7bA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ARG A 728
GLY A 725
ILE A 721
MET A 702
 None
 1.12A 4g0vA-2xyuA:
undetectable		 4g0vA-2xyuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu4 E3 SUMO-PROTEIN
LIGASE NSE2

(Homo sapiens) 		PF11789
(zf-Nse) 		4 GLY A   7
ILE A  76
ASN A  80
GLU A  16
 None
 1.07A 4g0vA-2yu4A:
undetectable		 4g0vA-2yu4A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00731
(AIRC) 		4 ARG A 111
GLY A 112
ILE A  21
GLU A 113
 None
 0.88A 4g0vA-2ywxA:
undetectable		 4g0vA-2ywxA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 GLY A 255
ILE A 348
GLU A 229
GLN A 250
 None
None
CA  A1001 (-2.2A)
None
 1.09A 4g0vA-2z2zA:
undetectable		 4g0vA-2z2zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		4 GLY A 142
ILE A 102
GLU A 181
GLN A   7
 None
DLZ  A 191 (-4.1A)
None
None
 1.09A 4g0vA-3a3gA:
undetectable		 4g0vA-3a3gA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 GLY A 253
ILE A 155
ASN A 156
GLU A 159
 SO4  A 460 ( 3.8A)
None
None
GOL  A 463 ( 4.9A)
 1.11A 4g0vA-3bq9A:
undetectable		 4g0vA-3bq9A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 181
GLY A 179
ILE A 177
GLN A 440
 None
 1.07A 4g0vA-3ddrA:
undetectable		 4g0vA-3ddrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		4 GLY A 239
ILE A 247
GLU A 266
MET A  44
 None
None
CO  A 999 ( 4.6A)
GOL  A 710 ( 3.7A)
 1.10A 4g0vA-3dwcA:
2.9		 4g0vA-3dwcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		4 ARG A 101
GLY A  97
ASN A  91
GLN A 103
 GOL  A 286 (-4.4A)
None
None
None
 0.91A 4g0vA-3gkbA:
undetectable		 4g0vA-3gkbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A  60
ILE A 302
ASN A 306
GLN A 101
 None
 1.07A 4g0vA-3ihvA:
2.3		 4g0vA-3ihvA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		4 ARG A  40
GLY A 260
ILE A 217
GLU A 262
 None
 1.07A 4g0vA-3kcxA:
undetectable		 4g0vA-3kcxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kho B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Mus musculus) 		no annotation 4 GLY B 136
ILE B 117
GLU B 138
GLN B  45
 None
 0.95A 4g0vA-3khoB:
undetectable		 4g0vA-3khoB:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		4 GLY A 129
ILE A 107
ASN A 136
MET A 213
 None
 1.08A 4g0vA-3lu2A:
undetectable		 4g0vA-3lu2A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		4 ARG A 304
GLY A 303
ILE A 157
GLN A  83
 None
 0.80A 4g0vA-3mizA:
3.2		 4g0vA-3mizA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		4 ARG A 304
GLY A 303
ILE A 157
GLU A 305
 None
 0.99A 4g0vA-3mizA:
3.2		 4g0vA-3mizA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE

(Yersinia pestis) 		PF00588
(SpoU_methylase) 		4 ARG A 109
GLY A 105
ASN A  14
GLU A 107
 None
SAH  A 201 (-3.1A)
None
None
 1.10A 4g0vA-3n4kA:
undetectable		 4g0vA-3n4kA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 328
ASN A 323
GLU A 325
GLN A 334
 None
 0.98A 4g0vA-3nqpA:
undetectable		 4g0vA-3nqpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Bacillus
halodurans) 		PF00551
(Formyl_trans_N) 		4 ILE A 108
ASN A  14
GLU A 174
GLN A 124
 None
SO4  A 211 (-4.0A)
None
None
 1.12A 4g0vA-3p9xA:
2.7		 4g0vA-3p9xA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 GLY A 497
ILE A 279
ASN A 303
GLN A 489
 None
 1.00A 4g0vA-3ps5A:
undetectable		 4g0vA-3ps5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 GLY A 257
ILE A 259
ASN A 198
GLU A 258
 None
GOL  A 311 (-4.0A)
GOL  A 311 (-3.4A)
GOL  A 311 (-3.1A)
 1.09A 4g0vA-3pvtA:
undetectable		 4g0vA-3pvtA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 ARG A 554
GLY A 561
GLU A 559
GLN A 593
 None
 1.04A 4g0vA-3qfsA:
undetectable		 4g0vA-3qfsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 ARG A 175
GLY A 166
ILE A 168
GLU A 171
 None
 1.03A 4g0vA-3s6dA:
undetectable		 4g0vA-3s6dA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A 208
ILE A 205
ASN A 232
GLN A 215
 None
 0.99A 4g0vA-3so4A:
undetectable		 4g0vA-3so4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9n SMALL-CONDUCTANCE
MECHANOSENSITIVE
CHANNEL

(Caldanaerobacter
subterraneus) 		PF00924
(MS_channel) 		4 GLY A 167
ILE A 169
ASN A 138
GLN A 111
 None
 0.85A 4g0vA-3t9nA:
undetectable		 4g0vA-3t9nA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 ARG A 189
GLY A 353
ILE A 350
GLU A 195
 None
 1.12A 4g0vA-3u44A:
2.9		 4g0vA-3u44A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 GLY A 104
ILE A 110
ASN A 150
MET A  28
 None
 1.12A 4g0vA-4axnA:
undetectable		 4g0vA-4axnA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 ARG A 315
GLY A 314
ILE A 271
ASN A 307
 None
 0.88A 4g0vA-4b46A:
4.5		 4g0vA-4b46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6i SMA2266

(Serratia
marcescens) 		PF16695
(Tai4) 		4 ARG A  40
GLY A  43
ASN A  85
GLN A  53
 None
 1.10A 4g0vA-4b6iA:
undetectable		 4g0vA-4b6iA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 ARG A  73
GLY A  86
ILE A  64
GLN A 109
 None
 0.88A 4g0vA-4czxA:
undetectable		 4g0vA-4czxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Chaetomium
thermophilum) 		no annotation 4 ARG A  71
GLY A  84
ILE A  62
GLN A 128
 None
 1.01A 4g0vA-4d0kA:
undetectable		 4g0vA-4d0kA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 GLY A 488
ASN A 504
GLU A 506
MET A 762
 None
 1.01A 4g0vA-4fm9A:
50.0		 4g0vA-4fm9A:
79.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		4 GLY A 271
ILE A 225
ASN A 285
MET A 343
 None
 1.00A 4g0vA-4h41A:
1.5		 4g0vA-4h41A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		4 ARG A 281
GLY A 171
ASN A 202
GLU A 172
 None
 0.99A 4g0vA-4m0hA:
undetectable		 4g0vA-4m0hA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A  15
GLY A  14
ILE A  22
MET A 159
 None
 1.04A 4g0vA-4na3A:
undetectable		 4g0vA-4na3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 GLY A 259
ILE A 161
ASN A 162
GLU A 165
 SO4  A 501 ( 3.9A)
None
None
None
 1.06A 4g0vA-4npaA:
2.5		 4g0vA-4npaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nso EFFECTOR PROTEIN
IMMUNITY PROTEIN

(Vibrio cholerae) 		no annotation 4 GLY B  89
ILE B  86
GLU B  94
GLN A 914
 None
 1.12A 4g0vA-4nsoB:
undetectable		 4g0vA-4nsoB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5v IRON-DEPENDENT
TRANSCRIPTION
REPRESSOR RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 ARG A  62
GLY A  63
ILE A  60
GLU A  61
 None
 1.08A 4g0vA-4o5vA:
2.1		 4g0vA-4o5vA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ARG A  55
GLY A  54
ILE A  49
ASN A  63
 None
 1.04A 4g0vA-4p52A:
undetectable		 4g0vA-4p52A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		4 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 UDP  A 601 (-3.8A)
UDP  A 601 ( 3.0A)
None
None
 1.09A 4g0vA-4pqgA:
2.6		 4g0vA-4pqgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 GLY A 658
ILE A 660
ASN A 664
GLN A 595
 None
 1.06A 4g0vA-4qi4A:
undetectable		 4g0vA-4qi4A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 ARG A 148
GLY A 100
ILE A 123
GLU A 102
 None
 1.00A 4g0vA-4r5zA:
undetectable		 4g0vA-4r5zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		4 ARG A 139
GLY A 192
ASN A 391
GLN A 273
 BMA  A 502 (-4.0A)
None
MAN  A 501 ( 4.9A)
None
 1.09A 4g0vA-4r9gA:
undetectable		 4g0vA-4r9gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 GLY A 141
ILE A 116
ASN A 105
GLN A 133
 None
 0.98A 4g0vA-4r9iA:
undetectable		 4g0vA-4r9iA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		4 ARG A 123
GLY A 125
ILE A 138
ASN A 140
 None
 0.96A 4g0vA-4rf3A:
2.1		 4g0vA-4rf3A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		4 ILE A 405
ASN A 417
GLU A 345
GLN A 443
 None
 0.97A 4g0vA-4tqtA:
undetectable		 4g0vA-4tqtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v03 SITE-DETERMINING
PROTEIN

(Aquifex
aeolicus) 		PF01656
(CbiA) 		4 ARG A 216
GLY A 217
ILE A  49
ASN A  22
 None
 0.95A 4g0vA-4v03A:
2.9		 4g0vA-4v03A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 GLY A 238
ILE A 262
GLU A 264
GLN A 212
 None
SO4  A 404 (-4.3A)
None
None
 1.12A 4g0vA-4z0nA:
2.4		 4g0vA-4z0nA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 617
ILE A 678
GLU A 606
GLN A 782
 None
 0.98A 4g0vA-5a0zA:
2.5		 4g0vA-5a0zA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 465
ILE A 463
ASN A 566
GLU A 467
 None
 1.02A 4g0vA-5c16A:
undetectable		 4g0vA-5c16A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ARG B 458
GLY B 459
ILE B 461
GLU B 477
 None
 1.08A 4g0vA-5cdoB:
5.5		 4g0vA-5cdoB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 GLY B 459
ILE B 461
ASN B 475
GLU B 477
 None
 0.80A 4g0vA-5cdoB:
5.5		 4g0vA-5cdoB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 GLY A 682
ILE A 735
GLU A 738
MET A 660
 None
 0.91A 4g0vA-5cjuA:
undetectable		 4g0vA-5cjuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		4 ILE A 206
ASN A 208
GLU A 158
MET A 347
 None
 1.07A 4g0vA-5d9nA:
undetectable		 4g0vA-5d9nA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 GLY A1365
GLU A1364
GLN A1903
MET A1388
 None
 1.07A 4g0vA-5deuA:
undetectable		 4g0vA-5deuA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLY A 294
ILE A 381
ASN A 298
GLU A 295
 None
 1.12A 4g0vA-5dl6A:
undetectable		 4g0vA-5dl6A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp1 CURK

(Moorea
producens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 252
ILE A 232
ASN A 225
GLU A 247
 None
 1.06A 4g0vA-5dp1A:
2.4		 4g0vA-5dp1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 ARG A 176
GLY A 143
ASN A 268
GLU A 147
 ALL  A 401 (-2.9A)
None
None
None
 0.94A 4g0vA-5dteA:
undetectable		 4g0vA-5dteA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		4 GLY A 138
ILE A 140
GLU A 137
MET B 332
 None
 0.98A 4g0vA-5dynA:
undetectable		 4g0vA-5dynA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		4 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 None
UDP  A 601 (-3.1A)
None
None
 0.90A 4g0vA-5e9uA:
undetectable		 4g0vA-5e9uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		4 GLY A  87
ILE A 113
ASN A 117
GLN A  62
 SAH  A 301 (-3.1A)
None
None
None
 0.93A 4g0vA-5gm2A:
undetectable		 4g0vA-5gm2A:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ARG A 503
GLY A 504
ILE A 506
ASN A 520
 N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
None
 1.00A 4g0vA-5gwjA:
53.7		 4g0vA-5gwjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		4 GLY A 270
ILE A 272
ASN A 142
MET A 334
 None
ACT  A1001 (-4.4A)
ACT  A1001 (-3.9A)
None
 1.03A 4g0vA-5j78A:
undetectable		 4g0vA-5j78A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 ARG A1306
GLY A1078
ILE A1073
ASN A1265
 None
 1.07A 4g0vA-5kk5A:
2.4		 4g0vA-5kk5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		4 ARG A  52
ILE A  75
ASN A 239
GLN A 278
 None
 1.10A 4g0vA-5l35A:
undetectable		 4g0vA-5l35A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 GLY A 662
ILE A 643
ASN A 647
MET A 292
 None
 0.85A 4g0vA-5lq3A:
undetectable		 4g0vA-5lq3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 ARG A  56
GLY A  80
ILE A 170
GLN A  64
 None
 1.12A 4g0vA-5malA:
undetectable		 4g0vA-5malA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 4 ARG A 402
GLY A 401
GLU A 400
GLN A 395
 None
GOL  A 808 (-4.0A)
GOL  A 811 ( 3.5A)
None
 1.02A 4g0vA-5n4aA:
undetectable		 4g0vA-5n4aA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 GLY B 374
ILE B 372
ASN B 449
GLU B 322
 None
 0.98A 4g0vA-5nd1B:
undetectable		 4g0vA-5nd1B:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 4 ARG A  35
GLY A  31
ILE A  56
GLU A  37
 None
 1.05A 4g0vA-5o96A:
undetectable		 4g0vA-5o96A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ARG A  87
GLY A  86
ILE A  84
GLN A  92
 None
 0.90A 4g0vA-5t2zA:
undetectable		 4g0vA-5t2zA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 GLY A 370
ILE A  51
GLU A 372
GLN A 422
 None
 1.08A 4g0vA-6a8mA:
undetectable		 4g0vA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 4 ARG U 258
GLY U 200
ILE U 202
GLN U 248
 None
 1.10A 4g0vA-6fdyU:
undetectable		 4g0vA-6fdyU:
undetectable