SIMILAR PATTERNS OF AMINO ACIDS FOR 4G0U_F_ASWF101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PRO A 333
GLY A 214
ALA A 342
GLN A 192
 None
HEM  A 503 ( 4.8A)
None
None
 1.12A 4g0uA-1a4eA:
undetectable		 4g0uA-1a4eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 GLY A 296
ALA A 182
GLU A 184
GLN A 349
 None
BGC  A 551 ( 3.5A)
BGC  A 551 (-4.1A)
None
 1.13A 4g0uA-1b1yA:
0.4		 4g0uA-1b1yA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		4 PRO A 140
GLY A  98
ALA A 248
GLN A  69
 None
 1.10A 4g0uA-1booA:
undetectable		 4g0uA-1booA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 GLY A 298
ALA A 184
GLU A 186
GLN A 351
 BME  A 504 ( 4.3A)
BME  A 502 ( 3.9A)
None
GLC  A 499 ( 3.6A)
 1.09A 4g0uA-1btcA:
undetectable		 4g0uA-1btcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 PRO A 137
GLY A 357
ALA A 139
GLU A 359
 None
 1.10A 4g0uA-1d2fA:
2.1		 4g0uA-1d2fA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 PRO A  35
ARG A 239
GLY A 188
ALA A  68
 FMN  A 501 (-4.0A)
FMN  A 501 (-2.7A)
None
FMN  A 501 (-3.1A)
 1.04A 4g0uA-1icpA:
undetectable		 4g0uA-1icpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PRO A  16
GLY A 101
ALA A 197
GLN A  83
 None
 1.09A 4g0uA-1iirA:
2.3		 4g0uA-1iirA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 ARG A 108
GLY A  36
ALA A  81
GLN A  30
 HEC  A1001 (-3.0A)
None
None
HEC  A1002 (-3.2A)
 1.13A 4g0uA-1jmzA:
undetectable		 4g0uA-1jmzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ARG A 110
ALA A 104
GLU A  99
GLN A  26
 None
 1.12A 4g0uA-1nneA:
undetectable		 4g0uA-1nneA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3i NA,K-ATPASE

(Sus scrofa) 		PF13246
(Cation_ATPase) 		4 GLY A 539
ALA A 382
GLU A 543
GLN A 532
 None
 1.12A 4g0uA-1q3iA:
undetectable		 4g0uA-1q3iA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3i NA,K-ATPASE

(Sus scrofa) 		PF13246
(Cation_ATPase) 		4 GLY A 540
ALA A 382
GLU A 543
GLN A 532
 None
 0.96A 4g0uA-1q3iA:
undetectable		 4g0uA-1q3iA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 PRO A 125
GLY A 158
GLU A 156
GLN A 392
 None
 0.98A 4g0uA-1sy7A:
undetectable		 4g0uA-1sy7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLY A 372
ALA A  19
GLU A 126
GLN A 689
 None
 1.08A 4g0uA-1w6jA:
undetectable		 4g0uA-1w6jA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wju NEDD8 ULTIMATE
BUSTER-1

(Homo sapiens) 		no annotation 4 ARG A  43
GLY A  42
GLU A  44
GLN A  68
 None
 1.13A 4g0uA-1wjuA:
undetectable		 4g0uA-1wjuA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 PRO A 110
GLY A  64
ALA A  14
GLN A  68
 NAP  A1500 (-4.4A)
NAP  A1500 (-4.9A)
None
None
 1.13A 4g0uA-2ahrA:
undetectable		 4g0uA-2ahrA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		4 PRO A 138
GLY A 208
ALA A 125
GLN A 188
 None
None
None
KMP  A1456 (-4.2A)
 0.85A 4g0uA-2c1zA:
2.0		 4g0uA-2c1zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO L  95
GLY L  99
ALA L   1
GLN H  41
 None
 1.05A 4g0uA-2f5aL:
2.9		 4g0uA-2f5aL:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		4 GLY A  27
ALA A 128
GLU A  70
GLN A  45
 None
 1.09A 4g0uA-2fk5A:
undetectable		 4g0uA-2fk5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		4 GLY A 217
ALA A 173
GLU A 212
GLN A 146
 None
 1.13A 4g0uA-2h2wA:
undetectable		 4g0uA-2h2wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		4 GLY A 243
ALA A  20
GLU A 247
GLN A 223
 None
 1.14A 4g0uA-2jh3A:
2.4		 4g0uA-2jh3A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 189
GLY A 193
ALA A 228
GLN A 164
 None
 1.01A 4g0uA-2oejA:
undetectable		 4g0uA-2oejA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Caldanaerobacter
subterraneus) 		PF03009
(GDPD) 		4 PRO A  25
GLY A  96
ALA A  30
GLU A  97
 None
 1.02A 4g0uA-2pz0A:
undetectable		 4g0uA-2pz0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 PRO A  31
ARG A 235
GLY A 184
ALA A  64
 FMN  A 373 (-4.2A)
FMN  A 373 (-2.7A)
None
FMN  A 373 (-3.3A)
 0.97A 4g0uA-2q3rA:
undetectable		 4g0uA-2q3rA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyo POLYSACCHARIDE
DEACETYLASE
DOMAIN-CONTAINING
PROTEIN ECU11_0510

(Encephalitozoon
cuniculi) 		PF01522
(Polysacc_deac_1) 		4 ARG A  86
GLY A  35
ALA A  84
GLN A 188
 None
 1.12A 4g0uA-2vyoA:
undetectable		 4g0uA-2vyoA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		4 ARG A 219
GLY A 217
ALA A 253
GLU A 256
 None
 0.95A 4g0uA-2xj9A:
undetectable		 4g0uA-2xj9A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ARG A 216
GLY A  73
GLU A  77
GLN A 204
 FE  A1307 ( 4.7A)
None
None
None
 1.11A 4g0uA-2xsrA:
undetectable		 4g0uA-2xsrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 PRO A 341
GLY A  58
ALA A  69
GLN A 133
 None
 1.12A 4g0uA-2y9xA:
undetectable		 4g0uA-2y9xA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A 188
ALA A 180
GLU A 164
GLN A 311
 None
 1.11A 4g0uA-2yv3A:
undetectable		 4g0uA-2yv3A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 PRO A 324
ARG A  27
GLY A  25
ALA A 306
 None
 1.10A 4g0uA-2zbwA:
undetectable		 4g0uA-2zbwA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 192
GLY A 196
ALA A 231
GLN A 167
 None
 1.03A 4g0uA-2zviA:
undetectable		 4g0uA-2zviA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 PRO A 267
GLY A 234
ALA A 255
GLN A 217
 None
 1.08A 4g0uA-3a9gA:
undetectable		 4g0uA-3a9gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		4 ARG A  54
GLY A 138
ALA A 145
GLN A  62
 None
 1.07A 4g0uA-3ajbA:
undetectable		 4g0uA-3ajbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 4 PRO E  42
GLY E  89
ALA E  96
GLN E  63
 None
 1.09A 4g0uA-3aoeE:
3.0		 4g0uA-3aoeE:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 PRO A  26
ARG A 249
GLY A 196
ALA A  61
 FMN  A 500 (-4.0A)
FMN  A 500 (-2.9A)
None
FMN  A 500 (-3.1A)
 1.00A 4g0uA-3atyA:
undetectable		 4g0uA-3atyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3l KETOHEXOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		4 PRO A  95
GLY A  61
ALA A  64
GLN A 146
 None
 1.07A 4g0uA-3b3lA:
undetectable		 4g0uA-3b3lA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A 573
GLY A 577
ALA A 499
GLN A 526
 None
 1.08A 4g0uA-3b96A:
1.0		 4g0uA-3b96A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bge PREDICTED ATPASE

(Haemophilus
influenzae) 		PF12002
(MgsA_C) 		4 ARG A 420
GLY A 421
ALA A 347
GLU A 423
 None
 1.07A 4g0uA-3bgeA:
undetectable		 4g0uA-3bgeA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		4 PRO A 254
GLY A 221
ALA A 242
GLN A 205
 None
CA  A 351 ( 4.6A)
None
PQQ  A4331 (-3.0A)
 1.07A 4g0uA-3dasA:
undetectable		 4g0uA-3dasA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eff VOLTAGE-GATED
POTASSIUM CHANNEL

(Streptomyces
lividans) 		PF07885
(Ion_trans_2) 		4 ARG K  89
GLY K  88
ALA K  57
GLU K  51
 None
 1.07A 4g0uA-3effK:
undetectable		 4g0uA-3effK:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 190
GLY A 194
ALA A 229
GLN A 165
 None
 1.08A 4g0uA-3fk4A:
undetectable		 4g0uA-3fk4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		4 PRO A 161
GLY A 203
ALA A 196
GLN A 174
 None
 0.85A 4g0uA-3gipA:
1.1		 4g0uA-3gipA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 PRO A 229
GLY A  80
GLU A  78
GLN A  87
 NAE  A 311 (-4.1A)
None
NAE  A 311 ( 2.9A)
None
 1.09A 4g0uA-3i3oA:
1.8		 4g0uA-3i3oA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		4 PRO A 314
GLY A 247
ALA A 238
GLN A 295
 None
 0.92A 4g0uA-3igfA:
undetectable		 4g0uA-3igfA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 PRO A 209
GLY A 252
ALA A 276
GLU A 280
 None
 1.03A 4g0uA-3ikmA:
undetectable		 4g0uA-3ikmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		4 PRO A 207
ARG A  64
GLY A  63
ALA A  69
 None
 1.11A 4g0uA-3iwkA:
undetectable		 4g0uA-3iwkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 ARG A 599
GLY A 722
GLU A 770
GLN A 651
 None
 0.89A 4g0uA-3j3iA:
undetectable		 4g0uA-3j3iA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0b PREDICTED
N6-ADENINE-SPECIFIC
DNA METHYLASE

(Listeria
monocytogenes) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ARG A 166
GLY A 200
ALA A 179
GLN A 270
 None
 1.14A 4g0uA-3k0bA:
undetectable		 4g0uA-3k0bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN
USHER SYNDROME
TYPE-1G PROTEIN

(Homo sapiens) 		PF00536
(SAM_1)
PF00595
(PDZ) 		4 PRO B 454
GLY A 104
ALA B 449
GLU A 107
 None
 1.10A 4g0uA-3k1rB:
undetectable		 4g0uA-3k1rB:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kst ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 PRO A 106
GLY A  67
ALA A  62
GLN A 300
 None
 0.84A 4g0uA-3kstA:
undetectable		 4g0uA-3kstA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		4 GLY A 118
ALA A 163
GLU A 167
GLN A  94
 None
None
ZN  A 302 (-2.1A)
None
 0.94A 4g0uA-3lubA:
1.6		 4g0uA-3lubA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PRO A  74
ARG A 141
GLY A 144
ALA A 138
 None
 1.10A 4g0uA-3m5hA:
undetectable		 4g0uA-3m5hA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 GLY A  94
ALA A  89
GLU A  91
GLN A  33
 None
 0.93A 4g0uA-3myoA:
undetectable		 4g0uA-3myoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 539
ALA A 382
GLU A 543
GLN A 532
 None
 0.97A 4g0uA-3n23A:
undetectable		 4g0uA-3n23A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		4 PRO A 314
GLY A 336
ALA A 321
GLN A 355
 None
 1.06A 4g0uA-3p1uA:
undetectable		 4g0uA-3p1uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  92
ALA A  39
GLU A  38
GLN A 558
 None
FAY  A 600 (-3.3A)
FAY  A 600 (-2.6A)
FAY  A 600 (-4.1A)
 1.11A 4g0uA-3q9tA:
undetectable		 4g0uA-3q9tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 ARG A 454
ALA A 402
GLU A 404
GLN A 583
 None
 1.12A 4g0uA-3wbkA:
undetectable		 4g0uA-3wbkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE

(Methanothermobacter
thermautotrophicus) 		PF02374
(ArsA_ATPase) 		4 ARG A 174
GLY A 177
ALA A 199
GLU A 196
 None
 1.12A 4g0uA-3zq6A:
3.7		 4g0uA-3zq6A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ARG A 617
GLY A 622
ALA A 600
GLN A 638
 None
 1.11A 4g0uA-4ayxA:
4.1		 4g0uA-4ayxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		4 PRO A 247
GLY A 276
ALA A 302
GLN A 314
 None
 1.08A 4g0uA-4b43A:
undetectable		 4g0uA-4b43A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 ARG A 188
GLY A 191
ALA A 271
GLN A  25
 None
 1.04A 4g0uA-4b45A:
2.4		 4g0uA-4b45A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 GLY A  29
ALA A  52
GLU A  51
GLN A 180
 PO4  A1004 ( 3.9A)
PO4  A1007 (-3.4A)
CL  A1401 ( 3.3A)
CL  A1400 (-4.0A)
 1.06A 4g0uA-4bucA:
undetectable		 4g0uA-4bucA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 450
ALA A  12
GLU A 453
GLN A 490
 None
 1.12A 4g0uA-4c7gA:
undetectable		 4g0uA-4c7gA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyz HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PRO A  74
ARG A 141
GLY A 143
ALA A 138
 None
 1.06A 4g0uA-4cyzA:
undetectable		 4g0uA-4cyzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyz HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PRO A  74
ARG A 141
GLY A 144
ALA A 138
 None
 1.06A 4g0uA-4cyzA:
undetectable		 4g0uA-4cyzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ARG A  78
GLY A 149
ALA A 177
GLU A  79
 None
 1.11A 4g0uA-4cztA:
3.0		 4g0uA-4cztA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE

(Burkholderia
thailandensis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 PRO A 188
GLY A 161
ALA A 115
GLN A 175
 None
 1.10A 4g0uA-4f4hA:
undetectable		 4g0uA-4f4hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 PRO A 259
GLY A 204
ALA A 121
GLU A 220
 None
 0.96A 4g0uA-4gaaA:
undetectable		 4g0uA-4gaaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  98
ALA A  47
GLU A  46
GLN A 558
 None
FED  A 801 (-3.5A)
FED  A 801 (-2.7A)
FED  A 801 (-4.3A)
 0.97A 4g0uA-4h7uA:
undetectable		 4g0uA-4h7uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		4 ARG A 234
GLY A 217
ALA A 271
GLN A 246
 None
 0.96A 4g0uA-4immA:
undetectable		 4g0uA-4immA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 PRO A  91
GLY A  24
ALA A 313
GLN A 351
 None
 1.06A 4g0uA-4knaA:
undetectable		 4g0uA-4knaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 PRO A 420
GLY A 369
ALA A 395
GLN A 361
 None
 1.11A 4g0uA-4mnrA:
undetectable		 4g0uA-4mnrA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		4 PRO A1264
GLY A2061
ALA A2112
GLN A2031
 2W4  A2205 (-4.4A)
2W4  A2205 (-4.9A)
None
2W4  A2205 ( 4.1A)
 1.12A 4g0uA-4pivA:
undetectable		 4g0uA-4pivA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 PRO A 188
GLY A 171
ALA A 161
GLU A 166
 None
 0.98A 4g0uA-4wutA:
undetectable		 4g0uA-4wutA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 546
ALA A 389
GLU A 550
GLN A 539
 None
 0.93A 4g0uA-5aw4A:
undetectable		 4g0uA-5aw4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 PRO A 281
ARG A  97
GLY A  99
GLN A  91
 None
 0.95A 4g0uA-5bu6A:
undetectable		 4g0uA-5bu6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GM-CSF/IL-2
INHIBITION FACTOR

(Orf virus) 		no annotation 4 ARG A  26
GLY A  24
ALA A 220
GLU A  25
 None
 1.05A 4g0uA-5d28A:
undetectable		 4g0uA-5d28A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		4 ARG A 305
GLY A 308
ALA A 153
GLU A 307
 TRS  A 403 ( 4.5A)
None
None
None
 1.13A 4g0uA-5enzA:
undetectable		 4g0uA-5enzA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		4 PRO A  25
ARG A 228
GLY A 177
ALA A  58
 None
 1.04A 4g0uA-5epdA:
undetectable		 4g0uA-5epdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		4 PRO D 469
ARG D 479
GLY D 478
GLU D 476
 None
 1.08A 4g0uA-5iknD:
7.1		 4g0uA-5iknD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 PRO A 655
GLY A 661
ALA A  61
GLN A 261
 None
 1.10A 4g0uA-5jxkA:
undetectable		 4g0uA-5jxkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 PRO A  33
ARG A 234
GLY A 183
ALA A  66
 FMN  A 400 (-3.7A)
FMN  A 400 (-2.9A)
None
TNF  A 401 ( 2.9A)
 0.97A 4g0uA-5k1uA:
undetectable		 4g0uA-5k1uA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 ARG A 390
GLY A 394
ALA A 404
GLN A 354
 None
 1.01A 4g0uA-5kjmA:
undetectable		 4g0uA-5kjmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 GLY A  85
ALA A  34
GLU A  33
GLN A 548
 None
FAD  A 602 (-3.6A)
FAD  A 602 (-2.7A)
FAD  A 602 (-4.7A)
 1.04A 4g0uA-5oc1A:
undetectable		 4g0uA-5oc1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 PRO A  23
ARG A 231
GLY A 179
ALA A  57
 FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
None
FMN  A 401 (-3.3A)
 1.03A 4g0uA-5ocsA:
undetectable		 4g0uA-5ocsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 PRO A 636
ARG A 680
GLY A 675
GLU A 673
 None
 1.10A 4g0uA-5svcA:
undetectable		 4g0uA-5svcA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ARG A 232
GLY A  88
GLU A  92
GLN A 220
 ZN  A 401 ( 4.7A)
None
None
None
 1.05A 4g0uA-5td3A:
undetectable		 4g0uA-5td3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 4 PRO G 112
GLY G 241
ALA G 233
GLN G  39
 None
 1.09A 4g0uA-5u0uG:
undetectable		 4g0uA-5u0uG:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PRO A 147
GLY A  50
ALA A 264
GLN A  93
 None
FAD  A 501 (-3.4A)
None
None
 1.10A 4g0uA-5u1oA:
undetectable		 4g0uA-5u1oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9o PLASTID DIVISION
PROTEIN CDP1,
CHLOROPLASTIC,PLASTI
D DIVISION PROTEIN
PDV1

(Arabidopsis
thaliana) 		no annotation 4 GLY A 856
ALA A 777
GLU A 775
GLN A 728
 None
 1.06A 4g0uA-5u9oA:
undetectable		 4g0uA-5u9oA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umh CATECHOL
1,2-DIOXYGENASE

(Burkholderia
multivorans) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ARG A 221
GLY A  77
GLU A  81
GLN A 209
 EDO  A 402 (-3.4A)
None
None
None
 0.96A 4g0uA-5umhA:
undetectable		 4g0uA-5umhA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		4 ARG A  63
GLY A  65
ALA A 424
GLU A  64
 None
 1.06A 4g0uA-5uzeA:
undetectable		 4g0uA-5uzeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6

(Homo sapiens) 		PF01399
(PCI)
PF10602
(RPN7) 		4 ARG Y 146
GLY Y 148
ALA Y 120
GLN Y  21
 None
 0.94A 4g0uA-5vhiY:
undetectable		 4g0uA-5vhiY:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 4 GLY A 471
ALA A 270
GLU A 473
GLN A 572
 None
 1.00A 4g0uA-5w1aA:
undetectable		 4g0uA-5w1aA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 PRO A 381
ARG A  66
GLY A  63
GLU A 511
 None
 1.09A 4g0uA-5w1eA:
3.1		 4g0uA-5w1eA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqs BETA-AMYLASE

(Ipomoea batatas) 		no annotation 4 GLY A 300
ALA A 185
GLU A 187
GLN A 353
 None
 1.10A 4g0uA-5wqsA:
undetectable		 4g0uA-5wqsA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 4 ARG A 201
ALA A 219
GLU A 208
GLN A 185
 None
 0.88A 4g0uA-5xbjA:
undetectable		 4g0uA-5xbjA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 PRO A 199
GLY A 222
GLU A 201
GLN A 142
 None
 1.01A 4g0uA-5xeoA:
undetectable		 4g0uA-5xeoA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 PRO A 421
ARG A 403
GLY A 401
ALA A 413
 None
 1.13A 4g0uA-5yp3A:
undetectable		 4g0uA-5yp3A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA

(Chromobacterium
violaceum) 		no annotation 4 GLY B  61
ALA B 180
GLU B  59
GLN B  40
 FAD  B 501 (-4.1A)
None
None
FAD  B 501 (-4.9A)
 1.01A 4g0uA-6esdB:
2.4		 4g0uA-6esdB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 4 PRO A 842
GLY A 768
ALA A 734
GLN A 753
 None
 1.13A 4g0uA-6f42A:
3.8		 4g0uA-6f42A:
6.97