SIMILAR PATTERNS OF AMINO ACIDS FOR 4G0U_B_ASWB1301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9k PROTEIN
(ALPHA-ADAPTIN
APPENDAGE DOMAIN)

(Mus musculus) 		PF02296
(Alpha_adaptin_C)
PF02883
(Alpha_adaptinC2) 		4 ILE A 820
PRO A 819
GLY A 714
GLN A 782
 None
 0.97A 4g0uB-1b9kA:
undetectable		 4g0uB-1b9kA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 108
GLY A 308
ALA A 111
GLN A  32
 None
 0.97A 4g0uB-1bkhA:
2.3		 4g0uB-1bkhA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		4 ILE A 361
PRO A 362
GLY A 381
GLN A 378
 None
 0.95A 4g0uB-1fs2A:
undetectable		 4g0uB-1fs2A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 ILE A 149
ARG A 171
ALA A 158
GLN A 323
 None
 0.93A 4g0uB-1gplA:
2.4		 4g0uB-1gplA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 PRO A 174
ARG A 181
GLY A 183
ALA A 161
 None
MG  A1338 (-4.7A)
None
None
 0.96A 4g0uB-1gzgA:
undetectable		 4g0uB-1gzgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 879
PRO A 857
GLY A 967
ALA A 898
 None
 0.92A 4g0uB-1kcwA:
undetectable		 4g0uB-1kcwA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		4 ILE A  81
GLY A 105
ALA A  83
GLN A  46
 None
 0.98A 4g0uB-1kp2A:
undetectable		 4g0uB-1kp2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 234
ARG A 258
GLY A 261
ALA A 175
 None
 0.97A 4g0uB-1lluA:
undetectable		 4g0uB-1lluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 ILE A 320
PRO A 321
GLY A 355
ALA A 339
 None
 0.96A 4g0uB-1obhA:
undetectable		 4g0uB-1obhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onl GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Thermus
thermophilus) 		PF01597
(GCV_H) 		4 ILE A   3
PRO A   4
GLY A  96
GLN A  92
 None
 0.94A 4g0uB-1onlA:
undetectable		 4g0uB-1onlA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4t OUTER MEMBRANE
PROTEIN NSPA

(Neisseria
meningitidis) 		PF02462
(Opacity) 		4 ILE A  69
ARG A  36
GLY A   5
ALA A  43
 ETA  A 501 (-4.9A)
None
None
None
 0.93A 4g0uB-1p4tA:
undetectable		 4g0uB-1p4tA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 ILE A 185
GLY A 169
ALA A 239
GLN A 207
 None
 0.96A 4g0uB-1pztA:
0.7		 4g0uB-1pztA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3i NA,K-ATPASE

(Sus scrofa) 		PF13246
(Cation_ATPase) 		4 GLY A 540
ALA A 382
GLU A 543
GLN A 532
 None
 0.97A 4g0uB-1q3iA:
undetectable		 4g0uB-1q3iA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 ILE A 198
GLY A 119
ALA A 216
GLN A 114
 None
 0.98A 4g0uB-1u9cA:
undetectable		 4g0uB-1u9cA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujd KIAA0559 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  53
GLY A  31
ALA A  62
GLN A  96
 None
 0.92A 4g0uB-1ujdA:
undetectable		 4g0uB-1ujdA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		4 ILE A 331
GLY A 335
ALA A  95
GLN A 340
 None
FMN  A1398 (-3.6A)
FMN  A1398 (-3.4A)
None
 0.93A 4g0uB-1uuoA:
undetectable		 4g0uB-1uuoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8y ADP-RIBOSE
PYROPHOSPHATASE

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 ILE A  64
PRO A  65
GLY A  88
ALA A  41
 None
 0.88A 4g0uB-1v8yA:
undetectable		 4g0uB-1v8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ILE A 134
PRO A 171
GLY A 144
GLN A 181
 None
 0.75A 4g0uB-1vljA:
2.6		 4g0uB-1vljA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ILE A 116
GLY A 121
GLU A 198
GLN A  96
 None
 0.95A 4g0uB-1wpqA:
undetectable		 4g0uB-1wpqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE

(Hevea
brasiliensis) 		PF00561
(Abhydrolase_1) 		4 ILE A  97
GLY A  82
ALA A  89
GLN A 238
 None
 0.87A 4g0uB-1yb6A:
1.8		 4g0uB-1yb6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		4 PRO A 138
GLY A 208
ALA A 125
GLN A 188
 None
None
None
KMP  A1456 (-4.2A)
 0.74A 4g0uB-2c1zA:
2.2		 4g0uB-2c1zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 ILE A 191
PRO A 192
GLY A 252
ALA A 197
 None
 0.95A 4g0uB-2d0oA:
undetectable		 4g0uB-2d0oA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 265
PRO A 262
GLY A 334
GLN A 227
 None
 0.86A 4g0uB-2dylA:
undetectable		 4g0uB-2dylA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kj9 INTEGRASE

(Pectobacterium
atrosepticum) 		no annotation 4 ILE A  64
PRO A  63
GLY A  48
ALA A  83
 None
 0.93A 4g0uB-2kj9A:
undetectable		 4g0uB-2kj9A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ILE A 285
PRO A 303
GLY A 100
ALA A 123
 None
 0.92A 4g0uB-2pvpA:
2.4		 4g0uB-2pvpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Caldanaerobacter
subterraneus) 		PF03009
(GDPD) 		4 PRO A  25
GLY A  96
ALA A  30
GLU A  97
 None
 0.95A 4g0uB-2pz0A:
undetectable		 4g0uB-2pz0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ILE A 292
PRO A 293
ALA A 303
GLN A 394
 None
 0.92A 4g0uB-2r6fA:
2.2		 4g0uB-2r6fA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ILE C 229
GLY C 107
ALA C 233
GLU C 196
 None
 0.94A 4g0uB-2v3cC:
undetectable		 4g0uB-2v3cC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		4 ARG A 219
GLY A 217
ALA A 253
GLU A 256
 None
 0.88A 4g0uB-2xj9A:
undetectable		 4g0uB-2xj9A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ILE A 519
GLY A 524
ALA A 595
GLN A 529
 None
 0.85A 4g0uB-2zwsA:
undetectable		 4g0uB-2zwsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 ILE A 316
GLY A 184
ALA A 328
GLU A 185
 None
 0.96A 4g0uB-3ay0A:
2.2		 4g0uB-3ay0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 ILE A  68
PRO A  69
GLY A 133
GLN A 139
 None
None
SO4  A 145 (-4.9A)
None
 0.84A 4g0uB-3ba3A:
undetectable		 4g0uB-3ba3A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 163
GLY A 241
ALA A 212
GLU A 223
 None
 0.77A 4g0uB-3ceaA:
undetectable		 4g0uB-3ceaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		4 ILE A 222
PRO A 221
GLY A 199
ALA A 232
 None
 0.91A 4g0uB-3cgwA:
undetectable		 4g0uB-3cgwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis) 		PF13419
(HAD_2) 		4 ILE A 212
PRO A 213
GLU A 216
GLN A  50
 None
 0.89A 4g0uB-3ed5A:
2.0		 4g0uB-3ed5A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		5 ILE A 337
GLY A 171
ALA A 335
GLU A  24
GLN A 306
 EDO  A 702 ( 4.2A)
None
None
None
None
 1.42A 4g0uB-3edyA:
2.1		 4g0uB-3edyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN
HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE B 108
GLY A  23
ALA A 321
GLN B  15
 None
 0.98A 4g0uB-3eykB:
undetectable		 4g0uB-3eykB:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		4 ILE A 214
PRO A 215
GLY A  78
ALA A 207
 None
 0.75A 4g0uB-3f9tA:
undetectable		 4g0uB-3f9tA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		4 PRO A 161
GLY A 203
ALA A 196
GLN A 174
 None
 0.92A 4g0uB-3gipA:
undetectable		 4g0uB-3gipA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00239
(Resolvase) 		4 ILE A 110
GLY A  45
ALA A  36
GLN A  62
 None
 0.94A 4g0uB-3guvA:
3.5		 4g0uB-3guvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 ILE A 206
GLY A 334
ALA A 269
GLN A 311
 None
 0.90A 4g0uB-3i5aA:
3.3		 4g0uB-3i5aA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 PRO A 209
GLY A 252
ALA A 276
GLU A 280
 None
 0.90A 4g0uB-3ikmA:
undetectable		 4g0uB-3ikmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itw PROTEIN TIOX

(Micromonospora
sp. ML1) 		PF00903
(Glyoxalase) 		4 ILE A  35
PRO A  10
ARG A  51
GLY A  53
 None
 0.76A 4g0uB-3itwA:
undetectable		 4g0uB-3itwA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 ARG A 599
GLY A 722
GLU A 770
GLN A 651
 None
 0.88A 4g0uB-3j3iA:
undetectable		 4g0uB-3j3iA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		4 ILE A 100
GLY A 131
ALA A 137
GLN A 109
 None
 0.93A 4g0uB-3kipA:
2.5		 4g0uB-3kipA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		4 GLY A 118
ALA A 163
GLU A 167
GLN A  94
 None
None
ZN  A 302 (-2.1A)
None
 0.98A 4g0uB-3lubA:
3.4		 4g0uB-3lubA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		4 ILE A 119
GLY A 271
ALA A 147
GLN A 106
 ZN  A 864 ( 4.8A)
None
None
None
 0.93A 4g0uB-3mmkA:
undetectable		 4g0uB-3mmkA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 GLY A  94
ALA A  89
GLU A  91
GLN A  33
 None
 0.92A 4g0uB-3myoA:
undetectable		 4g0uB-3myoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ILE A 775
GLY A 702
ALA A 718
GLN A 123
 None
None
None
MGD  A1803 (-2.9A)
 0.92A 4g0uB-3o5aA:
2.0		 4g0uB-3o5aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN

(Bordetella
bronchiseptica) 		PF13379
(NMT1_2) 		4 ILE A  52
PRO A  49
GLY A 299
GLN A 247
 None
 0.97A 4g0uB-3qslA:
undetectable		 4g0uB-3qslA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445

(Oleispira
antarctica) 		PF03009
(GDPD) 		4 ILE A  96
PRO A  97
GLY A  16
GLN A  20
 None
 0.88A 4g0uB-3qvqA:
undetectable		 4g0uB-3qvqA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 ILE A 379
GLY A 113
ALA A 421
GLN A  67
 EDO  A 452 ( 4.4A)
None
None
None
 0.83A 4g0uB-3r0zA:
1.2		 4g0uB-3r0zA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 ILE A 328
PRO A 329
GLY A 361
ALA A 305
 EDO  A 384 ( 3.9A)
None
None
None
 0.97A 4g0uB-3r67A:
undetectable		 4g0uB-3r67A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 425
GLY A 393
ALA A 567
GLN A 595
 None
 0.95A 4g0uB-3sunA:
4.1		 4g0uB-3sunA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 ILE A1426
GLY A1431
ALA A1434
GLN A 840
 None
 0.96A 4g0uB-4a5wA:
undetectable		 4g0uB-4a5wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 ILE A 364
PRO A 365
GLY A 217
GLN A 536
 None
 0.97A 4g0uB-4akvA:
undetectable		 4g0uB-4akvA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 ILE A 364
PRO A 365
GLY A 220
GLN A 536
 None
 0.94A 4g0uB-4akvA:
undetectable		 4g0uB-4akvA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 ILE A 318
PRO A 319
GLY A 353
ALA A 337
 None
 0.95A 4g0uB-4arcA:
undetectable		 4g0uB-4arcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 4 ILE A 219
ARG A 215
GLY A 181
ALA A 188
 None
None
F1P  A 702 (-3.6A)
None
 0.91A 4g0uB-4bb9A:
undetectable		 4g0uB-4bb9A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		4 ILE A 316
PRO A 317
GLY A 210
GLN A  22
 None
 0.89A 4g0uB-4cswA:
undetectable		 4g0uB-4cswA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		4 ILE A 346
PRO A 347
ARG A 388
GLY A 385
 None
 0.98A 4g0uB-4e2oA:
undetectable		 4g0uB-4e2oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 ILE A  89
PRO A  90
GLY A 304
GLN A 178
 None
 0.97A 4g0uB-4el8A:
undetectable		 4g0uB-4el8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 PRO A 259
GLY A 204
ALA A 121
GLU A 220
 None
 0.89A 4g0uB-4gaaA:
undetectable		 4g0uB-4gaaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 ILE A 232
PRO A 233
GLY A 376
ALA A 380
 None
 0.76A 4g0uB-4grxA:
undetectable		 4g0uB-4grxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 ILE A 133
PRO A 134
GLY A 171
ALA A  68
GLN A 178
 None
SO4  A 403 (-4.7A)
LLP  A  41 ( 3.2A)
SO4  A 402 (-3.3A)
None
 1.47A 4g0uB-4h27A:
undetectable		 4g0uB-4h27A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  98
ALA A  47
GLU A  46
GLN A 558
 None
FED  A 801 (-3.5A)
FED  A 801 (-2.7A)
FED  A 801 (-4.3A)
 0.98A 4g0uB-4h7uA:
undetectable		 4g0uB-4h7uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		4 ARG A 234
GLY A 217
ALA A 271
GLN A 246
 None
 0.91A 4g0uB-4immA:
undetectable		 4g0uB-4immA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		PF05238
(CENP-N)
no annotation 		4 ILE A 165
PRO A 166
GLU A 168
GLN B 448
 None
 0.87A 4g0uB-4je3A:
undetectable		 4g0uB-4je3A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 4 ILE E 212
PRO E 211
GLY E  99
ALA E  92
 None
 0.86A 4g0uB-4l95E:
2.1		 4g0uB-4l95E:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		4 ILE B  72
PRO B  73
GLY B 479
GLU B 404
 None
 0.85A 4g0uB-4mbgB:
undetectable		 4g0uB-4mbgB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 415
GLY A 406
ALA A 430
GLN A  49
 None
 0.87A 4g0uB-4q9dA:
undetectable		 4g0uB-4q9dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa9 EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 ILE A  77
PRO A 134
GLY A 146
ALA A 155
 None
EDO  A 414 (-3.7A)
None
None
 0.90A 4g0uB-4qa9A:
1.5		 4g0uB-4qa9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		4 ILE A 334
ALA A 338
GLU A 277
GLN A 297
 None
 0.98A 4g0uB-4r7pA:
undetectable		 4g0uB-4r7pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ILE A 268
PRO A 267
GLY A 275
ALA A 222
 None
 0.98A 4g0uB-4s17A:
undetectable		 4g0uB-4s17A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ILE A 164
GLY A 237
ALA A 155
GLU A 156
 None
 0.97A 4g0uB-4ubtA:
undetectable		 4g0uB-4ubtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		4 ILE A 751
PRO A 748
GLY A 662
ALA A 754
 None
 0.93A 4g0uB-4v36A:
undetectable		 4g0uB-4v36A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		4 ILE A 212
GLY A  76
ALA A 283
GLN A 347
 None
 0.81A 4g0uB-4x4jA:
undetectable		 4g0uB-4x4jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 ILE A  22
PRO A  23
GLY A  28
ALA A 450
 None
 0.96A 4g0uB-4xwtA:
2.3		 4g0uB-4xwtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 ILE A 218
GLY A 184
ALA A 245
GLU A 242
 6PC  A 404 (-4.3A)
None
6PC  A 404 ( 3.8A)
None
 0.94A 4g0uB-4yzzA:
undetectable		 4g0uB-4yzzA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 ILE A 342
PRO A 343
ARG A 384
GLY A 381
 None
 0.98A 4g0uB-5a2aA:
undetectable		 4g0uB-5a2aA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 ILE A 303
GLY A 245
GLU A 268
GLN A 196
 None
TXE  A 501 (-3.6A)
TXE  A 501 (-3.6A)
TXE  A 501 ( 4.1A)
 0.81A 4g0uB-5abmA:
undetectable		 4g0uB-5abmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 546
ALA A 389
GLU A 550
GLN A 539
 None
 0.94A 4g0uB-5aw4A:
undetectable		 4g0uB-5aw4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		4 ILE A2371
GLY A2405
ALA A2454
GLN A2311
 None
 0.97A 4g0uB-5b4xA:
undetectable		 4g0uB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 541
PRO A 540
GLY A  77
ALA A 444
 None
 0.94A 4g0uB-5b7iA:
undetectable		 4g0uB-5b7iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		4 ILE A  83
PRO A  84
GLY A 300
GLN A 177
 None
 0.71A 4g0uB-5bv9A:
undetectable		 4g0uB-5bv9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 219
ARG A 237
GLY A 239
ALA A 224
 None
PLP  A 401 (-4.2A)
PLP  A 401 (-3.4A)
None
 0.96A 4g0uB-5facA:
undetectable		 4g0uB-5facA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 ILE g 484
GLY g 498
ALA g 418
GLN g 156
 None
 0.93A 4g0uB-5gw4g:
1.1		 4g0uB-5gw4g:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		4 ILE A  85
PRO A  84
GLY A  67
GLU A  66
 None
 0.69A 4g0uB-5i3sA:
undetectable		 4g0uB-5i3sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 ILE A 347
GLY A 405
ALA A 256
GLN A 178
 None
ACT  A 502 (-3.4A)
ACT  A 503 (-4.8A)
None
 0.85A 4g0uB-5jy9A:
undetectable		 4g0uB-5jy9A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		4 ILE A 235
PRO A 236
GLY A 380
ALA A 384
 None
 0.81A 4g0uB-5kqwA:
undetectable		 4g0uB-5kqwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 421
PRO A 422
ARG A 470
GLY A 471
 None
 0.56A 4g0uB-5m4aA:
2.0		 4g0uB-5m4aA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		4 ILE A 642
GLY A  52
GLU A  53
GLN A 505
 None
 0.96A 4g0uB-5mqoA:
undetectable		 4g0uB-5mqoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 253
PRO A 254
GLY A  68
GLU A  67
 None
 0.65A 4g0uB-5n0cA:
2.6		 4g0uB-5n0cA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 579
GLY A 586
ALA A 547
GLU A 551
 None
 0.79A 4g0uB-5nd5A:
2.7		 4g0uB-5nd5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 4 ILE A  97
GLY A  82
ALA A  89
GLN A 238
 None
 0.94A 4g0uB-5tdxA:
1.2		 4g0uB-5tdxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 ILE C 585
PRO C 586
GLU C 924
GLN C 700
 None
 0.70A 4g0uB-5tw1C:
undetectable		 4g0uB-5tw1C:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9o PLASTID DIVISION
PROTEIN CDP1,
CHLOROPLASTIC,PLASTI
D DIVISION PROTEIN
PDV1

(Arabidopsis
thaliana) 		no annotation 5 ARG A 855
GLY A 856
ALA A 777
GLU A 775
GLN A 728
 None
 1.30A 4g0uB-5u9oA:
undetectable		 4g0uB-5u9oA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 ILE B 119
GLY B 219
ALA B 100
GLU B 221
 PEG  B 308 ( 4.6A)
None
None
None
 0.89A 4g0uB-5uniB:
3.2		 4g0uB-5uniB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 ILE B 119
GLY B 222
ALA B 100
GLU B 221
 PEG  B 308 ( 4.6A)
None
None
None
 0.89A 4g0uB-5uniB:
3.2		 4g0uB-5uniB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6

(Homo sapiens) 		PF01399
(PCI)
PF10602
(RPN7) 		4 ARG Y 146
GLY Y 148
ALA Y 120
GLN Y  21
 None
 0.97A 4g0uB-5vhiY:
undetectable		 4g0uB-5vhiY:
21.19