SIMILAR PATTERNS OF AMINO ACIDS FOR 4FZV_A_SAMA401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0k | PROTEIN (ACONITASE) (Sus scrofa) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | GLY A 175GLY A 176SER A 249GLY A 244LEU A 207 | None | 1.09A | 4fzvA-1b0kA:undetectable | 4fzvA-1b0kA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dct | PROTEIN(MODIFICATIONMETHYLASE HAEIII) (Haemophilusinfluenzae) |
PF00145(DNA_methylase) | 5 | GLY A 11GLY A 12ASN A 28ASP A 50PRO A 70 | None | 0.85A | 4fzvA-1dctA:8.5 | 4fzvA-1dctA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pisum sativum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 248LEU A 272GLY A 169PRO A 177LEU A 173 | None | 0.98A | 4fzvA-1dxlA:undetectable | 4fzvA-1dxlA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eiz | FTSJ (Escherichiacoli) |
PF01728(FtsJ) | 6 | PRO A 62GLY A 63GLY A 64LEU A 84ASP A 99LEU A 143 | SAM A 301 (-3.4A)SAM A 301 (-3.9A)SAM A 301 (-3.1A)SAM A 301 (-4.2A)SAM A 301 (-3.5A)SAM A 301 (-4.6A) | 0.86A | 4fzvA-1eizA:9.4 | 4fzvA-1eizA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 86GLY A 87ASP A 141GLY A 142LEU A 169 | None | 0.61A | 4fzvA-1mjfA:10.3 | 4fzvA-1mjfA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nff | PUTATIVEOXIDOREDUCTASERV2002 (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | GLY A 184ASN A 88SER A 22GLY A 14PRO A 189 | NoneNAD A1300 (-3.3A)NoneNAD A1300 (-3.5A)NAD A1300 (-3.5A) | 1.09A | 4fzvA-1nffA:4.2 | 4fzvA-1nffA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o75 | 47 KDA MEMBRANEANTIGEN (Treponemapallidum) |
PF14888(PBP-Tp47_c)PF14889(PBP-Tp47_a) | 5 | GLY A 61GLY A 59SER A 284GLY A 226LEU A 45 | None | 1.05A | 4fzvA-1o75A:undetectable | 4fzvA-1o75A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pca | PROCARBOXYPEPTIDASEA PCPA (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | GLY A 253GLY A 252SER A 266GLY A 241PRO A 213 | None | 1.09A | 4fzvA-1pcaA:undetectable | 4fzvA-1pcaA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rxt | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE 1 (Homo sapiens) |
PF01233(NMT)PF02799(NMT_C) | 5 | CYH A 172GLY A 207SER A 150GLY A 147LEU A 98 | None | 1.09A | 4fzvA-1rxtA:undetectable | 4fzvA-1rxtA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqg | SUN PROTEIN (Escherichiacoli) |
PF01029(NusB)PF01189(Methyltr_RsmB-F) | 7 | CYH A 254PRO A 257GLY A 258GLY A 259ASP A 303GLY A 304PRO A 324 | None | 0.92A | 4fzvA-1sqgA:27.0 | 4fzvA-1sqgA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wjm | BETA-SPECTRIN III (Homo sapiens) |
PF15410(PH_9) | 6 | GLY A 7ASN A 113LEU A 109SER A 107GLY A 72LEU A 87 | None | 1.31A | 4fzvA-1wjmA:undetectable | 4fzvA-1wjmA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9e | NOL1/NOP2/SUN DOMAINFAMILY, MEMBER 5ISOFORM 2 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 6 | CYH A 234PRO A 237GLY A 238LYS A 240LEU A 259ASP A 285 | SAM A1201 (-3.8A)SAM A1201 (-3.7A)SAM A1201 (-3.9A)SAM A1201 (-3.1A)SAM A1201 (-4.5A)SAM A1201 (-3.6A) | 0.48A | 4fzvA-2b9eA:23.3 | 4fzvA-2b9eA:25.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0w | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 94GLY A 95SER A 230GLY A 238LEU A 166 | None | 1.00A | 4fzvA-2e0wA:undetectable | 4fzvA-2e0wA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 94GLY A 95SER A 230GLY A 238LEU A 166 | None | 1.06A | 4fzvA-2e0xA:undetectable | 4fzvA-2e0xA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 296GLY A 297GLY A 381PRO A 350LEU A 383 | None | 0.94A | 4fzvA-2e0xA:undetectable | 4fzvA-2e0xA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128ASN A 148SER A 151GLY A 177PRO A 196LEU A 228 | None | 0.73A | 4fzvA-2frxA:28.9 | 4fzvA-2frxA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128GLY A 129ASN A 148SER A 151ASP A 176GLY A 177 | None | 1.15A | 4fzvA-2frxA:28.9 | 4fzvA-2frxA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128GLY A 129ASN A 148SER A 151GLY A 177PRO A 196 | None | 0.66A | 4fzvA-2frxA:28.9 | 4fzvA-2frxA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 5 | PRO A 128GLY A 129LYS A 131SER A 151PRO A 196 | None | 0.94A | 4fzvA-2frxA:28.9 | 4fzvA-2frxA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp4 | 6-PHOSPHOGLUCONATEDEHYDRATASE (Shewanellaoneidensis) |
PF00920(ILVD_EDD) | 5 | PRO A 120GLY A 121GLY A 118ASP A 509GLY A 510 | None | 1.00A | 4fzvA-2gp4A:undetectable | 4fzvA-2gp4A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hb6 | LEUCINEAMINOPEPTIDASE 1 (Caenorhabditiselegans) |
PF00883(Peptidase_M17) | 6 | GLY A 219GLY A 218ASN A 307GLY A 260PRO A 316LEU A 261 | None | 1.49A | 4fzvA-2hb6A:undetectable | 4fzvA-2hb6A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzg | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME/ENOLASESUPERFAMILY (Rhodobactersphaeroides) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 283GLY A 282ASN A 303LEU A 312SER A 313 | None | 0.86A | 4fzvA-2hzgA:undetectable | 4fzvA-2hzgA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 6 | GLY A 22GLY A 23ASN A 39ASP A 60PRO A 80LEU A 100 | NoneSAH A 328 (-3.6A)SAH A 328 (-4.3A)SAH A 328 (-3.6A)SAH A 328 (-4.0A)SAH A 328 ( 4.9A) | 1.01A | 4fzvA-2i9kA:8.2 | 4fzvA-2i9kA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iss | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermotogamaritima) |
PF01174(SNO) | 5 | PRO D 44GLY D 45GLY D 46LEU D 165LEU D 99 | None | 1.00A | 4fzvA-2issD:undetectable | 4fzvA-2issD:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | GLY A 146GLY A 147GLY A 135PRO A 711LEU A 139 | NoneNoneNoneNoneMGD A 811 ( 4.4A) | 1.01A | 4fzvA-2jirA:undetectable | 4fzvA-2jirA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kpk | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00595(PDZ) | 5 | GLY A 33GLY A 34LEU A 46GLY A 28LEU A 20 | None | 1.03A | 4fzvA-2kpkA:undetectable | 4fzvA-2kpkA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mu3 | ACINIFORM SPIDROIN 1 (Argiopetrifasciata) |
PF12042(RP1-2) | 5 | PRO A 3GLY A 6GLY A 5GLY A 109LEU A 117 | None | 1.08A | 4fzvA-2mu3A:undetectable | 4fzvA-2mu3A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyu | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 (Homo sapiens) |
PF01728(FtsJ) | 5 | PRO A 33GLY A 34LEU A 63ASP A 79LEU A 123 | SAM A 201 (-3.4A)SAM A 201 (-3.7A)SAM A 201 (-4.2A)SAM A 201 (-3.3A)None | 1.07A | 4fzvA-2nyuA:8.5 | 4fzvA-2nyuA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oo3 | PROTEIN INVOLVED INCATABOLISM OFEXTERNAL DNA (Legionellapneumophila) |
PF04378(RsmJ) | 5 | GLY A 46GLY A 100LEU A 120ASP A 144GLY A 145 | None | 0.83A | 4fzvA-2oo3A:8.8 | 4fzvA-2oo3A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qed | HYDROXYACYLGLUTATHIONE HYDROLASE (Salmonellaenterica) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 5 | GLY A 132GLY A 133ASN A 209PRO A 204LEU A 160 | None | 1.03A | 4fzvA-2qedA:undetectable | 4fzvA-2qedA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 5 | GLY A 806GLY A 795LEU A 712SER A 708GLY A 716 | None | 0.91A | 4fzvA-2yocA:undetectable | 4fzvA-2yocA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywd | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermusthermophilus) |
PF01174(SNO) | 5 | PRO A 46GLY A 47GLY A 48LEU A 167LEU A 103 | None | 0.98A | 4fzvA-2ywdA:undetectable | 4fzvA-2ywdA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 7 | PRO A 270GLY A 271GLY A 272LYS A 273ASP A 318PRO A 339LEU A 371 | SFG A5748 (-3.6A)SFG A5748 (-3.7A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)SFG A5748 (-3.7A)SFG A5748 (-4.0A)None | 0.36A | 4fzvA-2yxlA:28.1 | 4fzvA-2yxlA:25.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsu | SPERMIDINE SYNTHASE (Pyrococcushorikoshii) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 88GLY A 89ASP A 144GLY A 145LEU A 172 | None | 0.59A | 4fzvA-2zsuA:10.8 | 4fzvA-2zsuA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 9 | CYH A 91PRO A 94GLY A 95GLY A 96LYS A 97SER A 117ASP A 142PRO A 165LEU A 193 | SFG A 500 (-3.8A)SFG A 500 (-3.9A)SFG A 500 (-4.0A)SFG A 500 (-3.5A)SFG A 500 (-2.8A)NoneSFG A 500 (-4.0A)SFG A 500 (-3.9A)None | 0.69A | 4fzvA-3a4tA:26.1 | 4fzvA-3a4tA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ada | SARCOSINE OXIDASEBETA SUBUNIT (Corynebacteriumsp. U-96) |
PF01266(DAO) | 5 | CYH B 350GLY B 356GLY B 355LEU B 223LEU B 240 | NoneFAD B 1 (-3.0A)FAD B 1 (-3.4A)NoneNone | 0.88A | 4fzvA-3adaB:undetectable | 4fzvA-3adaB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | GLY A1152GLY A1153ASP A1193PRO A1228LEU A1250 | SAM A 1 (-4.1A)SAM A 1 (-3.6A)SAM A 1 (-3.6A)SAM A 1 ( 4.2A)SAM A 1 (-4.6A) | 0.85A | 4fzvA-3av6A:7.2 | 4fzvA-3av6A:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg2 | DGTPTRIPHOSPHOHYDROLASE (Leeuwenhoekiellablandensis) |
PF01966(HD) | 5 | GLY A 211LEU A 230GLY A 228PRO A 244LEU A 7 | None | 1.06A | 4fzvA-3bg2A:undetectable | 4fzvA-3bg2A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1j | GLYCOGEN SYNTHASE (Escherichiacoli) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | GLY A 18GLY A 17LEU A 245ASP A 403GLY A 400 | None | 1.03A | 4fzvA-3d1jA:2.7 | 4fzvA-3d1jA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dou | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Thermoplasmavolcanium) |
PF01728(FtsJ) | 5 | PRO A 49GLY A 50GLY A 51LEU A 68ASP A 83 | SAM A 1 (-3.5A)SAM A 1 (-3.8A)SAM A 1 (-3.2A)SAM A 1 (-4.2A)SAM A 1 (-3.6A) | 0.66A | 4fzvA-3douA:8.9 | 4fzvA-3douA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f70 | LETHAL(3)MALIGNANTBRAIN TUMOR-LIKE 2PROTEIN (Homo sapiens) |
PF02820(MBT) | 5 | GLY A 351GLY A 350LEU A 374PRO A 550LEU A 547 | None | 0.96A | 4fzvA-3f70A:undetectable | 4fzvA-3f70A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3feo | MBTDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF02820(MBT) | 5 | GLY A 184GLY A 183LEU A 208PRO A 377LEU A 374 | None | 1.05A | 4fzvA-3feoA:undetectable | 4fzvA-3feoA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib5 | SEX PHEROMONEPRECURSOR (Lactobacillussalivarius) |
PF07537(CamS) | 5 | GLY A 372GLY A 371GLY A 313PRO A 344LEU A 311 | None | 0.98A | 4fzvA-3ib5A:undetectable | 4fzvA-3ib5A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jty | BENF-LIKE PORIN (Pseudomonasprotegens) |
PF03573(OprD) | 5 | GLY A 153ASN A 307SER A 184PRO A 143LEU A 148 | None | 1.03A | 4fzvA-3jtyA:undetectable | 4fzvA-3jtyA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kwe | CARBON DIOXIDECONCENTRATINGMECHANISM PROTEIN (Thermosynechococcuselongatus) |
PF00132(Hexapep) | 5 | PRO A 109GLY A 108GLY A 76ASP A 114GLY A 95 | None | 1.08A | 4fzvA-3kweA:undetectable | 4fzvA-3kweA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4x | NOL1/NOP2/SUN FAMILYPROTEIN (Enterococcusfaecium) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 7 | CYH A 113PRO A 116GLY A 117GLY A 118LYS A 119ASN A 136PRO A 184 | None | 0.34A | 4fzvA-3m4xA:27.7 | 4fzvA-3m4xA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 7 | PRO A 112GLY A 113GLY A 114LYS A 115ASN A 132PRO A 179LEU A 211 | None | 0.44A | 4fzvA-3m6xA:28.7 | 4fzvA-3m6xA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvd | REGULATOR OFCHROMOSOMECONDENSATION (Drosophilamelanogaster) |
PF00415(RCC1) | 5 | GLY K 83GLY K 82ASN K 374GLY K 372LEU K 377 | None | 1.00A | 4fzvA-3mvdK:undetectable | 4fzvA-3mvdK:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naw | SECRETED EFFECTORPROTEIN (Escherichiacoli) |
PF00805(Pentapeptide)PF13979(SopA_C)PF13981(SopA) | 5 | GLY A 337GLY A 338LEU A 386PRO A 311LEU A 343 | None | 1.08A | 4fzvA-3nawA:undetectable | 4fzvA-3nawA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk7 | TRANSCRIPTIONALREGULATORS (Yersinia pestis) |
PF00532(Peripla_BP_1) | 5 | PRO A 237GLY A 277LEU A 198GLY A 201PRO A 226 | None | 1.04A | 4fzvA-3qk7A:undetectable | 4fzvA-3qk7A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r18 | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | GLY A 374GLY A 375ASN A 188SER A 349GLY A 207 | None | 1.03A | 4fzvA-3r18A:undetectable | 4fzvA-3r18A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 105GLY A 106ASP A 155GLY A 156LEU A 184 | NoneNoneDSH A 303 (-3.5A)DSH A 303 (-3.7A)DSH A 303 (-4.2A) | 0.62A | 4fzvA-3rw9A:9.5 | 4fzvA-3rw9A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3udu | 3-ISOPROPYLMALATEDEHYDROGENASE (Campylobacterjejuni) |
PF00180(Iso_dh) | 5 | PRO A 276GLY A 278GLY A 279LEU A 107LEU A 139 | None | 0.99A | 4fzvA-3uduA:undetectable | 4fzvA-3uduA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3urh | DIHYDROLIPOYLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 246LEU A 270GLY A 167PRO A 175LEU A 171 | None | 0.94A | 4fzvA-3urhA:undetectable | 4fzvA-3urhA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | GLY A 391GLY A 392ASN A 431LEU A 433GLY A 109 | None | 1.07A | 4fzvA-3vrbA:undetectable | 4fzvA-3vrbA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpa | TRIMERICAUTOTRANSPORTERADHESIN (Acinetobactersp. Tol 5) |
PF05662(YadA_stalk) | 5 | PRO A3502GLY A3488GLY A3487ASP A3508GLY A3507 | None | 1.00A | 4fzvA-3wpaA:undetectable | 4fzvA-3wpaA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgo | EFEM M75 PEPTIDASE (Pseudomonassyringae) |
PF09375(Peptidase_M75) | 5 | GLY A 280LEU A 213ASP A 47GLY A 43PRO A 216 | None | 1.00A | 4fzvA-4bgoA:undetectable | 4fzvA-4bgoA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8q | DNA TOPOISOMERASE2-ASSOCIATED PROTEINPAT1 (Saccharomycescerevisiae) |
PF09770(PAT1) | 5 | GLY H 473GLY H 474ASN H 521SER H 517ASP H 514 | None | 1.06A | 4fzvA-4c8qH:undetectable | 4fzvA-4c8qH:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cze | RODSHAPE-DETERMININGPROTEIN MREB (Caulobactervibrioides) |
PF06723(MreB_Mbl) | 5 | CYH A 323GLY A 329LYS A 330LEU A 321GLY A 294 | None | 1.04A | 4fzvA-4czeA:undetectable | 4fzvA-4czeA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e9o | IMV MEMBRANE PROTEIN (Vaccinia virus) |
PF00194(Carb_anhydrase) | 5 | GLY X 50GLY X 49LYS X 48ASP X 112GLY X 113 | IOD X 306 ( 4.6A)IOD X 306 ( 4.4A)NoneNoneNone | 0.82A | 4fzvA-4e9oX:undetectable | 4fzvA-4e9oX:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl0 | AMINOTRANSFERASEALD1 (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 5 | PRO A 405GLY A 406GLY A 408LEU A 75GLY A 421 | None | 1.08A | 4fzvA-4fl0A:2.9 | 4fzvA-4fl0A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fms | PROBABLE PORIN (Pseudomonasaeruginosa) |
no annotation | 5 | GLY B 128ASN B 282SER B 159PRO B 118LEU B 123 | BDP B 401 ( 4.4A)NoneNoneNoneNone | 1.05A | 4fzvA-4fmsB:undetectable | 4fzvA-4fmsB:22.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 12 | CYH A 181PRO A 185GLY A 185GLY A 186LYS A 187ASN A 203LEU A 205SER A 206ASP A 237GLY A 238PRO A 257LEU A 291 | SAM A 401 (-3.9A)SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)SAM A 401 ( 4.6A)SAM A 401 (-3.8A)SAM A 401 (-4.8A)SAM A 401 (-3.5A)SAM A 401 (-3.5A)SAM A 401 (-4.0A)None | 0.04A | 4fzvA-4fzvA:63.9 | 4fzvA-4fzvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | PRO A 185GLY A 185GLY A 186LYS A 187SER A 208 | SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)None | 1.06A | 4fzvA-4fzvA:63.9 | 4fzvA-4fzvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hr3 | PUTATIVE ACYL-COADEHYDROGENASE (Mycobacteroidesabscessus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | PRO A 74GLY A 81ASN A 105LEU A 133GLY A 136 | None | 1.08A | 4fzvA-4hr3A:undetectable | 4fzvA-4hr3A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 236GLY A 237LEU A 255SER A 256ASP A 281 | NoneNoneSAH A 501 (-4.3A)SAH A 501 (-4.5A)SAH A 501 (-3.5A) | 0.46A | 4fzvA-4ineA:10.4 | 4fzvA-4ineA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 236GLY A 238LEU A 255SER A 256ASP A 281 | NoneNoneSAH A 501 (-4.3A)SAH A 501 (-4.5A)SAH A 501 (-3.5A) | 0.92A | 4fzvA-4ineA:10.4 | 4fzvA-4ineA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | GLY A 232GLY A 233LEU A 251SER A 252ASP A 277 | NoneNoneSAH A 701 (-4.4A)SAH A 701 (-4.7A)SAH A 701 (-3.4A) | 0.36A | 4fzvA-4kriA:11.2 | 4fzvA-4kriA:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | GLY A 232GLY A 234LEU A 251SER A 252ASP A 277 | NoneNoneSAH A 701 (-4.4A)SAH A 701 (-4.7A)SAH A 701 (-3.4A) | 0.90A | 4fzvA-4kriA:11.2 | 4fzvA-4kriA:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kto | ISOVALERYL-COADEHYDROGENASE (Sinorhizobiummeliloti) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | CYH A 99GLY A 243LEU A 171GLY A 126LEU A 119 | None | 1.00A | 4fzvA-4ktoA:undetectable | 4fzvA-4ktoA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m88 | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Verminephrobactereiseniae) |
PF13458(Peripla_BP_6) | 6 | GLY A 288GLY A 24ASP A 323GLY A 325PRO A 254LEU A 261 | None | 1.46A | 4fzvA-4m88A:3.1 | 4fzvA-4m88A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n49 | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF01728(FtsJ) | 7 | CYH A 277PRO A 280GLY A 281GLY A 282LEU A 302ASP A 335LEU A 383 | SAM A 601 (-3.7A)SAM A 601 (-3.6A)SAM A 601 (-3.6A)SAM A 601 (-3.1A)SAM A 601 (-4.1A)SAM A 601 (-3.6A)SAM A 601 (-4.6A) | 1.02A | 4fzvA-4n49A:7.9 | 4fzvA-4n49A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnq | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesatroolivaceus) |
PF00378(ECH_1) | 5 | CYH A 67GLY A 64GLY A 63GLY A 118LEU A 33 | None | 0.77A | 4fzvA-4nnqA:undetectable | 4fzvA-4nnqA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7y | METHIONINEGAMMA-LYASE (Citrobacterfreundii) |
PF01053(Cys_Met_Meta_PP) | 5 | PRO A 309GLY A 310LEU A 301ASP A 167LEU A 199 | None | 1.05A | 4fzvA-4p7yA:undetectable | 4fzvA-4p7yA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxx | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | GLY A1149GLY A1150ASP A1190PRO A1225LEU A1247 | SAH A1706 ( 4.3A)SAH A1706 (-3.2A)SAH A1706 (-3.3A)SAH A1706 ( 4.7A)SAH A1706 (-4.6A) | 0.89A | 4fzvA-4wxxA:6.8 | 4fzvA-4wxxA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x33 | PROTEIN ATS1 (Saccharomycescerevisiae) |
PF00415(RCC1) | 5 | GLY B 113GLY B 112LEU B 168SER B 167GLY B 151 | None | 0.97A | 4fzvA-4x33B:undetectable | 4fzvA-4x33B:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg8 | ENDOGLUCANASE (Perinereisbrevicirris) |
PF00759(Glyco_hydro_9) | 5 | GLY A 58GLY A 57LEU A 70ASP A 155LEU A 147 | None | 0.91A | 4fzvA-4zg8A:undetectable | 4fzvA-4zg8A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7m | BETA-XYLOSIDASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | PRO A 549GLY A 553GLY A 554ASP A 95GLY A 431 | NoneNoneNone ZN A1903 ( 2.1A)None | 0.84A | 4fzvA-5a7mA:undetectable | 4fzvA-5a7mA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dq9 | S55-3 FAB (IGG2B)HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY A 53GLY A 54ASN A 76GLY A 24LEU A 4 | KD2 A 301 (-3.6A)KD2 A 301 (-4.2A)NoneNoneNone | 0.98A | 4fzvA-5dq9A:undetectable | 4fzvA-5dq9A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx5 | METHIONINEGAMMA-LYASE (Clostridiumsporogenes) |
PF01053(Cys_Met_Meta_PP) | 5 | PRO A 311GLY A 312LEU A 303ASP A 167LEU A 201 | None | 1.01A | 4fzvA-5dx5A:undetectable | 4fzvA-5dx5A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eow | 6-HYDROXYNICOTINATE3-MONOOXYGENASE (Pseudomonasputida) |
PF01494(FAD_binding_3) | 5 | GLY A 171SER A 285ASP A 313GLY A 293PRO A 282 | NoneNoneNoneFAD A 401 (-3.2A)None | 0.90A | 4fzvA-5eowA:undetectable | 4fzvA-5eowA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esy | SAL1 PHOSPHATASE (Arabidopsisthaliana) |
PF00459(Inositol_P) | 5 | GLY A 124GLY A 125LEU A 152GLY A 163LEU A 162 | None | 0.93A | 4fzvA-5esyA:undetectable | 4fzvA-5esyA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f15 | 4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N)TRANSFERASE (Cupriavidusmetallidurans) |
PF13231(PMT_2) | 5 | PRO A 146GLY A 292GLY A 291GLY A 358LEU A 361 | NoneMPG A 603 ( 4.3A)MPG A 625 ( 3.7A)NoneNone | 0.90A | 4fzvA-5f15A:undetectable | 4fzvA-5f15A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | GLY A 306GLY A 305LEU A 283PRO A 281LEU A 59 | None | 0.87A | 4fzvA-5fyqA:undetectable | 4fzvA-5fyqA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hn4 | HOMOISOCITRATEDEHYDROGENASE (Thermococcuskodakarensis) |
PF00180(Iso_dh) | 5 | PRO A 300GLY A 304GLY A 303GLY A 314PRO A 264 | None | 1.04A | 4fzvA-5hn4A:undetectable | 4fzvA-5hn4A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 5 | CYH A 381GLY A 335GLY A 336ASP A 428GLY A 429 | None | 0.85A | 4fzvA-5ic7A:undetectable | 4fzvA-5ic7A:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lf7 | PROTEASOME SUBUNITBETA TYPE-1 (Homo sapiens) |
PF00227(Proteasome) | 5 | GLY L 139GLY L 138SER L 30GLY L 59LEU L 62 | None | 1.08A | 4fzvA-5lf7L:undetectable | 4fzvA-5lf7L:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lh9 | OMEGA TRANSAMINASE (Pseudomonas sp.) |
PF00202(Aminotran_3) | 5 | GLY A 229GLY A 228GLY A 352PRO A 425LEU A 377 | None | 1.09A | 4fzvA-5lh9A:undetectable | 4fzvA-5lh9A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m58 | C-METHYLTRANSFERASECOUO (Streptomycesrishiriensis) |
PF13649(Methyltransf_25) | 5 | CYH A 47GLY A 51LEU A 71SER A 72ASP A 96 | SAH A 301 (-3.4A)NoneSAH A 301 (-3.9A)SAH A 301 (-4.6A)SAH A 301 (-3.5A) | 0.58A | 4fzvA-5m58A:11.4 | 4fzvA-5m58A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mgz | 8-DEMETHYLNOVOBIOCICACIDC(8)-METHYLTRANSFERASE (Streptomycesniveus) |
PF13649(Methyltransf_25) | 5 | CYH A 47GLY A 51LEU A 71SER A 72ASP A 96 | SAH A 301 (-3.3A)NoneSAH A 301 (-3.8A)SAH A 301 (-4.6A)SAH A 301 (-3.5A) | 0.60A | 4fzvA-5mgzA:11.2 | 4fzvA-5mgzA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | PRO A 5GLY A 175GLY A 176SER A 97PRO A 9 | None | 0.97A | 4fzvA-5n7qA:undetectable | 4fzvA-5n7qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvj | ENHANCEDINTRACELLULARSURVIVAL PROTEIN (Mycobacteriumtuberculosis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | GLY A 160GLY A 159LEU A 218GLY A 222LEU A 252 | None | 1.08A | 4fzvA-5tvjA:undetectable | 4fzvA-5tvjA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | GLY A 450ASN A 445SER A 79GLY A 864LEU A 868 | None | 1.02A | 4fzvA-5um6A:3.5 | 4fzvA-5um6A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 295LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 703 (-4.1A)SAH A 703 (-4.5A)SAH A 703 (-3.3A) | 0.45A | 4fzvA-5wp4A:10.4 | 4fzvA-5wp4A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 296LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 703 (-4.1A)SAH A 703 (-4.5A)SAH A 703 (-3.3A) | 0.84A | 4fzvA-5wp4A:10.4 | 4fzvA-5wp4A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 295LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 501 (-3.9A)NoneSAH A 501 (-3.4A) | 0.47A | 4fzvA-5wp5A:10.4 | 4fzvA-5wp5A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 296LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 501 (-3.9A)NoneSAH A 501 (-3.4A) | 0.87A | 4fzvA-5wp5A:10.4 | 4fzvA-5wp5A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwt | PUTATIVEMETHYLTRANSFERASENSUN6 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 9 | CYH A 242PRO A 245GLY A 246GLY A 247LYS A 248ASP A 293GLY A 294PRO A 325LEU A 354 | None C C 72 ( 4.7A)NoneNone C C 72 ( 3.1A)NoneNoneNoneNone | 0.56A | 4fzvA-5wwtA:26.7 | 4fzvA-5wwtA:25.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgv | PYRE3 (Streptomycesrugosporus) |
no annotation | 5 | GLY A 43GLY A 44LEU A 174SER A 253GLY A 215 | FAD A 501 ( 3.9A)NoneNoneNoneNone | 1.07A | 4fzvA-5xgvA:undetectable | 4fzvA-5xgvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z6o | PROTEASE (Penicilliumcyclopium) |
no annotation | 5 | GLY A 87GLY A 83SER A 17ASP A 259LEU A 241 | None | 0.80A | 4fzvA-5z6oA:3.0 | 4fzvA-5z6oA:undetectable |