SIMILAR PATTERNS OF AMINO ACIDS FOR 4FZV_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 175
GLY A 176
SER A 249
GLY A 244
LEU A 207
 None
 1.09A 4fzvA-1b0kA:
undetectable		 4fzvA-1b0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		5 GLY A  11
GLY A  12
ASN A  28
ASP A  50
PRO A  70
 None
 0.85A 4fzvA-1dctA:
8.5		 4fzvA-1dctA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.98A 4fzvA-1dxlA:
undetectable		 4fzvA-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 PRO A  62
GLY A  63
GLY A  64
LEU A  84
ASP A  99
LEU A 143
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.6A)
 0.86A 4fzvA-1eizA:
9.4		 4fzvA-1eizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  86
GLY A  87
ASP A 141
GLY A 142
LEU A 169
 None
 0.61A 4fzvA-1mjfA:
10.3		 4fzvA-1mjfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A 184
ASN A  88
SER A  22
GLY A  14
PRO A 189
 None
NAD  A1300 (-3.3A)
None
NAD  A1300 (-3.5A)
NAD  A1300 (-3.5A)
 1.09A 4fzvA-1nffA:
4.2		 4fzvA-1nffA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o75 47 KDA MEMBRANE
ANTIGEN

(Treponema
pallidum) 		PF14888
(PBP-Tp47_c)
PF14889
(PBP-Tp47_a) 		5 GLY A  61
GLY A  59
SER A 284
GLY A 226
LEU A  45
 None
 1.05A 4fzvA-1o75A:
undetectable		 4fzvA-1o75A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 253
GLY A 252
SER A 266
GLY A 241
PRO A 213
 None
 1.09A 4fzvA-1pcaA:
undetectable		 4fzvA-1pcaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 CYH A 172
GLY A 207
SER A 150
GLY A 147
LEU A  98
 None
 1.09A 4fzvA-1rxtA:
undetectable		 4fzvA-1rxtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		7 CYH A 254
PRO A 257
GLY A 258
GLY A 259
ASP A 303
GLY A 304
PRO A 324
 None
 0.92A 4fzvA-1sqgA:
27.0		 4fzvA-1sqgA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjm BETA-SPECTRIN III

(Homo sapiens) 		PF15410
(PH_9) 		6 GLY A   7
ASN A 113
LEU A 109
SER A 107
GLY A  72
LEU A  87
 None
 1.31A 4fzvA-1wjmA:
undetectable		 4fzvA-1wjmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 285
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.6A)
 0.48A 4fzvA-2b9eA:
23.3		 4fzvA-2b9eA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.00A 4fzvA-2e0wA:
undetectable		 4fzvA-2e0wA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fzvA-2e0xA:
undetectable		 4fzvA-2e0xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.94A 4fzvA-2e0xA:
undetectable		 4fzvA-2e0xA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
ASN A 148
SER A 151
GLY A 177
PRO A 196
LEU A 228
 None
 0.73A 4fzvA-2frxA:
28.9		 4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
GLY A 129
ASN A 148
SER A 151
ASP A 176
GLY A 177
 None
 1.15A 4fzvA-2frxA:
28.9		 4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
PRO A 196
 None
 0.66A 4fzvA-2frxA:
28.9		 4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 128
GLY A 129
LYS A 131
SER A 151
PRO A 196
 None
 0.94A 4fzvA-2frxA:
28.9		 4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		5 PRO A 120
GLY A 121
GLY A 118
ASP A 509
GLY A 510
 None
 1.00A 4fzvA-2gp4A:
undetectable		 4fzvA-2gp4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		6 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
 None
 1.49A 4fzvA-2hb6A:
undetectable		 4fzvA-2hb6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.86A 4fzvA-2hzgA:
undetectable		 4fzvA-2hzgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		6 GLY A  22
GLY A  23
ASN A  39
ASP A  60
PRO A  80
LEU A 100
 None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
 1.01A 4fzvA-2i9kA:
8.2		 4fzvA-2i9kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima) 		PF01174
(SNO) 		5 PRO D  44
GLY D  45
GLY D  46
LEU D 165
LEU D  99
 None
 1.00A 4fzvA-2issD:
undetectable		 4fzvA-2issD:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 146
GLY A 147
GLY A 135
PRO A 711
LEU A 139
 None
None
None
None
MGD  A 811 ( 4.4A)
 1.01A 4fzvA-2jirA:
undetectable		 4fzvA-2jirA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.03A 4fzvA-2kpkA:
undetectable		 4fzvA-2kpkA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mu3 ACINIFORM SPIDROIN 1

(Argiope
trifasciata) 		PF12042
(RP1-2) 		5 PRO A   3
GLY A   6
GLY A   5
GLY A 109
LEU A 117
 None
 1.08A 4fzvA-2mu3A:
undetectable		 4fzvA-2mu3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 PRO A  33
GLY A  34
LEU A  63
ASP A  79
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
None
 1.07A 4fzvA-2nyuA:
8.5		 4fzvA-2nyuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA

(Legionella
pneumophila) 		PF04378
(RsmJ) 		5 GLY A  46
GLY A 100
LEU A 120
ASP A 144
GLY A 145
 None
 0.83A 4fzvA-2oo3A:
8.8		 4fzvA-2oo3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 GLY A 132
GLY A 133
ASN A 209
PRO A 204
LEU A 160
 None
 1.03A 4fzvA-2qedA:
undetectable		 4fzvA-2qedA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 GLY A 806
GLY A 795
LEU A 712
SER A 708
GLY A 716
 None
 0.91A 4fzvA-2yocA:
undetectable		 4fzvA-2yocA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 0.98A 4fzvA-2ywdA:
undetectable		 4fzvA-2ywdA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.36A 4fzvA-2yxlA:
28.1		 4fzvA-2yxlA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  88
GLY A  89
ASP A 144
GLY A 145
LEU A 172
 None
 0.59A 4fzvA-2zsuA:
10.8		 4fzvA-2zsuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
 0.69A 4fzvA-3a4tA:
26.1		 4fzvA-3a4tA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 CYH B 350
GLY B 356
GLY B 355
LEU B 223
LEU B 240
 None
FAD  B   1 (-3.0A)
FAD  B   1 (-3.4A)
None
None
 0.88A 4fzvA-3adaB:
undetectable		 4fzvA-3adaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1152
GLY A1153
ASP A1193
PRO A1228
LEU A1250
 SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
 0.85A 4fzvA-3av6A:
7.2		 4fzvA-3av6A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 GLY A 211
LEU A 230
GLY A 228
PRO A 244
LEU A   7
 None
 1.06A 4fzvA-3bg2A:
undetectable		 4fzvA-3bg2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLY A  18
GLY A  17
LEU A 245
ASP A 403
GLY A 400
 None
 1.03A 4fzvA-3d1jA:
2.7		 4fzvA-3d1jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 PRO A  49
GLY A  50
GLY A  51
LEU A  68
ASP A  83
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.6A)
 0.66A 4fzvA-3douA:
8.9		 4fzvA-3douA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.96A 4fzvA-3f70A:
undetectable		 4fzvA-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 184
GLY A 183
LEU A 208
PRO A 377
LEU A 374
 None
 1.05A 4fzvA-3feoA:
undetectable		 4fzvA-3feoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		5 GLY A 372
GLY A 371
GLY A 313
PRO A 344
LEU A 311
 None
 0.98A 4fzvA-3ib5A:
undetectable		 4fzvA-3ib5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		5 GLY A 153
ASN A 307
SER A 184
PRO A 143
LEU A 148
 None
 1.03A 4fzvA-3jtyA:
undetectable		 4fzvA-3jtyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwe CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN

(Thermosynechococcus
elongatus) 		PF00132
(Hexapep) 		5 PRO A 109
GLY A 108
GLY A  76
ASP A 114
GLY A  95
 None
 1.08A 4fzvA-3kweA:
undetectable		 4fzvA-3kweA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		7 CYH A 113
PRO A 116
GLY A 117
GLY A 118
LYS A 119
ASN A 136
PRO A 184
 None
 0.34A 4fzvA-3m4xA:
27.7		 4fzvA-3m4xA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		7 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
PRO A 179
LEU A 211
 None
 0.44A 4fzvA-3m6xA:
28.7		 4fzvA-3m6xA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K  83
GLY K  82
ASN K 374
GLY K 372
LEU K 377
 None
 1.00A 4fzvA-3mvdK:
undetectable		 4fzvA-3mvdK:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 GLY A 337
GLY A 338
LEU A 386
PRO A 311
LEU A 343
 None
 1.08A 4fzvA-3nawA:
undetectable		 4fzvA-3nawA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS

(Yersinia pestis) 		PF00532
(Peripla_BP_1) 		5 PRO A 237
GLY A 277
LEU A 198
GLY A 201
PRO A 226
 None
 1.04A 4fzvA-3qk7A:
undetectable		 4fzvA-3qk7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 GLY A 374
GLY A 375
ASN A 188
SER A 349
GLY A 207
 None
 1.03A 4fzvA-3r18A:
undetectable		 4fzvA-3r18A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 105
GLY A 106
ASP A 155
GLY A 156
LEU A 184
 None
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.62A 4fzvA-3rw9A:
9.5		 4fzvA-3rw9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 PRO A 276
GLY A 278
GLY A 279
LEU A 107
LEU A 139
 None
 0.99A 4fzvA-3uduA:
undetectable		 4fzvA-3uduA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.94A 4fzvA-3urhA:
undetectable		 4fzvA-3urhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.07A 4fzvA-3vrbA:
undetectable		 4fzvA-3vrbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpa TRIMERIC
AUTOTRANSPORTER
ADHESIN

(Acinetobacter
sp. Tol 5) 		PF05662
(YadA_stalk) 		5 PRO A3502
GLY A3488
GLY A3487
ASP A3508
GLY A3507
 None
 1.00A 4fzvA-3wpaA:
undetectable		 4fzvA-3wpaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgo EFEM M75 PEPTIDASE

(Pseudomonas
syringae) 		PF09375
(Peptidase_M75) 		5 GLY A 280
LEU A 213
ASP A  47
GLY A  43
PRO A 216
 None
 1.00A 4fzvA-4bgoA:
undetectable		 4fzvA-4bgoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 GLY H 473
GLY H 474
ASN H 521
SER H 517
ASP H 514
 None
 1.06A 4fzvA-4c8qH:
undetectable		 4fzvA-4c8qH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.04A 4fzvA-4czeA:
undetectable		 4fzvA-4czeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9o IMV MEMBRANE PROTEIN

(Vaccinia virus) 		PF00194
(Carb_anhydrase) 		5 GLY X  50
GLY X  49
LYS X  48
ASP X 112
GLY X 113
 IOD  X 306 ( 4.6A)
IOD  X 306 ( 4.4A)
None
None
None
 0.82A 4fzvA-4e9oX:
undetectable		 4fzvA-4e9oX:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.08A 4fzvA-4fl0A:
2.9		 4fzvA-4fl0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fms PROBABLE PORIN

(Pseudomonas
aeruginosa) 		no annotation 5 GLY B 128
ASN B 282
SER B 159
PRO B 118
LEU B 123
 BDP  B 401 ( 4.4A)
None
None
None
None
 1.05A 4fzvA-4fmsB:
undetectable		 4fzvA-4fmsB:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
ASP A 237
GLY A 238
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
 0.04A 4fzvA-4fzvA:
63.9		 4fzvA-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.06A 4fzvA-4fzvA:
63.9		 4fzvA-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.08A 4fzvA-4hr3A:
undetectable		 4fzvA-4hr3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.46A 4fzvA-4ineA:
10.4		 4fzvA-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 GLY A 236
GLY A 238
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.92A 4fzvA-4ineA:
10.4		 4fzvA-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 GLY A 232
GLY A 233
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.36A 4fzvA-4kriA:
11.2		 4fzvA-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 GLY A 232
GLY A 234
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.90A 4fzvA-4kriA:
11.2		 4fzvA-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.00A 4fzvA-4ktoA:
undetectable		 4fzvA-4ktoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		6 GLY A 288
GLY A  24
ASP A 323
GLY A 325
PRO A 254
LEU A 261
 None
 1.46A 4fzvA-4m88A:
3.1		 4fzvA-4m88A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 335
LEU A 383
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
 1.02A 4fzvA-4n49A:
7.9		 4fzvA-4n49A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.77A 4fzvA-4nnqA:
undetectable		 4fzvA-4nnqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7y METHIONINE
GAMMA-LYASE

(Citrobacter
freundii) 		PF01053
(Cys_Met_Meta_PP) 		5 PRO A 309
GLY A 310
LEU A 301
ASP A 167
LEU A 199
 None
 1.05A 4fzvA-4p7yA:
undetectable		 4fzvA-4p7yA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1149
GLY A1150
ASP A1190
PRO A1225
LEU A1247
 SAH  A1706 ( 4.3A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
 0.89A 4fzvA-4wxxA:
6.8		 4fzvA-4wxxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		5 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.97A 4fzvA-4x33B:
undetectable		 4fzvA-4x33B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 GLY A  58
GLY A  57
LEU A  70
ASP A 155
LEU A 147
 None
 0.91A 4fzvA-4zg8A:
undetectable		 4fzvA-4zg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 PRO A 549
GLY A 553
GLY A 554
ASP A  95
GLY A 431
 None
None
None
ZN  A1903 ( 2.1A)
None
 0.84A 4fzvA-5a7mA:
undetectable		 4fzvA-5a7mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.98A 4fzvA-5dq9A:
undetectable		 4fzvA-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 PRO A 311
GLY A 312
LEU A 303
ASP A 167
LEU A 201
 None
 1.01A 4fzvA-5dx5A:
undetectable		 4fzvA-5dx5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY A 171
SER A 285
ASP A 313
GLY A 293
PRO A 282
 None
None
None
FAD  A 401 (-3.2A)
None
 0.90A 4fzvA-5eowA:
undetectable		 4fzvA-5eowA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		5 GLY A 124
GLY A 125
LEU A 152
GLY A 163
LEU A 162
 None
 0.93A 4fzvA-5esyA:
undetectable		 4fzvA-5esyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.90A 4fzvA-5f15A:
undetectable		 4fzvA-5f15A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.87A 4fzvA-5fyqA:
undetectable		 4fzvA-5fyqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.04A 4fzvA-5hn4A:
undetectable		 4fzvA-5hn4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
 None
 0.85A 4fzvA-5ic7A:
undetectable		 4fzvA-5ic7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf7 PROTEASOME SUBUNIT
BETA TYPE-1

(Homo sapiens) 		PF00227
(Proteasome) 		5 GLY L 139
GLY L 138
SER L  30
GLY L  59
LEU L  62
 None
 1.08A 4fzvA-5lf7L:
undetectable		 4fzvA-5lf7L:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 GLY A 229
GLY A 228
GLY A 352
PRO A 425
LEU A 377
 None
 1.09A 4fzvA-5lh9A:
undetectable		 4fzvA-5lh9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		5 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.58A 4fzvA-5m58A:
11.4		 4fzvA-5m58A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		5 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.60A 4fzvA-5mgzA:
11.2		 4fzvA-5mgzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 PRO A   5
GLY A 175
GLY A 176
SER A  97
PRO A   9
 None
 0.97A 4fzvA-5n7qA:
undetectable		 4fzvA-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 GLY A 160
GLY A 159
LEU A 218
GLY A 222
LEU A 252
 None
 1.08A 4fzvA-5tvjA:
undetectable		 4fzvA-5tvjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.02A 4fzvA-5um6A:
3.5		 4fzvA-5um6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.45A 4fzvA-5wp4A:
10.4		 4fzvA-5wp4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.84A 4fzvA-5wp4A:
10.4		 4fzvA-5wp4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.47A 4fzvA-5wp5A:
10.4		 4fzvA-5wp5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.87A 4fzvA-5wp5A:
10.4		 4fzvA-5wp5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
None
None
None
 0.56A 4fzvA-5wwtA:
26.7		 4fzvA-5wwtA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A  43
GLY A  44
LEU A 174
SER A 253
GLY A 215
 FAD  A 501 ( 3.9A)
None
None
None
None
 1.07A 4fzvA-5xgvA:
undetectable		 4fzvA-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium) 		no annotation 5 GLY A  87
GLY A  83
SER A  17
ASP A 259
LEU A 241
 None
 0.80A 4fzvA-5z6oA:
3.0		 4fzvA-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASP A 179
ARG A 174
ASP A 370
 None
 0.87A 4fzvA-1bf2A:
undetectable		 4fzvA-1bf2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		3 ASP A  42
ARG A  20
ASP A 130
 None
 0.88A 4fzvA-1e3hA:
undetectable		 4fzvA-1e3hA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		3 ASP A 382
ARG A 490
ASP A 340
 None
 0.87A 4fzvA-1fkmA:
undetectable		 4fzvA-1fkmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASP B 856
ARG B 377
ASP B 881
 None
 0.79A 4fzvA-1gl9B:
undetectable		 4fzvA-1gl9B:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gs9 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 ASP A 151
ARG A 103
ASP A 110
 None
 0.84A 4fzvA-1gs9A:
undetectable		 4fzvA-1gs9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ASP A  77
ARG A  72
ASP A  88
 None
 0.78A 4fzvA-1gsqA:
undetectable		 4fzvA-1gsqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		3 ASP A 130
ARG A 122
ASP A 175
 None
 0.79A 4fzvA-1hg0A:
undetectable		 4fzvA-1hg0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 429
ARG A 430
ASP A 169
 None
 0.83A 4fzvA-1hwwA:
undetectable		 4fzvA-1hwwA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		3 ASP A  34
ARG A  64
ASP A  27
 None
 0.78A 4fzvA-1l2uA:
undetectable		 4fzvA-1l2uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 518
ARG A 545
ASP A   9
 None
 0.88A 4fzvA-1qhoA:
undetectable		 4fzvA-1qhoA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ASP A 302
ARG A 306
ASP A  78
 None
 0.83A 4fzvA-1qlbA:
undetectable		 4fzvA-1qlbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		3 ASP A 123
ARG A 125
ASP A 112
 None
 0.82A 4fzvA-1qxoA:
undetectable		 4fzvA-1qxoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ASP A 483
ARG A 487
ASP A 386
 None
 0.85A 4fzvA-1ut9A:
undetectable		 4fzvA-1ut9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ASP A 412
ARG A 415
ASP A   4
 None
 0.79A 4fzvA-1v4gA:
undetectable		 4fzvA-1v4gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		3 ASP C 304
ARG C 146
ASP C 238
 None
 0.87A 4fzvA-1vrnC:
undetectable		 4fzvA-1vrnC:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP X 107
ARG X  38
ASP X  85
 None
 0.86A 4fzvA-1w52X:
undetectable		 4fzvA-1w52X:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		3 ASP A 136
ARG A 137
ASP A 468
 None
 0.85A 4fzvA-1yisA:
undetectable		 4fzvA-1yisA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 ASP A 195
ARG A  91
ASP A 221
 None
 0.84A 4fzvA-1z6rA:
undetectable		 4fzvA-1z6rA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.73A 4fzvA-2aeuA:
undetectable		 4fzvA-2aeuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.89A 4fzvA-2an2A:
undetectable		 4fzvA-2an2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 ASP A 337
ARG A 176
ASP A 266
 None
 0.86A 4fzvA-2axqA:
4.2		 4fzvA-2axqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.80A 4fzvA-2b9eA:
23.2		 4fzvA-2b9eA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASP A 160
ARG A 156
ASP A  84
 None
 0.81A 4fzvA-2f6dA:
undetectable		 4fzvA-2f6dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 ASP A 130
ARG A 122
ASP A 175
 None
 0.76A 4fzvA-2jk0A:
undetectable		 4fzvA-2jk0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4z DSRR

(Allochromatium
vinosum) 		PF01521
(Fe-S_biosyn) 		3 ASP A  51
ARG A  27
ASP A  66
 None
 0.72A 4fzvA-2k4zA:
undetectable		 4fzvA-2k4zA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.81A 4fzvA-2kbqA:
undetectable		 4fzvA-2kbqA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		3 ASP A 131
ARG A 133
ASP A  75
 None
 0.65A 4fzvA-2m5tA:
undetectable		 4fzvA-2m5tA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		3 ASP A  53
ARG A  31
ASP A  77
 None
 0.80A 4fzvA-2pblA:
undetectable		 4fzvA-2pblA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ASP A   3
ARG A 137
ASP A  43
 None
 0.82A 4fzvA-2rcqA:
undetectable		 4fzvA-2rcqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ASP A   3
ARG A 137
ASP A  45
 None
 0.75A 4fzvA-2rcqA:
undetectable		 4fzvA-2rcqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 612
ARG A 642
ASP A 104
 None
 0.79A 4fzvA-2va8A:
undetectable		 4fzvA-2va8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ASP A 257
ARG A 252
ASP A 286
 None
 0.81A 4fzvA-2vakA:
undetectable		 4fzvA-2vakA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.55A 4fzvA-2vp3A:
7.0		 4fzvA-2vp3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		3 ASP A 120
ARG A 121
ASP A 248
 FRU  A1335 (-2.5A)
FRU  A1335 (-4.1A)
FRU  A1335 (-2.8A)
 0.83A 4fzvA-2x7xA:
undetectable		 4fzvA-2x7xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A  58
ARG A  39
ASP A 106
 None
 0.81A 4fzvA-2z81A:
undetectable		 4fzvA-2z81A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		3 ASP P 354
ARG P 222
ASP P 181
 None
 0.71A 4fzvA-3c5wP:
undetectable		 4fzvA-3c5wP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		3 ASP A 186
ARG A 218
ASP A 269
 None
 0.81A 4fzvA-3e5mA:
4.4		 4fzvA-3e5mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frm UNCHARACTERIZED
CONSERVED PROTEIN

(Staphylococcus
epidermidis) 		PF13673
(Acetyltransf_10) 		3 ASP A 177
ARG A 163
ASP A  12
 None
 0.77A 4fzvA-3frmA:
undetectable		 4fzvA-3frmA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		3 ASP A  37
ARG A 100
ASP A 367
 None
 0.86A 4fzvA-3gwbA:
undetectable		 4fzvA-3gwbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		3 ASP A 109
ARG A 153
ASP A  75
 None
 0.83A 4fzvA-3h7uA:
undetectable		 4fzvA-3h7uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		3 ASP A 218
ARG A 272
ASP A 240
 None
 0.87A 4fzvA-3i2nA:
undetectable		 4fzvA-3i2nA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 268
ARG A 239
ASP A 243
 NA  A 387 ( 4.2A)
None
None
 0.82A 4fzvA-3i6eA:
undetectable		 4fzvA-3i6eA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		3 ASP A  84
ARG A  91
ASP A 147
 None
NHE  A   1 (-3.9A)
None
 0.71A 4fzvA-3k0zA:
undetectable		 4fzvA-3k0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.69A 4fzvA-3lahA:
undetectable		 4fzvA-3lahA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ASP A 155
ARG A 159
ASP A 239
 None
 0.78A 4fzvA-3moiA:
undetectable		 4fzvA-3moiA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ASP A 192
ARG A 399
ASP A 157
 SO4  A 434 ( 4.8A)
SO4  A 434 (-3.1A)
None
 0.82A 4fzvA-3nwrA:
undetectable		 4fzvA-3nwrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A  76
ARG A  33
ASP A 157
 None
 0.85A 4fzvA-3ppsA:
undetectable		 4fzvA-3ppsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		3 ASP A 149
ARG A 315
ASP A 142
 None
 0.75A 4fzvA-3psgA:
undetectable		 4fzvA-3psgA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 ASP A 626
ARG A 629
ASP A 668
 None
 0.77A 4fzvA-3sfzA:
undetectable		 4fzvA-3sfzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		3 ASP A 151
ARG A  91
ASP A 145
 None
 0.73A 4fzvA-3tosA:
undetectable		 4fzvA-3tosA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ASP A 294
ARG A 299
ASP A 267
 None
None
MN  A 601 ( 4.6A)
 0.86A 4fzvA-3u95A:
4.6		 4fzvA-3u95A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A 247
ARG A 248
ASP A  11
 ZN  A 474 ( 2.5A)
GOL  A 472 ( 4.0A)
None
 0.88A 4fzvA-3uw2A:
undetectable		 4fzvA-3uw2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		3 ASP A 241
ARG A 212
ASP A  94
 None
 0.82A 4fzvA-3wecA:
undetectable		 4fzvA-3wecA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		3 ASP A 143
ARG A 197
ASP A 115
 None
AQA  A1338 (-3.2A)
None
 0.86A 4fzvA-3zscA:
undetectable		 4fzvA-3zscA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 ASP A 329
ARG A 347
ASP A 373
 None
 0.87A 4fzvA-4af1A:
undetectable		 4fzvA-4af1A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ASP A  64
ARG A  27
ASP A  53
 None
 0.87A 4fzvA-4fnqA:
undetectable		 4fzvA-4fnqA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.02A 4fzvA-4fzvA:
63.9		 4fzvA-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		3 ASP A 565
ARG A 615
ASP A 515
 None
 0.78A 4fzvA-4g3nA:
undetectable		 4fzvA-4g3nA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0k CD276 ANTIGEN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		3 ASP A 116
ARG A 113
ASP A  45
 None
SO4  A 306 (-2.4A)
None
 0.76A 4fzvA-4i0kA:
undetectable		 4fzvA-4i0kA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9x PROTEIN UL141

(Human
betaherpesvirus
5) 		PF16758
(UL141) 		3 ASP A  91
ARG A 110
ASP A  88
 None
 0.89A 4fzvA-4i9xA:
undetectable		 4fzvA-4i9xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT

(Brucella
abortus) 		PF00132
(Hexapep) 		3 ASP A  48
ARG A  46
ASP A  69
 PE5  A 202 ( 4.0A)
PE5  A 202 (-4.0A)
PE5  A 202 (-3.9A)
 0.88A 4fzvA-4n27A:
undetectable		 4fzvA-4n27A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A 303
ARG A 304
ASP A  57
 MG  A 601 (-1.7A)
MG  A 601 ( 4.7A)
None
 0.83A 4fzvA-4qg5A:
undetectable		 4fzvA-4qg5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.82A 4fzvA-4rgkA:
undetectable		 4fzvA-4rgkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		3 ASP A 589
ARG A 530
ASP A 586
 None
None
GOL  A 605 ( 4.8A)
 0.83A 4fzvA-4tlvA:
undetectable		 4fzvA-4tlvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ASP A 406
ARG A 402
ASP A 414
 EDO  A 708 (-4.7A)
None
None
 0.87A 4fzvA-4wd1A:
2.5		 4fzvA-4wd1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ASP C  74
ARG C  76
ASP C  43
 None
 0.87A 4fzvA-4xl5C:
undetectable		 4fzvA-4xl5C:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ASP A 294
ARG A 305
ASP A 287
 None
 0.82A 4fzvA-4ydhA:
undetectable		 4fzvA-4ydhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		3 ASP A 366
ARG A 362
ASP A 450
 None
 0.87A 4fzvA-4z2eA:
undetectable		 4fzvA-4z2eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 ASP A 381
ARG A 336
ASP A 374
 None
 0.74A 4fzvA-4zc0A:
undetectable		 4fzvA-4zc0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		3 ASP A 120
ARG A 122
ASP A  89
 None
 0.88A 4fzvA-4zv6A:
undetectable		 4fzvA-4zv6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		3 ASP 6  81
ARG 6 103
ASP 6  26
 None
 0.79A 4fzvA-5ady6:
undetectable		 4fzvA-5ady6:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		3 ASP A 116
ARG A 187
ASP A 109
 None
 0.81A 4fzvA-5b7nA:
undetectable		 4fzvA-5b7nA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASP A 254
ARG A 252
ASP A 259
 None
 0.84A 4fzvA-5bp1A:
undetectable		 4fzvA-5bp1A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		3 ASP A 143
ARG A 147
ASP A 130
 None
 0.79A 4fzvA-5diyA:
undetectable		 4fzvA-5diyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwu CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
CYTOKINE RECEPTOR
COMMON SUBUNIT BETA

(Homo sapiens;
Homo sapiens) 		no annotation
PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 ASP A 116
ARG A 117
ASP B 241
 NAG  A 301 ( 4.9A)
None
None
 0.78A 4fzvA-5dwuA:
undetectable		 4fzvA-5dwuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		3 ASP A  66
ARG A  68
ASP A  94
 None
 0.69A 4fzvA-5gnmA:
undetectable		 4fzvA-5gnmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 3 ASP A 178
ARG A 276
ASP A 150
 None
 0.71A 4fzvA-5gt5A:
undetectable		 4fzvA-5gt5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		3 ASP A  54
ARG A  52
ASP A 390
 None
 0.82A 4fzvA-5hs1A:
undetectable		 4fzvA-5hs1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j46 PEPTIDE DEFORMYLASE

(Burkholderia
multivorans) 		PF01327
(Pep_deformylase) 		3 ASP A  39
ARG A  41
ASP A  36
 None
 0.56A 4fzvA-5j46A:
undetectable		 4fzvA-5j46A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		3 ASP A 106
ARG A 149
ASP A  72
 None
 0.88A 4fzvA-5jh1A:
undetectable		 4fzvA-5jh1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 ASP A  55
ARG A  53
ASP A 391
 None
 0.85A 4fzvA-5jlcA:
undetectable		 4fzvA-5jlcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		3 ASP A 305
ARG A 306
ASP A 274
 None
 0.82A 4fzvA-5jp9A:
undetectable		 4fzvA-5jp9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 3 ASP B 871
ARG B 851
ASP B 895
 None
 0.86A 4fzvA-5kdjB:
undetectable		 4fzvA-5kdjB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		3 ASP A  87
ARG A   9
ASP A 138
 None
 0.85A 4fzvA-5koiA:
4.7		 4fzvA-5koiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6

(Schizosaccharomyces
pombe) 		no annotation 3 ASP B 654
ARG B 656
ASP B 676
 None
 0.85A 4fzvA-5mg8B:
undetectable		 4fzvA-5mg8B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP0

(Parechovirus A;
Parechovirus A) 		no annotation
PF00073
(Rhv) 		3 ASP A 134
ARG A 139
ASP C 288
 None
 0.88A 4fzvA-5mjvA:
undetectable		 4fzvA-5mjvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzv NANOBODY 22E11

(Lama glama) 		no annotation 3 ASP D  66
ARG D  67
ASP D  62
 None
 0.79A 4fzvA-5mzvD:
undetectable		 4fzvA-5mzvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-) 		no annotation 3 ASP A  88
ARG A  89
ASP A 223
 AHR  A 407 ( 2.6A)
FUB  A 408 ( 3.9A)
AHR  A 407 ( 2.8A)
 0.87A 4fzvA-5ocpA:
undetectable		 4fzvA-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE

(Amycolatopsis
methanolica) 		no annotation 3 ASP A 247
ARG A 164
ASP A 272
 None
 0.77A 4fzvA-5ogxA:
undetectable		 4fzvA-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		3 ASP A 149
ARG A 316
ASP A 142
 None
 0.81A 4fzvA-5pepA:
undetectable		 4fzvA-5pepA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pq9 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		3 ASP A  50
ARG A  53
ASP A  76
 None
 0.88A 4fzvA-5pq9A:
undetectable		 4fzvA-5pq9A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A 298
ARG A 300
ASP A 271
 None
 0.89A 4fzvA-5tg8A:
undetectable		 4fzvA-5tg8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 488
ARG A 508
ASP A  56
 None
 0.77A 4fzvA-5vpuA:
2.7		 4fzvA-5vpuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 3 ASP C 237
ARG C 244
ASP C 208
 CA  C 407 (-2.7A)
None
None
 0.61A 4fzvA-5w4tC:
undetectable		 4fzvA-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.69A 4fzvA-5wm4A:
undetectable		 4fzvA-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		3 ASP A 128
ARG A 173
ASP A 122
 None
 0.81A 4fzvA-5wzrA:
undetectable		 4fzvA-5wzrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydn GENE PRODUCT J

(Escherichia
virus Mu) 		no annotation 3 ASP A  19
ARG A  15
ASP A  32
 None
 0.81A 4fzvA-5ydnA:
undetectable		 4fzvA-5ydnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0e 1260 ANTIBODY, HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASP B  95
ARG B  96
ASP B  58
 None
 0.73A 4fzvA-6b0eB:
undetectable		 4fzvA-6b0eB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.59A 4fzvA-6dg4A:
undetectable		 4fzvA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 856
ARG A 900
ASP A 793
 None
 0.83A 4fzvA-6eojA:
undetectable		 4fzvA-6eojA:
13.78