SIMILAR PATTERNS OF AMINO ACIDS FOR 4FVQ_A_ACTA904

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		3 PHE A  34
VAL A  67
GLU A  80
 None
 0.65A 4fvqA-1a5iA:
0.1		 4fvqA-1a5iA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avg TRIABIN

(Meccus
pallidipennis) 		PF03973
(Triabin) 		3 PHE I  67
VAL I  38
GLU I  55
 None
 0.71A 4fvqA-1avgI:
0.0		 4fvqA-1avgI:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		3 PHE A 152
VAL A 205
GLU A 196
 None
EDO  A   1 (-4.6A)
None
 0.83A 4fvqA-1dciA:
0.0		 4fvqA-1dciA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		3 PHE A 202
VAL A 266
GLU A 163
 None
 0.56A 4fvqA-1iz1A:
undetectable		 4fvqA-1iz1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 PHE A 134
VAL A 154
GLU A 104
 None
 0.75A 4fvqA-1j6uA:
0.0		 4fvqA-1j6uA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oq1 PROTEIN YESU

(Bacillus
subtilis) 		PF09224
(DUF1961) 		3 PHE A  78
VAL A  49
GLU A  25
 None
 0.78A 4fvqA-1oq1A:
0.0		 4fvqA-1oq1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		3 PHE A 102
VAL A 620
GLU A 614
 None
 0.76A 4fvqA-1pemA:
0.0		 4fvqA-1pemA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		3 PHE A  24
VAL A   3
GLU A 108
 None
 0.79A 4fvqA-1q77A:
undetectable		 4fvqA-1q77A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq1 CHORISMATE SYNTHASE

(Campylobacter
jejuni) 		PF01264
(Chorismate_synt) 		3 PHE A 179
VAL A 330
GLU A  42
 None
 0.69A 4fvqA-1sq1A:
0.0		 4fvqA-1sq1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuz DIACYLGLYCEROL
KINASE ALPHA

(Homo sapiens) 		PF14513
(DAG_kinase_N) 		3 PHE A  53
VAL A  94
GLU A  79
 None
 0.68A 4fvqA-1tuzA:
undetectable		 4fvqA-1tuzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 PHE A 327
VAL A  54
GLU A  50
 None
 0.80A 4fvqA-1wqlA:
undetectable		 4fvqA-1wqlA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfl THIOREDOXIN H1

(Arabidopsis
thaliana) 		PF00085
(Thioredoxin) 		3 PHE A  87
VAL A  97
GLU A 104
 None
 0.79A 4fvqA-1xflA:
undetectable		 4fvqA-1xflA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		3 PHE A  26
VAL A  89
GLU A 142
 None
 0.78A 4fvqA-1xkqA:
undetectable		 4fvqA-1xkqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		3 PHE A  70
VAL A  73
GLU A  96
 None
 0.80A 4fvqA-2bolA:
undetectable		 4fvqA-2bolA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw2 BYPASS OF FORESPORE
C

(Bacillus
subtilis) 		PF08955
(BofC_C)
PF08977
(BOFC_N) 		3 PHE A  58
VAL A  13
GLU A  31
 None
 0.65A 4fvqA-2bw2A:
undetectable		 4fvqA-2bw2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1u DI-HAEM CYTOCHROME C
PEROXIDASE

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 PHE A 274
VAL A 279
GLU A 284
 HEC  A 402 (-4.3A)
None
None
 0.84A 4fvqA-2c1uA:
undetectable		 4fvqA-2c1uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 PHE A  19
VAL A 270
GLU A 273
 None
 0.84A 4fvqA-2cy7A:
undetectable		 4fvqA-2cy7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmu HOMEOBOX PROTEIN
GOOSECOID

(Homo sapiens) 		PF00046
(Homeobox) 		3 PHE A  55
VAL A  51
GLU A  48
 None
 0.81A 4fvqA-2dmuA:
undetectable		 4fvqA-2dmuA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		3 PHE A  45
VAL A  83
GLU A  58
 None
 0.69A 4fvqA-2e11A:
undetectable		 4fvqA-2e11A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		3 PHE A  56
VAL A  47
GLU A 156
 None
 0.75A 4fvqA-2fg5A:
undetectable		 4fvqA-2fg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 PHE B 180
VAL B 111
GLU B 134
 None
 0.80A 4fvqA-2fhxB:
undetectable		 4fvqA-2fhxB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grx PROTEIN TONB

(Escherichia
coli) 		PF03544
(TonB_C) 		3 PHE C 230
VAL C 176
GLU C 203
 PHE  C 230 ( 1.3A)
VAL  C 176 ( 0.6A)
GLU  C 203 ( 0.6A)
 0.58A 4fvqA-2grxC:
undetectable		 4fvqA-2grxC:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk PROTEIN TONB

(Escherichia
coli) 		PF03544
(TonB_C) 		3 PHE B 230
VAL B 176
GLU B 203
 None
 0.55A 4fvqA-2gskB:
undetectable		 4fvqA-2gskB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PHE A 120
VAL A 299
GLU A 297
 None
 0.82A 4fvqA-2hdiA:
undetectable		 4fvqA-2hdiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 PHE A 136
VAL A 134
GLU A 128
 None
 0.79A 4fvqA-2hqmA:
undetectable		 4fvqA-2hqmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2n SENSOR PROTEIN

(Synechococcus
sp. RCC307) 		PF01590
(GAF) 		3 PHE A  45
VAL A 183
GLU A 180
 None
 0.75A 4fvqA-2k2nA:
undetectable		 4fvqA-2k2nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcn CD2-ASSOCIATED
PROTEIN

(Mus musculus) 		PF14604
(SH3_9) 		3 PHE A  49
VAL A   6
GLU A  24
 None
 0.58A 4fvqA-2mcnA:
undetectable		 4fvqA-2mcnA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		3 PHE A 216
VAL A 199
GLU A 339
 None
 0.83A 4fvqA-2qxlA:
undetectable		 4fvqA-2qxlA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		3 PHE A 127
VAL A 180
GLU A 171
 None
 0.81A 4fvqA-2vreA:
undetectable		 4fvqA-2vreA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 PHE A  25
VAL A 109
GLU A 106
 None
 0.83A 4fvqA-2z1uA:
undetectable		 4fvqA-2z1uA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z84 UFM1-SPECIFIC
PROTEASE 1

(Mus musculus) 		PF07910
(Peptidase_C78) 		3 PHE A 203
VAL A 199
GLU A 131
 None
 0.75A 4fvqA-2z84A:
undetectable		 4fvqA-2z84A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 PHE A 187
VAL A 185
GLU A 174
 None
 0.84A 4fvqA-2zsgA:
undetectable		 4fvqA-2zsgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 PHE A 159
VAL A 207
GLU A 211
 None
 0.83A 4fvqA-3aqsA:
undetectable		 4fvqA-3aqsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		3 PHE A 188
VAL A 190
GLU A 171
 None
None
FMC  A 229 (-4.7A)
 0.78A 4fvqA-3bl6A:
undetectable		 4fvqA-3bl6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		3 PHE A 208
VAL A 243
GLU A 220
 None
 0.83A 4fvqA-3cxlA:
undetectable		 4fvqA-3cxlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7a UPF0201 PROTEIN
PH1010

(Pyrococcus
horikoshii) 		PF01877
(RNA_binding) 		3 PHE A  39
VAL A  48
GLU A   9
 None
 0.78A 4fvqA-3d7aA:
undetectable		 4fvqA-3d7aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PHE A 685
VAL A 651
GLU A 617
 None
 0.81A 4fvqA-3ddrA:
undetectable		 4fvqA-3ddrA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		3 PHE A  70
VAL A 301
GLU A  88
 None
None
GAL  A 701 (-3.1A)
 0.80A 4fvqA-3dh4A:
undetectable		 4fvqA-3dh4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		3 PHE A 190
VAL A 192
GLU A 173
 None
 0.78A 4fvqA-3dp9A:
undetectable		 4fvqA-3dp9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		3 PHE A 452
VAL A 221
GLU A 231
 None
 0.80A 4fvqA-3e0jA:
undetectable		 4fvqA-3e0jA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		3 PHE A 279
VAL A 313
GLU A 309
 None
 0.79A 4fvqA-3e2vA:
0.0		 4fvqA-3e2vA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		3 PHE A 181
VAL A 248
GLU A 259
 None
 0.75A 4fvqA-3ed3A:
undetectable		 4fvqA-3ed3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enp TP53RK-BINDING
PROTEIN

(Homo sapiens) 		PF08617
(CGI-121) 		3 PHE A  96
VAL A  47
GLU A 144
 None
 0.59A 4fvqA-3enpA:
undetectable		 4fvqA-3enpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 PHE A 315
VAL A  49
GLU A  45
 None
 0.76A 4fvqA-3eqqA:
undetectable		 4fvqA-3eqqA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		3 PHE A 293
VAL A 289
GLU A 159
 None
 0.78A 4fvqA-3fkjA:
undetectable		 4fvqA-3fkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3t VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		3 PHE A 409
VAL A 383
GLU A 385
 None
 0.71A 4fvqA-3g3tA:
undetectable		 4fvqA-3g3tA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4s 50S RIBOSOMAL
PROTEIN L7AE

(Haloarcula
marismortui) 		PF01248
(Ribosomal_L7Ae) 		3 PHE F   6
VAL F   4
GLU F  52
 None
 0.79A 4fvqA-3g4sF:
undetectable		 4fvqA-3g4sF:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A

(Homo sapiens) 		PF04139
(Rad9) 		3 PHE A  84
VAL A  10
GLU A  95
 None
 0.82A 4fvqA-3ggrA:
undetectable		 4fvqA-3ggrA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 PHE A 325
VAL A  53
GLU A  49
 None
 0.83A 4fvqA-3gzyA:
undetectable		 4fvqA-3gzyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 PHE B 208
VAL B   8
GLU B   6
 None
ADP  B 479 (-4.8A)
None
 0.78A 4fvqA-3h0rB:
1.7		 4fvqA-3h0rB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		3 PHE A 223
VAL A 242
GLU A 113
 None
 0.70A 4fvqA-3hamA:
8.6		 4fvqA-3hamA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		3 PHE A 254
VAL A 237
GLU A 234
 None
None
CA  A 553 ( 4.6A)
 0.72A 4fvqA-3hjbA:
undetectable		 4fvqA-3hjbA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 PHE A 308
VAL A 288
GLU A 283
 None
 0.64A 4fvqA-3hpaA:
undetectable		 4fvqA-3hpaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		3 PHE A  27
VAL A 395
GLU A 358
 None
 0.70A 4fvqA-3ik2A:
2.1		 4fvqA-3ik2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		3 PHE R 161
VAL R 145
GLU R 149
 None
 0.82A 4fvqA-3jb9R:
undetectable		 4fvqA-3jb9R:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 PHE A 282
VAL A 278
GLU A 274
 None
 0.81A 4fvqA-3juxA:
undetectable		 4fvqA-3juxA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN

([Mannheimia]
succiniciproducens) 		PF09704
(Cas_Cas5d) 		3 PHE A 159
VAL A 108
GLU A  65
 None
 0.77A 4fvqA-3kg4A:
undetectable		 4fvqA-3kg4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn3 PUTATIVE PERIPLASMIC
PROTEIN

(Wolinella
succinogenes) 		PF12849
(PBP_like_2) 		3 PHE A 173
VAL A  84
GLU A 191
 None
 0.81A 4fvqA-3kn3A:
undetectable		 4fvqA-3kn3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13185
(GAF_2) 		3 PHE A  96
VAL A  90
GLU A 109
 None
None
SME  A6888 (-2.8A)
 0.78A 4fvqA-3ksgA:
undetectable		 4fvqA-3ksgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		3 PHE A 145
VAL A  71
GLU A  75
 None
 0.84A 4fvqA-3loiA:
undetectable		 4fvqA-3loiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 PHE A 688
VAL A 684
GLU A 700
 None
 0.69A 4fvqA-3lppA:
undetectable		 4fvqA-3lppA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 PHE A 189
VAL A 191
GLU A 172
 None
 0.72A 4fvqA-3o4vA:
undetectable		 4fvqA-3o4vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		3 PHE A 186
VAL A 182
GLU A 166
 None
 0.70A 4fvqA-3pshA:
undetectable		 4fvqA-3pshA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfn BB_1WNU_001

(Pyrococcus
horikoshii) 		no annotation 3 PHE A  86
VAL A 107
GLU A 109
 None
 0.70A 4fvqA-3rfnA:
undetectable		 4fvqA-3rfnA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 PHE A 317
VAL A 311
GLU A 308
 None
 0.59A 4fvqA-3snhA:
undetectable		 4fvqA-3snhA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		3 PHE A 183
VAL A 382
GLU A 163
 None
 0.56A 4fvqA-3up4A:
undetectable		 4fvqA-3up4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Deinococcus
radiodurans) 		PF01063
(Aminotran_4) 		3 PHE A 296
VAL A 255
GLU A 284
 None
 0.84A 4fvqA-3uzbA:
undetectable		 4fvqA-3uzbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 PHE A 409
VAL A  10
GLU A 118
 None
 0.61A 4fvqA-3vlaA:
undetectable		 4fvqA-3vlaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		3 PHE A 294
VAL A 462
GLU A 384
 None
 0.83A 4fvqA-3vsvA:
undetectable		 4fvqA-3vsvA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE

(Xanthomonas
oryzae) 		PF09704
(Cas_Cas5d) 		3 PHE A 159
VAL A 108
GLU A  65
 None
 0.71A 4fvqA-3vziA:
undetectable		 4fvqA-3vziA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		3 PHE A 186
VAL A 147
GLU A 150
 None
 0.76A 4fvqA-3w77A:
undetectable		 4fvqA-3w77A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 PHE A  21
VAL A 204
GLU A 212
 None
 0.70A 4fvqA-4e1lA:
undetectable		 4fvqA-4e1lA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edp ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF13416
(SBP_bac_8) 		3 PHE A 329
VAL A 332
GLU A 180
 CL  A 401 ( 4.5A)
None
ACT  A 405 (-2.8A)
 0.84A 4fvqA-4edpA:
undetectable		 4fvqA-4edpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		3 PHE A 348
VAL A 346
GLU A 365
 None
2OB  A 606 ( 4.9A)
None
 0.75A 4fvqA-4f2aA:
0.3		 4fvqA-4f2aA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 3 PHE A 220
VAL A 303
GLU A 305
 None
 0.79A 4fvqA-4g4iA:
undetectable		 4fvqA-4g4iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 PHE A 762
VAL A 544
GLU A 585
 None
 0.81A 4fvqA-4j3bA:
undetectable		 4fvqA-4j3bA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbu SIMILAR TO
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13420
(Acetyltransf_4) 		3 PHE A  70
VAL A 116
GLU A 158
 None
 0.70A 4fvqA-4mbuA:
undetectable		 4fvqA-4mbuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 PHE A 171
VAL A  53
GLU A  48
 None
 0.83A 4fvqA-4mk0A:
21.4		 4fvqA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		3 PHE A 180
VAL A 165
GLU A 191
 None
 0.77A 4fvqA-4n0qA:
undetectable		 4fvqA-4n0qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		3 PHE B 328
VAL B 326
GLU B 320
 None
 0.83A 4fvqA-4o9uB:
undetectable		 4fvqA-4o9uB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PHE A 134
VAL A 152
GLU A 143
 None
 0.57A 4fvqA-4q1vA:
undetectable		 4fvqA-4q1vA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF03604
(DNA_RNApol_7kD) 		3 PHE D  47
VAL P  46
GLU D  57
 None
 0.75A 4fvqA-4qiwD:
undetectable		 4fvqA-4qiwD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri2 PHOTOSYSTEM II 22
KDA PROTEIN,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		3 PHE A 191
VAL A 144
GLU A 141
 None
 0.84A 4fvqA-4ri2A:
undetectable		 4fvqA-4ri2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzn PROTEIN HTP-2

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		3 PHE A 193
VAL A 112
GLU A 123
 None
 0.79A 4fvqA-4tznA:
undetectable		 4fvqA-4tznA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		PF01661
(Macro) 		3 PHE A 223
VAL A  52
GLU A 194
 None
 0.78A 4fvqA-4umlA:
undetectable		 4fvqA-4umlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		3 PHE A 289
VAL A 159
GLU A 253
 None
 0.83A 4fvqA-4ut1A:
undetectable		 4fvqA-4ut1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 PHE A 154
VAL A 196
GLU A 212
 None
 0.81A 4fvqA-4xmvA:
undetectable		 4fvqA-4xmvA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aea NEURAL CELL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A  36
VAL A  78
GLU A  86
 None
 0.80A 4fvqA-5aeaA:
undetectable		 4fvqA-5aeaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 PHE A 327
VAL A  53
GLU A  49
 None
 0.82A 4fvqA-5aewA:
undetectable		 4fvqA-5aewA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boi GERMINATION PROTEIN
YPEB

(Bacillus
megaterium) 		PF03413
(PepSY)
PF14620
(YPEB) 		3 PHE A 231
VAL A 281
GLU A 283
 None
 0.79A 4fvqA-5boiA:
undetectable		 4fvqA-5boiA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 PHE A 805
VAL A 666
GLU A 651
 None
 0.43A 4fvqA-5dotA:
undetectable		 4fvqA-5dotA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 PHE A 573
VAL A 557
GLU A 522
 None
 0.71A 4fvqA-5e9aA:
undetectable		 4fvqA-5e9aA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		3 PHE A 110
VAL A 422
GLU A 480
 None
None
BGC  A 914 ( 2.9A)
 0.54A 4fvqA-5ej1A:
1.4		 4fvqA-5ej1A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		3 PHE A 389
VAL A 328
GLU A 329
 None
 0.78A 4fvqA-5eqiA:
undetectable		 4fvqA-5eqiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		3 PHE A 612
VAL A 426
GLU A 428
 None
None
GLC  A1117 (-2.8A)
 0.84A 4fvqA-5f7uA:
undetectable		 4fvqA-5f7uA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 PHE A 268
VAL A 495
GLU A 513
 None
 0.74A 4fvqA-5ficA:
undetectable		 4fvqA-5ficA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus) 		PF01248
(Ribosomal_L7Ae) 		3 PHE C  12
VAL C  10
GLU C  58
 None
 0.82A 4fvqA-5ginC:
undetectable		 4fvqA-5ginC:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 PHE A 228
VAL A 184
GLU A 220
 None
 0.83A 4fvqA-5gn5A:
undetectable		 4fvqA-5gn5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN

(Enterococcus
faecalis) 		no annotation 3 PHE A 523
VAL A 518
GLU A 486
 TRS  A 602 (-4.7A)
None
None
 0.60A 4fvqA-5h29A:
undetectable		 4fvqA-5h29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 PHE A 268
VAL A 495
GLU A 513
 None
 0.79A 4fvqA-5hqnA:
undetectable		 4fvqA-5hqnA:
19.42