SIMILAR PATTERNS OF AMINO ACIDS FOR 4FVQ_A_ACTA903

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l01 TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 714
CYH A 716
ARG A 755
TRP A 758
 None
 0.68A 4fvqA-4l01A:
37.5		 4fvqA-4l01A:
49.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 734
CYH A 736
ARG A 775
TRP A 778
 None
 0.43A 4fvqA-4oliA:
37.2		 4fvqA-4oliA:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASN A 734
CYH A 736
ARG A 775
TRP A 778
 SO4  A 903 (-4.1A)
None
None
None
 0.68A 4fvqA-4wovA:
37.0		 4fvqA-4wovA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-) 		no annotation 4 ASN A 673
CYH A 675
ARG A 715
TRP A 718
 None
 0.20A 4fvqA-5winA:
44.7		 4fvqA-5winA:
undetectable