SIMILAR PATTERNS OF AMINO ACIDS FOR 4FUB_A_ACTA311

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		3 TYR A 183
ARG A 345
HIS A 186
 None
CIT  A 379 (-2.8A)
CIT  A 379 (-3.8A)
 1.15A 4fubA-1a59A:
0.0		 4fubA-1a59A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		3 TYR A 185
ARG A 337
HIS A 188
 None
CIT  A1000 (-2.9A)
CIT  A1000 (-3.8A)
 1.11A 4fubA-1aj8A:
0.0		 4fubA-1aj8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		3 TYR A 266
ARG A 237
HIS A 236
 None
 1.09A 4fubA-1c8uA:
0.0		 4fubA-1c8uA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 TYR A 146
ARG A 137
HIS A 381
 None
 1.21A 4fubA-1ct9A:
0.0		 4fubA-1ct9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma) 		3 TYR C3050
ARG C3082
HIS C3043
 None
 1.12A 4fubA-1e6yC:
0.0		 4fubA-1e6yC:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqb AGGLUTININ ISOLECTIN
I

(Urtica dioica) 		PF00187
(Chitin_bind_1) 		3 TYR A  76
ARG A  62
HIS A  47
 None
None
ZN  A  90 (-3.3A)
 1.10A 4fubA-1iqbA:
undetectable		 4fubA-1iqbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		3 TYR A 601
ARG A 659
HIS A 578
 None
 0.88A 4fubA-1jj7A:
0.0		 4fubA-1jj7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TYR A1005
ARG A 896
HIS A 902
 MGD  A1018 (-3.3A)
MGD  A1018 ( 3.3A)
MGD  A1018 ( 3.7A)
 1.05A 4fubA-1kqfA:
0.0		 4fubA-1kqfA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 TYR A 267
ARG A 292
HIS A 117
 None
SO4  A 563 (-3.8A)
None
 1.25A 4fubA-1lxtA:
0.0		 4fubA-1lxtA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 TYR A 316
ARG A 283
HIS A 253
 None
 1.02A 4fubA-1sb3A:
undetectable		 4fubA-1sb3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 TYR B 207
ARG B 275
HIS B 206
 None
 1.23A 4fubA-1ta3B:
undetectable		 4fubA-1ta3B:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.) 		PF08787
(Alginate_lyase2) 		3 TYR A  70
ARG A 129
HIS A 112
 None
 1.00A 4fubA-1uaiA:
undetectable		 4fubA-1uaiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 TYR A 467
ARG A 366
HIS A 369
 None
 1.04A 4fubA-1yq2A:
undetectable		 4fubA-1yq2A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8r COXSACKIEVIRUS B4
POLYPROTEIN

(Enterovirus B) 		PF00947
(Pico_P2A) 		3 TYR A  63
ARG A 115
HIS A  71
 None
 1.04A 4fubA-1z8rA:
3.9		 4fubA-1z8rA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 TYR A 328
ARG A 339
HIS A 337
 None
 1.20A 4fubA-2bwmA:
undetectable		 4fubA-2bwmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		3 TYR A  92
ARG A 190
HIS A 124
 None
 1.17A 4fubA-2d7dA:
undetectable		 4fubA-2d7dA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8n RECOVERIN

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 TYR A 109
ARG A  71
HIS A  68
 None
 1.23A 4fubA-2d8nA:
undetectable		 4fubA-2d8nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 TYR A 263
ARG A 283
HIS A 271
 None
 1.02A 4fubA-2f00A:
undetectable		 4fubA-2f00A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		3 TYR A 123
ARG A 374
HIS A 443
 None
None
SO4  A 607 (-3.9A)
 1.07A 4fubA-2gwnA:
undetectable		 4fubA-2gwnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2het RECOVERIN

(Bos taurus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 TYR A 109
ARG A  71
HIS A  68
 None
 1.09A 4fubA-2hetA:
undetectable		 4fubA-2hetA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus) 		PF01593
(Amino_oxidase) 		3 TYR A 360
ARG A 331
HIS A 359
 None
 1.22A 4fubA-2jb1A:
undetectable		 4fubA-2jb1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TYR A 713
ARG A 617
HIS A 623
 MGD  A 811 (-3.6A)
MGD  A 811 (-3.2A)
MGD  A 811 ( 3.6A)
 1.14A 4fubA-2jirA:
undetectable		 4fubA-2jirA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kii PUTATIVE
UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF07700
(HNOB) 		3 TYR A 132
ARG A 131
HIS A 117
 HEM  A 182 (-4.3A)
None
None
 1.14A 4fubA-2kiiA:
undetectable		 4fubA-2kiiA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Shigella
flexneri) 		PF03009
(GDPD) 		3 TYR A 213
ARG A  13
HIS A  54
 PO4  A 301 (-4.0A)
PO4  A 301 (-4.5A)
PO4  A 301 ( 4.9A)
 0.98A 4fubA-2otdA:
undetectable		 4fubA-2otdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6y HYPOTHETICAL PROTEIN
VCA0587

(Vibrio cholerae) 		PF03479
(DUF296) 		3 TYR A 124
ARG A 116
HIS A  75
 None
None
ZN  A 201 (-3.3A)
 0.94A 4fubA-2p6yA:
undetectable		 4fubA-2p6yA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pc1 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
agalactiae) 		no annotation 3 TYR A  53
ARG A  97
HIS A  96
 None
 0.92A 4fubA-2pc1A:
undetectable		 4fubA-2pc1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 341
ARG A 159
HIS A 158
 None
 1.10A 4fubA-2pp3A:
undetectable		 4fubA-2pp3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqr JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		no annotation 3 TYR A1004
ARG A1000
HIS A 895
 None
 1.25A 4fubA-2qqrA:
undetectable		 4fubA-2qqrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 TYR A 441
ARG A 352
HIS A 255
 None
None
FAD  A1587 (-4.3A)
 1.10A 4fubA-2uuuA:
undetectable		 4fubA-2uuuA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmd DISCOIDIN-2

(Dictyostelium
discoideum) 		PF00754
(F5_F8_type_C)
PF09458
(H_lectin) 		3 TYR A  24
ARG A  81
HIS A  84
 EDO  A 504 ( 3.8A)
EDO  A 504 (-4.0A)
None
 1.20A 4fubA-2vmdA:
undetectable		 4fubA-2vmdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		3 TYR A 332
ARG A 274
HIS A 276
 None
None
XYP  A1001 (-3.9A)
 1.19A 4fubA-2w5fA:
undetectable		 4fubA-2w5fA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 TYR A 162
ARG A 377
HIS A 505
 None
 1.01A 4fubA-2wtzA:
undetectable		 4fubA-2wtzA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 TYR A 826
ARG A 806
HIS A 807
 None
 1.12A 4fubA-2x6kA:
undetectable		 4fubA-2x6kA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xeu RING FINGER PROTEIN
4

(Homo sapiens) 		PF13639
(zf-RING_2) 		3 TYR A  59
ARG A  58
HIS A  56
 SO4  A1068 (-4.2A)
None
None
 1.21A 4fubA-2xeuA:
undetectable		 4fubA-2xeuA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		3 TYR A 313
ARG A 286
HIS A 340
 None
 1.13A 4fubA-2y6vA:
undetectable		 4fubA-2y6vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 295
ARG A 319
HIS A 300
 None
 0.80A 4fubA-2z2wA:
undetectable		 4fubA-2z2wA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		3 TYR A  15
ARG A 196
HIS A  53
 None
 1.13A 4fubA-2zzjA:
undetectable		 4fubA-2zzjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 TYR A  61
ARG A  93
HIS A  64
 None
 1.08A 4fubA-3anxA:
undetectable		 4fubA-3anxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A  27
ARG A  46
HIS A  35
 None
 1.26A 4fubA-3bewA:
undetectable		 4fubA-3bewA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 TYR A 509
ARG A 410
HIS A 413
 None
 1.07A 4fubA-3bgaA:
undetectable		 4fubA-3bgaA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		3 TYR A 261
ARG A 272
HIS A 275
 None
 1.24A 4fubA-3cb5A:
undetectable		 4fubA-3cb5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 TYR A 485
ARG A 386
HIS A 389
 None
 1.08A 4fubA-3decA:
undetectable		 4fubA-3decA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		3 TYR A 262
ARG A 266
HIS A 214
 None
 1.26A 4fubA-3fe5A:
undetectable		 4fubA-3fe5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		3 TYR A  13
ARG A  69
HIS A 138
 None
 1.20A 4fubA-3g6sA:
undetectable		 4fubA-3g6sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 466
ARG A 470
HIS A 239
 None
 1.22A 4fubA-3hdxA:
undetectable		 4fubA-3hdxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR

(Streptococcus
gordonii) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		3 TYR A  73
ARG A 157
HIS A 159
 None
SO4  A 250 (-4.0A)
SO4  A 250 (-3.7A)
 0.94A 4fubA-3hrtA:
undetectable		 4fubA-3hrtA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 TYR A 764
ARG A 744
HIS A 745
 None
 1.08A 4fubA-3ihyA:
undetectable		 4fubA-3ihyA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S34,
MITOCHONDRIAL

(Bos taurus) 		PF00338
(Ribosomal_S10) 		3 TYR j  34
ARG j  43
HIS j  45
 A  A  60 ( 4.4A)
C  A  61 ( 3.8A)
None
 1.10A 4fubA-3jd5j:
undetectable		 4fubA-3jd5j:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 TYR A 362
ARG A 324
HIS A 296
 None
 0.98A 4fubA-3jurA:
undetectable		 4fubA-3jurA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 3 TYR B 197
ARG B 222
HIS B 219
 None
 0.84A 4fubA-3k1lB:
undetectable		 4fubA-3k1lB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 TYR A 487
ARG A 476
HIS A 479
 None
 1.20A 4fubA-3k7nA:
undetectable		 4fubA-3k7nA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 302
ARG A 125
HIS A 122
 None
 1.26A 4fubA-3kuxA:
undetectable		 4fubA-3kuxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 TYR A 701
ARG A 711
HIS A 709
 None
 1.22A 4fubA-3m1cA:
undetectable		 4fubA-3m1cA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
2) 		PF05259
(Herpes_UL1)
PF12524
(GlyL_C) 		3 TYR B  64
ARG B 122
HIS B 109
 None
 1.24A 4fubA-3m1cB:
undetectable		 4fubA-3m1cB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
2) 		PF05259
(Herpes_UL1)
PF12524
(GlyL_C) 		3 TYR B 126
ARG B 122
HIS B 109
 None
 0.98A 4fubA-3m1cB:
undetectable		 4fubA-3m1cB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 TYR A 129
ARG A 100
HIS A 135
 None
 1.25A 4fubA-3me5A:
undetectable		 4fubA-3me5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		3 TYR A 507
ARG A 386
HIS A 389
 None
None
GAL  A2001 (-3.8A)
 1.02A 4fubA-3ob8A:
undetectable		 4fubA-3ob8A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		3 TYR A 103
ARG A 140
HIS A 137
 None
 0.94A 4fubA-3pl1A:
undetectable		 4fubA-3pl1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 3 TYR A  75
ARG A  90
HIS A 124
 None
None
CA  A 501 (-3.4A)
 1.16A 4fubA-3s4lA:
undetectable		 4fubA-3s4lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		3 TYR A 126
ARG A 118
HIS A 134
 None
 0.92A 4fubA-3t44A:
undetectable		 4fubA-3t44A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		3 TYR A 180
ARG A 333
HIS A 183
 None
 1.02A 4fubA-3tqgA:
undetectable		 4fubA-3tqgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		3 TYR A  67
ARG A  74
HIS A 112
 None
 0.94A 4fubA-4dqvA:
undetectable		 4fubA-4dqvA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 188
ARG A 216
HIS A 214
 None
None
FMT  A 506 ( 4.7A)
 1.23A 4fubA-4e4fA:
undetectable		 4fubA-4e4fA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 TYR A 125
ARG A 137
HIS A 145
 None
 1.20A 4fubA-4ggjA:
undetectable		 4fubA-4ggjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A 199
ARG A 227
HIS A 225
 None
None
MG  A 501 ( 4.8A)
 1.26A 4fubA-4il2A:
undetectable		 4fubA-4il2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 TYR A  97
ARG A 365
HIS A 317
 None
 1.24A 4fubA-4jcmA:
undetectable		 4fubA-4jcmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 TYR A 364
ARG A 361
HIS A 356
 None
 0.73A 4fubA-4mafA:
undetectable		 4fubA-4mafA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR E 196
ARG E 244
HIS E 236
 None
 1.02A 4fubA-4md8E:
undetectable		 4fubA-4md8E:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 TYR A 528
ARG A 522
HIS A 920
 None
 1.22A 4fubA-4mz0A:
undetectable		 4fubA-4mz0A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		3 TYR A 109
ARG A 272
HIS A 106
 None
None
CO  A 301 ( 3.3A)
 1.06A 4fubA-4p7wA:
undetectable		 4fubA-4p7wA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 TYR A  66
ARG A 329
HIS A 325
 None
 1.13A 4fubA-4pf1A:
undetectable		 4fubA-4pf1A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q34 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12697
(Abhydrolase_6) 		3 TYR A 264
ARG A 135
HIS A 316
 None
 1.21A 4fubA-4q34A:
undetectable		 4fubA-4q34A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		3 TYR A 266
ARG A 237
HIS A 236
 None
 1.02A 4fubA-4qfwA:
undetectable		 4fubA-4qfwA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 TYR A 446
ARG A 529
HIS A 533
 None
 1.19A 4fubA-4rewA:
undetectable		 4fubA-4rewA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsd HP1029

(Helicobacter
pylori) 		no annotation 3 TYR B 157
ARG B 130
HIS B 132
 None
 1.23A 4fubA-4tsdB:
undetectable		 4fubA-4tsdB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		3 TYR A  88
ARG A  73
HIS A  71
 None
 1.24A 4fubA-4uouA:
undetectable		 4fubA-4uouA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase) 		3 TYR B 195
ARG B 193
HIS B 190
 None
 0.96A 4fubA-4xruB:
undetectable		 4fubA-4xruB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y89 CARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 7

(Homo sapiens) 		PF07686
(V-set) 		3 TYR A  35
ARG A  39
HIS A  41
 None
 1.16A 4fubA-4y89A:
undetectable		 4fubA-4y89A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		3 TYR A 440
ARG A 194
HIS A 443
 None
 1.12A 4fubA-4zelA:
undetectable		 4fubA-4zelA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 TYR A 307
ARG A 285
HIS A 282
 NKN  A 909 (-3.6A)
None
None
 1.17A 4fubA-4zg7A:
undetectable		 4fubA-4zg7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		3 TYR A 315
ARG A 164
HIS A 215
 DGT  A 701 (-3.6A)
DGT  A 701 (-3.3A)
DGT  A 701 (-3.6A)
 1.16A 4fubA-4zweA:
undetectable		 4fubA-4zweA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 TYR A  66
ARG A  70
HIS A  64
 None
 0.85A 4fubA-4zxiA:
undetectable		 4fubA-4zxiA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		3 TYR A 224
ARG A 243
HIS A 242
 None
 1.16A 4fubA-5diyA:
undetectable		 4fubA-5diyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		3 TYR A 335
ARG A 319
HIS A 346
 None
 1.01A 4fubA-5gqtA:
undetectable		 4fubA-5gqtA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 414
ARG A 482
HIS A 477
 None
 1.23A 4fubA-5m4aA:
undetectable		 4fubA-5m4aA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 196
ARG A 244
HIS A 236
 None
 1.25A 4fubA-5movA:
undetectable		 4fubA-5movA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 TYR F 439
ARG F 331
HIS F 328
 None
 1.26A 4fubA-5odrF:
undetectable		 4fubA-5odrF:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		3 TYR E 259
ARG E  44
HIS E  85
 G3P  E 302 (-3.8A)
G3P  E 302 (-3.8A)
G3P  E 302 (-3.8A)
 1.17A 4fubA-5t9cE:
undetectable		 4fubA-5t9cE:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		3 TYR A 617
ARG A 503
HIS A 507
 None
 1.23A 4fubA-5tj7A:
undetectable		 4fubA-5tj7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 TYR B 281
ARG B 291
HIS B 128
 None
None
ZN  B 401 (-3.2A)
 1.02A 4fubA-5tpwB:
undetectable		 4fubA-5tpwB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3l DH511.2 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 TYR H  59
ARG H  82
HIS H  81
 None
 1.05A 4fubA-5u3lH:
undetectable		 4fubA-5u3lH:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnw NB.B201

(synthetic
construct) 		no annotation 3 TYR C  27
ARG C  71
HIS C  53
 None
 1.22A 4fubA-5vnwC:
undetectable		 4fubA-5vnwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 3 TYR A 390
ARG A 452
HIS A 431
 PO4  A 604 (-4.7A)
PO4  A 604 (-3.3A)
None
 1.04A 4fubA-5xnrA:
undetectable		 4fubA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 3 TYR A 347
ARG A 196
HIS A 247
 DGT  A 701 (-3.8A)
DGT  A 701 (-3.5A)
DGT  A 701 (-3.7A)
 1.18A 4fubA-6brkA:
undetectable		 4fubA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 3 TYR A 227
ARG A 232
HIS A 240
 None
MAL  A 501 (-3.0A)
MAL  A 501 (-3.9A)
 1.25A 4fubA-6bvgA:
undetectable		 4fubA-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 3 TYR A 477
ARG A 473
HIS A 234
 None
C  B  43 ( 4.0A)
C  B  39 ( 3.5A)
 1.21A 4fubA-6d6vA:
undetectable		 4fubA-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 3 TYR A 424
ARG A 459
HIS A 458
 None
 0.90A 4fubA-6ej2A:
undetectable		 4fubA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 3 TYR A 466
ARG A 365
HIS A 368
 None
 1.07A 4fubA-6etzA:
undetectable		 4fubA-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25

(Homo sapiens) 		no annotation 3 TYR A 463
ARG A 494
HIS A 491
 None
 0.97A 4fubA-6flnA:
undetectable		 4fubA-6flnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g94 PROBABLE
NI/FE-HYDROGENASE 1
B-TYPE CYTOCHROME
SUBUNIT

(Escherichia
coli) 		no annotation 3 TYR A 136
ARG A  77
HIS A  22
 None
 1.20A 4fubA-6g94A:
undetectable		 4fubA-6g94A:
undetectable