SIMILAR PATTERNS OF AMINO ACIDS FOR 4FU9_A_ACTA311

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		3 GLN A 151
THR A 156
THR A 154
 None
 0.82A 4fu9A-1a6jA:
0.0		 4fu9A-1a6jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		3 GLN A 249
THR A 209
THR A 210
 None
 0.36A 4fu9A-1arlA:
0.0		 4fu9A-1arlA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfb DROSOPHILA
NEUROGLIAN

(Drosophila
melanogaster) 		PF00041
(fn3) 		3 GLN A 709
THR A 708
THR A 707
 None
 0.67A 4fu9A-1cfbA:
0.0		 4fu9A-1cfbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 GLN A 127
THR A 547
THR A 548
 None
 0.62A 4fu9A-1k3vA:
0.0		 4fu9A-1k3vA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nm3 PROTEIN HI0572

(Haemophilus
influenzae) 		PF00462
(Glutaredoxin)
PF08534
(Redoxin) 		3 GLN A 222
THR A 219
THR A 218
 None
 0.83A 4fu9A-1nm3A:
0.0		 4fu9A-1nm3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		3 GLN A 263
THR A 270
THR A 271
 None
 0.62A 4fu9A-1p9eA:
0.0		 4fu9A-1p9eA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		3 GLN A  28
THR A  27
THR A  26
 None
 0.82A 4fu9A-1q9hA:
0.0		 4fu9A-1q9hA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		3 GLN A 618
THR A 619
THR A 651
 None
 0.80A 4fu9A-1r6vA:
0.0		 4fu9A-1r6vA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj5 HYPOTHETICAL PROTEIN
(RIKEN CDNA
0610009H20)

(Mus musculus) 		PF09170
(STN1_2) 		3 GLN A  30
THR A 108
THR A 107
 None
 0.76A 4fu9A-1wj5A:
undetectable		 4fu9A-1wj5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		3 GLN A 263
THR A 264
THR A 259
 None
 0.79A 4fu9A-1wkrA:
undetectable		 4fu9A-1wkrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		3 GLN A 348
THR A 227
THR A 228
 None
 0.58A 4fu9A-1z3vA:
undetectable		 4fu9A-1z3vA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za7 COAT PROTEIN

(Cowpea
chlorotic
mottle virus) 		PF01318
(Bromo_coat) 		3 GLN A 113
THR A 115
THR A 114
 None
 0.71A 4fu9A-1za7A:
undetectable		 4fu9A-1za7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		3 GLN A 227
THR A 189
THR A 190
 None
 0.79A 4fu9A-2ahwA:
undetectable		 4fu9A-2ahwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfu COWPEA MOSAIC VIRUS,
LARGE (L) SUBUNIT

(Cowpea mosaic
virus) 		PF02247
(Como_LCP) 		3 GLN L 204
THR L 335
THR L 334
 None
 0.78A 4fu9A-2bfuL:
undetectable		 4fu9A-2bfuL:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjl SECRETED CHITINASE

(Streptomyces
coelicolor) 		PF00182
(Glyco_hydro_19) 		3 GLN A 152
THR A 153
THR A 159
 None
 0.77A 4fu9A-2cjlA:
undetectable		 4fu9A-2cjlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 GLN A 298
THR A  82
THR A  81
 None
 0.71A 4fu9A-2cl2A:
undetectable		 4fu9A-2cl2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00027
(cNMP_binding) 		3 GLN A 116
THR A  92
THR A  90
 None
 0.80A 4fu9A-2d93A:
undetectable		 4fu9A-2d93A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		3 GLN A  22
THR A  94
THR A  93
 None
 0.54A 4fu9A-2ddwA:
undetectable		 4fu9A-2ddwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		3 GLN A 128
THR A 100
THR A  99
 None
 0.82A 4fu9A-2fyiA:
undetectable		 4fu9A-2fyiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgw COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		3 GLN A 426
THR A 428
THR A 427
 None
 0.80A 4fu9A-2jgwA:
undetectable		 4fu9A-2jgwA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhs CBP21

(Serratia
marcescens) 		PF03067
(LPMO_10) 		3 GLN A 130
THR A 132
THR A  80
 None
 0.82A 4fu9A-2lhsA:
undetectable		 4fu9A-2lhsA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m70 POLY(A)-BINDING
PROTEIN 1

(Citrus sinensis) 		PF00076
(RRM_1) 		3 GLN A  66
THR A  65
THR A  62
 None
 0.80A 4fu9A-2m70A:
undetectable		 4fu9A-2m70A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwh ANTI-HIV LECTIN OAA

(Planktothrix
agardhii) 		no annotation 3 GLN A  45
THR A  46
THR A  64
 None
 0.75A 4fu9A-2mwhA:
undetectable		 4fu9A-2mwhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk2 CYCLIN-T1, PROTEIN
TAT

(Homo sapiens;
Equine
infectious
anemia virus) 		PF00134
(Cyclin_N) 		3 GLN A  39
THR A 185
THR A 186
 GLN  A  39 ( 0.6A)
THR  A 185 ( 0.8A)
THR  A 186 ( 0.8A)
 0.70A 4fu9A-2pk2A:
undetectable		 4fu9A-2pk2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		3 GLN A 105
THR A  24
THR A  25
 None
 0.60A 4fu9A-2q3yA:
undetectable		 4fu9A-2q3yA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		3 GLN A  95
THR A  93
THR A  92
 None
 0.72A 4fu9A-2qm1A:
undetectable		 4fu9A-2qm1A:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLN U 169
THR U 177
THR U 178
 None
SO4  U 401 (-3.1A)
None
 0.40A 4fu9A-2r2wU:
45.9		 4fu9A-2r2wU:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		3 GLN A  58
THR A  24
THR A  23
 None
 0.82A 4fu9A-2veoA:
undetectable		 4fu9A-2veoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		3 GLN A 264
THR A 241
THR A 240
 None
 0.82A 4fu9A-2vvtA:
undetectable		 4fu9A-2vvtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		3 GLN A 100
THR A 139
THR A 138
 None
 0.80A 4fu9A-2wedA:
undetectable		 4fu9A-2wedA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wst PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 GLN A 171
THR A 172
THR A 269
 None
 0.79A 4fu9A-2wstA:
undetectable		 4fu9A-2wstA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		3 GLN A 370
THR A 373
THR A 374
 CL  A1483 (-3.7A)
None
CL  A1483 (-4.1A)
 0.57A 4fu9A-2x98A:
undetectable		 4fu9A-2x98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 GLN A   6
THR A  44
THR A  43
 None
 0.76A 4fu9A-2yg1A:
undetectable		 4fu9A-2yg1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		3 GLN A 130
THR A 373
THR A 374
 None
 0.75A 4fu9A-3b9yA:
undetectable		 4fu9A-3b9yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbt PHOSPHATASE SC4828

(Streptomyces
coelicolor) 		PF04167
(DUF402) 		3 GLN A 172
THR A  87
THR A  90
 GLN  A 172 ( 0.6A)
THR  A  87 ( 0.8A)
THR  A  90 ( 0.8A)
 0.74A 4fu9A-3cbtA:
undetectable		 4fu9A-3cbtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLN A 186
THR A 184
THR A 209
 None
 0.69A 4fu9A-3dhvA:
undetectable		 4fu9A-3dhvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 GLN A 353
THR A1046
THR A1047
 None
 0.76A 4fu9A-3f2bA:
undetectable		 4fu9A-3f2bA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		3 GLN A 266
THR A 265
THR A 264
 None
 0.81A 4fu9A-3gvcA:
undetectable		 4fu9A-3gvcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw6 ENDO-N-ACETYLNEURAMI
NIDASE

(Enterobacteria
phage K1F) 		PF12219
(End_tail_spike)
PF13884
(Peptidase_S74) 		3 GLN A 853
THR A 850
THR A 849
 None
 0.75A 4fu9A-3gw6A:
undetectable		 4fu9A-3gw6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 GLN B 343
THR B 352
THR B 351
 None
 0.76A 4fu9A-3h0gB:
undetectable		 4fu9A-3h0gB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		3 GLN A 250
THR A 222
THR A 221
 None
 0.81A 4fu9A-3igfA:
undetectable		 4fu9A-3igfA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbe NANOBODY VHH PVSS8A

(Camelus
dromedarius) 		PF07686
(V-set) 		3 GLN 7  72
THR 7  53
THR 7  52
 None
 0.82A 4fu9A-3jbe7:
undetectable		 4fu9A-3jbe7:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		3 GLN A  51
THR A  50
THR A  47
 None
 0.82A 4fu9A-3kwpA:
undetectable		 4fu9A-3kwpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 GLN A 288
THR A  60
THR A  58
 None
 0.71A 4fu9A-3l22A:
undetectable		 4fu9A-3l22A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 GLN A 580
THR A 555
THR A 556
 None
 0.77A 4fu9A-3m07A:
undetectable		 4fu9A-3m07A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moj ATP-DEPENDENT RNA
HELICASE DBPA

(Bacillus
subtilis) 		PF03880
(DbpA) 		3 GLN B 471
THR B 465
THR B 466
 None
None
C  A2556 ( 3.9A)
 0.80A 4fu9A-3mojB:
undetectable		 4fu9A-3mojB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		3 GLN A 409
THR A 431
THR A 430
 None
 0.72A 4fu9A-3nvqA:
undetectable		 4fu9A-3nvqA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 GLN A  68
THR A 130
THR A 131
 None
None
GOL  A 327 (-4.4A)
 0.83A 4fu9A-3pkoA:
undetectable		 4fu9A-3pkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLN A   4
THR A  26
THR A  25
 None
 0.79A 4fu9A-3qtpA:
undetectable		 4fu9A-3qtpA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhf PUTATIVE
POLYPHOSPHATE KINASE
2 FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF03976
(PPK2) 		3 GLN A 174
THR A 172
THR A 176
 None
 0.67A 4fu9A-3rhfA:
undetectable		 4fu9A-3rhfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN K 166
THR K 165
THR K 164
 None
 0.74A 4fu9A-3ri5K:
undetectable		 4fu9A-3ri5K:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A   4
THR A  30
THR A  29
 None
 0.66A 4fu9A-3t4wA:
undetectable		 4fu9A-3t4wA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 GLN A 100
THR A 210
THR A 211
 None
 0.82A 4fu9A-3tsyA:
undetectable		 4fu9A-3tsyA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		3 GLN A 202
THR A 203
THR A 170
 None
 0.80A 4fu9A-3twkA:
undetectable		 4fu9A-3twkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufi HYPOTHETICAL PROTEIN
BACOVA_04980

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		3 GLN A 155
THR A 151
THR A 152
 MLY  A 184 ( 4.3A)
MLY  A 154 ( 4.3A)
CL  A 328 (-4.3A)
 0.75A 4fu9A-3ufiA:
undetectable		 4fu9A-3ufiA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		3 GLN A  58
THR A  24
THR A  23
 None
 0.82A 4fu9A-3zpxA:
undetectable		 4fu9A-3zpxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 GLN A 509
THR A 531
THR A 532
 None
 0.82A 4fu9A-4cakA:
undetectable		 4fu9A-4cakA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN

(Parabacteroides
merdae) 		PF06283
(ThuA) 		3 GLN A 261
THR A 254
THR A 253
 None
 0.74A 4fu9A-4e5vA:
undetectable		 4fu9A-4e5vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0r CAPSID PROTEIN VP1

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 GLN A 132
THR A 556
THR A 557
 None
 0.57A 4fu9A-4g0rA:
undetectable		 4fu9A-4g0rA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN L 156
THR L 158
THR L 157
 None
 0.83A 4fu9A-4hbcL:
undetectable		 4fu9A-4hbcL:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		3 GLN A 599
THR A 612
THR A 611
 None
 0.55A 4fu9A-4hsuA:
undetectable		 4fu9A-4hsuA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE

(Listeria
monocytogenes) 		PF00480
(ROK) 		3 GLN A 183
THR A 174
THR A 175
 None
 0.78A 4fu9A-4htlA:
undetectable		 4fu9A-4htlA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN L 154
THR L 153
THR L 152
 None
 0.79A 4fu9A-4jo2L:
undetectable		 4fu9A-4jo2L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN L 154
THR L 156
THR L 155
 None
 0.80A 4fu9A-4jo2L:
undetectable		 4fu9A-4jo2L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of0 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set)
PF08205
(C2-set_2) 		3 GLN A 210
THR A 209
THR A 208
 None
 0.83A 4fu9A-4of0A:
undetectable		 4fu9A-4of0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 GLN B 488
THR B 490
THR B 491
 None
 0.65A 4fu9A-4qiwB:
undetectable		 4fu9A-4qiwB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		3 GLN A 300
THR A 301
THR A 304
 None
 0.80A 4fu9A-4rk0A:
undetectable		 4fu9A-4rk0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 GLN B 103
THR B 100
THR B 124
 None
 0.68A 4fu9A-4rs1B:
undetectable		 4fu9A-4rs1B:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 GLN A 336
THR A 346
THR A 347
 None
 0.72A 4fu9A-4v1uA:
undetectable		 4fu9A-4v1uA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN L 154
THR L 156
THR L 155
 None
 0.81A 4fu9A-4ztpL:
undetectable		 4fu9A-4ztpL:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 3 GLN A  17
THR A   6
THR A   5
 None
 0.60A 4fu9A-5a3cA:
undetectable		 4fu9A-5a3cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 3 GLN A 186
THR A 187
THR A 190
 None
 0.83A 4fu9A-5ah1A:
undetectable		 4fu9A-5ah1A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		3 GLN A 196
THR A 195
THR A 194
 None
 0.80A 4fu9A-5czwA:
undetectable		 4fu9A-5czwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		3 GLN A 101
THR A  74
THR A  75
 None
 0.71A 4fu9A-5dgkA:
undetectable		 4fu9A-5dgkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsc FAB HOU24.B LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN B 154
THR B 153
THR B 152
 None
 0.81A 4fu9A-5dscB:
undetectable		 4fu9A-5dscB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dub FAB HPU98 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN B 154
THR B 153
THR B 152
 None
 0.67A 4fu9A-5dubB:
undetectable		 4fu9A-5dubB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		3 GLN A 201
THR A 202
THR A 203
 None
None
MAN  A 801 (-2.1A)
 0.56A 4fu9A-5erpA:
undetectable		 4fu9A-5erpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0p SORTING NEXIN-3

(Homo sapiens) 		PF00787
(PX) 		3 GLN C  37
THR C  38
THR C  47
 None
 0.83A 4fu9A-5f0pC:
undetectable		 4fu9A-5f0pC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		3 GLN A 370
THR A 376
THR A 377
 None
 0.79A 4fu9A-5h42A:
undetectable		 4fu9A-5h42A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5z MHC CLASS I ANTIGEN

(Ctenopharyngodon
idella) 		no annotation 3 GLN A 108
THR A 107
THR A 106
 None
 0.75A 4fu9A-5h5zA:
undetectable		 4fu9A-5h5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		3 GLN A 119
THR A 332
THR A 331
 None
 0.82A 4fu9A-5h7dA:
undetectable		 4fu9A-5h7dA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		3 GLN A 871
THR A 993
THR A 992
 None
 0.68A 4fu9A-5ijlA:
undetectable		 4fu9A-5ijlA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ize RNA-DIRECTED RNA
POLYMERASE L

(Hantaan
orthohantavirus) 		no annotation 3 GLN A 171
THR A 170
THR A 169
 None
 0.77A 4fu9A-5izeA:
undetectable		 4fu9A-5izeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0a FIBRONECTIN

(Homo sapiens) 		no annotation 3 GLN A 405
THR A 406
THR A 407
 None
 0.73A 4fu9A-5m0aA:
undetectable		 4fu9A-5m0aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 GLN A 356
THR A 298
THR A 299
 None
 0.82A 4fu9A-5nagA:
undetectable		 4fu9A-5nagA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA

(Escherichia
coli) 		no annotation 3 GLN E 341
THR E  53
THR E  54
 None
 0.60A 4fu9A-5ng5E:
undetectable		 4fu9A-5ng5E:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngn LYBATIDE 2

(Lycium barbarum) 		no annotation 3 GLN A  19
THR A  20
THR A  23
 None
 0.82A 4fu9A-5ngnA:
undetectable		 4fu9A-5ngnA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-) 		no annotation 3 GLN B 260
THR B 256
THR B 257
 None
 0.81A 4fu9A-5ochB:
undetectable		 4fu9A-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 GLN 5  96
THR 5  95
THR 5  92
 None
 0.75A 4fu9A-5udb5:
undetectable		 4fu9A-5udb5:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz8 CADHERIN-23

(Mus musculus) 		no annotation 3 GLN A2545
THR A2544
THR A2543
 None
 0.60A 4fu9A-5uz8A:
undetectable		 4fu9A-5uz8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L31

(Mycobacterium
tuberculosis) 		PF01197
(Ribosomal_L31) 		3 GLN 6  23
THR 6  24
THR 6  13
 None
 0.77A 4fu9A-5v7q6:
undetectable		 4fu9A-5v7q6:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vt8 CADHERIN-23

(Mus musculus) 		no annotation 3 GLN B2545
THR B2544
THR B2543
 None
 0.68A 4fu9A-5vt8B:
undetectable		 4fu9A-5vt8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w66 RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN7

(Saccharomyces
cerevisiae) 		no annotation 3 GLN P 435
THR P 344
THR P 343
 None
 0.76A 4fu9A-5w66P:
undetectable		 4fu9A-5w66P:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		3 GLN A 703
THR A 715
THR A 714
 None
 0.76A 4fu9A-5x7sA:
undetectable		 4fu9A-5x7sA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlk FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Serratia
marcescens) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		3 GLN A 110
THR A 109
THR A 108
 None
 0.77A 4fu9A-5xlkA:
undetectable		 4fu9A-5xlkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 3 GLN A 886
THR A 835
THR A 834
 None
 0.71A 4fu9A-6brrA:
undetectable		 4fu9A-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Paraburkholderia
phymatum) 		no annotation 3 GLN A 335
THR A 207
THR A 329
 None
 0.79A 4fu9A-6c0dA:
undetectable		 4fu9A-6c0dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 3 GLN A  42
THR A  41
THR A  40
 None
LLP  A 234 ( 3.4A)
None
 0.76A 4fu9A-6c9eA:
undetectable		 4fu9A-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 3 GLN A 154
THR A 156
THR A 155
 None
 0.81A 4fu9A-6cjkA:
undetectable		 4fu9A-6cjkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn7 AEROBACTIN SYNTHASE
IUCC

(Klebsiella
pneumoniae) 		no annotation 3 GLN A 399
THR A 398
THR A 395
 None
 0.78A 4fu9A-6cn7A:
undetectable		 4fu9A-6cn7A:
undetectable