SIMILAR PATTERNS OF AMINO ACIDS FOR 4FU8_A_ACTA304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		3 ARG A 146
HIS A 144
TYR A 162
 None
 0.61A 4fu8A-1a0dA:
undetectable		 4fu8A-1a0dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		3 ARG A 148
HIS A 146
TYR A 164
 None
 0.67A 4fu8A-1a0eA:
undetectable		 4fu8A-1a0eA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cic PROTEIN (IG HEAVY
CHAIN V REGIONS)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B  98
HIS B 106
TYR B  32
 None
 1.18A 4fu8A-1cicB:
0.0		 4fu8A-1cicB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep5 CAPSID PROTEIN C

(Venezuelan
equine
encephalitis
virus) 		no annotation 3 ARG B 228
HIS B 203
TYR B 139
 None
URE  B 946 (-4.7A)
None
 0.91A 4fu8A-1ep5B:
4.0		 4fu8A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep5 CAPSID PROTEIN C

(Venezuelan
equine
encephalitis
virus) 		no annotation 3 ARG B 228
HIS B 204
TYR B 139
 None
URE  B 946 (-4.3A)
None
 1.07A 4fu8A-1ep5B:
4.0		 4fu8A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1z TNSA ENDONUCLEASE

(Escherichia
coli) 		PF08721
(Tn7_Tnp_TnsA_C)
PF08722
(Tn7_Tnp_TnsA_N) 		3 ARG A  54
HIS A  56
TYR A  29
 None
 0.99A 4fu8A-1f1zA:
0.0		 4fu8A-1f1zA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i78 PROTEASE VII

(Escherichia
coli) 		PF01278
(Omptin) 		3 ARG A 218
HIS A 268
TYR A 213
 None
 1.07A 4fu8A-1i78A:
undetectable		 4fu8A-1i78A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 ARG A 321
HIS A 330
TYR A 284
 None
 1.08A 4fu8A-1jioA:
0.0		 4fu8A-1jioA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		3 ARG A 337
HIS A 340
TYR A 333
 None
 1.02A 4fu8A-1ltmA:
0.0		 4fu8A-1ltmA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		3 ARG A  87
HIS A 164
TYR A  89
 None
 1.24A 4fu8A-1miqA:
1.4		 4fu8A-1miqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0e PROTEIN MRAZ

(Mycoplasma
pneumoniae) 		PF02381
(MraZ) 		3 ARG A  68
HIS A 136
TYR A  76
 None
 1.10A 4fu8A-1n0eA:
undetectable		 4fu8A-1n0eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		3 ARG A  81
HIS A  74
TYR A  85
 None
 1.22A 4fu8A-1q50A:
undetectable		 4fu8A-1q50A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qok MFE-23 RECOMBINANT
ANTIBODY FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 ARG A 251
HIS A  61
TYR A 131
 None
 1.03A 4fu8A-1qokA:
undetectable		 4fu8A-1qokA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 ARG A 136
HIS A 161
TYR A 266
 None
 1.32A 4fu8A-1qpoA:
undetectable		 4fu8A-1qpoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 ARG A 178
HIS A 180
TYR A  65
 None
 1.33A 4fu8A-1t6pA:
undetectable		 4fu8A-1t6pA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		3 ARG A 192
HIS A 218
TYR A 143
 None
 0.97A 4fu8A-1uf2A:
undetectable		 4fu8A-1uf2A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 ARG A 220
HIS A 217
TYR A 240
 GOL  A1652 (-3.1A)
GOL  A1652 (-3.9A)
GOL  A1652 (-4.7A)
 0.99A 4fu8A-1w8oA:
undetectable		 4fu8A-1w8oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ARG A 313
HIS A 316
TYR A 447
 None
 1.26A 4fu8A-1w99A:
undetectable		 4fu8A-1w99A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 392
HIS A 399
TYR A 388
 None
 1.09A 4fu8A-1x55A:
undetectable		 4fu8A-1x55A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ARG A  71
HIS A  68
TYR A 363
 None
 1.23A 4fu8A-1xc6A:
undetectable		 4fu8A-1xc6A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 ARG A 480
HIS A 428
TYR A 449
 None
 1.14A 4fu8A-1xjeA:
undetectable		 4fu8A-1xjeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmq DEFENSIN 6

(Homo sapiens) 		PF00323
(Defensin_1) 		3 ARG A   7
HIS A   5
TYR A  11
 None
 1.25A 4fu8A-1zmqA:
undetectable		 4fu8A-1zmqA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj3 FAB M18, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B  94
HIS B  96
TYR B  32
 None
 1.28A 4fu8A-2aj3B:
undetectable		 4fu8A-2aj3B:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 3 ARG A 168
HIS A 165
TYR A 200
 None
 1.03A 4fu8A-2ajaA:
undetectable		 4fu8A-2ajaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		3 ARG A 479
HIS A 476
TYR A 499
 None
 0.90A 4fu8A-2bf6A:
undetectable		 4fu8A-2bf6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 ARG A 114
HIS A 113
TYR A  49
 None
None
GOL  A 502 (-4.8A)
 1.18A 4fu8A-2gv8A:
undetectable		 4fu8A-2gv8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 ARG A 114
HIS A 115
TYR A  49
 None
None
GOL  A 502 (-4.8A)
 1.05A 4fu8A-2gv8A:
undetectable		 4fu8A-2gv8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hs5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR GNTR

(Rhodococcus
jostii) 		PF00392
(GntR)
PF07729
(FCD) 		3 ARG A 104
HIS A 152
TYR A 101
 ACT  A 238 (-3.0A)
ACT  A 238 (-3.8A)
ACT  A 238 (-4.4A)
 1.26A 4fu8A-2hs5A:
undetectable		 4fu8A-2hs5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		3 ARG A 262
HIS A   9
TYR A 195
 None
 1.06A 4fu8A-2o69A:
undetectable		 4fu8A-2o69A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG A1518
HIS A1433
TYR A1438
 None
 1.01A 4fu8A-2pffA:
undetectable		 4fu8A-2pffA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz7 UNCHARACTERIZED
PROTEIN SCO6318

(Streptomyces
coelicolor) 		PF02342
(TerD) 		3 ARG A 104
HIS A  55
TYR A  49
 None
 1.32A 4fu8A-2qz7A:
undetectable		 4fu8A-2qz7A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG U  35
HIS U  37
TYR U  60
 None
 0.56A 4fu8A-2r2wU:
45.9		 4fu8A-2r2wU:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 ARG A  98
HIS A 101
TYR A 208
 None
MN  A1005 (-3.3A)
None
 1.26A 4fu8A-2vqaA:
undetectable		 4fu8A-2vqaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		3 ARG A 584
HIS A 581
TYR A 608
 None
 1.04A 4fu8A-2w20A:
undetectable		 4fu8A-2w20A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 506
HIS A 513
TYR A 502
 None
 1.10A 4fu8A-2xgtA:
undetectable		 4fu8A-2xgtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 ARG A 304
HIS A  51
TYR A  54
 PO4  A4001 (-3.1A)
PO4  A4001 (-4.1A)
None
 1.26A 4fu8A-2y38A:
undetectable		 4fu8A-2y38A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		3 ARG A1037
HIS B 407
TYR A1033
 None
 1.31A 4fu8A-2y9yA:
undetectable		 4fu8A-2y9yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE
DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE

(Saccharopolyspora
erythraea;
Saccharopolyspora
erythraea) 		PF06722
(DUF1205)
PF00067
(p450) 		3 ARG B  77
HIS A  88
TYR B  43
 None
 1.23A 4fu8A-2yjnB:
undetectable		 4fu8A-2yjnB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 211
HIS A 209
TYR A 183
 None
 1.27A 4fu8A-3dfhA:
undetectable		 4fu8A-3dfhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		3 ARG A  57
HIS A 373
TYR A  54
 None
 1.29A 4fu8A-3e0jA:
undetectable		 4fu8A-3e0jA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 ARG A 707
HIS A 705
TYR A 180
 None
 1.28A 4fu8A-3egwA:
undetectable		 4fu8A-3egwA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		3 ARG A 386
HIS A 326
TYR A 388
 None
 1.02A 4fu8A-3h1wA:
undetectable		 4fu8A-3h1wA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG B 299
HIS B 381
TYR B 375
 None
 1.10A 4fu8A-3hhsB:
undetectable		 4fu8A-3hhsB:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 305
HIS A 383
TYR A 377
 None
 1.15A 4fu8A-3hhsA:
undetectable		 4fu8A-3hhsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 ARG A1008
HIS A 796
TYR A1005
 None
 0.88A 4fu8A-3l4kA:
undetectable		 4fu8A-3l4kA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05411
(Peptidase_C32) 		3 ARG A  72
HIS A  46
TYR A  75
 None
 1.15A 4fu8A-3mtvA:
undetectable		 4fu8A-3mtvA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ARG A  71
HIS A  68
TYR A 362
 None
 1.28A 4fu8A-3ogrA:
undetectable		 4fu8A-3ogrA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qeg FAB FRAGMENT OF
HUMAN ANTI-HIV
ANTIBODY N12-I2,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  97
HIS H 100
TYR H  32
 None
 1.21A 4fu8A-3qegH:
undetectable		 4fu8A-3qegH:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		3 ARG A  92
HIS A  95
TYR A 200
 CO3  A 600 (-4.0A)
MN  A 500 ( 3.3A)
None
 0.97A 4fu8A-3s0mA:
undetectable		 4fu8A-3s0mA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		3 ARG A  59
HIS A  56
TYR A 331
 None
CL  A 801 (-4.4A)
None
 1.32A 4fu8A-3thcA:
undetectable		 4fu8A-3thcA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt3 MOUSE MONOCLONAL
1GG1 FAB FRAGMENT,
KAPPA LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  98
HIS H  32
TYR H 108
 None
 1.24A 4fu8A-3tt3H:
undetectable		 4fu8A-3tt3H:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ARG A 452
HIS A 164
TYR A 581
 None
 0.80A 4fu8A-3viuA:
undetectable		 4fu8A-3viuA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		3 ARG A  50
HIS A  47
TYR A 310
 None
CL  A 807 (-4.3A)
None
 1.30A 4fu8A-3w5fA:
undetectable		 4fu8A-3w5fA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ARG A 663
HIS A 689
TYR A 686
 None
 1.17A 4fu8A-3wfzA:
undetectable		 4fu8A-3wfzA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2g CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Sphaerobacter
thermophilus) 		PF07883
(Cupin_2) 		3 ARG A 113
HIS A  56
TYR A 116
 None
 0.86A 4fu8A-4e2gA:
undetectable		 4fu8A-4e2gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		3 ARG A  28
HIS A  25
TYR A 303
 None
 1.26A 4fu8A-4e8dA:
undetectable		 4fu8A-4e8dA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		3 ARG A1008
HIS A 796
TYR A1005
 None
 0.90A 4fu8A-4gfhA:
undetectable		 4fu8A-4gfhA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ARG A  71
HIS A  68
TYR A 362
 None
 1.23A 4fu8A-4iugA:
undetectable		 4fu8A-4iugA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		3 ARG A 220
HIS A 217
TYR A 240
 GOL  A 501 (-2.7A)
GOL  A 501 (-3.6A)
None
 0.97A 4fu8A-4j9tA:
undetectable		 4fu8A-4j9tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kml NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 ARG B  98
HIS B 113
TYR B  32
 None
 1.01A 4fu8A-4kmlB:
undetectable		 4fu8A-4kmlB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 ARG A 320
HIS A 671
TYR A 327
 BGC  A 801 ( 4.3A)
None
BGC  A 801 (-4.5A)
 0.75A 4fu8A-4ktpA:
undetectable		 4fu8A-4ktpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  94
HIS H 102
TYR H  32
 None
EDO  H 301 ( 4.5A)
None
 1.12A 4fu8A-4lsuH:
undetectable		 4fu8A-4lsuH:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 ARG A  28
HIS A  25
TYR A 299
 None
 1.30A 4fu8A-4madA:
undetectable		 4fu8A-4madA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		3 ARG A  33
HIS A  30
TYR A   9
 None
 1.24A 4fu8A-4nmwA:
undetectable		 4fu8A-4nmwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 ARG A 239
HIS A 240
TYR A 273
 None
 1.16A 4fu8A-4p22A:
undetectable		 4fu8A-4p22A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		3 ARG A 224
HIS A 200
TYR A 230
 3M5  A 403 ( 4.1A)
CO  A 402 (-3.3A)
None
 1.01A 4fu8A-4rdyA:
undetectable		 4fu8A-4rdyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 3 ARG A 298
HIS A 272
TYR A 312
 None
EEM  A 401 ( 4.7A)
None
 1.23A 4fu8A-4rh0A:
undetectable		 4fu8A-4rh0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1s FAB OF VRC01-LINEAGE
ANTIBODY,45-VRC01.H5
.F-185917 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  94
HIS H 102
TYR H  32
 None
 0.86A 4fu8A-4s1sH:
undetectable		 4fu8A-4s1sH:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txw HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 ARG A  63
HIS A  61
TYR A 139
 None
 1.31A 4fu8A-4txwA:
undetectable		 4fu8A-4txwA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uon CAPSID PROTEASE

(Aura virus) 		PF00944
(Peptidase_S3) 		3 ARG A 220
HIS A 195
TYR A 131
 None
 0.89A 4fu8A-4uonA:
9.7		 4fu8A-4uonA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uon CAPSID PROTEASE

(Aura virus) 		PF00944
(Peptidase_S3) 		3 ARG A 220
HIS A 196
TYR A 131
 None
 1.22A 4fu8A-4uonA:
9.7		 4fu8A-4uonA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 ARG A 334
HIS A 325
TYR A 332
 None
 0.96A 4fu8A-4uopA:
undetectable		 4fu8A-4uopA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 ARG A 191
HIS A 179
TYR A 301
 None
 0.97A 4fu8A-4v06A:
undetectable		 4fu8A-4v06A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		3 ARG A 183
HIS A 180
TYR A 212
 None
 1.16A 4fu8A-4x6dA:
undetectable		 4fu8A-4x6dA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		3 ARG A 519
HIS A 516
TYR A 536
 None
 0.96A 4fu8A-4x6kA:
undetectable		 4fu8A-4x6kA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 ARG A 414
HIS A 399
TYR A 427
 None
 0.60A 4fu8A-4xh9A:
undetectable		 4fu8A-4xh9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		3 ARG A 258
HIS A 238
TYR A 255
 None
 1.33A 4fu8A-4zhjA:
undetectable		 4fu8A-4zhjA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		3 ARG A  77
HIS A 237
TYR A 114
 None
 1.30A 4fu8A-4zn2A:
undetectable		 4fu8A-4zn2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs6 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 3 ARG H  98
HIS H 110
TYR H  32
 None
 1.05A 4fu8A-4zs6H:
undetectable		 4fu8A-4zs6H:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		3 ARG A  41
HIS A  62
TYR A  97
 None
 1.32A 4fu8A-5a2aA:
undetectable		 4fu8A-5a2aA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv3 M7GPPPX
DIPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		3 ARG A 158
HIS A 123
TYR A 264
 None
None
M7G  A 401 (-4.7A)
 1.14A 4fu8A-5bv3A:
undetectable		 4fu8A-5bv3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens;
Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3)
PF00169
(PH)
PF16746
(BAR_3) 		3 ARG B 299
HIS A 140
TYR B 283
 None
 1.12A 4fu8A-5c5bB:
undetectable		 4fu8A-5c5bB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cin FAB 4E10 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  94
HIS H 102
TYR H  32
 None
 1.03A 4fu8A-5cinH:
undetectable		 4fu8A-5cinH:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 ARG A 303
HIS A 154
TYR A 301
 None
 1.30A 4fu8A-5e5uA:
undetectable		 4fu8A-5e5uA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ARG A  71
HIS A  68
TYR A 362
 None
 1.28A 4fu8A-5ihrA:
undetectable		 4fu8A-5ihrA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		3 ARG A 146
HIS A 134
TYR A 256
 None
 1.01A 4fu8A-5jk6A:
undetectable		 4fu8A-5jk6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k24 METAL TRANSPORTER
CNNM3

(Mus musculus) 		PF00571
(CBS) 		3 ARG C 354
HIS C 418
TYR C 370
 None
 1.11A 4fu8A-5k24C:
undetectable		 4fu8A-5k24C:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ARG A  44
HIS A 100
TYR A  35
 None
 1.18A 4fu8A-5k3hA:
undetectable		 4fu8A-5k3hA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ARG A  42
HIS A  98
TYR A  33
 None
 1.24A 4fu8A-5k3jA:
undetectable		 4fu8A-5k3jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF13895
(Ig_2) 		3 ARG D  84
HIS A 197
TYR D  76
 None
 1.27A 4fu8A-5knmD:
undetectable		 4fu8A-5knmD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nst HEAVY CHAIN OF
ANTIBODY MGD21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF13895
(Ig_2) 		3 ARG B  34
HIS B  53
TYR B 235
 None
 1.24A 4fu8A-5nstB:
undetectable		 4fu8A-5nstB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ob5 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 3 ARG H  98
HIS H 108
TYR H  32
 SO4  H 304 (-3.0A)
SO4  H 303 ( 3.7A)
None
 0.99A 4fu8A-5ob5H:
undetectable		 4fu8A-5ob5H:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 ARG A 204
HIS A 208
TYR A 188
 PO4  A 503 ( 3.0A)
ZN  A 502 ( 3.1A)
EDO  A 511 ( 3.0A)
 1.27A 4fu8A-5uamA:
undetectable		 4fu8A-5uamA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 CAPSID PROTEIN

(Chikungunya
virus) 		no annotation 3 ARG I 215
HIS I 190
TYR I 126
 None
 1.02A 4fu8A-5vu2I:
4.1		 4fu8A-5vu2I:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcx VH(S112C)-SARAH
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		3 ARG A  94
HIS A 102
TYR A  32
 None
PO4  A 203 (-3.8A)
None
 1.16A 4fu8A-5xcxA:
undetectable		 4fu8A-5xcxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 3 ARG A 506
HIS A 513
TYR A 502
 None
 1.08A 4fu8A-5xixA:
undetectable		 4fu8A-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq4 SIDE

(Legionella
pneumophila) 		no annotation 3 ARG B 549
HIS B 446
TYR B 449
 None
 0.93A 4fu8A-5zq4B:
undetectable		 4fu8A-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S5
RIBOSOMAL PROTEIN
S21E

(Leishmania
donovani;
Leishmania
donovani) 		no annotation
no annotation 		3 ARG F 231
HIS Y  32
TYR F 228
 None
 1.26A 4fu8A-6az1F:
undetectable		 4fu8A-6az1F:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 3 ARG A2251
HIS A2367
TYR A2243
 None
 1.23A 4fu8A-6fayA:
undetectable		 4fu8A-6fayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 ARG A2336
HIS A2452
TYR A2328
 None
 1.18A 4fu8A-6fb3A:
undetectable		 4fu8A-6fb3A:
undetectable