SIMILAR PATTERNS OF AMINO ACIDS FOR 4FR0_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli)
PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3)
5 GLY A  50
LEU A  53
ILE A  44
VAL A  27
LEU A  30
None
1.05A 4fr0A-1b63A:
undetectable
4fr0A-1b63A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori)
PF00258
(Flavodoxin_1)
5 GLY A  99
GLY A  58
PHE A 134
ILE A 100
LEU A  86
None
FMN  A 165 (-3.8A)
None
None
FMN  A 165 (-3.7A)
1.14A 4fr0A-1fueA:
undetectable
4fr0A-1fueA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE


(Oryctolagus
cuniculus)
PF00135
(COesterase)
5 GLY A 210
GLY A 131
LEU A 127
ILE A 205
VAL A 164
None
1.11A 4fr0A-1k4yA:
undetectable
4fr0A-1k4yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 125
GLY A  66
ILE A  38
ASN A 123
VAL A 130
None
0.97A 4fr0A-1lluA:
5.6
4fr0A-1lluA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 125
LEU A 153
ILE A  38
ASN A 123
VAL A 130
None
1.04A 4fr0A-1lluA:
5.6
4fr0A-1lluA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE


(Xenopus laevis)
no annotation 5 GLY A 110
GLY A 149
ASN A 113
VAL A 115
LEU A 119
None
1.13A 4fr0A-1oe5A:
undetectable
4fr0A-1oe5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica)
PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M)
5 GLY A 421
LEU A 423
PHE A 380
ILE A 440
VAL A 445
None
1.14A 4fr0A-1pjqA:
4.6
4fr0A-1pjqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF


(Bacillus
subtilis)
PF01926
(MMR_HSR1)
5 GLY A 127
GLY A 174
ASP A 171
LEU A 176
VAL A 131
None
GNP  A 501 (-3.1A)
MG  A9001 ( 4.2A)
None
GNP  A 501 (-4.2A)
0.96A 4fr0A-1pujA:
2.0
4fr0A-1pujA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE


(Medicago sativa)
PF01596
(Methyltransf_3)
5 GLY A  87
ASP A 165
LEU A  94
ILE A 160
LEU A 108
SAH  A 301 (-3.4A)
SAH  A 301 ( 2.8A)
None
None
None
1.09A 4fr0A-1susA:
12.7
4fr0A-1susA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT


(Pyrococcus
horikoshii)
PF00694
(Aconitase_C)
5 GLY A  81
LEU A 103
ILE A  96
VAL A 145
LEU A 142
None
1.06A 4fr0A-1v7lA:
undetectable
4fr0A-1v7lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmj HYPOTHETICAL PROTEIN
TM0723


(Thermotoga
maritima)
PF01894
(UPF0047)
5 GLY A  99
ILE A  52
GLU A 117
ASN A  42
VAL A 102
None
1.03A 4fr0A-1vmjA:
undetectable
4fr0A-1vmjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Vibrio cholerae)
PF01408
(GFO_IDH_MocA)
5 GLY A   9
GLY A  11
LEU A  19
GLN A  15
ILE A   8
None
0.96A 4fr0A-1xeaA:
4.6
4fr0A-1xeaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME


(Rattus
norvegicus)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
6 GLY A 303
GLY A 305
GLN A 331
GLU A 394
ASN A 408
LEU A 387
None
1.39A 4fr0A-1zcjA:
6.1
4fr0A-1zcjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aan AURACYANIN A

(Chloroflexus
aurantiacus)
PF00127
(Copper-bind)
5 GLY A  66
ILE A 122
ASN A  93
VAL A  63
LEU A  62
None
0.98A 4fr0A-2aanA:
undetectable
4fr0A-2aanA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2


(Toxoplasma
gondii)
PF00179
(UQ_con)
5 GLY A  82
LEU A 119
ILE A 106
ASN A  53
VAL A  67
None
UNX  A 154 (-4.9A)
None
None
None
0.99A 4fr0A-2ayvA:
undetectable
4fr0A-2ayvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2


(Carnivore
protoparvovirus
1)
PF00740
(Parvo_coat)
5 GLY A 496
LEU A 498
ILE A 246
ASN A 180
VAL A 250
None
1.11A 4fr0A-2casA:
undetectable
4fr0A-2casA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Synechococcus
elongatus)
PF00202
(Aminotran_3)
5 GLY A 342
GLY A 386
LEU A 378
PHE A 345
VAL A 318
None
1.05A 4fr0A-2cfbA:
undetectable
4fr0A-2cfbA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE


(Aedes aegypti)
PF00266
(Aminotran_5)
5 GLY A 162
LEU A 150
GLN A 161
GLU A 196
LEU A 169
None
1.12A 4fr0A-2hufA:
undetectable
4fr0A-2hufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Staphylococcus
aureus)
PF00005
(ABC_tran)
5 LEU A  36
PHE A 203
ILE A 204
GLU A 205
ASN A 236
None
0.83A 4fr0A-2ihyA:
undetectable
4fr0A-2ihyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY


(Thermus
aquaticus)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 GLY D 109
GLY D 194
ASP D 191
LEU D 196
VAL D 113
None
GNP  D1400 (-3.3A)
MG  D1401 ( 4.0A)
None
GNP  D1400 (-4.1A)
0.97A 4fr0A-2j7pD:
2.3
4fr0A-2j7pD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A


(Methanocaldococcus
jannaschii)
PF00117
(GATase)
5 GLY A  46
GLY A 184
LEU A  19
ILE A  47
LEU A  73
None
1.09A 4fr0A-2lxnA:
undetectable
4fr0A-2lxnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE


(Thermobifida
fusca)
PF13378
(MR_MLE_C)
5 GLY A 239
LEU A 246
GLU A  56
VAL A 204
LEU A 207
None
1.13A 4fr0A-2opjA:
undetectable
4fr0A-2opjA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgx UBIQUITIN-CONJUGATIN
G ENZYME E2 Q1


(Homo sapiens)
PF00179
(UQ_con)
5 GLY A 101
LEU A  98
ILE A 126
ASN A  71
VAL A  85
None
1.12A 4fr0A-2qgxA:
undetectable
4fr0A-2qgxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF01494
(FAD_binding_3)
5 GLY A  16
ASP A 329
ILE A   7
VAL A 162
LEU A 161
None
1.04A 4fr0A-2rgjA:
undetectable
4fr0A-2rgjA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
5 GLY A 447
LEU A 401
ILE A 513
ASN A 474
VAL A 468
None
1.08A 4fr0A-2wk2A:
undetectable
4fr0A-2wk2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN


(Escherichia
coli)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 LEU B 290
ILE B 296
ASN B 266
VAL B 308
LEU B 355
None
0.86A 4fr0A-2y7cB:
9.8
4fr0A-2y7cB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 GLY A 358
GLY A 197
GLN A 356
ILE A 330
ASN A 194
None
None
None
None
SO4  A 411 ( 3.1A)
1.08A 4fr0A-3aatA:
undetectable
4fr0A-3aatA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi)
PF03211
(Pectate_lyase)
5 ASP A 133
LEU A 153
ILE A 184
ASN A 163
VAL A 187
None
1.14A 4fr0A-3b8yA:
undetectable
4fr0A-3b8yA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi)
PF03211
(Pectate_lyase)
5 ASP A 133
LEU A 153
ILE A 184
ASN A 163
VAL A 187
None
1.13A 4fr0A-3b90A:
undetectable
4fr0A-3b90A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280


(Methanosarcina
acetivorans)
PF13531
(SBP_bac_11)
5 GLY A 134
PHE A 254
ASN A 138
VAL A 257
LEU A 125
None
1.07A 4fr0A-3cfxA:
undetectable
4fr0A-3cfxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME


(Schistosoma
japonicum)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 GLY A  83
GLY A  84
ILE A  92
GLU A  96
ASN A  80
None
1.13A 4fr0A-3cruA:
undetectable
4fr0A-3cruA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d12 EPHRIN-B3

(Mus musculus)
PF00812
(Ephrin)
5 GLY B  89
LEU B 164
ILE B 138
VAL B  84
LEU B  83
None
1.13A 4fr0A-3d12B:
undetectable
4fr0A-3d12B:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7l LIN1944 PROTEIN

(Listeria
innocua)
PF13561
(adh_short_C2)
5 GLY A  97
LEU A 101
ILE A   6
ASN A  92
LEU A 109
None
1.09A 4fr0A-3d7lA:
4.4
4fr0A-3d7lA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmb PUTATIVE GENERAL
STRESS PROTEIN 26
WITH A PNP-OXIDASE
LIKE FOLD


(Xanthomonas
campestris)
PF16242
(Pyrid_ox_like)
5 GLY A  70
GLY A  24
LEU A  87
ILE A  83
VAL A  21
None
1.02A 4fr0A-3dmbA:
undetectable
4fr0A-3dmbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eix HTSA PROTEIN

(Staphylococcus
aureus)
PF01497
(Peripla_BP_2)
6 GLY A 205
ASP A 280
LEU A 207
GLN A 246
ILE A 262
LEU A 197
None
1.27A 4fr0A-3eixA:
2.2
4fr0A-3eixA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE


(Micrococcus
luteus)
PF04960
(Glutaminase)
5 GLY A 291
ASP A 283
LEU A 298
ASN A 287
VAL A 265
None
1.15A 4fr0A-3ihaA:
undetectable
4fr0A-3ihaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2


(Bacillus
anthracis)
PF00202
(Aminotran_3)
5 GLY A 358
GLY A 401
LEU A 394
ILE A 350
LEU A 333
None
1.14A 4fr0A-3k28A:
undetectable
4fr0A-3k28A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280


(Methanosarcina
acetivorans)
PF13531
(SBP_bac_11)
5 GLY A 134
PHE A 254
ASN A 138
VAL A 257
LEU A 125
None
1.04A 4fr0A-3k6xA:
undetectable
4fr0A-3k6xA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 GLY A   9
PHE A 121
ILE A 122
ASN A 135
VAL A 132
None
1.08A 4fr0A-3kjrA:
undetectable
4fr0A-3kjrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT


(Streptococcus
thermophilus)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 GLY A  37
ASP A 138
ILE A 185
GLU A 182
ASN A 262
None
0.91A 4fr0A-3lkdA:
10.1
4fr0A-3lkdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING


(Brucella suis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 123
GLY A  64
ILE A  36
ASN A 121
VAL A 128
None
1.01A 4fr0A-3meqA:
5.7
4fr0A-3meqA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN


(Escherichia
virus Qbeta)
no annotation 5 GLY G 237
GLY G 326
LEU G 302
GLN G 233
ILE G 239
None
1.10A 4fr0A-3mmpG:
undetectable
4fr0A-3mmpG:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN


(Bacteroides
fragilis)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 GLY A  75
PHE A 470
ILE A 471
ASN A 344
VAL A 347
None
1.01A 4fr0A-3nqpA:
undetectable
4fr0A-3nqpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis)
PF10988
(DUF2807)
5 ASP A 123
GLN A 148
ILE A 137
ASN A 144
VAL A 165
None
1.06A 4fr0A-3petA:
undetectable
4fr0A-3petA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT


(Cryptococcus
neoformans)
PF00432
(Prenyltrans)
5 GLY B 311
GLY B 313
GLN B 305
VAL B   9
LEU B  12
None
1.14A 4fr0A-3q75B:
undetectable
4fr0A-3q75B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE


(Bacillus cereus)
PF00296
(Bac_luciferase)
5 GLY A 299
GLN A 303
ILE A 308
VAL A 337
LEU A 340
None
SO4  A 354 (-4.6A)
None
None
None
1.10A 4fr0A-3raoA:
undetectable
4fr0A-3raoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY


(Cupriavidus
pinatubonensis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 123
GLY A  64
ILE A  36
ASN A 121
VAL A 128
None
1.11A 4fr0A-3s2gA:
5.9
4fr0A-3s2gA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY


(Cupriavidus
pinatubonensis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 123
LEU A 151
ILE A  36
ASN A 121
VAL A 128
None
1.12A 4fr0A-3s2gA:
5.9
4fr0A-3s2gA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8y CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE


(Thermotoga
maritima)
PF00072
(Response_reg)
6 GLY A  66
GLY A  40
ASP A  13
LEU A  72
ILE A  67
GLU A  97
None
None
PB  A 145 (-2.7A)
None
None
None
1.37A 4fr0A-3t8yA:
2.5
4fr0A-3t8yA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaf TTR-52

(Caenorhabditis
elegans)
PF01060
(TTR-52)
5 ASP A  67
LEU A  47
ILE A  93
ASN A  71
LEU A 123
None
1.12A 4fr0A-3uafA:
undetectable
4fr0A-3uafA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF04850
(Baculo_E66)
5 GLY A 132
LEU A 130
PHE A 193
VAL A 199
LEU A 200
None
1.00A 4fr0A-3vsmA:
undetectable
4fr0A-3vsmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8)
PF11602
(NTPase_P4)
5 GLY A  81
ASP A  78
MET A 196
GLN A 192
VAL A  53
None
0.98A 4fr0A-4blqA:
undetectable
4fr0A-4blqA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK


(Streptococcus
pneumoniae)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 GLY A 417
ASP A 414
ILE A 250
VAL A 420
LEU A 421
None
1.09A 4fr0A-4c23A:
undetectable
4fr0A-4c23A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica)
PF03377
(TAL_effector)
5 GLY A 162
PHE A 148
ILE A 153
VAL A 136
LEU A 139
None
1.13A 4fr0A-4cjaA:
undetectable
4fr0A-4cjaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica)
PF03377
(TAL_effector)
5 GLY A 228
PHE A 214
ILE A 219
VAL A 202
LEU A 205
None
1.08A 4fr0A-4cjaA:
undetectable
4fr0A-4cjaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica)
PF03377
(TAL_effector)
5 GLY A 360
PHE A 346
ILE A 351
VAL A 334
LEU A 337
None
1.10A 4fr0A-4cjaA:
undetectable
4fr0A-4cjaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica)
PF03377
(TAL_effector)
5 GLY A 492
PHE A 478
ILE A 483
VAL A 466
LEU A 469
None
1.05A 4fr0A-4cjaA:
undetectable
4fr0A-4cjaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica)
PF03377
(TAL_effector)
5 GLY A 591
PHE A 577
ILE A 582
VAL A 565
LEU A 568
None
1.12A 4fr0A-4cjaA:
undetectable
4fr0A-4cjaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE


(Staphylococcus
aureus)
PF00162
(PGK)
5 LEU A  41
ILE A  47
ASN A 148
VAL A  18
LEU A  56
None
1.08A 4fr0A-4dg5A:
undetectable
4fr0A-4dg5A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE


(Enterococcus
faecalis)
PF02557
(VanY)
5 PHE A 124
ILE A 122
ASN A  65
VAL A  68
LEU A 115
None
None
GOL  A 315 (-4.1A)
None
None
1.09A 4fr0A-4f78A:
undetectable
4fr0A-4f78A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1


(Pseudomonas
aeruginosa)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II)
5 GLY A  14
ASP A 107
ILE A 138
VAL A 282
LEU A 279
None
1.12A 4fr0A-4fn5A:
2.0
4fr0A-4fn5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
5 GLY A  81
LEU A  26
GLN A  31
ILE A 144
LEU A  89
None
1.12A 4fr0A-4fn7A:
undetectable
4fr0A-4fn7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE


(Escherichia
coli)
PF13847
(Methyltransf_31)
5 GLY B  56
GLY B  53
LEU B 117
ILE B  60
GLU B  64
None
SAM  B 301 (-3.8A)
None
None
None
1.12A 4fr0A-4htfB:
14.9
4fr0A-4htfB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF13365
(Trypsin_2)
5 GLY A 133
GLY A 268
ILE A 142
ASN A 223
VAL A 103
None
1.07A 4fr0A-4ic5A:
undetectable
4fr0A-4ic5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE


(Pseudomonas
fluorescens)
PF04909
(Amidohydro_2)
5 GLY A 230
ILE A 224
ASN A 148
VAL A 176
LEU A 175
None
1.04A 4fr0A-4ifrA:
undetectable
4fr0A-4ifrA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx2 HYPOTHETICAL PROTEIN

(Legionella
pneumophila)
no annotation 6 GLY A 133
MET A 137
LEU A 257
ASN A 191
VAL A 190
LEU A 187
None
1.42A 4fr0A-4jx2A:
undetectable
4fr0A-4jx2A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kw7 ARSENIC
METHYLTRANSFERASE


(Cyanidioschyzon
sp. 5508)
PF13847
(Methyltransf_31)
9 GLY A  91
ASP A  97
MET A 116
LEU A 117
PHE A 150
ILE A 151
GLU A 152
VAL A 175
LEU A 178
CA  A 401 (-4.4A)
None
None
None
None
None
None
None
None
1.04A 4fr0A-4kw7A:
46.9
4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kw7 ARSENIC
METHYLTRANSFERASE


(Cyanidioschyzon
sp. 5508)
PF13847
(Methyltransf_31)
8 GLY A  91
GLY A  93
ASP A  97
MET A 116
LEU A 117
GLN A 120
ILE A 151
GLU A 152
CA  A 401 (-4.4A)
None
None
None
None
None
None
None
0.75A 4fr0A-4kw7A:
46.9
4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kw7 ARSENIC
METHYLTRANSFERASE


(Cyanidioschyzon
sp. 5508)
PF13847
(Methyltransf_31)
8 GLY A  91
GLY A  93
ASP A  97
MET A 116
LEU A 117
PHE A 150
ILE A 151
GLU A 152
CA  A 401 (-4.4A)
None
None
None
None
None
None
None
0.73A 4fr0A-4kw7A:
46.9
4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kw7 ARSENIC
METHYLTRANSFERASE


(Cyanidioschyzon
sp. 5508)
PF13847
(Methyltransf_31)
7 GLY A  91
MET A 116
LEU A 117
GLN A 120
ILE A 151
GLU A 152
ASN A 173
CA  A 401 (-4.4A)
None
None
None
None
None
None
0.82A 4fr0A-4kw7A:
46.9
4fr0A-4kw7A:
98.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kw7 ARSENIC
METHYLTRANSFERASE


(Cyanidioschyzon
sp. 5508)
PF13847
(Methyltransf_31)
9 GLY A  91
MET A 116
LEU A 117
PHE A 150
ILE A 151
GLU A 152
ASN A 173
VAL A 175
LEU A 178
CA  A 401 (-4.4A)
None
None
None
None
None
None
None
None
0.92A 4fr0A-4kw7A:
46.9
4fr0A-4kw7A:
98.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN


(Ketogulonicigenium
vulgare)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 GLY A 108
MET A 112
LEU A 113
PHE A 200
VAL A 160
None
1.09A 4fr0A-4lswA:
5.4
4fr0A-4lswA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE


(Homo sapiens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 GLY A 281
ASP A  32
GLU A 447
ASN A 274
LEU A 285
None
FGP  A  70 (-3.0A)
None
CA  A 601 (-3.0A)
None
1.10A 4fr0A-4mivA:
undetectable
4fr0A-4mivA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Streptococcus
pneumoniae)
PF01070
(FMN_dh)
5 GLY A  68
GLY A  64
ASP A 101
ILE A  71
GLU A 282
None
1.15A 4fr0A-4n02A:
undetectable
4fr0A-4n02A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 ASP A 508
LEU A 569
ILE A 518
ASN A 509
LEU A 492
None
None
None
PZW  A 801 (-4.4A)
None
1.14A 4fr0A-4q9zA:
undetectable
4fr0A-4q9zA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis)
PF03403
(PAF-AH_p_II)
5 GLY A  98
LEU A 272
ILE A 126
ASN A 168
LEU A 150
None
1.14A 4fr0A-4wfiA:
2.4
4fr0A-4wfiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE


(Clostridium
acetobutylicum)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 GLY A 291
GLY A 282
MET A 288
GLN A 383
LEU A 377
None
1.10A 4fr0A-4wyrA:
undetectable
4fr0A-4wyrA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3


(Homo sapiens)
PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3)
5 GLY A 921
GLN A 858
ILE A 656
ASN A 919
LEU A 659
None
1.10A 4fr0A-5b16A:
undetectable
4fr0A-5b16A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c22 CHROMOSOMAL
HEMOLYSIN D


(Escherichia
coli)
PF13437
(HlyD_3)
5 GLY A 115
MET A 357
LEU A 341
ILE A 359
VAL A 118
None
1.15A 4fr0A-5c22A:
undetectable
4fr0A-5c22A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3


(Homo sapiens)
PF00083
(Sugar_tr)
5 GLY A 152
GLY A 155
GLU A 452
VAL A 326
LEU A 334
None
1.10A 4fr0A-5c65A:
undetectable
4fr0A-5c65A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1
PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pseudomonas
stutzeri;
Pseudomonas
stutzeri)
PF00115
(COX1)
no annotation
5 ASP A 304
PHE N  27
ILE N  28
VAL A 311
LEU A 314
None
0.82A 4fr0A-5djqA:
undetectable
4fr0A-5djqA:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5evj ARSENITE
METHYLTRANSFERASE


(Chlamydomonas
reinhardtii)
PF13847
(Methyltransf_31)
10 GLY A  91
GLY A  93
ASP A  97
MET A 116
GLN A 120
ILE A 150
GLU A 151
ASN A 169
VAL A 171
LEU A 174
None
0.57A 4fr0A-5evjA:
39.4
4fr0A-5evjA:
45.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1m PHOSPHORYLATED
PROTEIN PHOSPHATASE


(Staphylococcus
aureus)
PF13672
(PP2C_2)
5 GLY A  38
GLY A  40
ASP A 233
MET A  99
ASN A 234
MN  A 302 (-3.9A)
MN  A 302 ( 4.7A)
MN  A 301 (-2.4A)
None
None
1.15A 4fr0A-5f1mA:
undetectable
4fr0A-5f1mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3


(Arabidopsis
thaliana)
PF00311
(PEPcase)
5 GLY A 968
LEU A 964
PHE A 776
ILE A 775
VAL A 787
None
1.08A 4fr0A-5fdnA:
undetectable
4fr0A-5fdnA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY


(Escherichia
coli)
PF00238
(Ribosomal_L14)
5 GLY l 300
GLY l 385
ASP l 382
LEU l 387
VAL l 304
None
GNP  l1400 ( 3.3A)
MG  l1401 ( 4.1A)
None
GNP  l1400 ( 4.1A)
0.97A 4fr0A-5gadl:
undetectable
4fr0A-5gadl:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE


(Homo sapiens)
PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16)
5 GLY A 461
GLY A 463
ASP A 469
ASN A 472
VAL A 476
None
0.98A 4fr0A-5jz8A:
undetectable
4fr0A-5jz8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 GLY A 183
GLY A 268
ASP A 265
LEU A 270
VAL A 187
None
GCP  A 401 (-3.4A)
MG  A 402 (-3.9A)
GCP  B 401 ( 4.9A)
GCP  A 401 (-4.2A)
1.05A 4fr0A-5l3rA:
2.3
4fr0A-5l3rA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum)
PF00232
(Glyco_hydro_1)
5 GLY A  16
GLN A  78
PHE A 153
ILE A 115
ASN A 164
None
1.14A 4fr0A-5naqA:
undetectable
4fr0A-5naqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 GLY A 106
GLY A 148
ILE A 110
GLU A  97
ASN A 101
None
None
None
None
GTP  A 500 (-3.3A)
1.12A 4fr0A-5nd4A:
3.2
4fr0A-5nd4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE


(Amycolatopsis
methanolica)
no annotation 5 GLY A  41
GLY A  38
GLN A  76
ASN A  33
LEU A  45
FES  A 402 (-3.7A)
FES  A 402 (-3.4A)
None
None
NA  A 403 ( 4.9A)
1.09A 4fr0A-5ogxA:
5.5
4fr0A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens)
no annotation 5 GLY B 205
GLY B 207
ILE B 204
ASN B 277
VAL B 278
SAH  B 501 (-3.5A)
SAH  B 501 (-3.3A)
None
GOL  B 502 (-4.3A)
SAH  B 501 (-4.1A)
1.03A 4fr0A-5thzB:
14.5
4fr0A-5thzB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE


(Marinobacter
hydrocarbonoclasticus)
PF00171
(Aldedh)
5 LEU A 212
ILE A  10
ASN A  37
VAL A   8
LEU A 201
None
0.97A 4fr0A-5u0lA:
undetectable
4fr0A-5u0lA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubc PROTEIN TOC75-3,
CHLOROPLASTIC


(Arabidopsis
thaliana)
no annotation 5 GLY A 409
ILE A 366
ASN A 428
VAL A 441
LEU A 369
None
0.92A 4fr0A-5ubcA:
undetectable
4fr0A-5ubcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvn PARAQUAT-INDUCIBLE
PROTEIN B


(Escherichia
coli)
PF02470
(MlaD)
5 GLY A 370
LEU A 368
ILE A 339
VAL A 305
LEU A 312
None
1.12A 4fr0A-5uvnA:
undetectable
4fr0A-5uvnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum)
no annotation 5 GLY A 140
LEU A 330
ILE A 319
ASN A 352
LEU A 134
GLY  A 140 ( 0.0A)
LEU  A 330 ( 0.5A)
ILE  A 319 ( 0.7A)
ASN  A 352 ( 0.6A)
LEU  A 134 ( 0.6A)
1.05A 4fr0A-5w0aA:
undetectable
4fr0A-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9y DNA MISMATCH REPAIR
PROTEIN MUTL


(Aquifex
aeolicus)
no annotation 5 ASP C  18
PHE C 182
ILE C  39
VAL C 163
LEU C 164
None
1.15A 4fr0A-5x9yC:
undetectable
4fr0A-5x9yC:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN


(Homo sapiens)
PF00415
(RCC1)
PF13540
(RCC1_2)
5 GLY A 302
LEU A 304
ASN A 284
VAL A 283
LEU A 280
None
1.12A 4fr0A-5xgsA:
undetectable
4fr0A-5xgsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens)
no annotation 5 GLY A 449
LEU A 403
ILE A 515
ASN A 476
VAL A 470
None
1.04A 4fr0A-5zl9A:
undetectable
4fr0A-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
ADP-RIBOSYLATION
FACTOR 1


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
5 GLY B  50
ASP B  67
ILE A 538
VAL A 502
LEU A 505
None
0.89A 4fr0A-6faeB:
undetectable
4fr0A-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans)
no annotation 5 GLY A 123
LEU A  74
ILE A 139
ASN A 151
LEU A 134
None
1.10A 4fr0A-6fi2A:
undetectable
4fr0A-6fi2A:
undetectable