SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_D_SAMD401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
5 GLY A 175
GLY A 176
SER A 249
GLY A 244
LEU A 207
None
1.03A 4fp9D-1b0kA:
undetectable
4fp9D-1b0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)


(Salmonella
enterica)
PF00180
(Iso_dh)
5 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
None
1.02A 4fp9D-1cnzA:
undetectable
4fp9D-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)


(Haemophilus
influenzae)
PF00145
(DNA_methylase)
5 GLY A  11
GLY A  12
ASN A  28
ASP A  50
PRO A  70
None
0.86A 4fp9D-1dctA:
8.2
4fp9D-1dctA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pisum sativum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
None
0.96A 4fp9D-1dxlA:
undetectable
4fp9D-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli)
PF01728
(FtsJ)
6 PRO A  62
GLY A  63
GLY A  64
LEU A  84
ASP A  99
LEU A 143
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.6A)
0.88A 4fp9D-1eizA:
9.5
4fp9D-1eizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A  86
GLY A  87
ASP A 141
GLY A 142
LEU A 169
None
0.67A 4fp9D-1mjfA:
10.7
4fp9D-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
6 CYH A 254
GLY A 258
GLY A 259
ASP A 303
GLY A 304
PRO A 324
None
1.01A 4fp9D-1sqgA:
27.1
4fp9D-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
6 CYH A 254
PRO A 257
GLY A 258
GLY A 259
ASP A 303
GLY A 304
None
0.64A 4fp9D-1sqgA:
27.1
4fp9D-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE


(Vibrio
proteolyticus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
5 GLY A 273
GLY A 271
LYS A 270
ASP A 210
GLY A 211
None
1.00A 4fp9D-1v7vA:
undetectable
4fp9D-1v7vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
6 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 285
SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.6A)
0.51A 4fp9D-2b9eA:
23.5
4fp9D-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR


(Sus scrofa)
PF13516
(LRR_6)
6 CYH A 382
GLY A 349
GLY A 352
ASN A 379
GLY A 409
LEU A 413
None
1.40A 4fp9D-2bnhA:
undetectable
4fp9D-2bnhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Escherichia
coli)
PF01019
(G_glu_transpept)
5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
None
1.06A 4fp9D-2e0wA:
undetectable
4fp9D-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Escherichia
coli)
PF01019
(G_glu_transpept)
5 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
None
0.92A 4fp9D-2e0xA:
undetectable
4fp9D-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
6 PRO A 128
ASN A 148
SER A 151
GLY A 177
PRO A 196
LEU A 228
None
0.74A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
6 PRO A 128
GLY A 129
ASN A 148
SER A 151
ASP A 176
GLY A 177
None
1.10A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
6 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
PRO A 196
None
0.61A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
5 PRO A 128
GLY A 129
LYS A 131
SER A 151
PRO A 196
None
0.89A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
5 PRO A 128
LYS A 131
SER A 151
PRO A 196
LEU A 228
None
1.06A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE


(Shewanella
oneidensis)
PF00920
(ILVD_EDD)
5 PRO A 120
GLY A 121
GLY A 118
ASP A 509
GLY A 510
None
1.02A 4fp9D-2gp4A:
undetectable
4fp9D-2gp4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY


(Rhodobacter
sphaeroides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
None
0.94A 4fp9D-2hzgA:
undetectable
4fp9D-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
5 GLY A  22
GLY A  23
ASN A  39
ASP A  60
LEU A 100
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 ( 4.9A)
0.74A 4fp9D-2i9kA:
8.3
4fp9D-2i9kA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
5 GLY A  22
GLY A  23
ASN A  39
ASP A  60
PRO A  80
None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
0.74A 4fp9D-2i9kA:
8.3
4fp9D-2i9kA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermotoga
maritima)
PF01174
(SNO)
5 PRO D  44
GLY D  45
GLY D  46
LEU D 165
LEU D  99
None
1.07A 4fp9D-2issD:
undetectable
4fp9D-2issD:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 GLY A 146
GLY A 147
GLY A 135
PRO A 711
LEU A 139
None
None
None
None
MGD  A 811 ( 4.4A)
1.04A 4fp9D-2jirA:
undetectable
4fp9D-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00595
(PDZ)
5 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
None
1.01A 4fp9D-2kpkA:
undetectable
4fp9D-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA


(Legionella
pneumophila)
PF04378
(RsmJ)
5 GLY A  46
GLY A 100
LEU A 120
ASP A 144
GLY A 145
None
0.85A 4fp9D-2oo3A:
9.1
4fp9D-2oo3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
5 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
None
0.90A 4fp9D-2p1rA:
undetectable
4fp9D-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII


(synthetic
construct;
synthetic
construct)
PF00514
(Arm)
PF00514
(Arm)
PF16186
(Arm_3)
6 GLY A 115
GLY B 116
ASN A  33
LEU A  29
ASP A  31
GLY A  32
None
1.35A 4fp9D-2ru4A:
undetectable
4fp9D-2ru4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 PRO A 489
GLY A 487
LEU A 478
GLY A 357
LEU A 369
None
1.05A 4fp9D-2wpgA:
undetectable
4fp9D-2wpgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca)
PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372)
5 GLY A 806
GLY A 795
LEU A 712
SER A 708
GLY A 716
None
0.93A 4fp9D-2yocA:
undetectable
4fp9D-2yocA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermus
thermophilus)
PF01174
(SNO)
5 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
None
1.05A 4fp9D-2ywdA:
undetectable
4fp9D-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN


(Pyrococcus
horikoshii)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
7 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
0.40A 4fp9D-2yxlA:
28.3
4fp9D-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A  88
GLY A  89
ASP A 144
GLY A 145
LEU A 172
None
0.62A 4fp9D-2zsuA:
11.0
4fp9D-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026


(Methanocaldococcus
jannaschii)
PF01189
(Methyltr_RsmB-F)
5 CYH A  91
GLY A  95
LYS A  97
PRO A 165
LEU A 193
SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.9A)
None
1.06A 4fp9D-3a4tA:
26.4
4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026


(Methanocaldococcus
jannaschii)
PF01189
(Methyltr_RsmB-F)
9 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
0.68A 4fp9D-3a4tA:
26.4
4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT


(Corynebacterium
sp. U-96)
PF01266
(DAO)
5 CYH B 350
GLY B 356
GLY B 355
LEU B 223
LEU B 240
None
FAD  B   1 (-3.0A)
FAD  B   1 (-3.4A)
None
None
0.88A 4fp9D-3adaB:
undetectable
4fp9D-3adaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 GLY A1152
GLY A1153
ASP A1193
PRO A1228
LEU A1250
SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
0.81A 4fp9D-3av6A:
7.3
4fp9D-3av6A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
5 PRO A 415
GLY A 416
GLY A 422
SER A 411
GLY A 402
None
0.97A 4fp9D-3b9eA:
undetectable
4fp9D-3b9eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J


(Thermoplasma
volcanium)
PF01728
(FtsJ)
5 PRO A  49
GLY A  50
GLY A  51
LEU A  68
ASP A  83
SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.6A)
0.64A 4fp9D-3douA:
9.1
4fp9D-3douA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN


(Homo sapiens)
PF02820
(MBT)
5 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
None
0.93A 4fp9D-3f70A:
undetectable
4fp9D-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF02820
(MBT)
5 GLY A 184
GLY A 183
LEU A 208
PRO A 377
LEU A 374
None
1.05A 4fp9D-3feoA:
undetectable
4fp9D-3feoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae)
PF00933
(Glyco_hydro_3)
5 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
None
1.08A 4fp9D-3gs6A:
undetectable
4fp9D-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR


(Lactobacillus
salivarius)
PF07537
(CamS)
5 GLY A 372
GLY A 371
GLY A 313
PRO A 344
LEU A 311
None
0.97A 4fp9D-3ib5A:
undetectable
4fp9D-3ib5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens)
PF03573
(OprD)
5 GLY A 153
ASN A 307
SER A 184
PRO A 143
LEU A 148
None
1.08A 4fp9D-3jtyA:
undetectable
4fp9D-3jtyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1


(Bacillus
anthracis)
PF00202
(Aminotran_3)
5 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
LLP  A 270 ( 4.0A)
None
None
None
None
0.96A 4fp9D-3l44A:
undetectable
4fp9D-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN


(Enterococcus
faecium)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
7 CYH A 113
PRO A 116
GLY A 117
GLY A 118
LYS A 119
ASN A 136
PRO A 184
None
0.34A 4fp9D-3m4xA:
27.8
4fp9D-3m4xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
7 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
PRO A 179
LEU A 211
None
0.45A 4fp9D-3m6xA:
28.9
4fp9D-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION


(Drosophila
melanogaster)
PF00415
(RCC1)
5 GLY K  83
GLY K  82
ASN K 374
GLY K 372
LEU K 377
None
0.99A 4fp9D-3mvdK:
undetectable
4fp9D-3mvdK:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntn USPA1

(Moraxella
catarrhalis)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A 203
GLY A 188
ASN A 213
LEU A 223
GLY A 210
None
1.05A 4fp9D-3ntnA:
undetectable
4fp9D-3ntnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
5 GLY A 374
GLY A 375
ASN A 188
SER A 349
GLY A 207
None
1.02A 4fp9D-3r18A:
undetectable
4fp9D-3r18A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A 105
GLY A 106
ASP A 155
GLY A 156
LEU A 184
None
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
0.66A 4fp9D-3rw9A:
9.6
4fp9D-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE


(Campylobacter
jejuni)
PF00180
(Iso_dh)
5 PRO A 276
GLY A 278
GLY A 279
LEU A 107
LEU A 139
None
0.99A 4fp9D-3uduA:
undetectable
4fp9D-3uduA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
None
0.92A 4fp9D-3urhA:
undetectable
4fp9D-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ


(Streptoalloteichus
tenebrarius)
PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C)
6 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
None
None
None
SO4  A 603 (-3.4A)
None
None
1.41A 4fp9D-3vexA:
undetectable
4fp9D-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
None
1.05A 4fp9D-3vrbA:
undetectable
4fp9D-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpa TRIMERIC
AUTOTRANSPORTER
ADHESIN


(Acinetobacter
sp. Tol 5)
PF05662
(YadA_stalk)
5 PRO A3502
GLY A3488
GLY A3487
ASP A3508
GLY A3507
None
0.99A 4fp9D-3wpaA:
undetectable
4fp9D-3wpaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1


(Saccharomyces
cerevisiae)
PF09770
(PAT1)
5 GLY H 473
GLY H 474
ASN H 521
SER H 517
ASP H 514
None
1.07A 4fp9D-4c8qH:
undetectable
4fp9D-4c8qH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB


(Caulobacter
vibrioides)
PF06723
(MreB_Mbl)
5 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
None
1.00A 4fp9D-4czeA:
undetectable
4fp9D-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9o IMV MEMBRANE PROTEIN

(Vaccinia virus)
PF00194
(Carb_anhydrase)
5 GLY X  50
GLY X  49
LYS X  48
ASP X 112
GLY X 113
IOD  X 306 ( 4.6A)
IOD  X 306 ( 4.4A)
None
None
None
0.79A 4fp9D-4e9oX:
undetectable
4fp9D-4e9oX:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1


(Arabidopsis
thaliana)
PF00155
(Aminotran_1_2)
5 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
None
1.04A 4fp9D-4fl0A:
2.9
4fp9D-4fl0A:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
ASP A 237
GLY A 238
PRO A 257
LEU A 291
SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
0.21A 4fp9D-4fzvA:
57.7
4fp9D-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
5 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
1.01A 4fp9D-4fzvA:
57.7
4fp9D-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL


(Mus musculus)
PF00398
(RrnaAD)
5 PRO A  66
GLY A  67
GLY A  68
ASP A 111
PRO A 143
None
None
None
None
ACT  A 402 ( 4.9A)
0.61A 4fp9D-4gc5A:
9.3
4fp9D-4gc5A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
None
1.07A 4fp9D-4hq1A:
undetectable
4fp9D-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE


(Mycobacteroides
abscessus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
None
1.08A 4fp9D-4hr3A:
undetectable
4fp9D-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ild ENVELOPE
GLYCOPROTEIN E2


(Pestivirus A)
PF16329
(Pestivirus_E2)
5 PRO A 943
GLY A 901
ASN A 935
ASP A 962
GLY A 938
None
1.08A 4fp9D-4ildA:
undetectable
4fp9D-4ildA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
5 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 281
None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
0.58A 4fp9D-4ineA:
10.9
4fp9D-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
5 GLY A 236
GLY A 238
LEU A 255
SER A 256
ASP A 281
None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
1.00A 4fp9D-4ineA:
10.9
4fp9D-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG


(Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
5 GLY A 230
GLY A 231
LEU A 179
ASP A 159
GLY A 158
None
1.03A 4fp9D-4kmhA:
undetectable
4fp9D-4kmhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
5 GLY A 232
GLY A 233
LEU A 251
SER A 252
ASP A 277
None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
0.47A 4fp9D-4kriA:
11.3
4fp9D-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
5 GLY A 232
GLY A 234
LEU A 251
SER A 252
ASP A 277
None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
0.97A 4fp9D-4kriA:
11.3
4fp9D-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
None
1.02A 4fp9D-4ktoA:
undetectable
4fp9D-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Verminephrobacter
eiseniae)
PF13458
(Peripla_BP_6)
6 GLY A 288
GLY A  24
ASP A 323
GLY A 325
PRO A 254
LEU A 261
None
1.49A 4fp9D-4m88A:
undetectable
4fp9D-4m88A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1


(Homo sapiens)
PF01728
(FtsJ)
7 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 335
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
1.03A 4fp9D-4n49A:
8.4
4fp9D-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
atroolivaceus)
PF00378
(ECH_1)
5 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
None
0.74A 4fp9D-4nnqA:
undetectable
4fp9D-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE


(Streptococcus
pneumoniae)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
None
1.04A 4fp9D-4rl6A:
4.1
4fp9D-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Homo sapiens)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 GLY A1149
GLY A1150
ASP A1190
PRO A1225
LEU A1247
SAH  A1706 ( 4.3A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
0.85A 4fp9D-4wxxA:
7.2
4fp9D-4wxxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae)
PF00415
(RCC1)
5 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
None
0.97A 4fp9D-4x33B:
undetectable
4fp9D-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris)
PF00759
(Glyco_hydro_9)
5 GLY A  58
GLY A  57
LEU A  70
ASP A 155
LEU A 147
None
1.02A 4fp9D-4zg8A:
undetectable
4fp9D-4zg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 PRO A 549
GLY A 553
GLY A 554
ASP A  95
GLY A 431
None
None
None
ZN  A1903 ( 2.1A)
None
0.84A 4fp9D-5a7mA:
undetectable
4fp9D-5a7mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
0.97A 4fp9D-5dq9A:
undetectable
4fp9D-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE


(Pseudomonas
putida)
PF01494
(FAD_binding_3)
5 GLY A 171
SER A 285
ASP A 313
GLY A 293
PRO A 282
None
None
None
FAD  A 401 (-3.2A)
None
0.93A 4fp9D-5eowA:
2.1
4fp9D-5eowA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana)
PF00459
(Inositol_P)
5 GLY A 124
GLY A 125
LEU A 152
GLY A 163
LEU A 162
None
0.89A 4fp9D-5esyA:
undetectable
4fp9D-5esyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE


(Cupriavidus
metallidurans)
PF13231
(PMT_2)
5 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
0.87A 4fp9D-5f15A:
undetectable
4fp9D-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
None
0.88A 4fp9D-5fyqA:
undetectable
4fp9D-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE


(Thermococcus
kodakarensis)
PF00180
(Iso_dh)
5 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
None
1.02A 4fp9D-5hn4A:
undetectable
4fp9D-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
no annotation 5 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
None
0.80A 4fp9D-5ic7A:
undetectable
4fp9D-5ic7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO


(Streptomyces
rishiriensis)
PF13649
(Methyltransf_25)
5 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
0.58A 4fp9D-5m58A:
12.6
4fp9D-5m58A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
5 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
None
1.03A 4fp9D-5m60A:
undetectable
4fp9D-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
5 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
None
0.86A 4fp9D-5m60A:
undetectable
4fp9D-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE


(Streptomyces
niveus)
PF13649
(Methyltransf_25)
5 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
0.58A 4fp9D-5mgzA:
12.5
4fp9D-5mgzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus)
no annotation 5 PRO A   5
GLY A 175
GLY A 176
SER A  97
PRO A   9
None
0.99A 4fp9D-5n7qA:
undetectable
4fp9D-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1


(Schizosaccharomyces
pombe)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
5 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
None
1.02A 4fp9D-5um6A:
3.5
4fp9D-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 5 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
0.53A 4fp9D-5wp4A:
10.5
4fp9D-5wp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 5 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
0.90A 4fp9D-5wp4A:
10.5
4fp9D-5wp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2


(Arabidopsis
thaliana)
no annotation 5 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
0.45A 4fp9D-5wp5A:
10.6
4fp9D-5wp5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2


(Arabidopsis
thaliana)
no annotation 5 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
0.87A 4fp9D-5wp5A:
10.6
4fp9D-5wp5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
9 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
LEU A 354
None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
None
None
None
0.58A 4fp9D-5wwtA:
26.5
4fp9D-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus)
no annotation 5 GLY A  43
GLY A  44
LEU A 174
SER A 253
GLY A 215
FAD  A 501 ( 3.9A)
None
None
None
None
1.03A 4fp9D-5xgvA:
undetectable
4fp9D-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium)
no annotation 5 GLY A  87
GLY A  83
SER A  17
ASP A 259
LEU A 241
None
0.83A 4fp9D-5z6oA:
2.1
4fp9D-5z6oA:
undetectable