SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_D_SAMD401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0k | PROTEIN (ACONITASE) (Sus scrofa) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | GLY A 175GLY A 176SER A 249GLY A 244LEU A 207 | None | 1.03A | 4fp9D-1b0kA:undetectable | 4fp9D-1b0kA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnz | PROTEIN(3-ISOPROPYLMALATEDEHYDROGENASE) (Salmonellaenterica) |
PF00180(Iso_dh) | 5 | PRO A 282GLY A 284GLY A 285LEU A 108LEU A 140 | None | 1.02A | 4fp9D-1cnzA:undetectable | 4fp9D-1cnzA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dct | PROTEIN(MODIFICATIONMETHYLASE HAEIII) (Haemophilusinfluenzae) |
PF00145(DNA_methylase) | 5 | GLY A 11GLY A 12ASN A 28ASP A 50PRO A 70 | None | 0.86A | 4fp9D-1dctA:8.2 | 4fp9D-1dctA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pisum sativum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 248LEU A 272GLY A 169PRO A 177LEU A 173 | None | 0.96A | 4fp9D-1dxlA:undetectable | 4fp9D-1dxlA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eiz | FTSJ (Escherichiacoli) |
PF01728(FtsJ) | 6 | PRO A 62GLY A 63GLY A 64LEU A 84ASP A 99LEU A 143 | SAM A 301 (-3.4A)SAM A 301 (-3.9A)SAM A 301 (-3.1A)SAM A 301 (-4.2A)SAM A 301 (-3.5A)SAM A 301 (-4.6A) | 0.88A | 4fp9D-1eizA:9.5 | 4fp9D-1eizA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 86GLY A 87ASP A 141GLY A 142LEU A 169 | None | 0.67A | 4fp9D-1mjfA:10.7 | 4fp9D-1mjfA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqg | SUN PROTEIN (Escherichiacoli) |
PF01029(NusB)PF01189(Methyltr_RsmB-F) | 6 | CYH A 254GLY A 258GLY A 259ASP A 303GLY A 304PRO A 324 | None | 1.01A | 4fp9D-1sqgA:27.1 | 4fp9D-1sqgA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqg | SUN PROTEIN (Escherichiacoli) |
PF01029(NusB)PF01189(Methyltr_RsmB-F) | 6 | CYH A 254PRO A 257GLY A 258GLY A 259ASP A 303GLY A 304 | None | 0.64A | 4fp9D-1sqgA:27.1 | 4fp9D-1sqgA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7v | CHITOBIOSEPHOSPHORYLASE (Vibrioproteolyticus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 5 | GLY A 273GLY A 271LYS A 270ASP A 210GLY A 211 | None | 1.00A | 4fp9D-1v7vA:undetectable | 4fp9D-1v7vA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9e | NOL1/NOP2/SUN DOMAINFAMILY, MEMBER 5ISOFORM 2 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 6 | CYH A 234PRO A 237GLY A 238LYS A 240LEU A 259ASP A 285 | SAM A1201 (-3.8A)SAM A1201 (-3.7A)SAM A1201 (-3.9A)SAM A1201 (-3.1A)SAM A1201 (-4.5A)SAM A1201 (-3.6A) | 0.51A | 4fp9D-2b9eA:23.5 | 4fp9D-2b9eA:25.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnh | RIBONUCLEASEINHIBITOR (Sus scrofa) |
PF13516(LRR_6) | 6 | CYH A 382GLY A 349GLY A 352ASN A 379GLY A 409LEU A 413 | None | 1.40A | 4fp9D-2bnhA:undetectable | 4fp9D-2bnhA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0w | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 94GLY A 95SER A 230GLY A 238LEU A 166 | None | 1.06A | 4fp9D-2e0wA:undetectable | 4fp9D-2e0wA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 296GLY A 297GLY A 381PRO A 350LEU A 383 | None | 0.92A | 4fp9D-2e0xA:undetectable | 4fp9D-2e0xA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128ASN A 148SER A 151GLY A 177PRO A 196LEU A 228 | None | 0.74A | 4fp9D-2frxA:29.2 | 4fp9D-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128GLY A 129ASN A 148SER A 151ASP A 176GLY A 177 | None | 1.10A | 4fp9D-2frxA:29.2 | 4fp9D-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128GLY A 129ASN A 148SER A 151GLY A 177PRO A 196 | None | 0.61A | 4fp9D-2frxA:29.2 | 4fp9D-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 5 | PRO A 128GLY A 129LYS A 131SER A 151PRO A 196 | None | 0.89A | 4fp9D-2frxA:29.2 | 4fp9D-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 5 | PRO A 128LYS A 131SER A 151PRO A 196LEU A 228 | None | 1.06A | 4fp9D-2frxA:29.2 | 4fp9D-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp4 | 6-PHOSPHOGLUCONATEDEHYDRATASE (Shewanellaoneidensis) |
PF00920(ILVD_EDD) | 5 | PRO A 120GLY A 121GLY A 118ASP A 509GLY A 510 | None | 1.02A | 4fp9D-2gp4A:undetectable | 4fp9D-2gp4A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzg | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME/ENOLASESUPERFAMILY (Rhodobactersphaeroides) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 283GLY A 282ASN A 303LEU A 312SER A 313 | None | 0.94A | 4fp9D-2hzgA:undetectable | 4fp9D-2hzgA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 5 | GLY A 22GLY A 23ASN A 39ASP A 60LEU A 100 | NoneSAH A 328 (-3.6A)SAH A 328 (-4.3A)SAH A 328 (-3.6A)SAH A 328 ( 4.9A) | 0.74A | 4fp9D-2i9kA:8.3 | 4fp9D-2i9kA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 5 | GLY A 22GLY A 23ASN A 39ASP A 60PRO A 80 | NoneSAH A 328 (-3.6A)SAH A 328 (-4.3A)SAH A 328 (-3.6A)SAH A 328 (-4.0A) | 0.74A | 4fp9D-2i9kA:8.3 | 4fp9D-2i9kA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iss | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermotogamaritima) |
PF01174(SNO) | 5 | PRO D 44GLY D 45GLY D 46LEU D 165LEU D 99 | None | 1.07A | 4fp9D-2issD:undetectable | 4fp9D-2issD:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | GLY A 146GLY A 147GLY A 135PRO A 711LEU A 139 | NoneNoneNoneNoneMGD A 811 ( 4.4A) | 1.04A | 4fp9D-2jirA:undetectable | 4fp9D-2jirA:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kpk | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00595(PDZ) | 5 | GLY A 33GLY A 34LEU A 46GLY A 28LEU A 20 | None | 1.01A | 4fp9D-2kpkA:undetectable | 4fp9D-2kpkA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oo3 | PROTEIN INVOLVED INCATABOLISM OFEXTERNAL DNA (Legionellapneumophila) |
PF04378(RsmJ) | 5 | GLY A 46GLY A 100LEU A 120ASP A 144GLY A 145 | None | 0.85A | 4fp9D-2oo3A:9.1 | 4fp9D-2oo3A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1r | LIPID KINASE YEGS (Salmonellaenterica) |
PF00781(DAGK_cat) | 5 | GLY A 65GLY A 64ASN A 137GLY A 201LEU A 297 | None | 0.90A | 4fp9D-2p1rA:undetectable | 4fp9D-2p1rA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ru4 | ARMADILLO REPEATPROTEIN, N-TERMINALFRAGMENT, YIIM2ARMADILLO REPEATPROTEIN, C-TERMINALFRAGMENT, MAII (syntheticconstruct;syntheticconstruct) |
PF00514(Arm)PF00514(Arm)PF16186(Arm_3) | 6 | GLY A 115GLY B 116ASN A 33LEU A 29ASP A 31GLY A 32 | None | 1.35A | 4fp9D-2ru4A:undetectable | 4fp9D-2ru4A:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | PRO A 489GLY A 487LEU A 478GLY A 357LEU A 369 | None | 1.05A | 4fp9D-2wpgA:undetectable | 4fp9D-2wpgA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 5 | GLY A 806GLY A 795LEU A 712SER A 708GLY A 716 | None | 0.93A | 4fp9D-2yocA:undetectable | 4fp9D-2yocA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywd | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermusthermophilus) |
PF01174(SNO) | 5 | PRO A 46GLY A 47GLY A 48LEU A 167LEU A 103 | None | 1.05A | 4fp9D-2ywdA:undetectable | 4fp9D-2ywdA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 7 | PRO A 270GLY A 271GLY A 272LYS A 273ASP A 318PRO A 339LEU A 371 | SFG A5748 (-3.6A)SFG A5748 (-3.7A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)SFG A5748 (-3.7A)SFG A5748 (-4.0A)None | 0.40A | 4fp9D-2yxlA:28.3 | 4fp9D-2yxlA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsu | SPERMIDINE SYNTHASE (Pyrococcushorikoshii) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 88GLY A 89ASP A 144GLY A 145LEU A 172 | None | 0.62A | 4fp9D-2zsuA:11.0 | 4fp9D-2zsuA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 5 | CYH A 91GLY A 95LYS A 97PRO A 165LEU A 193 | SFG A 500 (-3.8A)SFG A 500 (-4.0A)SFG A 500 (-2.8A)SFG A 500 (-3.9A)None | 1.06A | 4fp9D-3a4tA:26.4 | 4fp9D-3a4tA:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 9 | CYH A 91PRO A 94GLY A 95GLY A 96LYS A 97SER A 117ASP A 142PRO A 165LEU A 193 | SFG A 500 (-3.8A)SFG A 500 (-3.9A)SFG A 500 (-4.0A)SFG A 500 (-3.5A)SFG A 500 (-2.8A)NoneSFG A 500 (-4.0A)SFG A 500 (-3.9A)None | 0.68A | 4fp9D-3a4tA:26.4 | 4fp9D-3a4tA:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ada | SARCOSINE OXIDASEBETA SUBUNIT (Corynebacteriumsp. U-96) |
PF01266(DAO) | 5 | CYH B 350GLY B 356GLY B 355LEU B 223LEU B 240 | NoneFAD B 1 (-3.0A)FAD B 1 (-3.4A)NoneNone | 0.88A | 4fp9D-3adaB:undetectable | 4fp9D-3adaB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | GLY A1152GLY A1153ASP A1193PRO A1228LEU A1250 | SAM A 1 (-4.1A)SAM A 1 (-3.6A)SAM A 1 (-3.6A)SAM A 1 ( 4.2A)SAM A 1 (-4.6A) | 0.81A | 4fp9D-3av6A:7.3 | 4fp9D-3av6A:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9e | CHITINASE A (Vibrio harveyi) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 5 | PRO A 415GLY A 416GLY A 422SER A 411GLY A 402 | None | 0.97A | 4fp9D-3b9eA:undetectable | 4fp9D-3b9eA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dou | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Thermoplasmavolcanium) |
PF01728(FtsJ) | 5 | PRO A 49GLY A 50GLY A 51LEU A 68ASP A 83 | SAM A 1 (-3.5A)SAM A 1 (-3.8A)SAM A 1 (-3.2A)SAM A 1 (-4.2A)SAM A 1 (-3.6A) | 0.64A | 4fp9D-3douA:9.1 | 4fp9D-3douA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f70 | LETHAL(3)MALIGNANTBRAIN TUMOR-LIKE 2PROTEIN (Homo sapiens) |
PF02820(MBT) | 5 | GLY A 351GLY A 350LEU A 374PRO A 550LEU A 547 | None | 0.93A | 4fp9D-3f70A:undetectable | 4fp9D-3f70A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3feo | MBTDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF02820(MBT) | 5 | GLY A 184GLY A 183LEU A 208PRO A 377LEU A 374 | None | 1.05A | 4fp9D-3feoA:undetectable | 4fp9D-3feoA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs6 | BETA-HEXOSAMINIDASE (Vibrio cholerae) |
PF00933(Glyco_hydro_3) | 5 | GLY A 65GLY A 66LEU A 147GLY A 159LEU A 118 | None | 1.08A | 4fp9D-3gs6A:undetectable | 4fp9D-3gs6A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib5 | SEX PHEROMONEPRECURSOR (Lactobacillussalivarius) |
PF07537(CamS) | 5 | GLY A 372GLY A 371GLY A 313PRO A 344LEU A 311 | None | 0.97A | 4fp9D-3ib5A:undetectable | 4fp9D-3ib5A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jty | BENF-LIKE PORIN (Pseudomonasprotegens) |
PF03573(OprD) | 5 | GLY A 153ASN A 307SER A 184PRO A 143LEU A 148 | None | 1.08A | 4fp9D-3jtyA:undetectable | 4fp9D-3jtyA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l44 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE1 (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | GLY A 273GLY A 274ASN A 118PRO A 307LEU A 89 | LLP A 270 ( 4.0A)NoneNoneNoneNone | 0.96A | 4fp9D-3l44A:undetectable | 4fp9D-3l44A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4x | NOL1/NOP2/SUN FAMILYPROTEIN (Enterococcusfaecium) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 7 | CYH A 113PRO A 116GLY A 117GLY A 118LYS A 119ASN A 136PRO A 184 | None | 0.34A | 4fp9D-3m4xA:27.8 | 4fp9D-3m4xA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 7 | PRO A 112GLY A 113GLY A 114LYS A 115ASN A 132PRO A 179LEU A 211 | None | 0.45A | 4fp9D-3m6xA:28.9 | 4fp9D-3m6xA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvd | REGULATOR OFCHROMOSOMECONDENSATION (Drosophilamelanogaster) |
PF00415(RCC1) | 5 | GLY K 83GLY K 82ASN K 374GLY K 372LEU K 377 | None | 0.99A | 4fp9D-3mvdK:undetectable | 4fp9D-3mvdK:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntn | USPA1 (Moraxellacatarrhalis) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 203GLY A 188ASN A 213LEU A 223GLY A 210 | None | 1.05A | 4fp9D-3ntnA:undetectable | 4fp9D-3ntnA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r18 | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | GLY A 374GLY A 375ASN A 188SER A 349GLY A 207 | None | 1.02A | 4fp9D-3r18A:undetectable | 4fp9D-3r18A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 105GLY A 106ASP A 155GLY A 156LEU A 184 | NoneNoneDSH A 303 (-3.5A)DSH A 303 (-3.7A)DSH A 303 (-4.2A) | 0.66A | 4fp9D-3rw9A:9.6 | 4fp9D-3rw9A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3udu | 3-ISOPROPYLMALATEDEHYDROGENASE (Campylobacterjejuni) |
PF00180(Iso_dh) | 5 | PRO A 276GLY A 278GLY A 279LEU A 107LEU A 139 | None | 0.99A | 4fp9D-3uduA:undetectable | 4fp9D-3uduA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3urh | DIHYDROLIPOYLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 246LEU A 270GLY A 167PRO A 175LEU A 171 | None | 0.92A | 4fp9D-3urhA:undetectable | 4fp9D-3urhA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vex | O-CARBAMOYLTRANSFERASE TOBZ (Streptoalloteichustenebrarius) |
PF02543(Carbam_trans_N)PF16861(Carbam_trans_C) | 6 | GLY A 413GLY A 367LEU A 425SER A 530GLY A 407LEU A 557 | NoneNoneNoneSO4 A 603 (-3.4A)NoneNone | 1.41A | 4fp9D-3vexA:undetectable | 4fp9D-3vexA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | GLY A 391GLY A 392ASN A 431LEU A 433GLY A 109 | None | 1.05A | 4fp9D-3vrbA:undetectable | 4fp9D-3vrbA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wpa | TRIMERICAUTOTRANSPORTERADHESIN (Acinetobactersp. Tol 5) |
PF05662(YadA_stalk) | 5 | PRO A3502GLY A3488GLY A3487ASP A3508GLY A3507 | None | 0.99A | 4fp9D-3wpaA:undetectable | 4fp9D-3wpaA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c8q | DNA TOPOISOMERASE2-ASSOCIATED PROTEINPAT1 (Saccharomycescerevisiae) |
PF09770(PAT1) | 5 | GLY H 473GLY H 474ASN H 521SER H 517ASP H 514 | None | 1.07A | 4fp9D-4c8qH:undetectable | 4fp9D-4c8qH:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cze | RODSHAPE-DETERMININGPROTEIN MREB (Caulobactervibrioides) |
PF06723(MreB_Mbl) | 5 | CYH A 323GLY A 329LYS A 330LEU A 321GLY A 294 | None | 1.00A | 4fp9D-4czeA:undetectable | 4fp9D-4czeA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e9o | IMV MEMBRANE PROTEIN (Vaccinia virus) |
PF00194(Carb_anhydrase) | 5 | GLY X 50GLY X 49LYS X 48ASP X 112GLY X 113 | IOD X 306 ( 4.6A)IOD X 306 ( 4.4A)NoneNoneNone | 0.79A | 4fp9D-4e9oX:undetectable | 4fp9D-4e9oX:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl0 | AMINOTRANSFERASEALD1 (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 5 | PRO A 405GLY A 406GLY A 408LEU A 75GLY A 421 | None | 1.04A | 4fp9D-4fl0A:2.9 | 4fp9D-4fl0A:20.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 12 | CYH A 181PRO A 185GLY A 185GLY A 186LYS A 187ASN A 203LEU A 205SER A 206ASP A 237GLY A 238PRO A 257LEU A 291 | SAM A 401 (-3.9A)SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)SAM A 401 ( 4.6A)SAM A 401 (-3.8A)SAM A 401 (-4.8A)SAM A 401 (-3.5A)SAM A 401 (-3.5A)SAM A 401 (-4.0A)None | 0.21A | 4fp9D-4fzvA:57.7 | 4fp9D-4fzvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | PRO A 185GLY A 185GLY A 186LYS A 187SER A 208 | SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)None | 1.01A | 4fp9D-4fzvA:57.7 | 4fp9D-4fzvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 5 | PRO A 66GLY A 67GLY A 68ASP A 111PRO A 143 | NoneNoneNoneNoneACT A 402 ( 4.9A) | 0.61A | 4fp9D-4gc5A:9.3 | 4fp9D-4gc5A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hq1 | PROBABLE RECEPTORPROTEIN KINASE TMK1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | GLY A 424GLY A 444ASN A 420LEU A 393GLY A 394 | None | 1.07A | 4fp9D-4hq1A:undetectable | 4fp9D-4hq1A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hr3 | PUTATIVE ACYL-COADEHYDROGENASE (Mycobacteroidesabscessus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | PRO A 74GLY A 81ASN A 105LEU A 133GLY A 136 | None | 1.08A | 4fp9D-4hr3A:undetectable | 4fp9D-4hr3A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ild | ENVELOPEGLYCOPROTEIN E2 (Pestivirus A) |
PF16329(Pestivirus_E2) | 5 | PRO A 943GLY A 901ASN A 935ASP A 962GLY A 938 | None | 1.08A | 4fp9D-4ildA:undetectable | 4fp9D-4ildA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 236GLY A 237LEU A 255SER A 256ASP A 281 | NoneNoneSAH A 501 (-4.3A)SAH A 501 (-4.5A)SAH A 501 (-3.5A) | 0.58A | 4fp9D-4ineA:10.9 | 4fp9D-4ineA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 236GLY A 238LEU A 255SER A 256ASP A 281 | NoneNoneSAH A 501 (-4.3A)SAH A 501 (-4.5A)SAH A 501 (-3.5A) | 1.00A | 4fp9D-4ineA:10.9 | 4fp9D-4ineA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kmh | SUPPRESSOR OF FUSEDHOMOLOG (Homo sapiens) |
PF05076(SUFU)PF12470(SUFU_C) | 5 | GLY A 230GLY A 231LEU A 179ASP A 159GLY A 158 | None | 1.03A | 4fp9D-4kmhA:undetectable | 4fp9D-4kmhA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | GLY A 232GLY A 233LEU A 251SER A 252ASP A 277 | NoneNoneSAH A 701 (-4.4A)SAH A 701 (-4.7A)SAH A 701 (-3.4A) | 0.47A | 4fp9D-4kriA:11.3 | 4fp9D-4kriA:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | GLY A 232GLY A 234LEU A 251SER A 252ASP A 277 | NoneNoneSAH A 701 (-4.4A)SAH A 701 (-4.7A)SAH A 701 (-3.4A) | 0.97A | 4fp9D-4kriA:11.3 | 4fp9D-4kriA:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kto | ISOVALERYL-COADEHYDROGENASE (Sinorhizobiummeliloti) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | CYH A 99GLY A 243LEU A 171GLY A 126LEU A 119 | None | 1.02A | 4fp9D-4ktoA:undetectable | 4fp9D-4ktoA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m88 | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Verminephrobactereiseniae) |
PF13458(Peripla_BP_6) | 6 | GLY A 288GLY A 24ASP A 323GLY A 325PRO A 254LEU A 261 | None | 1.49A | 4fp9D-4m88A:undetectable | 4fp9D-4m88A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n49 | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF01728(FtsJ) | 7 | CYH A 277PRO A 280GLY A 281GLY A 282LEU A 302ASP A 335LEU A 383 | SAM A 601 (-3.7A)SAM A 601 (-3.6A)SAM A 601 (-3.6A)SAM A 601 (-3.1A)SAM A 601 (-4.1A)SAM A 601 (-3.6A)SAM A 601 (-4.6A) | 1.03A | 4fp9D-4n49A:8.4 | 4fp9D-4n49A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnq | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesatroolivaceus) |
PF00378(ECH_1) | 5 | CYH A 67GLY A 64GLY A 63GLY A 118LEU A 33 | None | 0.74A | 4fp9D-4nnqA:undetectable | 4fp9D-4nnqA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rl6 | SACCHAROPINEDEHYDROGENASE (Streptococcuspneumoniae) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | GLY A 192GLY A 323LEU A 187GLY A 328PRO A 238 | None | 1.04A | 4fp9D-4rl6A:4.1 | 4fp9D-4rl6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxx | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | GLY A1149GLY A1150ASP A1190PRO A1225LEU A1247 | SAH A1706 ( 4.3A)SAH A1706 (-3.2A)SAH A1706 (-3.3A)SAH A1706 ( 4.7A)SAH A1706 (-4.6A) | 0.85A | 4fp9D-4wxxA:7.2 | 4fp9D-4wxxA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x33 | PROTEIN ATS1 (Saccharomycescerevisiae) |
PF00415(RCC1) | 5 | GLY B 113GLY B 112LEU B 168SER B 167GLY B 151 | None | 0.97A | 4fp9D-4x33B:undetectable | 4fp9D-4x33B:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg8 | ENDOGLUCANASE (Perinereisbrevicirris) |
PF00759(Glyco_hydro_9) | 5 | GLY A 58GLY A 57LEU A 70ASP A 155LEU A 147 | None | 1.02A | 4fp9D-4zg8A:undetectable | 4fp9D-4zg8A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7m | BETA-XYLOSIDASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | PRO A 549GLY A 553GLY A 554ASP A 95GLY A 431 | NoneNoneNone ZN A1903 ( 2.1A)None | 0.84A | 4fp9D-5a7mA:undetectable | 4fp9D-5a7mA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dq9 | S55-3 FAB (IGG2B)HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY A 53GLY A 54ASN A 76GLY A 24LEU A 4 | KD2 A 301 (-3.6A)KD2 A 301 (-4.2A)NoneNoneNone | 0.97A | 4fp9D-5dq9A:undetectable | 4fp9D-5dq9A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eow | 6-HYDROXYNICOTINATE3-MONOOXYGENASE (Pseudomonasputida) |
PF01494(FAD_binding_3) | 5 | GLY A 171SER A 285ASP A 313GLY A 293PRO A 282 | NoneNoneNoneFAD A 401 (-3.2A)None | 0.93A | 4fp9D-5eowA:2.1 | 4fp9D-5eowA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esy | SAL1 PHOSPHATASE (Arabidopsisthaliana) |
PF00459(Inositol_P) | 5 | GLY A 124GLY A 125LEU A 152GLY A 163LEU A 162 | None | 0.89A | 4fp9D-5esyA:undetectable | 4fp9D-5esyA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f15 | 4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N)TRANSFERASE (Cupriavidusmetallidurans) |
PF13231(PMT_2) | 5 | PRO A 146GLY A 292GLY A 291GLY A 358LEU A 361 | NoneMPG A 603 ( 4.3A)MPG A 625 ( 3.7A)NoneNone | 0.87A | 4fp9D-5f15A:undetectable | 4fp9D-5f15A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | GLY A 306GLY A 305LEU A 283PRO A 281LEU A 59 | None | 0.88A | 4fp9D-5fyqA:undetectable | 4fp9D-5fyqA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hn4 | HOMOISOCITRATEDEHYDROGENASE (Thermococcuskodakarensis) |
PF00180(Iso_dh) | 5 | PRO A 300GLY A 304GLY A 303GLY A 314PRO A 264 | None | 1.02A | 4fp9D-5hn4A:undetectable | 4fp9D-5hn4A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 5 | CYH A 381GLY A 335GLY A 336ASP A 428GLY A 429 | None | 0.80A | 4fp9D-5ic7A:undetectable | 4fp9D-5ic7A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m58 | C-METHYLTRANSFERASECOUO (Streptomycesrishiriensis) |
PF13649(Methyltransf_25) | 5 | CYH A 47GLY A 51LEU A 71SER A 72ASP A 96 | SAH A 301 (-3.4A)NoneSAH A 301 (-3.9A)SAH A 301 (-4.6A)SAH A 301 (-3.5A) | 0.58A | 4fp9D-5m58A:12.6 | 4fp9D-5m58A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m60 | BETA-1,3-GLUCANASE (Chaetomiumthermophilum) |
PF12708(Pectate_lyase_3) | 5 | GLY A 476ASN A 611LEU A 574GLY A 612PRO A 487 | None | 1.03A | 4fp9D-5m60A:undetectable | 4fp9D-5m60A:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m60 | BETA-1,3-GLUCANASE (Chaetomiumthermophilum) |
PF12708(Pectate_lyase_3) | 5 | GLY A 476GLY A 477LEU A 574GLY A 612PRO A 487 | None | 0.86A | 4fp9D-5m60A:undetectable | 4fp9D-5m60A:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mgz | 8-DEMETHYLNOVOBIOCICACIDC(8)-METHYLTRANSFERASE (Streptomycesniveus) |
PF13649(Methyltransf_25) | 5 | CYH A 47GLY A 51LEU A 71SER A 72ASP A 96 | SAH A 301 (-3.3A)NoneSAH A 301 (-3.8A)SAH A 301 (-4.6A)SAH A 301 (-3.5A) | 0.58A | 4fp9D-5mgzA:12.5 | 4fp9D-5mgzA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | PRO A 5GLY A 175GLY A 176SER A 97PRO A 9 | None | 0.99A | 4fp9D-5n7qA:undetectable | 4fp9D-5n7qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | GLY A 450ASN A 445SER A 79GLY A 864LEU A 868 | None | 1.02A | 4fp9D-5um6A:3.5 | 4fp9D-5um6A:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 295LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 703 (-4.1A)SAH A 703 (-4.5A)SAH A 703 (-3.3A) | 0.53A | 4fp9D-5wp4A:10.5 | 4fp9D-5wp4A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 296LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 703 (-4.1A)SAH A 703 (-4.5A)SAH A 703 (-3.3A) | 0.90A | 4fp9D-5wp4A:10.5 | 4fp9D-5wp4A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 295LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 501 (-3.9A)NoneSAH A 501 (-3.4A) | 0.45A | 4fp9D-5wp5A:10.6 | 4fp9D-5wp5A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 294GLY A 296LEU A 313SER A 314ASP A 338 | NoneNoneSAH A 501 (-3.9A)NoneSAH A 501 (-3.4A) | 0.87A | 4fp9D-5wp5A:10.6 | 4fp9D-5wp5A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwt | PUTATIVEMETHYLTRANSFERASENSUN6 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 9 | CYH A 242PRO A 245GLY A 246GLY A 247LYS A 248ASP A 293GLY A 294PRO A 325LEU A 354 | None C C 72 ( 4.7A)NoneNone C C 72 ( 3.1A)NoneNoneNoneNone | 0.58A | 4fp9D-5wwtA:26.5 | 4fp9D-5wwtA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgv | PYRE3 (Streptomycesrugosporus) |
no annotation | 5 | GLY A 43GLY A 44LEU A 174SER A 253GLY A 215 | FAD A 501 ( 3.9A)NoneNoneNoneNone | 1.03A | 4fp9D-5xgvA:undetectable | 4fp9D-5xgvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z6o | PROTEASE (Penicilliumcyclopium) |
no annotation | 5 | GLY A 87GLY A 83SER A 17ASP A 259LEU A 241 | None | 0.83A | 4fp9D-5z6oA:2.1 | 4fp9D-5z6oA:undetectable |