SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_D_SAMD401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 175
GLY A 176
SER A 249
GLY A 244
LEU A 207
 None
 1.03A 4fp9D-1b0kA:
undetectable		 4fp9D-1b0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9D-1cnzA:
undetectable		 4fp9D-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		5 GLY A  11
GLY A  12
ASN A  28
ASP A  50
PRO A  70
 None
 0.86A 4fp9D-1dctA:
8.2		 4fp9D-1dctA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.96A 4fp9D-1dxlA:
undetectable		 4fp9D-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 PRO A  62
GLY A  63
GLY A  64
LEU A  84
ASP A  99
LEU A 143
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.6A)
 0.88A 4fp9D-1eizA:
9.5		 4fp9D-1eizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  86
GLY A  87
ASP A 141
GLY A 142
LEU A 169
 None
 0.67A 4fp9D-1mjfA:
10.7		 4fp9D-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
GLY A 258
GLY A 259
ASP A 303
GLY A 304
PRO A 324
 None
 1.01A 4fp9D-1sqgA:
27.1		 4fp9D-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
PRO A 257
GLY A 258
GLY A 259
ASP A 303
GLY A 304
 None
 0.64A 4fp9D-1sqgA:
27.1		 4fp9D-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLY A 273
GLY A 271
LYS A 270
ASP A 210
GLY A 211
 None
 1.00A 4fp9D-1v7vA:
undetectable		 4fp9D-1v7vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 285
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.6A)
 0.51A 4fp9D-2b9eA:
23.5		 4fp9D-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		6 CYH A 382
GLY A 349
GLY A 352
ASN A 379
GLY A 409
LEU A 413
 None
 1.40A 4fp9D-2bnhA:
undetectable		 4fp9D-2bnhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fp9D-2e0wA:
undetectable		 4fp9D-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.92A 4fp9D-2e0xA:
undetectable		 4fp9D-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
ASN A 148
SER A 151
GLY A 177
PRO A 196
LEU A 228
 None
 0.74A 4fp9D-2frxA:
29.2		 4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
GLY A 129
ASN A 148
SER A 151
ASP A 176
GLY A 177
 None
 1.10A 4fp9D-2frxA:
29.2		 4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
PRO A 196
 None
 0.61A 4fp9D-2frxA:
29.2		 4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 128
GLY A 129
LYS A 131
SER A 151
PRO A 196
 None
 0.89A 4fp9D-2frxA:
29.2		 4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 128
LYS A 131
SER A 151
PRO A 196
LEU A 228
 None
 1.06A 4fp9D-2frxA:
29.2		 4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		5 PRO A 120
GLY A 121
GLY A 118
ASP A 509
GLY A 510
 None
 1.02A 4fp9D-2gp4A:
undetectable		 4fp9D-2gp4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.94A 4fp9D-2hzgA:
undetectable		 4fp9D-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 GLY A  22
GLY A  23
ASN A  39
ASP A  60
LEU A 100
 None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 ( 4.9A)
 0.74A 4fp9D-2i9kA:
8.3		 4fp9D-2i9kA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 GLY A  22
GLY A  23
ASN A  39
ASP A  60
PRO A  80
 None
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.0A)
 0.74A 4fp9D-2i9kA:
8.3		 4fp9D-2i9kA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima) 		PF01174
(SNO) 		5 PRO D  44
GLY D  45
GLY D  46
LEU D 165
LEU D  99
 None
 1.07A 4fp9D-2issD:
undetectable		 4fp9D-2issD:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 146
GLY A 147
GLY A 135
PRO A 711
LEU A 139
 None
None
None
None
MGD  A 811 ( 4.4A)
 1.04A 4fp9D-2jirA:
undetectable		 4fp9D-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.01A 4fp9D-2kpkA:
undetectable		 4fp9D-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA

(Legionella
pneumophila) 		PF04378
(RsmJ) 		5 GLY A  46
GLY A 100
LEU A 120
ASP A 144
GLY A 145
 None
 0.85A 4fp9D-2oo3A:
9.1		 4fp9D-2oo3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.90A 4fp9D-2p1rA:
undetectable		 4fp9D-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct) 		PF00514
(Arm)
PF00514
(Arm)
PF16186
(Arm_3) 		6 GLY A 115
GLY B 116
ASN A  33
LEU A  29
ASP A  31
GLY A  32
 None
 1.35A 4fp9D-2ru4A:
undetectable		 4fp9D-2ru4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 PRO A 489
GLY A 487
LEU A 478
GLY A 357
LEU A 369
 None
 1.05A 4fp9D-2wpgA:
undetectable		 4fp9D-2wpgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 GLY A 806
GLY A 795
LEU A 712
SER A 708
GLY A 716
 None
 0.93A 4fp9D-2yocA:
undetectable		 4fp9D-2yocA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.05A 4fp9D-2ywdA:
undetectable		 4fp9D-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.40A 4fp9D-2yxlA:
28.3		 4fp9D-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  88
GLY A  89
ASP A 144
GLY A 145
LEU A 172
 None
 0.62A 4fp9D-2zsuA:
11.0		 4fp9D-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 CYH A  91
GLY A  95
LYS A  97
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.9A)
None
 1.06A 4fp9D-3a4tA:
26.4		 4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
 0.68A 4fp9D-3a4tA:
26.4		 4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 CYH B 350
GLY B 356
GLY B 355
LEU B 223
LEU B 240
 None
FAD  B   1 (-3.0A)
FAD  B   1 (-3.4A)
None
None
 0.88A 4fp9D-3adaB:
undetectable		 4fp9D-3adaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1152
GLY A1153
ASP A1193
PRO A1228
LEU A1250
 SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
 0.81A 4fp9D-3av6A:
7.3		 4fp9D-3av6A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 PRO A 415
GLY A 416
GLY A 422
SER A 411
GLY A 402
 None
 0.97A 4fp9D-3b9eA:
undetectable		 4fp9D-3b9eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 PRO A  49
GLY A  50
GLY A  51
LEU A  68
ASP A  83
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.6A)
 0.64A 4fp9D-3douA:
9.1		 4fp9D-3douA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.93A 4fp9D-3f70A:
undetectable		 4fp9D-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 184
GLY A 183
LEU A 208
PRO A 377
LEU A 374
 None
 1.05A 4fp9D-3feoA:
undetectable		 4fp9D-3feoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		5 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.08A 4fp9D-3gs6A:
undetectable		 4fp9D-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		5 GLY A 372
GLY A 371
GLY A 313
PRO A 344
LEU A 311
 None
 0.97A 4fp9D-3ib5A:
undetectable		 4fp9D-3ib5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		5 GLY A 153
ASN A 307
SER A 184
PRO A 143
LEU A 148
 None
 1.08A 4fp9D-3jtyA:
undetectable		 4fp9D-3jtyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.96A 4fp9D-3l44A:
undetectable		 4fp9D-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		7 CYH A 113
PRO A 116
GLY A 117
GLY A 118
LYS A 119
ASN A 136
PRO A 184
 None
 0.34A 4fp9D-3m4xA:
27.8		 4fp9D-3m4xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		7 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
PRO A 179
LEU A 211
 None
 0.45A 4fp9D-3m6xA:
28.9		 4fp9D-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K  83
GLY K  82
ASN K 374
GLY K 372
LEU K 377
 None
 0.99A 4fp9D-3mvdK:
undetectable		 4fp9D-3mvdK:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntn USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 203
GLY A 188
ASN A 213
LEU A 223
GLY A 210
 None
 1.05A 4fp9D-3ntnA:
undetectable		 4fp9D-3ntnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 GLY A 374
GLY A 375
ASN A 188
SER A 349
GLY A 207
 None
 1.02A 4fp9D-3r18A:
undetectable		 4fp9D-3r18A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 105
GLY A 106
ASP A 155
GLY A 156
LEU A 184
 None
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.66A 4fp9D-3rw9A:
9.6		 4fp9D-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 PRO A 276
GLY A 278
GLY A 279
LEU A 107
LEU A 139
 None
 0.99A 4fp9D-3uduA:
undetectable		 4fp9D-3uduA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.92A 4fp9D-3urhA:
undetectable		 4fp9D-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		6 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9D-3vexA:
undetectable		 4fp9D-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.05A 4fp9D-3vrbA:
undetectable		 4fp9D-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpa TRIMERIC
AUTOTRANSPORTER
ADHESIN

(Acinetobacter
sp. Tol 5) 		PF05662
(YadA_stalk) 		5 PRO A3502
GLY A3488
GLY A3487
ASP A3508
GLY A3507
 None
 0.99A 4fp9D-3wpaA:
undetectable		 4fp9D-3wpaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 GLY H 473
GLY H 474
ASN H 521
SER H 517
ASP H 514
 None
 1.07A 4fp9D-4c8qH:
undetectable		 4fp9D-4c8qH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.00A 4fp9D-4czeA:
undetectable		 4fp9D-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9o IMV MEMBRANE PROTEIN

(Vaccinia virus) 		PF00194
(Carb_anhydrase) 		5 GLY X  50
GLY X  49
LYS X  48
ASP X 112
GLY X 113
 IOD  X 306 ( 4.6A)
IOD  X 306 ( 4.4A)
None
None
None
 0.79A 4fp9D-4e9oX:
undetectable		 4fp9D-4e9oX:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9D-4fl0A:
2.9		 4fp9D-4fl0A:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
ASP A 237
GLY A 238
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
 0.21A 4fp9D-4fzvA:
57.7		 4fp9D-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9D-4fzvA:
57.7		 4fp9D-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 PRO A  66
GLY A  67
GLY A  68
ASP A 111
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.61A 4fp9D-4gc5A:
9.3		 4fp9D-4gc5A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
 None
 1.07A 4fp9D-4hq1A:
undetectable		 4fp9D-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.08A 4fp9D-4hr3A:
undetectable		 4fp9D-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ild ENVELOPE
GLYCOPROTEIN E2

(Pestivirus A) 		PF16329
(Pestivirus_E2) 		5 PRO A 943
GLY A 901
ASN A 935
ASP A 962
GLY A 938
 None
 1.08A 4fp9D-4ildA:
undetectable		 4fp9D-4ildA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.58A 4fp9D-4ineA:
10.9		 4fp9D-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 GLY A 236
GLY A 238
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 1.00A 4fp9D-4ineA:
10.9		 4fp9D-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG

(Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 GLY A 230
GLY A 231
LEU A 179
ASP A 159
GLY A 158
 None
 1.03A 4fp9D-4kmhA:
undetectable		 4fp9D-4kmhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 GLY A 232
GLY A 233
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.47A 4fp9D-4kriA:
11.3		 4fp9D-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 GLY A 232
GLY A 234
LEU A 251
SER A 252
ASP A 277
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.4A)
 0.97A 4fp9D-4kriA:
11.3		 4fp9D-4kriA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.02A 4fp9D-4ktoA:
undetectable		 4fp9D-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		6 GLY A 288
GLY A  24
ASP A 323
GLY A 325
PRO A 254
LEU A 261
 None
 1.49A 4fp9D-4m88A:
undetectable		 4fp9D-4m88A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 335
LEU A 383
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
 1.03A 4fp9D-4n49A:
8.4		 4fp9D-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.74A 4fp9D-4nnqA:
undetectable		 4fp9D-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.04A 4fp9D-4rl6A:
4.1		 4fp9D-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1149
GLY A1150
ASP A1190
PRO A1225
LEU A1247
 SAH  A1706 ( 4.3A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
 0.85A 4fp9D-4wxxA:
7.2		 4fp9D-4wxxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		5 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.97A 4fp9D-4x33B:
undetectable		 4fp9D-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 GLY A  58
GLY A  57
LEU A  70
ASP A 155
LEU A 147
 None
 1.02A 4fp9D-4zg8A:
undetectable		 4fp9D-4zg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 PRO A 549
GLY A 553
GLY A 554
ASP A  95
GLY A 431
 None
None
None
ZN  A1903 ( 2.1A)
None
 0.84A 4fp9D-5a7mA:
undetectable		 4fp9D-5a7mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.97A 4fp9D-5dq9A:
undetectable		 4fp9D-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY A 171
SER A 285
ASP A 313
GLY A 293
PRO A 282
 None
None
None
FAD  A 401 (-3.2A)
None
 0.93A 4fp9D-5eowA:
2.1		 4fp9D-5eowA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		5 GLY A 124
GLY A 125
LEU A 152
GLY A 163
LEU A 162
 None
 0.89A 4fp9D-5esyA:
undetectable		 4fp9D-5esyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9D-5f15A:
undetectable		 4fp9D-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.88A 4fp9D-5fyqA:
undetectable		 4fp9D-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.02A 4fp9D-5hn4A:
undetectable		 4fp9D-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
 None
 0.80A 4fp9D-5ic7A:
undetectable		 4fp9D-5ic7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		5 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.58A 4fp9D-5m58A:
12.6		 4fp9D-5m58A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.03A 4fp9D-5m60A:
undetectable		 4fp9D-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.86A 4fp9D-5m60A:
undetectable		 4fp9D-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		5 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.58A 4fp9D-5mgzA:
12.5		 4fp9D-5mgzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 PRO A   5
GLY A 175
GLY A 176
SER A  97
PRO A   9
 None
 0.99A 4fp9D-5n7qA:
undetectable		 4fp9D-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.02A 4fp9D-5um6A:
3.5		 4fp9D-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.53A 4fp9D-5wp4A:
10.5		 4fp9D-5wp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.90A 4fp9D-5wp4A:
10.5		 4fp9D-5wp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.45A 4fp9D-5wp5A:
10.6		 4fp9D-5wp5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.87A 4fp9D-5wp5A:
10.6		 4fp9D-5wp5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
None
None
None
 0.58A 4fp9D-5wwtA:
26.5		 4fp9D-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A  43
GLY A  44
LEU A 174
SER A 253
GLY A 215
 FAD  A 501 ( 3.9A)
None
None
None
None
 1.03A 4fp9D-5xgvA:
undetectable		 4fp9D-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium) 		no annotation 5 GLY A  87
GLY A  83
SER A  17
ASP A 259
LEU A 241
 None
 0.83A 4fp9D-5z6oA:
2.1		 4fp9D-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASP A 179
ARG A 174
ASP A 370
 None
 0.90A 4fp9D-1bf2A:
undetectable		 4fp9D-1bf2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		3 ASP A  42
ARG A  20
ASP A 130
 None
 0.74A 4fp9D-1e3hA:
undetectable		 4fp9D-1e3hA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASP B 856
ARG B 377
ASP B 881
 None
 0.82A 4fp9D-1gl9B:
undetectable		 4fp9D-1gl9B:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gs9 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 ASP A 151
ARG A 103
ASP A 110
 None
 0.68A 4fp9D-1gs9A:
undetectable		 4fp9D-1gs9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		3 ASP A 130
ARG A 122
ASP A 175
 None
 0.83A 4fp9D-1hg0A:
undetectable		 4fp9D-1hg0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 429
ARG A 430
ASP A 169
 None
 0.89A 4fp9D-1hwwA:
undetectable		 4fp9D-1hwwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 ASP A 618
ARG A 524
ASP A 521
 None
 0.81A 4fp9D-1i5pA:
undetectable		 4fp9D-1i5pA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ASP A 113
ARG A 132
ASP A   3
 None
 0.85A 4fp9D-1lpjA:
undetectable		 4fp9D-1lpjA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwi G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Escherichia
coli) 		PF03167
(UDG) 		3 ASP A  48
ARG A  49
ASP A  61
 None
 0.66A 4fp9D-1mwiA:
undetectable		 4fp9D-1mwiA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 ASP A  46
ARG A  70
ASP A  48
 None
 0.79A 4fp9D-1p88A:
undetectable		 4fp9D-1p88A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 518
ARG A 545
ASP A   9
 None
 0.89A 4fp9D-1qhoA:
undetectable		 4fp9D-1qhoA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		3 ASP A 123
ARG A 125
ASP A 112
 None
 0.81A 4fp9D-1qxoA:
undetectable		 4fp9D-1qxoA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		3 ASP A1222
ARG A1221
ASP A1229
 None
SO4  A 300 (-2.9A)
None
 0.83A 4fp9D-1s35A:
undetectable		 4fp9D-1s35A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ASP A 483
ARG A 487
ASP A 386
 None
 0.82A 4fp9D-1ut9A:
undetectable		 4fp9D-1ut9A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ASP A 412
ARG A 415
ASP A   4
 None
 0.80A 4fp9D-1v4gA:
undetectable		 4fp9D-1v4gA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		3 ASP C 304
ARG C 146
ASP C 238
 None
 0.84A 4fp9D-1vrnC:
undetectable		 4fp9D-1vrnC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		3 ASP A 136
ARG A 137
ASP A 468
 None
 0.86A 4fp9D-1yisA:
undetectable		 4fp9D-1yisA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ASP A 929
ARG A 955
ASP A 714
 None
 0.69A 4fp9D-1yq2A:
undetectable		 4fp9D-1yq2A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 ASP A 195
ARG A  91
ASP A 221
 None
 0.87A 4fp9D-1z6rA:
undetectable		 4fp9D-1z6rA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.63A 4fp9D-2aeuA:
undetectable		 4fp9D-2aeuA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.52A 4fp9D-2b9eA:
23.5		 4fp9D-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d04 NEOCULIN ACIDIC
SUBUNIT

(Molineria
latifolia) 		PF01453
(B_lectin) 		3 ASP A  59
ARG A  57
ASP A  76
 None
 0.86A 4fp9D-2d04A:
undetectable		 4fp9D-2d04A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 3 ASP A 291
ARG A 294
ASP A 251
 None
 0.76A 4fp9D-2d4yA:
undetectable		 4fp9D-2d4yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		3 ASP A 160
ARG A 200
ASP A 444
 None
 0.88A 4fp9D-2dpyA:
undetectable		 4fp9D-2dpyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 ASP A 279
ARG A 275
ASP A 314
 CA  A 803 ( 2.9A)
None
None
 0.84A 4fp9D-2e3xA:
undetectable		 4fp9D-2e3xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		3 ASP A 324
ARG A 330
ASP A 407
 None
 0.86A 4fp9D-2eidA:
undetectable		 4fp9D-2eidA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eve HYPOTHETICAL PROTEIN
PSPTO5229

(Pseudomonas
syringae group
genomosp. 3) 		PF01878
(EVE) 		3 ASP A  72
ARG A  25
ASP A  77
 None
 0.76A 4fp9D-2eveA:
undetectable		 4fp9D-2eveA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASP A 160
ARG A 156
ASP A  84
 None
 0.69A 4fp9D-2f6dA:
undetectable		 4fp9D-2f6dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		3 ASP A 819
ARG A 859
ASP A 794
 None
 0.82A 4fp9D-2g28A:
undetectable		 4fp9D-2g28A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ASP A  18
ARG A  19
ASP A  23
 None
 0.84A 4fp9D-2ipiA:
undetectable		 4fp9D-2ipiA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 ASP A 130
ARG A 122
ASP A 175
 None
 0.85A 4fp9D-2jk0A:
undetectable		 4fp9D-2jk0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4z DSRR

(Allochromatium
vinosum) 		PF01521
(Fe-S_biosyn) 		3 ASP A  51
ARG A  27
ASP A  66
 None
 0.78A 4fp9D-2k4zA:
undetectable		 4fp9D-2k4zA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.85A 4fp9D-2kbqA:
undetectable		 4fp9D-2kbqA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvc OBSCURIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		3 ASP A  30
ARG A  31
ASP A  81
 None
 0.81A 4fp9D-2lvcA:
undetectable		 4fp9D-2lvcA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		3 ASP A 131
ARG A 133
ASP A  75
 None
 0.60A 4fp9D-2m5tA:
undetectable		 4fp9D-2m5tA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		3 ASP A 148
ARG A 212
ASP A 145
 None
 0.87A 4fp9D-2nwbA:
undetectable		 4fp9D-2nwbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		3 ASP A2069
ARG A2068
ASP A1114
 None
 0.75A 4fp9D-2o61A:
undetectable		 4fp9D-2o61A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oka HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF10262
(Rdx) 		3 ASP A  83
ARG A  86
ASP A  35
 None
 0.88A 4fp9D-2okaA:
undetectable		 4fp9D-2okaA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		3 ASP A  53
ARG A  31
ASP A  77
 None
 0.57A 4fp9D-2pblA:
undetectable		 4fp9D-2pblA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ASP A   3
ARG A 137
ASP A  45
 None
 0.71A 4fp9D-2rcqA:
undetectable		 4fp9D-2rcqA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ASP A 257
ARG A 252
ASP A 286
 None
 0.80A 4fp9D-2vakA:
undetectable		 4fp9D-2vakA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.70A 4fp9D-2vp3A:
7.1		 4fp9D-2vp3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 ASP B 461
ARG B 456
ASP B 330
 None
 0.79A 4fp9D-2y7cB:
9.6		 4fp9D-2y7cB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		3 ASP B 397
ARG A1035
ASP B 181
 None
 0.85A 4fp9D-2y9yB:
undetectable		 4fp9D-2y9yB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ASP A  30
ARG A 146
ASP A  75
 None
 0.87A 4fp9D-2yxzA:
undetectable		 4fp9D-2yxzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 231
ARG A 230
ASP A 286
 None
 0.80A 4fp9D-2z81A:
undetectable		 4fp9D-2z81A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 ASP A 345
ARG A 341
ASP A 350
 None
 0.85A 4fp9D-2zygA:
3.7		 4fp9D-2zygA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		3 ASP A  57
ARG A  73
ASP A 480
 None
 0.81A 4fp9D-3al8A:
undetectable		 4fp9D-3al8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		3 ASP P 354
ARG P 222
ASP P 181
 None
 0.88A 4fp9D-3c5wP:
undetectable		 4fp9D-3c5wP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpt RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF16095
(COR) 		3 ASP A 758
ARG A 754
ASP A 768
 None
 0.88A 4fp9D-3dptA:
undetectable		 4fp9D-3dptA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		3 ASP A 186
ARG A 218
ASP A 269
 None
 0.87A 4fp9D-3e5mA:
4.4		 4fp9D-3e5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		3 ASP A 172
ARG A 180
ASP A 158
 None
SO4  A 272 (-4.5A)
None
 0.88A 4fp9D-3en0A:
2.3		 4fp9D-3en0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frm UNCHARACTERIZED
CONSERVED PROTEIN

(Staphylococcus
epidermidis) 		PF13673
(Acetyltransf_10) 		3 ASP A 177
ARG A 163
ASP A  12
 None
 0.75A 4fp9D-3frmA:
undetectable		 4fp9D-3frmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		3 ASP A 109
ARG A 153
ASP A  75
 None
 0.82A 4fp9D-3h7uA:
undetectable		 4fp9D-3h7uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		3 ASP A 218
ARG A 272
ASP A 240
 None
 0.87A 4fp9D-3i2nA:
undetectable		 4fp9D-3i2nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		3 ASP A  84
ARG A  91
ASP A 147
 None
NHE  A   1 (-3.9A)
None
 0.63A 4fp9D-3k0zA:
undetectable		 4fp9D-3k0zA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA
SOXX

(Starkeya
novella;
Starkeya
novella) 		no annotation
PF00034
(Cytochrom_C) 		3 ASP B 168
ARG B  86
ASP A 180
 None
 0.87A 4fp9D-3ocdB:
undetectable		 4fp9D-3ocdB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		3 ASP A 149
ARG A 315
ASP A 142
 None
 0.75A 4fp9D-3psgA:
undetectable		 4fp9D-3psgA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 ASP A 626
ARG A 629
ASP A 668
 None
 0.77A 4fp9D-3sfzA:
undetectable		 4fp9D-3sfzA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqw METHIONINE-BINDING
PROTEIN

(Coxiella
burnetii) 		PF03180
(Lipoprotein_9) 		3 ASP A  51
ARG A   3
ASP A  47
 None
 0.81A 4fp9D-3tqwA:
undetectable		 4fp9D-3tqwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ASP A 294
ARG A 299
ASP A 267
 None
None
MN  A 601 ( 4.6A)
 0.85A 4fp9D-3u95A:
5.2		 4fp9D-3u95A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		3 ASP A 241
ARG A 212
ASP A  94
 None
 0.80A 4fp9D-3wecA:
undetectable		 4fp9D-3wecA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 ASP A 329
ARG A 347
ASP A 373
 None
 0.68A 4fp9D-4af1A:
undetectable		 4fp9D-4af1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		3 ASP A  65
ARG A 109
ASP A 151
 None
 0.88A 4fp9D-4c1rA:
3.0		 4fp9D-4c1rA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.34A 4fp9D-4fzvA:
57.7		 4fp9D-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ASP A 138
ARG A 128
ASP A 169
 None
 0.88A 4fp9D-4gklA:
undetectable		 4fp9D-4gklA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvz 26 KDA PERIPLASMIC
IMMUNOGENIC PROTEIN

(Brucella
abortus) 		PF04402
(SIMPL) 		3 ASP A  95
ARG A  94
ASP A 163
 None
 0.79A 4fp9D-4hvzA:
undetectable		 4fp9D-4hvzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0k CD276 ANTIGEN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		3 ASP A 116
ARG A 113
ASP A  45
 None
SO4  A 306 (-2.4A)
None
 0.81A 4fp9D-4i0kA:
undetectable		 4fp9D-4i0kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9x PROTEIN UL141

(Human
betaherpesvirus
5) 		PF16758
(UL141) 		3 ASP A  91
ARG A 110
ASP A  88
 None
 0.86A 4fp9D-4i9xA:
undetectable		 4fp9D-4i9xA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 ASP A 115
ARG A 135
ASP A 110
 None
 0.86A 4fp9D-4iglA:
undetectable		 4fp9D-4iglA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4khb UNCHARACTERIZED
PROTEIN POB3N

(Chaetomium
thermophilum) 		no annotation 3 ASP D  79
ARG D  82
ASP D   8
 None
 0.85A 4fp9D-4khbD:
undetectable		 4fp9D-4khbD:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		3 ASP A 115
ARG A 317
ASP A 338
 None
 0.86A 4fp9D-4pyrA:
undetectable		 4fp9D-4pyrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		3 ASP A 338
ARG A 341
ASP A 363
 None
 0.84A 4fp9D-4pyrA:
undetectable		 4fp9D-4pyrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.88A 4fp9D-4rgkA:
undetectable		 4fp9D-4rgkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		3 ASP A 239
ARG A 240
ASP A 232
 None
 0.81A 4fp9D-4yxfA:
5.2		 4fp9D-4yxfA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 ASP A 381
ARG A 336
ASP A 374
 None
 0.79A 4fp9D-4zc0A:
2.5		 4fp9D-4zc0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		3 ASP A 120
ARG A 122
ASP A  89
 None
 0.78A 4fp9D-4zv6A:
undetectable		 4fp9D-4zv6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		3 ASP A 116
ARG A 187
ASP A 109
 None
 0.66A 4fp9D-5b7nA:
undetectable		 4fp9D-5b7nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		3 ASP A 143
ARG A 147
ASP A 130
 None
 0.89A 4fp9D-5diyA:
undetectable		 4fp9D-5diyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwu CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
CYTOKINE RECEPTOR
COMMON SUBUNIT BETA

(Homo sapiens;
Homo sapiens) 		no annotation
PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 ASP A 116
ARG A 117
ASP B 241
 NAG  A 301 ( 4.9A)
None
None
 0.60A 4fp9D-5dwuA:
undetectable		 4fp9D-5dwuA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		3 ASP A 356
ARG A 352
ASP A 134
 None
 0.84A 4fp9D-5fw4A:
undetectable		 4fp9D-5fw4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		3 ASP A1196
ARG A1236
ASP A1203
 None
 0.88A 4fp9D-5gjvA:
undetectable		 4fp9D-5gjvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ASP A 559
ARG A 553
ASP A 577
 None
 0.80A 4fp9D-5hm5A:
undetectable		 4fp9D-5hm5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 ASP A 562
ARG A 567
ASP A 536
 None
 0.87A 4fp9D-5ivaA:
undetectable		 4fp9D-5ivaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j46 PEPTIDE DEFORMYLASE

(Burkholderia
multivorans) 		PF01327
(Pep_deformylase) 		3 ASP A  39
ARG A  41
ASP A  36
 None
 0.63A 4fp9D-5j46A:
undetectable		 4fp9D-5j46A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		3 ASP A 305
ARG A 306
ASP A 274
 None
 0.83A 4fp9D-5jp9A:
undetectable		 4fp9D-5jp9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 3 ASP A 509
ARG A 545
ASP A 417
 None
 0.80A 4fp9D-5nxkA:
undetectable		 4fp9D-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 3 ASP A  63
ARG A  43
ASP A  73
 None
 0.89A 4fp9D-5o7gA:
undetectable		 4fp9D-5o7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		3 ASP A 149
ARG A 316
ASP A 142
 None
 0.77A 4fp9D-5pepA:
undetectable		 4fp9D-5pepA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 ASP A 243
ARG A 236
ASP A 315
 None
 0.84A 4fp9D-5uamA:
undetectable		 4fp9D-5uamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 349
ARG A 320
ASP A 424
 None
PEP  A 504 (-3.9A)
CO  A 503 (-3.4A)
 0.85A 4fp9D-5uxnA:
undetectable		 4fp9D-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 3 ASP C 237
ARG C 244
ASP C 208
 CA  C 407 (-2.7A)
None
None
 0.62A 4fp9D-5w4tC:
undetectable		 4fp9D-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		3 ASP A 128
ARG A 173
ASP A 122
 None
 0.80A 4fp9D-5wzrA:
undetectable		 4fp9D-5wzrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 3 ASP B 546
ARG B 542
ASP B 583
 None
 0.85A 4fp9D-5xguB:
undetectable		 4fp9D-5xguB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC
DRAXIN

(Rattus
norvegicus;
Rattus
norvegicus) 		no annotation
no annotation 		3 ASP B 300
ARG B 308
ASP A  77
 None
 0.82A 4fp9D-5z5kB:
undetectable		 4fp9D-5z5kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0e 1260 ANTIBODY, HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASP B  95
ARG B  96
ASP B  58
 None
 0.76A 4fp9D-6b0eB:
undetectable		 4fp9D-6b0eB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 ASP A1196
ARG A1236
ASP A1151
 None
 0.86A 4fp9D-6byoA:
undetectable		 4fp9D-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.88A 4fp9D-6byoA:
undetectable		 4fp9D-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.77A 4fp9D-6dg4A:
undetectable		 4fp9D-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2

(Saccharomyces
cerevisiae) 		no annotation 3 ASP l  81
ARG l 126
ASP l   4
 None
 0.89A 4fp9D-6fail:
undetectable		 4fp9D-6fail:
undetectable