SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_C_SAMC401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ASP A 618
ARG A 354
ASP A 623
 None
 0.89A 4fp9C-1br2A:
undetectable		 4fp9C-1br2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ASP A 614
ARG A 590
ASP A 558
 None
 0.78A 4fp9C-1c30A:
2.2		 4fp9C-1c30A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 ASP A 675
ARG A 641
ASP A 678
 None
 0.73A 4fp9C-1d0nA:
undetectable		 4fp9C-1d0nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASP A 569
ARG A 567
ASP A 511
 None
 0.82A 4fp9C-1d6mA:
undetectable		 4fp9C-1d6mA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE
MYELOPEROXIDASE

(Homo sapiens;
Homo sapiens) 		PF03098
(An_peroxidase)
PF03098
(An_peroxidase) 		3 ASP C 400
ARG C 403
ASP A  74
 SO4  A1602 (-4.7A)
None
None
 0.65A 4fp9C-1d7wC:
undetectable		 4fp9C-1d7wC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9s CYCLIN-DEPENDENT
KINASE 4 INHIBITOR B

(Mus musculus) 		PF12796
(Ank_2) 		3 ASP A  78
ARG A  81
ASP A  68
 None
 0.75A 4fp9C-1d9sA:
undetectable		 4fp9C-1d9sA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ASP A 396
ARG A 395
ASP A 134
 None
 0.71A 4fp9C-1fotA:
undetectable		 4fp9C-1fotA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		3 ASP A 419
ARG A 422
ASP A 412
 None
 0.80A 4fp9C-1io1A:
undetectable		 4fp9C-1io1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		3 ASP A 226
ARG A 223
ASP A 250
 None
 0.90A 4fp9C-1k2wA:
2.7		 4fp9C-1k2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 205
ARG A  17
ASP A  29
 None
 0.75A 4fp9C-1mdfA:
undetectable		 4fp9C-1mdfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ASP A 193
ARG A 331
ASP A 186
 None
 0.76A 4fp9C-1nfgA:
undetectable		 4fp9C-1nfgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		3 ASP A 292
ARG A 288
ASP A 351
 None
 0.90A 4fp9C-1q5dA:
undetectable		 4fp9C-1q5dA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASP A 357
ARG A 361
ASP A 117
 None
 0.65A 4fp9C-1qk1A:
undetectable		 4fp9C-1qk1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		3 ASP A  51
ARG A  24
ASP A  44
 None
 0.77A 4fp9C-1rytA:
undetectable		 4fp9C-1rytA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 ASP A  43
ARG A 225
ASP A  53
 None
 0.88A 4fp9C-1s9cA:
undetectable		 4fp9C-1s9cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 ASP A 214
ARG A 213
ASP A 167
 None
 0.86A 4fp9C-1susA:
10.4		 4fp9C-1susA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		3 ASP 1  53
ARG 1  50
ASP 1  45
 None
 0.76A 4fp9C-1t6t1:
undetectable		 4fp9C-1t6t1:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ASP A 231
ARG A 267
ASP A 224
 None
 0.90A 4fp9C-1up2A:
undetectable		 4fp9C-1up2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcc DNA TOPOISOMERASE I

(Vaccinia virus) 		PF09266
(VirDNA-topo-I_N) 		3 ASP A  63
ARG A  67
ASP A  42
 None
 0.75A 4fp9C-1vccA:
undetectable		 4fp9C-1vccA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr1 CELL-DIVISION
INITIATION PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 ASP A 195
ARG A 212
ASP A 162
 None
 0.90A 4fp9C-1yr1A:
undetectable		 4fp9C-1yr1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 ASP C 181
ARG C 179
ASP C 164
 None
 0.77A 4fp9C-1zq1C:
undetectable		 4fp9C-1zq1C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 ASP A 199
ARG A 187
ASP A 212
 None
 0.88A 4fp9C-2b3xA:
undetectable		 4fp9C-2b3xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ARG A 263
ASP A 285
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
 0.52A 4fp9C-2b9eA:
23.3		 4fp9C-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 ASP A 437
ARG A 424
ASP A 386
 None
 0.86A 4fp9C-2cn3A:
undetectable		 4fp9C-2cn3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 ASP A 184
ARG A 186
ASP A 181
 None
 0.82A 4fp9C-2eb5A:
undetectable		 4fp9C-2eb5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ASP A 898
ARG A 688
ASP A 499
 None
 0.73A 4fp9C-2inyA:
undetectable		 4fp9C-2inyA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 205
ARG A 557
ASP A 208
 None
 0.90A 4fp9C-2iujA:
undetectable		 4fp9C-2iujA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 621
ARG A 823
ASP A 454
 None
 0.89A 4fp9C-2iujA:
undetectable		 4fp9C-2iujA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		3 ASP A  72
ARG A  96
ASP A 143
 None
 0.74A 4fp9C-2j0aA:
undetectable		 4fp9C-2j0aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 204
ARG A 206
ASP A 225
 MGD  A 812 (-2.7A)
MGD  A 812 (-3.9A)
MGD  A 812 (-3.4A)
 0.64A 4fp9C-2jirA:
undetectable		 4fp9C-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsz PROBABLE THIOL
PEROXIDASE

(Bacillus
subtilis) 		PF08534
(Redoxin) 		3 ASP A  61
ARG A  65
ASP A  56
 None
 0.73A 4fp9C-2jszA:
undetectable		 4fp9C-2jszA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 ASP A 156
ARG A  77
ASP A 130
 None
 0.54A 4fp9C-2nqaA:
undetectable		 4fp9C-2nqaA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyb NEUTROPHIL
ACTIVATING PROTEIN

(Borreliella
burgdorferi) 		PF00210
(Ferritin) 		3 ASP A 132
ARG A  70
ASP A 128
 None
 0.86A 4fp9C-2pybA:
undetectable		 4fp9C-2pybA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9C-2qcmA:
undetectable		 4fp9C-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A 319
ARG A 321
ASP A 306
 ASP  A 319 ( 0.6A)
ARG  A 321 ( 0.6A)
ASP  A 306 ( 0.6A)
 0.71A 4fp9C-2vbfA:
undetectable		 4fp9C-2vbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		3 ASP A 134
ARG A 137
ASP A 127
 None
 0.78A 4fp9C-2wu8A:
undetectable		 4fp9C-2wu8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ASP A 251
ARG A  86
ASP A 242
 None
FMT  A1333 (-2.9A)
None
 0.82A 4fp9C-2ymvA:
undetectable		 4fp9C-2ymvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn3 PUTATIVE INNER
MEMBRANE PROTEIN

(Salmonella
enterica) 		PF12245
(Big_3_2) 		3 ASP A5183
ARG A5182
ASP A5170
 None
 0.84A 4fp9C-2yn3A:
undetectable		 4fp9C-2yn3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		3 ASP A 217
ARG A 206
ASP A 214
 None
SO4  A 512 (-3.1A)
None
 0.82A 4fp9C-2z02A:
undetectable		 4fp9C-2z02A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		3 ASP A 120
ARG A 122
ASP A  59
 None
 0.80A 4fp9C-2zylA:
undetectable		 4fp9C-2zylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		3 ASP A 109
ARG A 112
ASP A 104
 None
 0.52A 4fp9C-3bhwA:
undetectable		 4fp9C-3bhwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 3 ASP A  28
ARG A 123
ASP A  34
 None
 0.71A 4fp9C-3d0kA:
undetectable		 4fp9C-3d0kA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzb PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
putrefaciens) 		PF12680
(SnoaL_2) 		3 ASP A  47
ARG A  46
ASP A 128
 None
 0.55A 4fp9C-3gzbA:
undetectable		 4fp9C-3gzbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		3 ASP 7  39
ARG 7  75
ASP 7  36
 None
 0.68A 4fp9C-3i9v7:
undetectable		 4fp9C-3i9v7:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		3 ASP A 222
ARG A 218
ASP A  32
 None
 0.79A 4fp9C-3lg3A:
undetectable		 4fp9C-3lg3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ASP A 323
ARG A 325
ASP A 299
 None
 0.88A 4fp9C-3lmlA:
undetectable		 4fp9C-3lmlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		3 ASP A 272
ARG A  85
ASP A 113
 None
 0.82A 4fp9C-3obiA:
2.3		 4fp9C-3obiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oov METHYL-ACCEPTING
CHEMOTAXIS PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		3 ASP A 130
ARG A  33
ASP A 142
 GOL  A 167 (-3.6A)
None
None
 0.69A 4fp9C-3oovA:
undetectable		 4fp9C-3oovA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plt SPHINGOLIPID LONG
CHAIN
BASE-RESPONSIVE
PROTEIN LSP1

(Saccharomyces
cerevisiae) 		PF13805
(Pil1) 		3 ASP A 123
ARG A 126
ASP A 116
 None
 0.75A 4fp9C-3pltA:
undetectable		 4fp9C-3pltA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		3 ASP A 300
ARG A 304
ASP A 288
 None
 0.87A 4fp9C-3q54A:
undetectable		 4fp9C-3q54A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 ASP A 439
ARG A 438
ASP A 414
 ASP  A 439 ( 0.6A)
ARG  A 438 ( 0.6A)
ASP  A 414 ( 0.6A)
 0.86A 4fp9C-3sagA:
undetectable		 4fp9C-3sagA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		3 ASP A  86
ARG A 162
ASP A  36
 None
 0.89A 4fp9C-3tisA:
undetectable		 4fp9C-3tisA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 ASP A 216
ARG A 221
ASP A 243
 None
 0.83A 4fp9C-3tmaA:
14.1		 4fp9C-3tmaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP A 100
ARG A  99
ASP A  80
 None
 0.73A 4fp9C-3wa1A:
undetectable		 4fp9C-3wa1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfv ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 3 ASP A 618
ARG A 614
ASP A 545
 None
 0.86A 4fp9C-3wfvA:
undetectable		 4fp9C-3wfvA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ASP A 260
ARG A 257
ASP A 280
 None
 0.60A 4fp9C-3wfzA:
undetectable		 4fp9C-3wfzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		3 ASP A 292
ARG A 310
ASP A 295
 None
 0.76A 4fp9C-3x0vA:
2.5		 4fp9C-3x0vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 ASP A 550
ARG A 546
ASP A 641
 None
 0.73A 4fp9C-4ay2A:
undetectable		 4fp9C-4ay2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		3 ASP A 554
ARG A 559
ASP A 547
 None
 0.75A 4fp9C-4c4aA:
6.9		 4fp9C-4c4aA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 146
ARG A 193
ASP A 141
 None
 0.70A 4fp9C-4e4uA:
undetectable		 4fp9C-4e4uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 3 ASP D 131
ARG D 134
ASP D 124
 None
 0.79A 4fp9C-4em6D:
undetectable		 4fp9C-4em6D:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		3 ASP A 209
ARG A 199
ASP A 202
 None
AIR  A 301 (-3.1A)
None
 0.86A 4fp9C-4fe2A:
undetectable		 4fp9C-4fe2A:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 237
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.30A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 3 ASP A  13
ARG A  61
ASP A  17
 None
 0.90A 4fp9C-4i4nA:
undetectable		 4fp9C-4i4nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg3 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF16175
(DUF4875) 		3 ASP A 176
ARG A 178
ASP A 172
 None
 0.65A 4fp9C-4lg3A:
undetectable		 4fp9C-4lg3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		3 ASP A 157
ARG A 154
ASP A 186
 None
 0.67A 4fp9C-4m6rA:
undetectable		 4fp9C-4m6rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 ASP A 111
ARG A 107
ASP A  31
 None
 0.62A 4fp9C-4mrpA:
undetectable		 4fp9C-4mrpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mur D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE

(Enterococcus
gallinarum) 		PF02557
(VanY) 		3 ASP A  29
ARG A  56
ASP A  31
 None
 0.87A 4fp9C-4murA:
undetectable		 4fp9C-4murA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN

(Cupriavidus
taiwanensis) 		PF13561
(adh_short_C2) 		3 ASP A  36
ARG A  41
ASP A  62
 None
 0.69A 4fp9C-4nbvA:
7.2		 4fp9C-4nbvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		3 ASP A 311
ARG A 314
ASP A 304
 None
 0.83A 4fp9C-4nx9A:
undetectable		 4fp9C-4nx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 550
ARG A 546
ASP A 641
 None
 0.80A 4fp9C-4on9A:
2.8		 4fp9C-4on9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe8 TAT-LINKED QUALITY
CONTROL PROTEIN TATD

(Escherichia
coli) 		PF01026
(TatD_DNase) 		3 ASP A  95
ARG A 129
ASP A  65
 None
 0.87A 4fp9C-4pe8A:
undetectable		 4fp9C-4pe8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py4 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF00644
(PARP) 		3 ASP A1731
ARG A1735
ASP A1725
 None
 0.86A 4fp9C-4py4A:
undetectable		 4fp9C-4py4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		3 ASP A 105
ARG A  86
ASP A  80
 None
 0.83A 4fp9C-4qnyA:
undetectable		 4fp9C-4qnyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 ASP A 153
ARG A 151
ASP A 222
 None
 0.47A 4fp9C-4zoyA:
undetectable		 4fp9C-4zoyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ASP B 278
ARG B 274
ASP B 298
 None
 0.86A 4fp9C-5a8rB:
undetectable		 4fp9C-5a8rB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0

(Dictyostelium
discoideum) 		PF00466
(Ribosomal_L10) 		3 ASP C  69
ARG C  65
ASP C 193
 None
 0.78A 4fp9C-5an9C:
undetectable		 4fp9C-5an9C:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 ASP A 298
ARG A 464
ASP A 294
 None
 0.53A 4fp9C-5cwaA:
undetectable		 4fp9C-5cwaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6h CSUC

(Acinetobacter
baumannii) 		PF00345
(PapD_N) 		3 ASP A  47
ARG A  89
ASP A  43
 None
 0.88A 4fp9C-5d6hA:
undetectable		 4fp9C-5d6hA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ASP A 216
ARG A 219
ASP A 213
 None
 0.79A 4fp9C-5djwA:
undetectable		 4fp9C-5djwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		3 ASP A 221
ARG A 218
ASP A 245
 None
 0.76A 4fp9C-5f1pA:
4.1		 4fp9C-5f1pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		3 ASP A 372
ARG A 232
ASP A 370
 None
 0.84A 4fp9C-5fgnA:
undetectable		 4fp9C-5fgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP B 100
ARG B  99
ASP B  80
 None
 0.87A 4fp9C-5fozB:
undetectable		 4fp9C-5fozB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		3 ASP A 579
ARG A 585
ASP A 606
 None
 0.83A 4fp9C-5gslA:
undetectable		 4fp9C-5gslA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		3 ASP A 439
ARG A 354
ASP A 166
 None
 0.82A 4fp9C-5gylA:
undetectable		 4fp9C-5gylA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ASP A 124
ARG A 283
ASP A 121
 None
 0.90A 4fp9C-5hm5A:
undetectable		 4fp9C-5hm5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ASP A1022
ARG A1084
ASP A1000
 None
 0.80A 4fp9C-5hy7A:
undetectable		 4fp9C-5hy7A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idm CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF02518
(HATPase_c) 		3 ASP A 403
ARG A 401
ASP A 437
 None
 0.88A 4fp9C-5idmA:
undetectable		 4fp9C-5idmA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		3 ASP A  61
ARG A  63
ASP A  42
 None
 0.79A 4fp9C-5idvA:
undetectable		 4fp9C-5idvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 ASP A 424
ARG A 422
ASP A 141
 None
 0.86A 4fp9C-5jvkA:
undetectable		 4fp9C-5jvkA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		3 ASP B  57
ARG B  56
ASP B  23
 None
 0.79A 4fp9C-5k5aB:
undetectable		 4fp9C-5k5aB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ASP A 962
ARG A 958
ASP A 936
 None
 0.85A 4fp9C-5kf7A:
3.0		 4fp9C-5kf7A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 3 ASP B 120
ARG B 466
ASP B 170
 None
None
MDO  B 168 ( 4.3A)
 0.73A 4fp9C-5ltmB:
undetectable		 4fp9C-5ltmB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 ASP A 566
ARG A 569
ASP A 240
 None
 0.57A 4fp9C-5mfaA:
undetectable		 4fp9C-5mfaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ASP Y 102
ARG Y 104
ASP Y  91
 None
 0.51A 4fp9C-5svaY:
undetectable		 4fp9C-5svaY:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		3 ASP f 496
ARG f 494
ASP f 460
 None
 0.78A 4fp9C-5vhif:
undetectable		 4fp9C-5vhif:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 3 ASP A 416
ARG A 447
ASP A 412
 None
 0.84A 4fp9C-5ws4A:
undetectable		 4fp9C-5ws4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 3 ASP A 707
ARG A 733
ASP A 737
 None
 0.72A 4fp9C-5ze3A:
undetectable		 4fp9C-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ank SYNAPTOTAGMIN-7

(Rattus
norvegicus) 		PF00168
(C2) 		3 ASP A 303
ARG A 327
ASP A 365
 CA  A 505 (-3.3A)
None
CA  A 506 (-3.4A)
 0.81A 4fp9C-6ankA:
undetectable		 4fp9C-6ankA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 3 ASP B 271
ARG B 251
ASP B  11
 None
 0.69A 4fp9C-6emkB:
undetectable		 4fp9C-6emkB:
undetectable