SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_C_SAMC401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0k | PROTEIN (ACONITASE) (Sus scrofa) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | GLY A 175GLY A 176SER A 249GLY A 244LEU A 207 | None | 1.03A | 4fp9C-1b0kA:undetectable | 4fp9C-1b0kA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnz | PROTEIN(3-ISOPROPYLMALATEDEHYDROGENASE) (Salmonellaenterica) |
PF00180(Iso_dh) | 5 | PRO A 282GLY A 284GLY A 285LEU A 108LEU A 140 | None | 1.02A | 4fp9C-1cnzA:undetectable | 4fp9C-1cnzA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pisum sativum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 248LEU A 272GLY A 169PRO A 177LEU A 173 | None | 0.96A | 4fp9C-1dxlA:undetectable | 4fp9C-1dxlA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eiz | FTSJ (Escherichiacoli) |
PF01728(FtsJ) | 6 | PRO A 62GLY A 63GLY A 64LEU A 84ASP A 124LEU A 143 | SAM A 301 (-3.4A)SAM A 301 (-3.9A)SAM A 301 (-3.1A)SAM A 301 (-4.2A)SAM A 301 (-3.6A)SAM A 301 (-4.6A) | 0.71A | 4fp9C-1eizA:9.6 | 4fp9C-1eizA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hlk | BETA-LACTAMASE, TYPEII (Bacteroidesfragilis) |
no annotation | 5 | GLY A 159GLY A 160LEU A 144GLY A 139ASP A 165 | None | 0.96A | 4fp9C-1hlkA:undetectable | 4fp9C-1hlkA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1im5 | 180AA LONGHYPOTHETICALPYRAZINAMIDASE/NICOTINAMIDASE (Pyrococcushorikoshii) |
PF00857(Isochorismatase) | 5 | PRO A 22GLY A 19GLY A 18GLY A 127ASP A 27 | None | 0.97A | 4fp9C-1im5A:undetectable | 4fp9C-1im5A:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1inl | SPERMIDINE SYNTHASE (Thermotogamaritima) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 102GLY A 103GLY A 153ASP A 170LEU A 182 | None | 0.87A | 4fp9C-1inlA:10.6 | 4fp9C-1inlA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixk | METHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | GLY A 130GLY A 131LYS A 132ASP A 194LEU A 228 | None | 1.04A | 4fp9C-1ixkA:25.0 | 4fp9C-1ixkA:29.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 86GLY A 87GLY A 142ASP A 158LEU A 169 | None | 1.02A | 4fp9C-1mjfA:10.4 | 4fp9C-1mjfA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nff | PUTATIVEOXIDOREDUCTASERV2002 (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | GLY A 184ASN A 88SER A 22GLY A 14PRO A 189 | NoneNAD A1300 (-3.3A)NoneNAD A1300 (-3.5A)NAD A1300 (-3.5A) | 1.04A | 4fp9C-1nffA:3.3 | 4fp9C-1nffA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr0 | ACTIN INTERACTINGPROTEIN 1 (Caenorhabditiselegans) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 6 | CYH A 430GLY A 466GLY A 467LEU A 417PRO A 414LEU A 410 | None | 1.42A | 4fp9C-1nr0A:undetectable | 4fp9C-1nr0A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqg | SUN PROTEIN (Escherichiacoli) |
PF01029(NusB)PF01189(Methyltr_RsmB-F) | 6 | CYH A 254GLY A 258GLY A 259GLY A 304ASP A 322PRO A 324 | None | 0.95A | 4fp9C-1sqgA:26.9 | 4fp9C-1sqgA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqg | SUN PROTEIN (Escherichiacoli) |
PF01029(NusB)PF01189(Methyltr_RsmB-F) | 6 | CYH A 254PRO A 257GLY A 258GLY A 259GLY A 302ASP A 322 | None | 1.26A | 4fp9C-1sqgA:26.9 | 4fp9C-1sqgA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqg | SUN PROTEIN (Escherichiacoli) |
PF01029(NusB)PF01189(Methyltr_RsmB-F) | 6 | CYH A 254PRO A 257GLY A 258GLY A 259GLY A 304ASP A 322 | None | 0.65A | 4fp9C-1sqgA:26.9 | 4fp9C-1sqgA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wxx | HYPOTHETICAL PROTEINTTHA1280 (Thermusthermophilus) |
PF10672(Methyltrans_SAM) | 5 | GLY A 221GLY A 222SER A 240ASP A 286PRO A 288 | None | 0.56A | 4fp9C-1wxxA:13.1 | 4fp9C-1wxxA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2as0 | HYPOTHETICAL PROTEINPH1915 (Pyrococcushorikoshii) |
PF01472(PUA)PF10672(Methyltrans_SAM) | 5 | GLY A 229GLY A 230SER A 249ASP A 296PRO A 298 | None | 0.74A | 4fp9C-2as0A:14.3 | 4fp9C-2as0A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9e | NOL1/NOP2/SUN DOMAINFAMILY, MEMBER 5ISOFORM 2 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 6 | CYH A 234PRO A 237GLY A 238LYS A 240LEU A 259ASP A 305 | SAM A1201 (-3.8A)SAM A1201 (-3.7A)SAM A1201 (-3.9A)SAM A1201 (-3.1A)SAM A1201 (-4.5A)SAM A1201 (-3.7A) | 0.49A | 4fp9C-2b9eA:23.2 | 4fp9C-2b9eA:25.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bf4 | NADPH-CYTOCHROMEP450 REDUCTASE (Saccharomycescerevisiae) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | ASN A 161LEU A 152GLY A 151ASP A 122PRO A 124 | NoneFMN A 751 (-4.1A)NoneNoneNone | 1.03A | 4fp9C-2bf4A:undetectable | 4fp9C-2bf4A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 71GLY A 70ASN A 80GLY A 83ASP A 87 | FAD A 600 (-3.2A)FAD A 600 (-2.9A)NoneNoneNone | 1.03A | 4fp9C-2bvgA:undetectable | 4fp9C-2bvgA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cvz | 3-HYDROXYISOBUTYRATEDEHYDROGENASE (Thermusthermophilus) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | GLY A 161GLY A 159LEU A 128SER A 117ASP A 88 | None | 1.04A | 4fp9C-2cvzA:3.5 | 4fp9C-2cvzA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0w | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 94GLY A 95SER A 230GLY A 238LEU A 166 | None | 1.06A | 4fp9C-2e0wA:undetectable | 4fp9C-2e0wA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | GLY A 296GLY A 297GLY A 381PRO A 350LEU A 383 | None | 0.93A | 4fp9C-2e0xA:undetectable | 4fp9C-2e0xA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 7 | PRO A 128ASN A 148SER A 151GLY A 177ASP A 194PRO A 196LEU A 228 | None | 0.75A | 4fp9C-2frxA:29.1 | 4fp9C-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 7 | PRO A 128GLY A 129ASN A 148SER A 151GLY A 177ASP A 194PRO A 196 | None | 0.71A | 4fp9C-2frxA:29.1 | 4fp9C-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128GLY A 129LYS A 131SER A 151ASP A 194PRO A 196 | None | 1.00A | 4fp9C-2frxA:29.1 | 4fp9C-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128LYS A 131SER A 151ASP A 194PRO A 196LEU A 228 | None | 1.08A | 4fp9C-2frxA:29.1 | 4fp9C-2frxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hb6 | LEUCINEAMINOPEPTIDASE 1 (Caenorhabditiselegans) |
PF00883(Peptidase_M17) | 6 | GLY A 219GLY A 218ASN A 307GLY A 260PRO A 316LEU A 261 | None | 1.49A | 4fp9C-2hb6A:undetectable | 4fp9C-2hb6A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzg | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME/ENOLASESUPERFAMILY (Rhodobactersphaeroides) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 283GLY A 282ASN A 303LEU A 312SER A 313 | None | 0.95A | 4fp9C-2hzgA:undetectable | 4fp9C-2hzgA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iss | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermotogamaritima) |
PF01174(SNO) | 5 | PRO D 44GLY D 45GLY D 46LEU D 165LEU D 99 | None | 1.06A | 4fp9C-2issD:undetectable | 4fp9C-2issD:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | GLY A 146GLY A 147GLY A 135PRO A 711LEU A 139 | NoneNoneNoneNoneMGD A 811 ( 4.4A) | 1.03A | 4fp9C-2jirA:undetectable | 4fp9C-2jirA:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k1s | INNER MEMBRANELIPOPROTEIN YIAD (Escherichiacoli) |
PF00691(OmpA) | 5 | GLY A 79GLY A 78LEU A 113GLY A 72ASP A 75 | None | 0.94A | 4fp9C-2k1sA:undetectable | 4fp9C-2k1sA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kpk | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00595(PDZ) | 5 | GLY A 33GLY A 34LEU A 46GLY A 28LEU A 20 | None | 1.00A | 4fp9C-2kpkA:undetectable | 4fp9C-2kpkA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m5j | HASR PROTEIN (Serratiamarcescens) |
PF07660(STN) | 6 | GLY A 95ASN A 110LEU A 87GLY A 109ASP A 100LEU A 105 | None | 1.25A | 4fp9C-2m5jA:undetectable | 4fp9C-2m5jA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyu | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 (Homo sapiens) |
PF01728(FtsJ) | 5 | PRO A 33GLY A 34LEU A 63ASP A 104LEU A 123 | SAM A 201 (-3.4A)SAM A 201 (-3.7A)SAM A 201 (-4.2A)SAM A 201 (-3.7A)None | 0.92A | 4fp9C-2nyuA:9.4 | 4fp9C-2nyuA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1r | LIPID KINASE YEGS (Salmonellaenterica) |
PF00781(DAGK_cat) | 5 | GLY A 65GLY A 64ASN A 137GLY A 201LEU A 297 | None | 0.88A | 4fp9C-2p1rA:undetectable | 4fp9C-2p1rA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | PRO A 489GLY A 487LEU A 478GLY A 357LEU A 369 | None | 1.05A | 4fp9C-2wpgA:undetectable | 4fp9C-2wpgA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y8n | 4-HYDROXYPHENYLACETATE DECARBOXYLASELARGE SUBUNIT (Clostridiumscatologenes) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | GLY A 624LYS A 602SER A 632GLY A 534ASP A 598 | None | 0.94A | 4fp9C-2y8nA:undetectable | 4fp9C-2y8nA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycj | 5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE (Carboxydothermushydrogenoformans) |
PF00809(Pterin_bind) | 5 | SER A 138GLY A 122ASP A 225PRO A 192LEU A 158 | None | 1.03A | 4fp9C-2ycjA:undetectable | 4fp9C-2ycjA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 5 | GLY A 806GLY A 795LEU A 712SER A 708GLY A 716 | None | 0.94A | 4fp9C-2yocA:undetectable | 4fp9C-2yocA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywd | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermusthermophilus) |
PF01174(SNO) | 5 | PRO A 46GLY A 47GLY A 48LEU A 167LEU A 103 | None | 1.04A | 4fp9C-2ywdA:undetectable | 4fp9C-2ywdA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 7 | PRO A 270GLY A 271GLY A 272LYS A 273ASP A 337PRO A 339LEU A 371 | SFG A5748 (-3.6A)SFG A5748 (-3.7A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)SFG A5748 (-3.6A)SFG A5748 (-4.0A)None | 0.30A | 4fp9C-2yxlA:28.2 | 4fp9C-2yxlA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zat | DEHYDROGENASE/REDUCTASE SDR FAMILYMEMBER 4 (Sus scrofa) |
PF13561(adh_short_C2) | 5 | GLY A 143GLY A 142LEU A 147ASP A 93LEU A 34 | None | 1.05A | 4fp9C-2zatA:7.1 | 4fp9C-2zatA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsu | SPERMIDINE SYNTHASE (Pyrococcushorikoshii) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 88GLY A 89GLY A 145ASP A 161LEU A 172 | NoneNoneNoneAG3 A1001 (-2.8A)None | 0.88A | 4fp9C-2zsuA:10.9 | 4fp9C-2zsuA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 6 | CYH A 91GLY A 95LYS A 97ASP A 163PRO A 165LEU A 193 | SFG A 500 (-3.8A)SFG A 500 (-4.0A)SFG A 500 (-2.8A)SFG A 500 (-3.7A)SFG A 500 (-3.9A)None | 1.02A | 4fp9C-3a4tA:26.3 | 4fp9C-3a4tA:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 9 | CYH A 91PRO A 94GLY A 95GLY A 96LYS A 97SER A 117ASP A 163PRO A 165LEU A 193 | SFG A 500 (-3.8A)SFG A 500 (-3.9A)SFG A 500 (-4.0A)SFG A 500 (-3.5A)SFG A 500 (-2.8A)NoneSFG A 500 (-3.7A)SFG A 500 (-3.9A)None | 0.50A | 4fp9C-3a4tA:26.3 | 4fp9C-3a4tA:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ada | SARCOSINE OXIDASEBETA SUBUNIT (Corynebacteriumsp. U-96) |
PF01266(DAO) | 5 | CYH B 350GLY B 356GLY B 355LEU B 223LEU B 240 | NoneFAD B 1 (-3.0A)FAD B 1 (-3.4A)NoneNone | 0.89A | 4fp9C-3adaB:2.2 | 4fp9C-3adaB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 5 | GLY A 693LEU A 684GLY A 889ASP A 852PRO A 655 | None | 0.98A | 4fp9C-3aibA:undetectable | 4fp9C-3aibA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9e | CHITINASE A (Vibrio harveyi) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 5 | PRO A 415GLY A 416GLY A 422SER A 411GLY A 402 | None | 0.97A | 4fp9C-3b9eA:undetectable | 4fp9C-3b9eA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dou | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Thermoplasmavolcanium) |
PF01728(FtsJ) | 5 | PRO A 49GLY A 50GLY A 51LEU A 68ASP A 111 | SAM A 1 (-3.5A)SAM A 1 (-3.8A)SAM A 1 (-3.2A)SAM A 1 (-4.2A)SAM A 1 (-3.7A) | 0.58A | 4fp9C-3douA:7.9 | 4fp9C-3douA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f70 | LETHAL(3)MALIGNANTBRAIN TUMOR-LIKE 2PROTEIN (Homo sapiens) |
PF02820(MBT) | 5 | GLY A 351GLY A 350LEU A 374PRO A 550LEU A 547 | None | 0.93A | 4fp9C-3f70A:undetectable | 4fp9C-3f70A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3feo | MBTDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF02820(MBT) | 5 | GLY A 184GLY A 183LEU A 208PRO A 377LEU A 374 | None | 1.05A | 4fp9C-3feoA:undetectable | 4fp9C-3feoA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs6 | BETA-HEXOSAMINIDASE (Vibrio cholerae) |
PF00933(Glyco_hydro_3) | 5 | GLY A 65GLY A 66LEU A 147GLY A 159LEU A 118 | None | 1.07A | 4fp9C-3gs6A:undetectable | 4fp9C-3gs6A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2y | GTPASE FAMILYPROTEIN (Bacillusanthracis) |
PF01926(MMR_HSR1) | 5 | GLY A 159GLY A 160LYS A 161GLY A 95ASP A 70 | None | 1.04A | 4fp9C-3h2yA:undetectable | 4fp9C-3h2yA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib5 | SEX PHEROMONEPRECURSOR (Lactobacillussalivarius) |
PF07537(CamS) | 5 | GLY A 372GLY A 371GLY A 313PRO A 344LEU A 311 | None | 0.97A | 4fp9C-3ib5A:undetectable | 4fp9C-3ib5A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l44 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE1 (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | GLY A 273GLY A 274ASN A 118PRO A 307LEU A 89 | LLP A 270 ( 4.0A)NoneNoneNoneNone | 0.94A | 4fp9C-3l44A:undetectable | 4fp9C-3l44A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lac | PYRROLIDONE-CARBOXYLATE PEPTIDASE (Bacillusanthracis) |
PF01470(Peptidase_C15) | 5 | GLY A 72GLY A 73GLY A 192ASP A 76LEU A 125 | None | 0.95A | 4fp9C-3lacA:undetectable | 4fp9C-3lacA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4x | NOL1/NOP2/SUN FAMILYPROTEIN (Enterococcusfaecium) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 8 | CYH A 113PRO A 116GLY A 117GLY A 118LYS A 119ASN A 136ASP A 182PRO A 184 | None | 0.42A | 4fp9C-3m4xA:27.7 | 4fp9C-3m4xA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 5 | GLY A 113LYS A 115ASP A 177PRO A 179LEU A 211 | None | 0.92A | 4fp9C-3m6xA:28.8 | 4fp9C-3m6xA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 8 | PRO A 112GLY A 113GLY A 114LYS A 115ASN A 132ASP A 177PRO A 179LEU A 211 | None | 0.46A | 4fp9C-3m6xA:28.8 | 4fp9C-3m6xA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvd | REGULATOR OFCHROMOSOMECONDENSATION (Drosophilamelanogaster) |
PF00415(RCC1) | 5 | GLY K 83GLY K 82ASN K 374GLY K 372LEU K 377 | None | 1.01A | 4fp9C-3mvdK:undetectable | 4fp9C-3mvdK:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntn | USPA1 (Moraxellacatarrhalis) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 203GLY A 188ASN A 213LEU A 223GLY A 210 | None | 1.07A | 4fp9C-3ntnA:undetectable | 4fp9C-3ntnA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 105GLY A 106GLY A 156ASP A 173LEU A 184 | NoneNoneDSH A 303 (-3.7A)DSH A 303 (-3.0A)DSH A 303 (-4.2A) | 0.82A | 4fp9C-3rw9A:9.7 | 4fp9C-3rw9A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s55 | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Mycobacteroidesabscessus) |
PF00106(adh_short) | 5 | GLY A 199ASN A 103SER A 22GLY A 14PRO A 204 | NoneNAD A 279 (-3.3A)NoneNAD A 279 (-3.4A)NAD A 279 (-3.8A) | 1.06A | 4fp9C-3s55A:6.7 | 4fp9C-3s55A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL-COENZYME MREDUCTASE, BETASUBUNITMETHYL-COENZYME MREDUCTASE, GAMMASUBUNIT (unculturedarchaeon;unculturedarchaeon) |
PF02241(MCR_beta)PF02783(MCR_beta_N)PF02240(MCR_gamma) | 5 | PRO C 251GLY C 247GLY C 248LEU B 297ASP B 344 | None | 0.92A | 4fp9C-3sqgC:undetectable | 4fp9C-3sqgC:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tkt | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | GLY A 192LEU A 423SER A 422GLY A 280ASP A 272 | None | 1.04A | 4fp9C-3tktA:undetectable | 4fp9C-3tktA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3udu | 3-ISOPROPYLMALATEDEHYDROGENASE (Campylobacterjejuni) |
PF00180(Iso_dh) | 5 | PRO A 276GLY A 278GLY A 279LEU A 107LEU A 139 | None | 0.99A | 4fp9C-3uduA:undetectable | 4fp9C-3uduA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3urh | DIHYDROLIPOYLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 246LEU A 270GLY A 167PRO A 175LEU A 171 | None | 0.92A | 4fp9C-3urhA:undetectable | 4fp9C-3urhA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vex | O-CARBAMOYLTRANSFERASE TOBZ (Streptoalloteichustenebrarius) |
PF02543(Carbam_trans_N)PF16861(Carbam_trans_C) | 6 | GLY A 413GLY A 367LEU A 425SER A 530GLY A 407LEU A 557 | NoneNoneNoneSO4 A 603 (-3.4A)NoneNone | 1.41A | 4fp9C-3vexA:undetectable | 4fp9C-3vexA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | GLY A 391GLY A 392ASN A 431LEU A 433GLY A 109 | None | 1.07A | 4fp9C-3vrbA:undetectable | 4fp9C-3vrbA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amc | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 5 | GLY A1236LEU A1227GLY A1443ASP A1406PRO A1198 | None | 1.04A | 4fp9C-4amcA:undetectable | 4fp9C-4amcA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ayg | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 5 | GLY A1239LEU A1230GLY A1438ASP A1401PRO A1201 | None | 1.06A | 4fp9C-4aygA:undetectable | 4fp9C-4aygA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cze | RODSHAPE-DETERMININGPROTEIN MREB (Caulobactervibrioides) |
PF06723(MreB_Mbl) | 5 | CYH A 323GLY A 329LYS A 330LEU A 321GLY A 294 | None | 1.02A | 4fp9C-4czeA:undetectable | 4fp9C-4czeA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl0 | AMINOTRANSFERASEALD1 (Arabidopsisthaliana) |
PF00155(Aminotran_1_2) | 5 | PRO A 405GLY A 406GLY A 408LEU A 75GLY A 421 | None | 1.04A | 4fp9C-4fl0A:2.7 | 4fp9C-4fl0A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fx5 | VON WILLEBRANDFACTOR TYPE A (Catenulisporaacidiphila) |
PF13768(VWA_3) | 5 | GLY A 135LEU A 162GLY A 192ASP A 167LEU A 202 | None | 0.90A | 4fp9C-4fx5A:undetectable | 4fp9C-4fx5A:22.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 12 | CYH A 181PRO A 185GLY A 185GLY A 186LYS A 187ASN A 203LEU A 205SER A 206GLY A 238ASP A 255PRO A 257LEU A 291 | SAM A 401 (-3.9A)SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)SAM A 401 ( 4.6A)SAM A 401 (-3.8A)SAM A 401 (-4.8A)SAM A 401 (-3.5A)SAM A 401 (-3.7A)SAM A 401 (-4.0A)None | 0.20A | 4fp9C-4fzvA:59.2 | 4fp9C-4fzvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | PRO A 185GLY A 185GLY A 186LYS A 187SER A 208 | SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)None | 1.01A | 4fp9C-4fzvA:59.2 | 4fp9C-4fzvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hq1 | PROBABLE RECEPTORPROTEIN KINASE TMK1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | GLY A 424GLY A 444ASN A 420LEU A 393GLY A 394 | None | 1.06A | 4fp9C-4hq1A:undetectable | 4fp9C-4hq1A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hr3 | PUTATIVE ACYL-COADEHYDROGENASE (Mycobacteroidesabscessus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | PRO A 74GLY A 81ASN A 105LEU A 133GLY A 136 | None | 1.06A | 4fp9C-4hr3A:undetectable | 4fp9C-4hr3A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 236GLY A 237LEU A 255SER A 256ASP A 230 | NoneNoneSAH A 501 (-4.3A)SAH A 501 (-4.5A)SAH A 501 ( 4.8A) | 1.07A | 4fp9C-4ineA:9.8 | 4fp9C-4ineA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n49 | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF01728(FtsJ) | 7 | CYH A 277PRO A 280GLY A 281GLY A 282LEU A 302ASP A 364LEU A 383 | SAM A 601 (-3.7A)SAM A 601 (-3.6A)SAM A 601 (-3.6A)SAM A 601 (-3.1A)SAM A 601 (-4.1A)SAM A 601 (-3.6A)SAM A 601 (-4.6A) | 0.97A | 4fp9C-4n49A:8.2 | 4fp9C-4n49A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nh0 | CELLDIVISIONFTSK/SPOIIIE (Thermomonosporacurvata) |
PF01580(FtsK_SpoIIIE) | 5 | GLY A 514LEU A 598SER A 599ASP A 592LEU A 624 | None | 1.06A | 4fp9C-4nh0A:undetectable | 4fp9C-4nh0A:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnq | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesatroolivaceus) |
PF00378(ECH_1) | 5 | CYH A 67GLY A 64GLY A 63GLY A 118LEU A 33 | None | 0.75A | 4fp9C-4nnqA:undetectable | 4fp9C-4nnqA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rl6 | SACCHAROPINEDEHYDROGENASE (Streptococcuspneumoniae) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | GLY A 192GLY A 323LEU A 187GLY A 328PRO A 238 | None | 1.04A | 4fp9C-4rl6A:4.0 | 4fp9C-4rl6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x33 | PROTEIN ATS1 (Saccharomycescerevisiae) |
PF00415(RCC1) | 5 | GLY B 113GLY B 112LEU B 168SER B 167GLY B 151 | None | 0.98A | 4fp9C-4x33B:undetectable | 4fp9C-4x33B:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8d | SULFOXIDE SYNTHASEEGTB (Mycolicibacteriumthermoresistibile) |
PF03781(FGE-sulfatase)PF12867(DinB_2) | 5 | GLY A 331GLY A 330LEU A 154ASP A 139LEU A 45 | CL A 514 ( 4.2A)NoneNoneNoneNone | 0.90A | 4fp9C-4x8dA:undetectable | 4fp9C-4x8dA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dq9 | S55-3 FAB (IGG2B)HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY A 53GLY A 54ASN A 76GLY A 24LEU A 4 | KD2 A 301 (-3.6A)KD2 A 301 (-4.2A)NoneNoneNone | 0.94A | 4fp9C-5dq9A:undetectable | 4fp9C-5dq9A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esy | SAL1 PHOSPHATASE (Arabidopsisthaliana) |
PF00459(Inositol_P) | 5 | GLY A 124GLY A 125LEU A 152GLY A 163LEU A 162 | None | 0.90A | 4fp9C-5esyA:undetectable | 4fp9C-5esyA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f15 | 4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N)TRANSFERASE (Cupriavidusmetallidurans) |
PF13231(PMT_2) | 5 | PRO A 146GLY A 292GLY A 291GLY A 358LEU A 361 | NoneMPG A 603 ( 4.3A)MPG A 625 ( 3.7A)NoneNone | 0.87A | 4fp9C-5f15A:undetectable | 4fp9C-5f15A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | GLY A 306GLY A 305LEU A 283PRO A 281LEU A 59 | None | 0.89A | 4fp9C-5fyqA:undetectable | 4fp9C-5fyqA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hn4 | HOMOISOCITRATEDEHYDROGENASE (Thermococcuskodakarensis) |
PF00180(Iso_dh) | 5 | PRO A 300GLY A 304GLY A 303GLY A 314PRO A 264 | None | 1.01A | 4fp9C-5hn4A:undetectable | 4fp9C-5hn4A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k5z | PARA (Sulfolobus sp.NOB8H2) |
PF13614(AAA_31) | 5 | GLY A 14GLY A 13LEU A 264SER A 262ASP A 41 | ANP A 701 (-3.5A)ANP A 701 ( 3.5A)NoneANP A 701 (-3.2A) MG A 702 ( 3.4A) | 0.97A | 4fp9C-5k5zA:undetectable | 4fp9C-5k5zA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m60 | BETA-1,3-GLUCANASE (Chaetomiumthermophilum) |
PF12708(Pectate_lyase_3) | 5 | GLY A 476ASN A 611LEU A 574GLY A 612PRO A 487 | None | 1.02A | 4fp9C-5m60A:undetectable | 4fp9C-5m60A:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m60 | BETA-1,3-GLUCANASE (Chaetomiumthermophilum) |
PF12708(Pectate_lyase_3) | 5 | GLY A 476GLY A 477LEU A 574GLY A 612PRO A 487 | None | 0.85A | 4fp9C-5m60A:undetectable | 4fp9C-5m60A:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | PRO A 5GLY A 175GLY A 176SER A 97PRO A 9 | None | 0.99A | 4fp9C-5n7qA:undetectable | 4fp9C-5n7qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5x | CRYPTOCHROME-1 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | GLY A 258LYS A 11GLY A 351ASP A 389LEU A 385 | CL A 501 (-3.3A)NoneNoneNoneNone | 1.03A | 4fp9C-5t5xA:undetectable | 4fp9C-5t5xA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | GLY A 450ASN A 445SER A 79GLY A 864LEU A 868 | None | 1.00A | 4fp9C-5um6A:3.5 | 4fp9C-5um6A:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwt | PUTATIVEMETHYLTRANSFERASENSUN6 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 9 | CYH A 242PRO A 245GLY A 246GLY A 247LYS A 248GLY A 294ASP A 323PRO A 325LEU A 354 | None C C 72 ( 4.7A)NoneNone C C 72 ( 3.1A)None C C 72 ( 2.8A)NoneNone | 0.48A | 4fp9C-5wwtA:26.8 | 4fp9C-5wwtA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgv | PYRE3 (Streptomycesrugosporus) |
no annotation | 5 | GLY A 43GLY A 44LEU A 174SER A 253GLY A 215 | FAD A 501 ( 3.9A)NoneNoneNoneNone | 1.04A | 4fp9C-5xgvA:2.1 | 4fp9C-5xgvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | X-RAY REPAIRCROSS-COMPLEMENTINGPROTEIN 5 (Homo sapiens) |
PF02735(Ku)PF03730(Ku_C)PF03731(Ku_N) | 5 | GLY B 70GLY B 71ASN B 76LEU B 58GLY B 60 | None | 1.07A | 4fp9C-5y3rB:undetectable | 4fp9C-5y3rB:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2c | METHYLGLYOXALSYNTHASE (Bacillussubtilis) |
no annotation | 5 | CYH A 98LEU A 72GLY A 64ASP A 99LEU A 94 | None | 1.03A | 4fp9C-6f2cA:2.1 | 4fp9C-6f2cA:undetectable |