SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_C_SAMC401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 175
GLY A 176
SER A 249
GLY A 244
LEU A 207
 None
 1.03A 4fp9C-1b0kA:
undetectable		 4fp9C-1b0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9C-1cnzA:
undetectable		 4fp9C-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.96A 4fp9C-1dxlA:
undetectable		 4fp9C-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 PRO A  62
GLY A  63
GLY A  64
LEU A  84
ASP A 124
LEU A 143
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.6A)
 0.71A 4fp9C-1eizA:
9.6		 4fp9C-1eizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II

(Bacteroides
fragilis) 		no annotation 5 GLY A 159
GLY A 160
LEU A 144
GLY A 139
ASP A 165
 None
 0.96A 4fp9C-1hlkA:
undetectable		 4fp9C-1hlkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		5 PRO A  22
GLY A  19
GLY A  18
GLY A 127
ASP A  27
 None
 0.97A 4fp9C-1im5A:
undetectable		 4fp9C-1im5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 102
GLY A 103
GLY A 153
ASP A 170
LEU A 182
 None
 0.87A 4fp9C-1inlA:
10.6		 4fp9C-1inlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
 None
 1.04A 4fp9C-1ixkA:
25.0		 4fp9C-1ixkA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  86
GLY A  87
GLY A 142
ASP A 158
LEU A 169
 None
 1.02A 4fp9C-1mjfA:
10.4		 4fp9C-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A 184
ASN A  88
SER A  22
GLY A  14
PRO A 189
 None
NAD  A1300 (-3.3A)
None
NAD  A1300 (-3.5A)
NAD  A1300 (-3.5A)
 1.04A 4fp9C-1nffA:
3.3		 4fp9C-1nffA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		6 CYH A 430
GLY A 466
GLY A 467
LEU A 417
PRO A 414
LEU A 410
 None
 1.42A 4fp9C-1nr0A:
undetectable		 4fp9C-1nr0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
GLY A 258
GLY A 259
GLY A 304
ASP A 322
PRO A 324
 None
 0.95A 4fp9C-1sqgA:
26.9		 4fp9C-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
PRO A 257
GLY A 258
GLY A 259
GLY A 302
ASP A 322
 None
 1.26A 4fp9C-1sqgA:
26.9		 4fp9C-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
PRO A 257
GLY A 258
GLY A 259
GLY A 304
ASP A 322
 None
 0.65A 4fp9C-1sqgA:
26.9		 4fp9C-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		5 GLY A 221
GLY A 222
SER A 240
ASP A 286
PRO A 288
 None
 0.56A 4fp9C-1wxxA:
13.1		 4fp9C-1wxxA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 GLY A 229
GLY A 230
SER A 249
ASP A 296
PRO A 298
 None
 0.74A 4fp9C-2as0A:
14.3		 4fp9C-2as0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.7A)
 0.49A 4fp9C-2b9eA:
23.2		 4fp9C-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 ASN A 161
LEU A 152
GLY A 151
ASP A 122
PRO A 124
 None
FMN  A 751 (-4.1A)
None
None
None
 1.03A 4fp9C-2bf4A:
undetectable		 4fp9C-2bf4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A  71
GLY A  70
ASN A  80
GLY A  83
ASP A  87
 FAD  A 600 (-3.2A)
FAD  A 600 (-2.9A)
None
None
None
 1.03A 4fp9C-2bvgA:
undetectable		 4fp9C-2bvgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 161
GLY A 159
LEU A 128
SER A 117
ASP A  88
 None
 1.04A 4fp9C-2cvzA:
3.5		 4fp9C-2cvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.06A 4fp9C-2e0wA:
undetectable		 4fp9C-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.93A 4fp9C-2e0xA:
undetectable		 4fp9C-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 128
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
LEU A 228
 None
 0.75A 4fp9C-2frxA:
29.1		 4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
 None
 0.71A 4fp9C-2frxA:
29.1		 4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
GLY A 129
LYS A 131
SER A 151
ASP A 194
PRO A 196
 None
 1.00A 4fp9C-2frxA:
29.1		 4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
LYS A 131
SER A 151
ASP A 194
PRO A 196
LEU A 228
 None
 1.08A 4fp9C-2frxA:
29.1		 4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		6 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
 None
 1.49A 4fp9C-2hb6A:
undetectable		 4fp9C-2hb6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.95A 4fp9C-2hzgA:
undetectable		 4fp9C-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima) 		PF01174
(SNO) 		5 PRO D  44
GLY D  45
GLY D  46
LEU D 165
LEU D  99
 None
 1.06A 4fp9C-2issD:
undetectable		 4fp9C-2issD:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 146
GLY A 147
GLY A 135
PRO A 711
LEU A 139
 None
None
None
None
MGD  A 811 ( 4.4A)
 1.03A 4fp9C-2jirA:
undetectable		 4fp9C-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1s INNER MEMBRANE
LIPOPROTEIN YIAD

(Escherichia
coli) 		PF00691
(OmpA) 		5 GLY A  79
GLY A  78
LEU A 113
GLY A  72
ASP A  75
 None
 0.94A 4fp9C-2k1sA:
undetectable		 4fp9C-2k1sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.00A 4fp9C-2kpkA:
undetectable		 4fp9C-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5j HASR PROTEIN

(Serratia
marcescens) 		PF07660
(STN) 		6 GLY A  95
ASN A 110
LEU A  87
GLY A 109
ASP A 100
LEU A 105
 None
 1.25A 4fp9C-2m5jA:
undetectable		 4fp9C-2m5jA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 PRO A  33
GLY A  34
LEU A  63
ASP A 104
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
None
 0.92A 4fp9C-2nyuA:
9.4		 4fp9C-2nyuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.88A 4fp9C-2p1rA:
undetectable		 4fp9C-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 PRO A 489
GLY A 487
LEU A 478
GLY A 357
LEU A 369
 None
 1.05A 4fp9C-2wpgA:
undetectable		 4fp9C-2wpgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 624
LYS A 602
SER A 632
GLY A 534
ASP A 598
 None
 0.94A 4fp9C-2y8nA:
undetectable		 4fp9C-2y8nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 SER A 138
GLY A 122
ASP A 225
PRO A 192
LEU A 158
 None
 1.03A 4fp9C-2ycjA:
undetectable		 4fp9C-2ycjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 GLY A 806
GLY A 795
LEU A 712
SER A 708
GLY A 716
 None
 0.94A 4fp9C-2yocA:
undetectable		 4fp9C-2yocA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.04A 4fp9C-2ywdA:
undetectable		 4fp9C-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.30A 4fp9C-2yxlA:
28.2		 4fp9C-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		5 GLY A 143
GLY A 142
LEU A 147
ASP A  93
LEU A  34
 None
 1.05A 4fp9C-2zatA:
7.1		 4fp9C-2zatA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9C-2zsuA:
10.9		 4fp9C-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 4fp9C-3a4tA:
26.3		 4fp9C-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.50A 4fp9C-3a4tA:
26.3		 4fp9C-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 CYH B 350
GLY B 356
GLY B 355
LEU B 223
LEU B 240
 None
FAD  B   1 (-3.0A)
FAD  B   1 (-3.4A)
None
None
 0.89A 4fp9C-3adaB:
2.2		 4fp9C-3adaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		5 GLY A 693
LEU A 684
GLY A 889
ASP A 852
PRO A 655
 None
 0.98A 4fp9C-3aibA:
undetectable		 4fp9C-3aibA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 PRO A 415
GLY A 416
GLY A 422
SER A 411
GLY A 402
 None
 0.97A 4fp9C-3b9eA:
undetectable		 4fp9C-3b9eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 PRO A  49
GLY A  50
GLY A  51
LEU A  68
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.7A)
 0.58A 4fp9C-3douA:
7.9		 4fp9C-3douA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.93A 4fp9C-3f70A:
undetectable		 4fp9C-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 184
GLY A 183
LEU A 208
PRO A 377
LEU A 374
 None
 1.05A 4fp9C-3feoA:
undetectable		 4fp9C-3feoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		5 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.07A 4fp9C-3gs6A:
undetectable		 4fp9C-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		5 GLY A 159
GLY A 160
LYS A 161
GLY A  95
ASP A  70
 None
 1.04A 4fp9C-3h2yA:
undetectable		 4fp9C-3h2yA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		5 GLY A 372
GLY A 371
GLY A 313
PRO A 344
LEU A 311
 None
 0.97A 4fp9C-3ib5A:
undetectable		 4fp9C-3ib5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.94A 4fp9C-3l44A:
undetectable		 4fp9C-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		5 GLY A  72
GLY A  73
GLY A 192
ASP A  76
LEU A 125
 None
 0.95A 4fp9C-3lacA:
undetectable		 4fp9C-3lacA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		8 CYH A 113
PRO A 116
GLY A 117
GLY A 118
LYS A 119
ASN A 136
ASP A 182
PRO A 184
 None
 0.42A 4fp9C-3m4xA:
27.7		 4fp9C-3m4xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 GLY A 113
LYS A 115
ASP A 177
PRO A 179
LEU A 211
 None
 0.92A 4fp9C-3m6xA:
28.8		 4fp9C-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		8 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
ASP A 177
PRO A 179
LEU A 211
 None
 0.46A 4fp9C-3m6xA:
28.8		 4fp9C-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K  83
GLY K  82
ASN K 374
GLY K 372
LEU K 377
 None
 1.01A 4fp9C-3mvdK:
undetectable		 4fp9C-3mvdK:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntn USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 203
GLY A 188
ASN A 213
LEU A 223
GLY A 210
 None
 1.07A 4fp9C-3ntnA:
undetectable		 4fp9C-3ntnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 105
GLY A 106
GLY A 156
ASP A 173
LEU A 184
 None
None
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.82A 4fp9C-3rw9A:
9.7		 4fp9C-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		5 GLY A 199
ASN A 103
SER A  22
GLY A  14
PRO A 204
 None
NAD  A 279 (-3.3A)
None
NAD  A 279 (-3.4A)
NAD  A 279 (-3.8A)
 1.06A 4fp9C-3s55A:
6.7		 4fp9C-3s55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon;
uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 PRO C 251
GLY C 247
GLY C 248
LEU B 297
ASP B 344
 None
 0.92A 4fp9C-3sqgC:
undetectable		 4fp9C-3sqgC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 GLY A 192
LEU A 423
SER A 422
GLY A 280
ASP A 272
 None
 1.04A 4fp9C-3tktA:
undetectable		 4fp9C-3tktA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 PRO A 276
GLY A 278
GLY A 279
LEU A 107
LEU A 139
 None
 0.99A 4fp9C-3uduA:
undetectable		 4fp9C-3uduA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.92A 4fp9C-3urhA:
undetectable		 4fp9C-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		6 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9C-3vexA:
undetectable		 4fp9C-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.07A 4fp9C-3vrbA:
undetectable		 4fp9C-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 GLY A1236
LEU A1227
GLY A1443
ASP A1406
PRO A1198
 None
 1.04A 4fp9C-4amcA:
undetectable		 4fp9C-4amcA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 GLY A1239
LEU A1230
GLY A1438
ASP A1401
PRO A1201
 None
 1.06A 4fp9C-4aygA:
undetectable		 4fp9C-4aygA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 1.02A 4fp9C-4czeA:
undetectable		 4fp9C-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9C-4fl0A:
2.7		 4fp9C-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 135
LEU A 162
GLY A 192
ASP A 167
LEU A 202
 None
 0.90A 4fp9C-4fx5A:
undetectable		 4fp9C-4fx5A:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
GLY A 238
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.20A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
 None
 1.06A 4fp9C-4hq1A:
undetectable		 4fp9C-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.06A 4fp9C-4hr3A:
undetectable		 4fp9C-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 230
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 ( 4.8A)
 1.07A 4fp9C-4ineA:
9.8		 4fp9C-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 364
LEU A 383
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
 0.97A 4fp9C-4n49A:
8.2		 4fp9C-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 GLY A 514
LEU A 598
SER A 599
ASP A 592
LEU A 624
 None
 1.06A 4fp9C-4nh0A:
undetectable		 4fp9C-4nh0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.75A 4fp9C-4nnqA:
undetectable		 4fp9C-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.04A 4fp9C-4rl6A:
4.0		 4fp9C-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		5 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.98A 4fp9C-4x33B:
undetectable		 4fp9C-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		5 GLY A 331
GLY A 330
LEU A 154
ASP A 139
LEU A  45
 CL  A 514 ( 4.2A)
None
None
None
None
 0.90A 4fp9C-4x8dA:
undetectable		 4fp9C-4x8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.94A 4fp9C-5dq9A:
undetectable		 4fp9C-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		5 GLY A 124
GLY A 125
LEU A 152
GLY A 163
LEU A 162
 None
 0.90A 4fp9C-5esyA:
undetectable		 4fp9C-5esyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9C-5f15A:
undetectable		 4fp9C-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.89A 4fp9C-5fyqA:
undetectable		 4fp9C-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.01A 4fp9C-5hn4A:
undetectable		 4fp9C-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 GLY A  14
GLY A  13
LEU A 264
SER A 262
ASP A  41
 ANP  A 701 (-3.5A)
ANP  A 701 ( 3.5A)
None
ANP  A 701 (-3.2A)
MG  A 702 ( 3.4A)
 0.97A 4fp9C-5k5zA:
undetectable		 4fp9C-5k5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.02A 4fp9C-5m60A:
undetectable		 4fp9C-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.85A 4fp9C-5m60A:
undetectable		 4fp9C-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 PRO A   5
GLY A 175
GLY A 176
SER A  97
PRO A   9
 None
 0.99A 4fp9C-5n7qA:
undetectable		 4fp9C-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLY A 258
LYS A  11
GLY A 351
ASP A 389
LEU A 385
 CL  A 501 (-3.3A)
None
None
None
None
 1.03A 4fp9C-5t5xA:
undetectable		 4fp9C-5t5xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.00A 4fp9C-5um6A:
3.5		 4fp9C-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
GLY A 294
ASP A 323
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
C  C  72 ( 2.8A)
None
None
 0.48A 4fp9C-5wwtA:
26.8		 4fp9C-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A  43
GLY A  44
LEU A 174
SER A 253
GLY A 215
 FAD  A 501 ( 3.9A)
None
None
None
None
 1.04A 4fp9C-5xgvA:
2.1		 4fp9C-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 GLY B  70
GLY B  71
ASN B  76
LEU B  58
GLY B  60
 None
 1.07A 4fp9C-5y3rB:
undetectable		 4fp9C-5y3rB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 5 CYH A  98
LEU A  72
GLY A  64
ASP A  99
LEU A  94
 None
 1.03A 4fp9C-6f2cA:
2.1		 4fp9C-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ASP A 618
ARG A 354
ASP A 623
 None
 0.89A 4fp9C-1br2A:
undetectable		 4fp9C-1br2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ASP A 614
ARG A 590
ASP A 558
 None
 0.78A 4fp9C-1c30A:
2.2		 4fp9C-1c30A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 ASP A 675
ARG A 641
ASP A 678
 None
 0.73A 4fp9C-1d0nA:
undetectable		 4fp9C-1d0nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASP A 569
ARG A 567
ASP A 511
 None
 0.82A 4fp9C-1d6mA:
undetectable		 4fp9C-1d6mA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE
MYELOPEROXIDASE

(Homo sapiens;
Homo sapiens) 		PF03098
(An_peroxidase)
PF03098
(An_peroxidase) 		3 ASP C 400
ARG C 403
ASP A  74
 SO4  A1602 (-4.7A)
None
None
 0.65A 4fp9C-1d7wC:
undetectable		 4fp9C-1d7wC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9s CYCLIN-DEPENDENT
KINASE 4 INHIBITOR B

(Mus musculus) 		PF12796
(Ank_2) 		3 ASP A  78
ARG A  81
ASP A  68
 None
 0.75A 4fp9C-1d9sA:
undetectable		 4fp9C-1d9sA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ASP A 396
ARG A 395
ASP A 134
 None
 0.71A 4fp9C-1fotA:
undetectable		 4fp9C-1fotA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		3 ASP A 419
ARG A 422
ASP A 412
 None
 0.80A 4fp9C-1io1A:
undetectable		 4fp9C-1io1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		3 ASP A 226
ARG A 223
ASP A 250
 None
 0.90A 4fp9C-1k2wA:
2.7		 4fp9C-1k2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 205
ARG A  17
ASP A  29
 None
 0.75A 4fp9C-1mdfA:
undetectable		 4fp9C-1mdfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ASP A 193
ARG A 331
ASP A 186
 None
 0.76A 4fp9C-1nfgA:
undetectable		 4fp9C-1nfgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		3 ASP A 292
ARG A 288
ASP A 351
 None
 0.90A 4fp9C-1q5dA:
undetectable		 4fp9C-1q5dA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASP A 357
ARG A 361
ASP A 117
 None
 0.65A 4fp9C-1qk1A:
undetectable		 4fp9C-1qk1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		3 ASP A  51
ARG A  24
ASP A  44
 None
 0.77A 4fp9C-1rytA:
undetectable		 4fp9C-1rytA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 ASP A  43
ARG A 225
ASP A  53
 None
 0.88A 4fp9C-1s9cA:
undetectable		 4fp9C-1s9cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 ASP A 214
ARG A 213
ASP A 167
 None
 0.86A 4fp9C-1susA:
10.4		 4fp9C-1susA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		3 ASP 1  53
ARG 1  50
ASP 1  45
 None
 0.76A 4fp9C-1t6t1:
undetectable		 4fp9C-1t6t1:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		3 ASP A 231
ARG A 267
ASP A 224
 None
 0.90A 4fp9C-1up2A:
undetectable		 4fp9C-1up2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcc DNA TOPOISOMERASE I

(Vaccinia virus) 		PF09266
(VirDNA-topo-I_N) 		3 ASP A  63
ARG A  67
ASP A  42
 None
 0.75A 4fp9C-1vccA:
undetectable		 4fp9C-1vccA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr1 CELL-DIVISION
INITIATION PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 ASP A 195
ARG A 212
ASP A 162
 None
 0.90A 4fp9C-1yr1A:
undetectable		 4fp9C-1yr1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 ASP C 181
ARG C 179
ASP C 164
 None
 0.77A 4fp9C-1zq1C:
undetectable		 4fp9C-1zq1C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 ASP A 199
ARG A 187
ASP A 212
 None
 0.88A 4fp9C-2b3xA:
undetectable		 4fp9C-2b3xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ARG A 263
ASP A 285
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
 0.52A 4fp9C-2b9eA:
23.3		 4fp9C-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 ASP A 437
ARG A 424
ASP A 386
 None
 0.86A 4fp9C-2cn3A:
undetectable		 4fp9C-2cn3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 ASP A 184
ARG A 186
ASP A 181
 None
 0.82A 4fp9C-2eb5A:
undetectable		 4fp9C-2eb5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ASP A 898
ARG A 688
ASP A 499
 None
 0.73A 4fp9C-2inyA:
undetectable		 4fp9C-2inyA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 205
ARG A 557
ASP A 208
 None
 0.90A 4fp9C-2iujA:
undetectable		 4fp9C-2iujA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 621
ARG A 823
ASP A 454
 None
 0.89A 4fp9C-2iujA:
undetectable		 4fp9C-2iujA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		3 ASP A  72
ARG A  96
ASP A 143
 None
 0.74A 4fp9C-2j0aA:
undetectable		 4fp9C-2j0aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 204
ARG A 206
ASP A 225
 MGD  A 812 (-2.7A)
MGD  A 812 (-3.9A)
MGD  A 812 (-3.4A)
 0.64A 4fp9C-2jirA:
undetectable		 4fp9C-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsz PROBABLE THIOL
PEROXIDASE

(Bacillus
subtilis) 		PF08534
(Redoxin) 		3 ASP A  61
ARG A  65
ASP A  56
 None
 0.73A 4fp9C-2jszA:
undetectable		 4fp9C-2jszA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 ASP A 156
ARG A  77
ASP A 130
 None
 0.54A 4fp9C-2nqaA:
undetectable		 4fp9C-2nqaA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyb NEUTROPHIL
ACTIVATING PROTEIN

(Borreliella
burgdorferi) 		PF00210
(Ferritin) 		3 ASP A 132
ARG A  70
ASP A 128
 None
 0.86A 4fp9C-2pybA:
undetectable		 4fp9C-2pybA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9C-2qcmA:
undetectable		 4fp9C-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A 319
ARG A 321
ASP A 306
 ASP  A 319 ( 0.6A)
ARG  A 321 ( 0.6A)
ASP  A 306 ( 0.6A)
 0.71A 4fp9C-2vbfA:
undetectable		 4fp9C-2vbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		3 ASP A 134
ARG A 137
ASP A 127
 None
 0.78A 4fp9C-2wu8A:
undetectable		 4fp9C-2wu8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ASP A 251
ARG A  86
ASP A 242
 None
FMT  A1333 (-2.9A)
None
 0.82A 4fp9C-2ymvA:
undetectable		 4fp9C-2ymvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn3 PUTATIVE INNER
MEMBRANE PROTEIN

(Salmonella
enterica) 		PF12245
(Big_3_2) 		3 ASP A5183
ARG A5182
ASP A5170
 None
 0.84A 4fp9C-2yn3A:
undetectable		 4fp9C-2yn3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		3 ASP A 217
ARG A 206
ASP A 214
 None
SO4  A 512 (-3.1A)
None
 0.82A 4fp9C-2z02A:
undetectable		 4fp9C-2z02A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		3 ASP A 120
ARG A 122
ASP A  59
 None
 0.80A 4fp9C-2zylA:
undetectable		 4fp9C-2zylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		3 ASP A 109
ARG A 112
ASP A 104
 None
 0.52A 4fp9C-3bhwA:
undetectable		 4fp9C-3bhwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 3 ASP A  28
ARG A 123
ASP A  34
 None
 0.71A 4fp9C-3d0kA:
undetectable		 4fp9C-3d0kA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzb PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
putrefaciens) 		PF12680
(SnoaL_2) 		3 ASP A  47
ARG A  46
ASP A 128
 None
 0.55A 4fp9C-3gzbA:
undetectable		 4fp9C-3gzbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		3 ASP 7  39
ARG 7  75
ASP 7  36
 None
 0.68A 4fp9C-3i9v7:
undetectable		 4fp9C-3i9v7:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		3 ASP A 222
ARG A 218
ASP A  32
 None
 0.79A 4fp9C-3lg3A:
undetectable		 4fp9C-3lg3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ASP A 323
ARG A 325
ASP A 299
 None
 0.88A 4fp9C-3lmlA:
undetectable		 4fp9C-3lmlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		3 ASP A 272
ARG A  85
ASP A 113
 None
 0.82A 4fp9C-3obiA:
2.3		 4fp9C-3obiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oov METHYL-ACCEPTING
CHEMOTAXIS PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		3 ASP A 130
ARG A  33
ASP A 142
 GOL  A 167 (-3.6A)
None
None
 0.69A 4fp9C-3oovA:
undetectable		 4fp9C-3oovA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plt SPHINGOLIPID LONG
CHAIN
BASE-RESPONSIVE
PROTEIN LSP1

(Saccharomyces
cerevisiae) 		PF13805
(Pil1) 		3 ASP A 123
ARG A 126
ASP A 116
 None
 0.75A 4fp9C-3pltA:
undetectable		 4fp9C-3pltA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		3 ASP A 300
ARG A 304
ASP A 288
 None
 0.87A 4fp9C-3q54A:
undetectable		 4fp9C-3q54A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 ASP A 439
ARG A 438
ASP A 414
 ASP  A 439 ( 0.6A)
ARG  A 438 ( 0.6A)
ASP  A 414 ( 0.6A)
 0.86A 4fp9C-3sagA:
undetectable		 4fp9C-3sagA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		3 ASP A  86
ARG A 162
ASP A  36
 None
 0.89A 4fp9C-3tisA:
undetectable		 4fp9C-3tisA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 ASP A 216
ARG A 221
ASP A 243
 None
 0.83A 4fp9C-3tmaA:
14.1		 4fp9C-3tmaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP A 100
ARG A  99
ASP A  80
 None
 0.73A 4fp9C-3wa1A:
undetectable		 4fp9C-3wa1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfv ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 3 ASP A 618
ARG A 614
ASP A 545
 None
 0.86A 4fp9C-3wfvA:
undetectable		 4fp9C-3wfvA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ASP A 260
ARG A 257
ASP A 280
 None
 0.60A 4fp9C-3wfzA:
undetectable		 4fp9C-3wfzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		3 ASP A 292
ARG A 310
ASP A 295
 None
 0.76A 4fp9C-3x0vA:
2.5		 4fp9C-3x0vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 ASP A 550
ARG A 546
ASP A 641
 None
 0.73A 4fp9C-4ay2A:
undetectable		 4fp9C-4ay2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		3 ASP A 554
ARG A 559
ASP A 547
 None
 0.75A 4fp9C-4c4aA:
6.9		 4fp9C-4c4aA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 146
ARG A 193
ASP A 141
 None
 0.70A 4fp9C-4e4uA:
undetectable		 4fp9C-4e4uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 3 ASP D 131
ARG D 134
ASP D 124
 None
 0.79A 4fp9C-4em6D:
undetectable		 4fp9C-4em6D:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		3 ASP A 209
ARG A 199
ASP A 202
 None
AIR  A 301 (-3.1A)
None
 0.86A 4fp9C-4fe2A:
undetectable		 4fp9C-4fe2A:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 237
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.30A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 3 ASP A  13
ARG A  61
ASP A  17
 None
 0.90A 4fp9C-4i4nA:
undetectable		 4fp9C-4i4nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg3 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF16175
(DUF4875) 		3 ASP A 176
ARG A 178
ASP A 172
 None
 0.65A 4fp9C-4lg3A:
undetectable		 4fp9C-4lg3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		3 ASP A 157
ARG A 154
ASP A 186
 None
 0.67A 4fp9C-4m6rA:
undetectable		 4fp9C-4m6rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 ASP A 111
ARG A 107
ASP A  31
 None
 0.62A 4fp9C-4mrpA:
undetectable		 4fp9C-4mrpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mur D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE

(Enterococcus
gallinarum) 		PF02557
(VanY) 		3 ASP A  29
ARG A  56
ASP A  31
 None
 0.87A 4fp9C-4murA:
undetectable		 4fp9C-4murA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN

(Cupriavidus
taiwanensis) 		PF13561
(adh_short_C2) 		3 ASP A  36
ARG A  41
ASP A  62
 None
 0.69A 4fp9C-4nbvA:
7.2		 4fp9C-4nbvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx9 FLAGELLIN

(Pseudomonas
aeruginosa) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		3 ASP A 311
ARG A 314
ASP A 304
 None
 0.83A 4fp9C-4nx9A:
undetectable		 4fp9C-4nx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 550
ARG A 546
ASP A 641
 None
 0.80A 4fp9C-4on9A:
2.8		 4fp9C-4on9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe8 TAT-LINKED QUALITY
CONTROL PROTEIN TATD

(Escherichia
coli) 		PF01026
(TatD_DNase) 		3 ASP A  95
ARG A 129
ASP A  65
 None
 0.87A 4fp9C-4pe8A:
undetectable		 4fp9C-4pe8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py4 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF00644
(PARP) 		3 ASP A1731
ARG A1735
ASP A1725
 None
 0.86A 4fp9C-4py4A:
undetectable		 4fp9C-4py4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		3 ASP A 105
ARG A  86
ASP A  80
 None
 0.83A 4fp9C-4qnyA:
undetectable		 4fp9C-4qnyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 ASP A 153
ARG A 151
ASP A 222
 None
 0.47A 4fp9C-4zoyA:
undetectable		 4fp9C-4zoyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ASP B 278
ARG B 274
ASP B 298
 None
 0.86A 4fp9C-5a8rB:
undetectable		 4fp9C-5a8rB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0

(Dictyostelium
discoideum) 		PF00466
(Ribosomal_L10) 		3 ASP C  69
ARG C  65
ASP C 193
 None
 0.78A 4fp9C-5an9C:
undetectable		 4fp9C-5an9C:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 ASP A 298
ARG A 464
ASP A 294
 None
 0.53A 4fp9C-5cwaA:
undetectable		 4fp9C-5cwaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6h CSUC

(Acinetobacter
baumannii) 		PF00345
(PapD_N) 		3 ASP A  47
ARG A  89
ASP A  43
 None
 0.88A 4fp9C-5d6hA:
undetectable		 4fp9C-5d6hA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ASP A 216
ARG A 219
ASP A 213
 None
 0.79A 4fp9C-5djwA:
undetectable		 4fp9C-5djwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		3 ASP A 221
ARG A 218
ASP A 245
 None
 0.76A 4fp9C-5f1pA:
4.1		 4fp9C-5f1pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		3 ASP A 372
ARG A 232
ASP A 370
 None
 0.84A 4fp9C-5fgnA:
undetectable		 4fp9C-5fgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP B 100
ARG B  99
ASP B  80
 None
 0.87A 4fp9C-5fozB:
undetectable		 4fp9C-5fozB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		3 ASP A 579
ARG A 585
ASP A 606
 None
 0.83A 4fp9C-5gslA:
undetectable		 4fp9C-5gslA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		3 ASP A 439
ARG A 354
ASP A 166
 None
 0.82A 4fp9C-5gylA:
undetectable		 4fp9C-5gylA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ASP A 124
ARG A 283
ASP A 121
 None
 0.90A 4fp9C-5hm5A:
undetectable		 4fp9C-5hm5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ASP A1022
ARG A1084
ASP A1000
 None
 0.80A 4fp9C-5hy7A:
undetectable		 4fp9C-5hy7A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idm CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF02518
(HATPase_c) 		3 ASP A 403
ARG A 401
ASP A 437
 None
 0.88A 4fp9C-5idmA:
undetectable		 4fp9C-5idmA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		3 ASP A  61
ARG A  63
ASP A  42
 None
 0.79A 4fp9C-5idvA:
undetectable		 4fp9C-5idvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 ASP A 424
ARG A 422
ASP A 141
 None
 0.86A 4fp9C-5jvkA:
undetectable		 4fp9C-5jvkA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		3 ASP B  57
ARG B  56
ASP B  23
 None
 0.79A 4fp9C-5k5aB:
undetectable		 4fp9C-5k5aB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ASP A 962
ARG A 958
ASP A 936
 None
 0.85A 4fp9C-5kf7A:
3.0		 4fp9C-5kf7A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 3 ASP B 120
ARG B 466
ASP B 170
 None
None
MDO  B 168 ( 4.3A)
 0.73A 4fp9C-5ltmB:
undetectable		 4fp9C-5ltmB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 ASP A 566
ARG A 569
ASP A 240
 None
 0.57A 4fp9C-5mfaA:
undetectable		 4fp9C-5mfaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ASP Y 102
ARG Y 104
ASP Y  91
 None
 0.51A 4fp9C-5svaY:
undetectable		 4fp9C-5svaY:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		3 ASP f 496
ARG f 494
ASP f 460
 None
 0.78A 4fp9C-5vhif:
undetectable		 4fp9C-5vhif:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 3 ASP A 416
ARG A 447
ASP A 412
 None
 0.84A 4fp9C-5ws4A:
undetectable		 4fp9C-5ws4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 3 ASP A 707
ARG A 733
ASP A 737
 None
 0.72A 4fp9C-5ze3A:
undetectable		 4fp9C-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ank SYNAPTOTAGMIN-7

(Rattus
norvegicus) 		PF00168
(C2) 		3 ASP A 303
ARG A 327
ASP A 365
 CA  A 505 (-3.3A)
None
CA  A 506 (-3.4A)
 0.81A 4fp9C-6ankA:
undetectable		 4fp9C-6ankA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 3 ASP B 271
ARG B 251
ASP B  11
 None
 0.69A 4fp9C-6emkB:
undetectable		 4fp9C-6emkB:
undetectable