SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_A_SAMA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
5 GLY A 175
GLY A 176
SER A 249
GLY A 244
LEU A 207
None
1.02A 4fp9A-1b0kA:
undetectable
4fp9A-1b0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)


(Salmonella
enterica)
PF00180
(Iso_dh)
5 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
None
1.02A 4fp9A-1cnzA:
undetectable
4fp9A-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pisum sativum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
None
0.96A 4fp9A-1dxlA:
undetectable
4fp9A-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli)
PF01728
(FtsJ)
6 PRO A  62
GLY A  63
GLY A  64
LEU A  84
ASP A 124
LEU A 143
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.6A)
0.71A 4fp9A-1eizA:
9.5
4fp9A-1eizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II


(Bacteroides
fragilis)
no annotation 5 GLY A 159
GLY A 160
LEU A 144
GLY A 139
ASP A 165
None
0.97A 4fp9A-1hlkA:
undetectable
4fp9A-1hlkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE


(Pyrococcus
horikoshii)
PF00857
(Isochorismatase)
5 PRO A  22
GLY A  19
GLY A  18
GLY A 127
ASP A  27
None
0.98A 4fp9A-1im5A:
undetectable
4fp9A-1im5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A 102
GLY A 103
GLY A 153
ASP A 170
LEU A 182
None
0.87A 4fp9A-1inlA:
10.7
4fp9A-1inlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
5 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
None
1.04A 4fp9A-1ixkA:
25.1
4fp9A-1ixkA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A  86
GLY A  87
GLY A 142
ASP A 158
LEU A 169
None
1.02A 4fp9A-1mjfA:
10.4
4fp9A-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1


(Caenorhabditis
elegans)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
6 CYH A 430
GLY A 466
GLY A 467
LEU A 417
PRO A 414
LEU A 410
None
1.41A 4fp9A-1nr0A:
undetectable
4fp9A-1nr0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1


(Homo sapiens)
PF01233
(NMT)
PF02799
(NMT_C)
5 CYH A 172
GLY A 207
SER A 150
GLY A 147
LEU A  98
None
1.06A 4fp9A-1rxtA:
undetectable
4fp9A-1rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
6 CYH A 254
GLY A 258
GLY A 259
GLY A 304
ASP A 322
PRO A 324
None
0.97A 4fp9A-1sqgA:
27.0
4fp9A-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
6 CYH A 254
PRO A 257
GLY A 258
GLY A 259
GLY A 304
ASP A 322
None
0.66A 4fp9A-1sqgA:
27.0
4fp9A-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
5 PRO A 257
GLY A 258
GLY A 259
GLY A 302
ASP A 322
None
1.03A 4fp9A-1sqgA:
27.0
4fp9A-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280


(Thermus
thermophilus)
PF10672
(Methyltrans_SAM)
5 GLY A 221
GLY A 222
SER A 240
ASP A 286
PRO A 288
None
0.57A 4fp9A-1wxxA:
13.9
4fp9A-1wxxA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF10672
(Methyltrans_SAM)
5 GLY A 229
GLY A 230
SER A 249
ASP A 296
PRO A 298
None
0.74A 4fp9A-2as0A:
14.3
4fp9A-2as0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
6 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 305
SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.7A)
0.47A 4fp9A-2b9eA:
23.3
4fp9A-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE


(Saccharomyces
cerevisiae)
PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1)
5 ASN A 161
LEU A 152
GLY A 151
ASP A 122
PRO A 124
None
FMN  A 751 (-4.1A)
None
None
None
1.05A 4fp9A-2bf4A:
undetectable
4fp9A-2bf4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR


(Sus scrofa)
PF13516
(LRR_6)
6 CYH A 382
GLY A 349
GLY A 352
ASN A 379
GLY A 409
LEU A 413
None
1.43A 4fp9A-2bnhA:
undetectable
4fp9A-2bnhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE


(Thermus
thermophilus)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 GLY A 161
GLY A 159
LEU A 128
SER A 117
ASP A  88
None
1.03A 4fp9A-2cvzA:
3.5
4fp9A-2cvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Escherichia
coli)
PF01019
(G_glu_transpept)
5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
None
1.07A 4fp9A-2e0wA:
undetectable
4fp9A-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Escherichia
coli)
PF01019
(G_glu_transpept)
5 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
None
0.93A 4fp9A-2e0xA:
undetectable
4fp9A-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
7 PRO A 128
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
LEU A 228
None
0.75A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
7 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
None
0.71A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
6 PRO A 128
GLY A 129
LYS A 131
SER A 151
ASP A 194
PRO A 196
None
1.00A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU


(Escherichia
coli)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
6 PRO A 128
LYS A 131
SER A 151
ASP A 194
PRO A 196
LEU A 228
None
1.07A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1


(Caenorhabditis
elegans)
PF00883
(Peptidase_M17)
6 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
None
1.50A 4fp9A-2hb6A:
undetectable
4fp9A-2hb6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY


(Rhodobacter
sphaeroides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
None
0.94A 4fp9A-2hzgA:
undetectable
4fp9A-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermotoga
maritima)
PF01174
(SNO)
5 PRO D  44
GLY D  45
GLY D  46
LEU D 165
LEU D  99
None
1.06A 4fp9A-2issD:
undetectable
4fp9A-2issD:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 GLY A 146
GLY A 147
GLY A 135
PRO A 711
LEU A 139
None
None
None
None
MGD  A 811 ( 4.4A)
1.03A 4fp9A-2jirA:
undetectable
4fp9A-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1s INNER MEMBRANE
LIPOPROTEIN YIAD


(Escherichia
coli)
PF00691
(OmpA)
5 GLY A  79
GLY A  78
LEU A 113
GLY A  72
ASP A  75
None
0.94A 4fp9A-2k1sA:
undetectable
4fp9A-2k1sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00595
(PDZ)
5 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
None
1.00A 4fp9A-2kpkA:
undetectable
4fp9A-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5j HASR PROTEIN

(Serratia
marcescens)
PF07660
(STN)
6 GLY A  95
ASN A 110
LEU A  87
GLY A 109
ASP A 100
LEU A 105
None
1.25A 4fp9A-2m5jA:
undetectable
4fp9A-2m5jA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2


(Homo sapiens)
PF01728
(FtsJ)
5 PRO A  33
GLY A  34
LEU A  63
ASP A 104
LEU A 123
SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
None
0.92A 4fp9A-2nyuA:
9.4
4fp9A-2nyuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
5 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
None
0.89A 4fp9A-2p1rA:
undetectable
4fp9A-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 PRO A 489
GLY A 487
LEU A 478
GLY A 357
LEU A 369
None
1.06A 4fp9A-2wpgA:
undetectable
4fp9A-2wpgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT


(Clostridium
scatologenes)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 GLY A 624
LYS A 602
SER A 632
GLY A 534
ASP A 598
None
0.94A 4fp9A-2y8nA:
undetectable
4fp9A-2y8nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Carboxydothermus
hydrogenoformans)
PF00809
(Pterin_bind)
5 SER A 138
GLY A 122
ASP A 225
PRO A 192
LEU A 158
None
1.04A 4fp9A-2ycjA:
undetectable
4fp9A-2ycjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca)
PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372)
5 GLY A 806
GLY A 795
LEU A 712
SER A 708
GLY A 716
None
0.93A 4fp9A-2yocA:
undetectable
4fp9A-2yocA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermus
thermophilus)
PF01174
(SNO)
5 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
None
1.04A 4fp9A-2ywdA:
undetectable
4fp9A-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN


(Pyrococcus
horikoshii)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
7 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
0.32A 4fp9A-2yxlA:
28.2
4fp9A-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4


(Sus scrofa)
PF13561
(adh_short_C2)
5 GLY A 143
GLY A 142
LEU A 147
ASP A  93
LEU A  34
None
1.04A 4fp9A-2zatA:
6.5
4fp9A-2zatA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
None
None
None
AG3  A1001 (-2.8A)
None
0.88A 4fp9A-2zsuA:
11.0
4fp9A-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026


(Methanocaldococcus
jannaschii)
PF01189
(Methyltr_RsmB-F)
6 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
1.05A 4fp9A-3a4tA:
26.3
4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026


(Methanocaldococcus
jannaschii)
PF01189
(Methyltr_RsmB-F)
9 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
0.50A 4fp9A-3a4tA:
26.3
4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT


(Corynebacterium
sp. U-96)
PF01266
(DAO)
5 CYH B 350
GLY B 356
GLY B 355
LEU B 223
LEU B 240
None
FAD  B   1 (-3.0A)
FAD  B   1 (-3.4A)
None
None
0.89A 4fp9A-3adaB:
undetectable
4fp9A-3adaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI


(Streptococcus
mutans)
PF02324
(Glyco_hydro_70)
5 GLY A 693
LEU A 684
GLY A 889
ASP A 852
PRO A 655
None
0.98A 4fp9A-3aibA:
undetectable
4fp9A-3aibA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
5 PRO A 415
GLY A 416
GLY A 422
SER A 411
GLY A 402
None
0.96A 4fp9A-3b9eA:
undetectable
4fp9A-3b9eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J


(Thermoplasma
volcanium)
PF01728
(FtsJ)
5 PRO A  49
GLY A  50
GLY A  51
LEU A  68
ASP A 111
SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.7A)
0.58A 4fp9A-3douA:
8.8
4fp9A-3douA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN


(Homo sapiens)
PF02820
(MBT)
5 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
None
0.92A 4fp9A-3f70A:
undetectable
4fp9A-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF02820
(MBT)
5 GLY A 184
GLY A 183
LEU A 208
PRO A 377
LEU A 374
None
1.05A 4fp9A-3feoA:
undetectable
4fp9A-3feoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae)
PF00933
(Glyco_hydro_3)
5 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
None
1.07A 4fp9A-3gs6A:
undetectable
4fp9A-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN


(Bacillus
anthracis)
PF01926
(MMR_HSR1)
5 GLY A 159
GLY A 160
LYS A 161
GLY A  95
ASP A  70
None
1.04A 4fp9A-3h2yA:
undetectable
4fp9A-3h2yA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR


(Lactobacillus
salivarius)
PF07537
(CamS)
5 GLY A 372
GLY A 371
GLY A 313
PRO A 344
LEU A 311
None
0.97A 4fp9A-3ib5A:
undetectable
4fp9A-3ib5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1


(Bacillus
anthracis)
PF00202
(Aminotran_3)
5 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
LLP  A 270 ( 4.0A)
None
None
None
None
0.96A 4fp9A-3l44A:
undetectable
4fp9A-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE


(Bacillus
anthracis)
PF01470
(Peptidase_C15)
5 GLY A  72
GLY A  73
GLY A 192
ASP A  76
LEU A 125
None
0.95A 4fp9A-3lacA:
undetectable
4fp9A-3lacA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN


(Enterococcus
faecium)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
8 CYH A 113
PRO A 116
GLY A 117
GLY A 118
LYS A 119
ASN A 136
ASP A 182
PRO A 184
None
0.41A 4fp9A-3m4xA:
27.8
4fp9A-3m4xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
5 GLY A 113
LYS A 115
ASP A 177
PRO A 179
LEU A 211
None
0.92A 4fp9A-3m6xA:
28.8
4fp9A-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
8 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
ASP A 177
PRO A 179
LEU A 211
None
0.44A 4fp9A-3m6xA:
28.8
4fp9A-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION


(Drosophila
melanogaster)
PF00415
(RCC1)
5 GLY K  83
GLY K  82
ASN K 374
GLY K 372
LEU K 377
None
0.98A 4fp9A-3mvdK:
undetectable
4fp9A-3mvdK:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntn USPA1

(Moraxella
catarrhalis)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A 203
GLY A 188
ASN A 213
LEU A 223
GLY A 210
None
1.07A 4fp9A-3ntnA:
undetectable
4fp9A-3ntnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 GLY A 105
GLY A 106
GLY A 156
ASP A 173
LEU A 184
None
None
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
0.82A 4fp9A-3rw9A:
9.7
4fp9A-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT


(uncultured
archaeon;
uncultured
archaeon)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma)
5 PRO C 251
GLY C 247
GLY C 248
LEU B 297
ASP B 344
None
0.92A 4fp9A-3sqgC:
undetectable
4fp9A-3sqgC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 GLY A 192
LEU A 423
SER A 422
GLY A 280
ASP A 272
None
1.03A 4fp9A-3tktA:
undetectable
4fp9A-3tktA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE


(Campylobacter
jejuni)
PF00180
(Iso_dh)
5 PRO A 276
GLY A 278
GLY A 279
LEU A 107
LEU A 139
None
0.99A 4fp9A-3uduA:
undetectable
4fp9A-3uduA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
None
0.92A 4fp9A-3urhA:
undetectable
4fp9A-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ


(Streptoalloteichus
tenebrarius)
PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C)
6 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
None
None
None
SO4  A 603 (-3.4A)
None
None
1.41A 4fp9A-3vexA:
undetectable
4fp9A-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
None
1.05A 4fp9A-3vrbA:
undetectable
4fp9A-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
5 GLY A1236
LEU A1227
GLY A1443
ASP A1406
PRO A1198
None
1.04A 4fp9A-4amcA:
undetectable
4fp9A-4amcA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
5 GLY A1239
LEU A1230
GLY A1438
ASP A1401
PRO A1201
None
1.06A 4fp9A-4aygA:
undetectable
4fp9A-4aygA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB


(Caulobacter
vibrioides)
PF06723
(MreB_Mbl)
5 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
None
0.99A 4fp9A-4czeA:
undetectable
4fp9A-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1


(Arabidopsis
thaliana)
PF00155
(Aminotran_1_2)
5 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
None
1.04A 4fp9A-4fl0A:
2.8
4fp9A-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A


(Catenulispora
acidiphila)
PF13768
(VWA_3)
5 GLY A 135
LEU A 162
GLY A 192
ASP A 167
LEU A 202
None
0.91A 4fp9A-4fx5A:
undetectable
4fp9A-4fx5A:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
6 CYH A 181
GLY A 186
LYS A 187
ASP A 255
PRO A 257
LEU A 291
SAM  A 401 (-3.9A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
1.07A 4fp9A-4fzvA:
59.1
4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
GLY A 238
ASP A 255
PRO A 257
LEU A 291
SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
0.18A 4fp9A-4fzvA:
59.1
4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
5 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
1.01A 4fp9A-4fzvA:
59.1
4fp9A-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
None
1.06A 4fp9A-4hq1A:
undetectable
4fp9A-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE


(Mycobacteroides
abscessus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
None
1.07A 4fp9A-4hr3A:
undetectable
4fp9A-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
None
1.05A 4fp9A-4ktoA:
undetectable
4fp9A-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1


(Homo sapiens)
PF01728
(FtsJ)
7 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 364
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
0.96A 4fp9A-4n49A:
8.1
4fp9A-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
5 GLY A 514
LEU A 598
SER A 599
ASP A 592
LEU A 624
None
1.06A 4fp9A-4nh0A:
undetectable
4fp9A-4nh0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
atroolivaceus)
PF00378
(ECH_1)
5 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
None
0.75A 4fp9A-4nnqA:
undetectable
4fp9A-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE


(Streptococcus
pneumoniae)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
None
1.05A 4fp9A-4rl6A:
4.0
4fp9A-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae)
PF00415
(RCC1)
5 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
None
0.97A 4fp9A-4x33B:
undetectable
4fp9A-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB


(Mycolicibacterium
thermoresistibile)
PF03781
(FGE-sulfatase)
PF12867
(DinB_2)
5 GLY A 331
GLY A 330
LEU A 154
ASP A 139
LEU A  45
CL  A 514 ( 4.2A)
None
None
None
None
0.91A 4fp9A-4x8dA:
undetectable
4fp9A-4x8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
0.96A 4fp9A-5dq9A:
undetectable
4fp9A-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana)
PF00459
(Inositol_P)
5 GLY A 124
GLY A 125
LEU A 152
GLY A 163
LEU A 162
None
0.89A 4fp9A-5esyA:
undetectable
4fp9A-5esyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE


(Cupriavidus
metallidurans)
PF13231
(PMT_2)
5 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
0.87A 4fp9A-5f15A:
undetectable
4fp9A-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
None
0.88A 4fp9A-5fyqA:
undetectable
4fp9A-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE


(Thermococcus
kodakarensis)
PF00180
(Iso_dh)
5 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
None
1.01A 4fp9A-5hn4A:
undetectable
4fp9A-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2)
PF13614
(AAA_31)
5 GLY A  14
GLY A  13
LEU A 264
SER A 262
ASP A  41
ANP  A 701 (-3.5A)
ANP  A 701 ( 3.5A)
None
ANP  A 701 (-3.2A)
MG  A 702 ( 3.4A)
0.96A 4fp9A-5k5zA:
undetectable
4fp9A-5k5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
5 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
None
1.03A 4fp9A-5m60A:
undetectable
4fp9A-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
5 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
None
0.85A 4fp9A-5m60A:
undetectable
4fp9A-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus)
no annotation 5 PRO A   5
GLY A 175
GLY A 176
SER A  97
PRO A   9
None
1.00A 4fp9A-5n7qA:
undetectable
4fp9A-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
5 GLY A 258
LYS A  11
GLY A 351
ASP A 389
LEU A 385
CL  A 501 (-3.3A)
None
None
None
None
1.03A 4fp9A-5t5xA:
undetectable
4fp9A-5t5xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1


(Schizosaccharomyces
pombe)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
5 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
None
1.00A 4fp9A-5um6A:
3.5
4fp9A-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
6 CYH A 242
GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
None
None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
1.14A 4fp9A-5wwtA:
26.8
4fp9A-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
9 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
GLY A 294
ASP A 323
PRO A 325
LEU A 354
None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
C  C  72 ( 2.8A)
None
None
0.48A 4fp9A-5wwtA:
26.8
4fp9A-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus)
no annotation 5 GLY A  43
GLY A  44
LEU A 174
SER A 253
GLY A 215
FAD  A 501 ( 3.9A)
None
None
None
None
1.04A 4fp9A-5xgvA:
undetectable
4fp9A-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE


(Bacillus
subtilis)
no annotation 5 CYH A  98
LEU A  72
GLY A  64
ASP A  99
LEU A  94
None
1.06A 4fp9A-6f2cA:
2.2
4fp9A-6f2cA:
undetectable