SIMILAR PATTERNS OF AMINO ACIDS FOR 4FP9_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 175
GLY A 176
SER A 249
GLY A 244
LEU A 207
 None
 1.02A 4fp9A-1b0kA:
undetectable		 4fp9A-1b0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9A-1cnzA:
undetectable		 4fp9A-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.96A 4fp9A-1dxlA:
undetectable		 4fp9A-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 PRO A  62
GLY A  63
GLY A  64
LEU A  84
ASP A 124
LEU A 143
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.6A)
 0.71A 4fp9A-1eizA:
9.5		 4fp9A-1eizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II

(Bacteroides
fragilis) 		no annotation 5 GLY A 159
GLY A 160
LEU A 144
GLY A 139
ASP A 165
 None
 0.97A 4fp9A-1hlkA:
undetectable		 4fp9A-1hlkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		5 PRO A  22
GLY A  19
GLY A  18
GLY A 127
ASP A  27
 None
 0.98A 4fp9A-1im5A:
undetectable		 4fp9A-1im5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 102
GLY A 103
GLY A 153
ASP A 170
LEU A 182
 None
 0.87A 4fp9A-1inlA:
10.7		 4fp9A-1inlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
 None
 1.04A 4fp9A-1ixkA:
25.1		 4fp9A-1ixkA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  86
GLY A  87
GLY A 142
ASP A 158
LEU A 169
 None
 1.02A 4fp9A-1mjfA:
10.4		 4fp9A-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		6 CYH A 430
GLY A 466
GLY A 467
LEU A 417
PRO A 414
LEU A 410
 None
 1.41A 4fp9A-1nr0A:
undetectable		 4fp9A-1nr0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 CYH A 172
GLY A 207
SER A 150
GLY A 147
LEU A  98
 None
 1.06A 4fp9A-1rxtA:
undetectable		 4fp9A-1rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
GLY A 258
GLY A 259
GLY A 304
ASP A 322
PRO A 324
 None
 0.97A 4fp9A-1sqgA:
27.0		 4fp9A-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		6 CYH A 254
PRO A 257
GLY A 258
GLY A 259
GLY A 304
ASP A 322
 None
 0.66A 4fp9A-1sqgA:
27.0		 4fp9A-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 PRO A 257
GLY A 258
GLY A 259
GLY A 302
ASP A 322
 None
 1.03A 4fp9A-1sqgA:
27.0		 4fp9A-1sqgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		5 GLY A 221
GLY A 222
SER A 240
ASP A 286
PRO A 288
 None
 0.57A 4fp9A-1wxxA:
13.9		 4fp9A-1wxxA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 GLY A 229
GLY A 230
SER A 249
ASP A 296
PRO A 298
 None
 0.74A 4fp9A-2as0A:
14.3		 4fp9A-2as0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.7A)
 0.47A 4fp9A-2b9eA:
23.3		 4fp9A-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 ASN A 161
LEU A 152
GLY A 151
ASP A 122
PRO A 124
 None
FMN  A 751 (-4.1A)
None
None
None
 1.05A 4fp9A-2bf4A:
undetectable		 4fp9A-2bf4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		6 CYH A 382
GLY A 349
GLY A 352
ASN A 379
GLY A 409
LEU A 413
 None
 1.43A 4fp9A-2bnhA:
undetectable		 4fp9A-2bnhA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 161
GLY A 159
LEU A 128
SER A 117
ASP A  88
 None
 1.03A 4fp9A-2cvzA:
3.5		 4fp9A-2cvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A  94
GLY A  95
SER A 230
GLY A 238
LEU A 166
 None
 1.07A 4fp9A-2e0wA:
undetectable		 4fp9A-2e0wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 GLY A 296
GLY A 297
GLY A 381
PRO A 350
LEU A 383
 None
 0.93A 4fp9A-2e0xA:
undetectable		 4fp9A-2e0xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 128
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
LEU A 228
 None
 0.75A 4fp9A-2frxA:
29.1		 4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
 None
 0.71A 4fp9A-2frxA:
29.1		 4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
GLY A 129
LYS A 131
SER A 151
ASP A 194
PRO A 196
 None
 1.00A 4fp9A-2frxA:
29.1		 4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 128
LYS A 131
SER A 151
ASP A 194
PRO A 196
LEU A 228
 None
 1.07A 4fp9A-2frxA:
29.1		 4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		6 GLY A 219
GLY A 218
ASN A 307
GLY A 260
PRO A 316
LEU A 261
 None
 1.50A 4fp9A-2hb6A:
undetectable		 4fp9A-2hb6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 283
GLY A 282
ASN A 303
LEU A 312
SER A 313
 None
 0.94A 4fp9A-2hzgA:
undetectable		 4fp9A-2hzgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima) 		PF01174
(SNO) 		5 PRO D  44
GLY D  45
GLY D  46
LEU D 165
LEU D  99
 None
 1.06A 4fp9A-2issD:
undetectable		 4fp9A-2issD:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 146
GLY A 147
GLY A 135
PRO A 711
LEU A 139
 None
None
None
None
MGD  A 811 ( 4.4A)
 1.03A 4fp9A-2jirA:
undetectable		 4fp9A-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1s INNER MEMBRANE
LIPOPROTEIN YIAD

(Escherichia
coli) 		PF00691
(OmpA) 		5 GLY A  79
GLY A  78
LEU A 113
GLY A  72
ASP A  75
 None
 0.94A 4fp9A-2k1sA:
undetectable		 4fp9A-2k1sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  33
GLY A  34
LEU A  46
GLY A  28
LEU A  20
 None
 1.00A 4fp9A-2kpkA:
undetectable		 4fp9A-2kpkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5j HASR PROTEIN

(Serratia
marcescens) 		PF07660
(STN) 		6 GLY A  95
ASN A 110
LEU A  87
GLY A 109
ASP A 100
LEU A 105
 None
 1.25A 4fp9A-2m5jA:
undetectable		 4fp9A-2m5jA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 PRO A  33
GLY A  34
LEU A  63
ASP A 104
LEU A 123
 SAM  A 201 (-3.4A)
SAM  A 201 (-3.7A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.7A)
None
 0.92A 4fp9A-2nyuA:
9.4		 4fp9A-2nyuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 GLY A  65
GLY A  64
ASN A 137
GLY A 201
LEU A 297
 None
 0.89A 4fp9A-2p1rA:
undetectable		 4fp9A-2p1rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 PRO A 489
GLY A 487
LEU A 478
GLY A 357
LEU A 369
 None
 1.06A 4fp9A-2wpgA:
undetectable		 4fp9A-2wpgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 624
LYS A 602
SER A 632
GLY A 534
ASP A 598
 None
 0.94A 4fp9A-2y8nA:
undetectable		 4fp9A-2y8nA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 SER A 138
GLY A 122
ASP A 225
PRO A 192
LEU A 158
 None
 1.04A 4fp9A-2ycjA:
undetectable		 4fp9A-2ycjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 GLY A 806
GLY A 795
LEU A 712
SER A 708
GLY A 716
 None
 0.93A 4fp9A-2yocA:
undetectable		 4fp9A-2yocA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.04A 4fp9A-2ywdA:
undetectable		 4fp9A-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		7 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.32A 4fp9A-2yxlA:
28.2		 4fp9A-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		5 GLY A 143
GLY A 142
LEU A 147
ASP A  93
LEU A  34
 None
 1.04A 4fp9A-2zatA:
6.5		 4fp9A-2zatA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9A-2zsuA:
11.0		 4fp9A-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.05A 4fp9A-3a4tA:
26.3		 4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.50A 4fp9A-3a4tA:
26.3		 4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 CYH B 350
GLY B 356
GLY B 355
LEU B 223
LEU B 240
 None
FAD  B   1 (-3.0A)
FAD  B   1 (-3.4A)
None
None
 0.89A 4fp9A-3adaB:
undetectable		 4fp9A-3adaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		5 GLY A 693
LEU A 684
GLY A 889
ASP A 852
PRO A 655
 None
 0.98A 4fp9A-3aibA:
undetectable		 4fp9A-3aibA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 PRO A 415
GLY A 416
GLY A 422
SER A 411
GLY A 402
 None
 0.96A 4fp9A-3b9eA:
undetectable		 4fp9A-3b9eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 PRO A  49
GLY A  50
GLY A  51
LEU A  68
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.8A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.7A)
 0.58A 4fp9A-3douA:
8.8		 4fp9A-3douA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 351
GLY A 350
LEU A 374
PRO A 550
LEU A 547
 None
 0.92A 4fp9A-3f70A:
undetectable		 4fp9A-3f70A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A 184
GLY A 183
LEU A 208
PRO A 377
LEU A 374
 None
 1.05A 4fp9A-3feoA:
undetectable		 4fp9A-3feoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		5 GLY A  65
GLY A  66
LEU A 147
GLY A 159
LEU A 118
 None
 1.07A 4fp9A-3gs6A:
undetectable		 4fp9A-3gs6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		5 GLY A 159
GLY A 160
LYS A 161
GLY A  95
ASP A  70
 None
 1.04A 4fp9A-3h2yA:
undetectable		 4fp9A-3h2yA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		5 GLY A 372
GLY A 371
GLY A 313
PRO A 344
LEU A 311
 None
 0.97A 4fp9A-3ib5A:
undetectable		 4fp9A-3ib5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.96A 4fp9A-3l44A:
undetectable		 4fp9A-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		5 GLY A  72
GLY A  73
GLY A 192
ASP A  76
LEU A 125
 None
 0.95A 4fp9A-3lacA:
undetectable		 4fp9A-3lacA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		8 CYH A 113
PRO A 116
GLY A 117
GLY A 118
LYS A 119
ASN A 136
ASP A 182
PRO A 184
 None
 0.41A 4fp9A-3m4xA:
27.8		 4fp9A-3m4xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 GLY A 113
LYS A 115
ASP A 177
PRO A 179
LEU A 211
 None
 0.92A 4fp9A-3m6xA:
28.8		 4fp9A-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		8 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
ASP A 177
PRO A 179
LEU A 211
 None
 0.44A 4fp9A-3m6xA:
28.8		 4fp9A-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 GLY K  83
GLY K  82
ASN K 374
GLY K 372
LEU K 377
 None
 0.98A 4fp9A-3mvdK:
undetectable		 4fp9A-3mvdK:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntn USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 203
GLY A 188
ASN A 213
LEU A 223
GLY A 210
 None
 1.07A 4fp9A-3ntnA:
undetectable		 4fp9A-3ntnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 105
GLY A 106
GLY A 156
ASP A 173
LEU A 184
 None
None
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.82A 4fp9A-3rw9A:
9.7		 4fp9A-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon;
uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 PRO C 251
GLY C 247
GLY C 248
LEU B 297
ASP B 344
 None
 0.92A 4fp9A-3sqgC:
undetectable		 4fp9A-3sqgC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 GLY A 192
LEU A 423
SER A 422
GLY A 280
ASP A 272
 None
 1.03A 4fp9A-3tktA:
undetectable		 4fp9A-3tktA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 PRO A 276
GLY A 278
GLY A 279
LEU A 107
LEU A 139
 None
 0.99A 4fp9A-3uduA:
undetectable		 4fp9A-3uduA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.92A 4fp9A-3urhA:
undetectable		 4fp9A-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		6 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9A-3vexA:
undetectable		 4fp9A-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.05A 4fp9A-3vrbA:
undetectable		 4fp9A-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 GLY A1236
LEU A1227
GLY A1443
ASP A1406
PRO A1198
 None
 1.04A 4fp9A-4amcA:
undetectable		 4fp9A-4amcA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 GLY A1239
LEU A1230
GLY A1438
ASP A1401
PRO A1201
 None
 1.06A 4fp9A-4aygA:
undetectable		 4fp9A-4aygA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 CYH A 323
GLY A 329
LYS A 330
LEU A 321
GLY A 294
 None
 0.99A 4fp9A-4czeA:
undetectable		 4fp9A-4czeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 PRO A 405
GLY A 406
GLY A 408
LEU A  75
GLY A 421
 None
 1.04A 4fp9A-4fl0A:
2.8		 4fp9A-4fl0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 135
LEU A 162
GLY A 192
ASP A 167
LEU A 202
 None
 0.91A 4fp9A-4fx5A:
undetectable		 4fp9A-4fx5A:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 181
GLY A 186
LYS A 187
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 1.07A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
GLY A 238
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.18A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
 None
 1.06A 4fp9A-4hq1A:
undetectable		 4fp9A-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.07A 4fp9A-4hr3A:
undetectable		 4fp9A-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 CYH A  99
GLY A 243
LEU A 171
GLY A 126
LEU A 119
 None
 1.05A 4fp9A-4ktoA:
undetectable		 4fp9A-4ktoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		7 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 364
LEU A 383
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
 0.96A 4fp9A-4n49A:
8.1		 4fp9A-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 GLY A 514
LEU A 598
SER A 599
ASP A 592
LEU A 624
 None
 1.06A 4fp9A-4nh0A:
undetectable		 4fp9A-4nh0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.75A 4fp9A-4nnqA:
undetectable		 4fp9A-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.05A 4fp9A-4rl6A:
4.0		 4fp9A-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		5 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.97A 4fp9A-4x33B:
undetectable		 4fp9A-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		5 GLY A 331
GLY A 330
LEU A 154
ASP A 139
LEU A  45
 CL  A 514 ( 4.2A)
None
None
None
None
 0.91A 4fp9A-4x8dA:
undetectable		 4fp9A-4x8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq9 S55-3 FAB (IGG2B)
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A  53
GLY A  54
ASN A  76
GLY A  24
LEU A   4
 KD2  A 301 (-3.6A)
KD2  A 301 (-4.2A)
None
None
None
 0.96A 4fp9A-5dq9A:
undetectable		 4fp9A-5dq9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		5 GLY A 124
GLY A 125
LEU A 152
GLY A 163
LEU A 162
 None
 0.89A 4fp9A-5esyA:
undetectable		 4fp9A-5esyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PRO A 146
GLY A 292
GLY A 291
GLY A 358
LEU A 361
 None
MPG  A 603 ( 4.3A)
MPG  A 625 ( 3.7A)
None
None
 0.87A 4fp9A-5f15A:
undetectable		 4fp9A-5f15A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.88A 4fp9A-5fyqA:
undetectable		 4fp9A-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 PRO A 300
GLY A 304
GLY A 303
GLY A 314
PRO A 264
 None
 1.01A 4fp9A-5hn4A:
undetectable		 4fp9A-5hn4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 GLY A  14
GLY A  13
LEU A 264
SER A 262
ASP A  41
 ANP  A 701 (-3.5A)
ANP  A 701 ( 3.5A)
None
ANP  A 701 (-3.2A)
MG  A 702 ( 3.4A)
 0.96A 4fp9A-5k5zA:
undetectable		 4fp9A-5k5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.03A 4fp9A-5m60A:
undetectable		 4fp9A-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.85A 4fp9A-5m60A:
undetectable		 4fp9A-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 PRO A   5
GLY A 175
GLY A 176
SER A  97
PRO A   9
 None
 1.00A 4fp9A-5n7qA:
undetectable		 4fp9A-5n7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5x CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 GLY A 258
LYS A  11
GLY A 351
ASP A 389
LEU A 385
 CL  A 501 (-3.3A)
None
None
None
None
 1.03A 4fp9A-5t5xA:
undetectable		 4fp9A-5t5xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLY A 450
ASN A 445
SER A  79
GLY A 864
LEU A 868
 None
 1.00A 4fp9A-5um6A:
3.5		 4fp9A-5um6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		6 CYH A 242
GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
 None
None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
 1.14A 4fp9A-5wwtA:
26.8		 4fp9A-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		9 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
GLY A 294
ASP A 323
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
C  C  72 ( 2.8A)
None
None
 0.48A 4fp9A-5wwtA:
26.8		 4fp9A-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A  43
GLY A  44
LEU A 174
SER A 253
GLY A 215
 FAD  A 501 ( 3.9A)
None
None
None
None
 1.04A 4fp9A-5xgvA:
undetectable		 4fp9A-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis) 		no annotation 5 CYH A  98
LEU A  72
GLY A  64
ASP A  99
LEU A  94
 None
 1.06A 4fp9A-6f2cA:
2.2		 4fp9A-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ASP A 618
ARG A 354
ASP A 623
 None
 0.86A 4fp9A-1br2A:
undetectable		 4fp9A-1br2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ASP A 614
ARG A 590
ASP A 558
 None
 0.77A 4fp9A-1c30A:
2.2		 4fp9A-1c30A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 599
ARG A 600
ASP A 497
 None
 0.83A 4fp9A-1ciyA:
undetectable		 4fp9A-1ciyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 ASP A 675
ARG A 641
ASP A 678
 None
 0.75A 4fp9A-1d0nA:
undetectable		 4fp9A-1d0nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE
MYELOPEROXIDASE

(Homo sapiens;
Homo sapiens) 		PF03098
(An_peroxidase)
PF03098
(An_peroxidase) 		3 ASP C 400
ARG C 403
ASP A  74
 SO4  A1602 (-4.7A)
None
None
 0.65A 4fp9A-1d7wC:
undetectable		 4fp9A-1d7wC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9s CYCLIN-DEPENDENT
KINASE 4 INHIBITOR B

(Mus musculus) 		PF12796
(Ank_2) 		3 ASP A  78
ARG A  81
ASP A  68
 None
 0.75A 4fp9A-1d9sA:
undetectable		 4fp9A-1d9sA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ASP A 396
ARG A 395
ASP A 134
 None
 0.65A 4fp9A-1fotA:
undetectable		 4fp9A-1fotA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 ASP A 157
ARG A 156
ASP A 503
 None
 0.85A 4fp9A-1hzvA:
undetectable		 4fp9A-1hzvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		3 ASP A 419
ARG A 422
ASP A 412
 None
 0.81A 4fp9A-1io1A:
undetectable		 4fp9A-1io1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		3 ASP A 187
ARG A 170
ASP A 156
 None
 0.81A 4fp9A-1jy1A:
undetectable		 4fp9A-1jy1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 205
ARG A  17
ASP A  29
 None
 0.75A 4fp9A-1mdfA:
undetectable		 4fp9A-1mdfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ASP A 193
ARG A 331
ASP A 186
 None
 0.61A 4fp9A-1nfgA:
undetectable		 4fp9A-1nfgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A 304
ARG A 159
ASP A 323
 None
 0.62A 4fp9A-1ozhA:
undetectable		 4fp9A-1ozhA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		3 ASP A  94
ARG A  95
ASP A  89
 None
 0.82A 4fp9A-1q0zA:
undetectable		 4fp9A-1q0zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASP A 357
ARG A 361
ASP A 117
 None
 0.66A 4fp9A-1qk1A:
undetectable		 4fp9A-1qk1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		3 ASP A  51
ARG A  24
ASP A  44
 None
 0.83A 4fp9A-1rytA:
undetectable		 4fp9A-1rytA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 ASP A  43
ARG A 225
ASP A  53
 None
 0.80A 4fp9A-1s9cA:
undetectable		 4fp9A-1s9cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		3 ASP A  78
ARG A  80
ASP A  47
 NAD  A 342 (-3.2A)
None
NAD  A 342 (-2.8A)
 0.78A 4fp9A-1sb8A:
7.0		 4fp9A-1sb8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 ASP A 214
ARG A 213
ASP A 167
 None
 0.78A 4fp9A-1susA:
10.6		 4fp9A-1susA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6t PUTATIVE PROTEIN

(Aquifex
aeolicus) 		PF01751
(Toprim) 		3 ASP 1  53
ARG 1  50
ASP 1  45
 None
 0.80A 4fp9A-1t6t1:
undetectable		 4fp9A-1t6t1:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		3 ASP A 114
ARG A 116
ASP A 151
 None
 0.80A 4fp9A-1u2qA:
undetectable		 4fp9A-1u2qA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 ASP A 167
ARG A 183
ASP A 151
 None
 0.79A 4fp9A-1u8vA:
undetectable		 4fp9A-1u8vA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcc DNA TOPOISOMERASE I

(Vaccinia virus) 		PF09266
(VirDNA-topo-I_N) 		3 ASP A  63
ARG A  67
ASP A  42
 None
 0.63A 4fp9A-1vccA:
undetectable		 4fp9A-1vccA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 626
ARG A 627
ASP A 507
 None
 0.83A 4fp9A-1w99A:
undetectable		 4fp9A-1w99A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 ASP A 369
ARG A 381
ASP A 321
 None
None
GOL  A1001 (-4.9A)
 0.85A 4fp9A-1x1nA:
undetectable		 4fp9A-1x1nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		3 ASP A  35
ARG A  37
ASP A  55
 None
 0.74A 4fp9A-1x25A:
undetectable		 4fp9A-1x25A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 ASP A  28
ARG A  30
ASP A  64
 None
 0.83A 4fp9A-1y30A:
undetectable		 4fp9A-1y30A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 ASP C 181
ARG C 179
ASP C 164
 None
 0.78A 4fp9A-1zq1C:
undetectable		 4fp9A-1zq1C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		3 ASP A 243
ARG A 254
ASP A 251
 None
 0.73A 4fp9A-2a4mA:
undetectable		 4fp9A-2a4mA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ARG A 263
ASP A 285
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
 0.71A 4fp9A-2b9eA:
23.4		 4fp9A-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		3 ASP A 274
ARG A 315
ASP A 296
 None
 0.85A 4fp9A-2bcoA:
undetectable		 4fp9A-2bcoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 ASP C 176
ARG C 174
ASP C 159
 None
 0.76A 4fp9A-2d6fC:
undetectable		 4fp9A-2d6fC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 ASP A 184
ARG A 186
ASP A 181
 None
 0.80A 4fp9A-2eb5A:
undetectable		 4fp9A-2eb5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		3 ASP A 244
ARG A 188
ASP A 194
 None
 0.83A 4fp9A-2gsnA:
undetectable		 4fp9A-2gsnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ASP A 898
ARG A 688
ASP A 499
 None
 0.86A 4fp9A-2inyA:
undetectable		 4fp9A-2inyA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 205
ARG A 557
ASP A 208
 None
 0.86A 4fp9A-2iujA:
undetectable		 4fp9A-2iujA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 204
ARG A 206
ASP A 225
 MGD  A 812 (-2.7A)
MGD  A 812 (-3.9A)
MGD  A 812 (-3.4A)
 0.56A 4fp9A-2jirA:
undetectable		 4fp9A-2jirA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsz PROBABLE THIOL
PEROXIDASE

(Bacillus
subtilis) 		PF08534
(Redoxin) 		3 ASP A  61
ARG A  65
ASP A  56
 None
 0.71A 4fp9A-2jszA:
undetectable		 4fp9A-2jszA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 ASP A 156
ARG A  77
ASP A 130
 None
 0.65A 4fp9A-2nqaA:
undetectable		 4fp9A-2nqaA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ASP A  96
ARG A 124
ASP A  70
 None
None
GOL  A2000 (-2.9A)
 0.86A 4fp9A-2p1fA:
undetectable		 4fp9A-2p1fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 ASP A 113
ARG A 115
ASP A  88
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-2.9A)
 0.62A 4fp9A-2pxxA:
10.3		 4fp9A-2pxxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyb NEUTROPHIL
ACTIVATING PROTEIN

(Borreliella
burgdorferi) 		PF00210
(Ferritin) 		3 ASP A 132
ARG A  70
ASP A 128
 None
 0.82A 4fp9A-2pybA:
undetectable		 4fp9A-2pybA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9A-2qcmA:
undetectable		 4fp9A-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASP A 616
ARG A 615
ASP A 609
 None
 0.85A 4fp9A-2qykA:
undetectable		 4fp9A-2qykA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A 319
ARG A 321
ASP A 306
 ASP  A 319 ( 0.6A)
ARG  A 321 ( 0.6A)
ASP  A 306 ( 0.6A)
 0.82A 4fp9A-2vbfA:
undetectable		 4fp9A-2vbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		3 ASP A 134
ARG A 137
ASP A 127
 None
 0.87A 4fp9A-2wu8A:
undetectable		 4fp9A-2wu8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 ASP A 205
ARG A 163
ASP A 133
 None
 0.78A 4fp9A-2ybuA:
undetectable		 4fp9A-2ybuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn3 PUTATIVE INNER
MEMBRANE PROTEIN

(Salmonella
enterica) 		PF12245
(Big_3_2) 		3 ASP A5183
ARG A5182
ASP A5170
 None
 0.87A 4fp9A-2yn3A:
undetectable		 4fp9A-2yn3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		3 ASP A 217
ARG A 206
ASP A 214
 None
SO4  A 512 (-3.1A)
None
 0.78A 4fp9A-2z02A:
undetectable		 4fp9A-2z02A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		3 ASP A 120
ARG A 122
ASP A  59
 None
 0.76A 4fp9A-2zylA:
undetectable		 4fp9A-2zylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		3 ASP A 251
ARG A 253
ASP A 223
 ADN  A 401 (-3.8A)
None
ADN  A 401 (-2.6A)
 0.85A 4fp9A-3ay0A:
11.5		 4fp9A-3ay0A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		3 ASP A 150
ARG A 147
ASP A 142
 None
 0.82A 4fp9A-3b1bA:
undetectable		 4fp9A-3b1bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		3 ASP A 112
ARG A 137
ASP A 105
 None
 0.81A 4fp9A-3bgkA:
4.5		 4fp9A-3bgkA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh3 ACETOACETATE
DECARBOXYLASE

(Chromobacterium
violaceum) 		PF06314
(ADC) 		3 ASP A 135
ARG A 140
ASP A 100
 None
 0.82A 4fp9A-3bh3A:
undetectable		 4fp9A-3bh3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		3 ASP A 109
ARG A 112
ASP A 104
 None
 0.67A 4fp9A-3bhwA:
undetectable		 4fp9A-3bhwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 3 ASP B 369
ARG B  26
ASP B  52
 None
 0.81A 4fp9A-3bxwB:
undetectable		 4fp9A-3bxwB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 3 ASP A  28
ARG A 123
ASP A  34
 None
 0.85A 4fp9A-3d0kA:
undetectable		 4fp9A-3d0kA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Burkholderia
pseudomallei) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 ASP A 101
ARG A 102
ASP A 136
 None
AMP  A 401 ( 4.7A)
None
 0.67A 4fp9A-3dahA:
undetectable		 4fp9A-3dahA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00814
(Peptidase_M22) 		3 ASP A 318
ARG A 316
ASP A 321
 None
 0.86A 4fp9A-3enoA:
undetectable		 4fp9A-3enoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 565
ARG A 595
ASP A 584
 None
 0.79A 4fp9A-3gwjA:
undetectable		 4fp9A-3gwjA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzb PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
putrefaciens) 		PF12680
(SnoaL_2) 		3 ASP A  47
ARG A  46
ASP A 128
 None
 0.59A 4fp9A-3gzbA:
undetectable		 4fp9A-3gzbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		3 ASP 7  39
ARG 7  75
ASP 7  36
 None
 0.80A 4fp9A-3i9v7:
undetectable		 4fp9A-3i9v7:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jci CAPSID PROTEIN

(Porcine
circovirus 2) 		PF02443
(Circo_capsid) 		3 ASP A 127
ARG A  73
ASP A 168
 None
 0.72A 4fp9A-3jciA:
undetectable		 4fp9A-3jciA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		3 ASP A 125
ARG A 122
ASP A 212
 None
 0.87A 4fp9A-3khsA:
undetectable		 4fp9A-3khsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR

(Rhodopseudomonas
palustris) 		PF01042
(Ribonuc_L-PSP) 		3 ASP A  83
ARG A  79
ASP A  64
 None
 0.77A 4fp9A-3lmeA:
undetectable		 4fp9A-3lmeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 ASP A 271
ARG A 371
ASP A 274
 None
 0.78A 4fp9A-3lq1A:
2.2		 4fp9A-3lq1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		3 ASP A 343
ARG A 347
ASP A 238
 None
 0.82A 4fp9A-3nvqA:
undetectable		 4fp9A-3nvqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		3 ASP A 272
ARG A  85
ASP A 113
 None
 0.84A 4fp9A-3obiA:
2.5		 4fp9A-3obiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oov METHYL-ACCEPTING
CHEMOTAXIS PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		3 ASP A 130
ARG A  33
ASP A 142
 GOL  A 167 (-3.6A)
None
None
 0.74A 4fp9A-3oovA:
undetectable		 4fp9A-3oovA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plt SPHINGOLIPID LONG
CHAIN
BASE-RESPONSIVE
PROTEIN LSP1

(Saccharomyces
cerevisiae) 		PF13805
(Pil1) 		3 ASP A 123
ARG A 126
ASP A 116
 None
 0.73A 4fp9A-3pltA:
undetectable		 4fp9A-3pltA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		3 ASP A 332
ARG A 364
ASP A 283
 None
 0.81A 4fp9A-3q6tA:
undetectable		 4fp9A-3q6tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0r PORCINE CIRCOVIRUS 2
(PCV2) CAPSID
PROTEIN

(Porcine
circovirus 2) 		PF02443
(Circo_capsid) 		3 ASP A 122
ARG A  68
ASP A 163
 None
 0.73A 4fp9A-3r0rA:
undetectable		 4fp9A-3r0rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 ASP A 405
ARG A 466
ASP A 385
 None
 0.85A 4fp9A-3sfzA:
undetectable		 4fp9A-3sfzA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP A 100
ARG A  99
ASP A  80
 None
 0.72A 4fp9A-3wa1A:
undetectable		 4fp9A-3wa1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ASP A 260
ARG A 257
ASP A 280
 None
 0.61A 4fp9A-3wfzA:
undetectable		 4fp9A-3wfzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ASP A 108
ARG A 516
ASP A 519
 None
 0.80A 4fp9A-3zifA:
undetectable		 4fp9A-3zifA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		3 ASP A 554
ARG A 559
ASP A 547
 None
 0.75A 4fp9A-4c4aA:
7.0		 4fp9A-4c4aA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chd POLYMERASE ACIDIC
PROTEIN

(Thogoto
thogotovirus) 		no annotation 3 ASP A 666
ARG A 617
ASP A 656
 None
 0.73A 4fp9A-4chdA:
undetectable		 4fp9A-4chdA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 146
ARG A 193
ASP A 141
 None
 0.73A 4fp9A-4e4uA:
undetectable		 4fp9A-4e4uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		3 ASP A 209
ARG A 199
ASP A 202
 None
AIR  A 301 (-3.1A)
None
 0.81A 4fp9A-4fe2A:
undetectable		 4fp9A-4fe2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj4 UNCHARACTERIZED
PROTEIN

(Halobacterium
salinarum) 		PF07920
(DUF1684) 		3 ASP A 187
ARG A 185
ASP A  47
 None
 0.58A 4fp9A-4fj4A:
undetectable		 4fp9A-4fj4A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 237
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.18A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmq PUTATIVE RIBOSOME
ASSOCIATED PROTEIN

(Chaetomium
thermophilum) 		PF16717
(RAC_head) 		3 ASP A 392
ARG A 365
ASP A 385
 None
 0.75A 4fp9A-4gmqA:
undetectable		 4fp9A-4gmqA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		3 ASP A 151
ARG A 129
ASP A 148
 None
 0.77A 4fp9A-4gn8A:
undetectable		 4fp9A-4gn8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		3 ASP A  55
ARG A  57
ASP A  52
 None
 0.87A 4fp9A-4h0fA:
undetectable		 4fp9A-4h0fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		3 ASP A 241
ARG A 240
ASP A 230
 MG  A 402 ( 4.5A)
None
None
 0.74A 4fp9A-4injA:
undetectable		 4fp9A-4injA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF05488
(PAAR_motif) 		3 ASP D  77
ARG D  74
ASP D  41
 None
 0.68A 4fp9A-4jiwD:
undetectable		 4fp9A-4jiwD:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		3 ASP A  97
ARG A  96
ASP A 115
 None
 0.81A 4fp9A-4kw7A:
8.7		 4fp9A-4kw7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwy PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caulobacter
vibrioides) 		PF04390
(LptE) 		3 ASP A 125
ARG A  93
ASP A 139
 None
 0.74A 4fp9A-4kwyA:
undetectable		 4fp9A-4kwyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg3 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF16175
(DUF4875) 		3 ASP A 176
ARG A 178
ASP A 172
 None
 0.73A 4fp9A-4lg3A:
undetectable		 4fp9A-4lg3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj2 CHORISMATE SYNTHASE

(Acinetobacter
baumannii) 		PF01264
(Chorismate_synt) 		3 ASP A 342
ARG A 346
ASP A  28
 None
 0.82A 4fp9A-4lj2A:
undetectable		 4fp9A-4lj2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		3 ASP A 157
ARG A 154
ASP A 186
 None
 0.66A 4fp9A-4m6rA:
undetectable		 4fp9A-4m6rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjd KETOSTEROID
ISOMERASE FOLD
PROTEIN HMUK_0747

(Halomicrobium
mukohataei) 		PF12680
(SnoaL_2) 		3 ASP A  33
ARG A 104
ASP A  36
 None
 0.83A 4fp9A-4mjdA:
undetectable		 4fp9A-4mjdA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 ASP A 111
ARG A 107
ASP A  31
 None
 0.55A 4fp9A-4mrpA:
undetectable		 4fp9A-4mrpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mur D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE

(Enterococcus
gallinarum) 		PF02557
(VanY) 		3 ASP A  29
ARG A  56
ASP A  31
 None
 0.85A 4fp9A-4murA:
undetectable		 4fp9A-4murA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN

(Cupriavidus
taiwanensis) 		PF13561
(adh_short_C2) 		3 ASP A  36
ARG A  41
ASP A  62
 None
 0.87A 4fp9A-4nbvA:
7.2		 4fp9A-4nbvA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ASP A 276
ARG A 296
ASP A 258
 None
 0.86A 4fp9A-4p8rA:
4.0		 4fp9A-4p8rA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py4 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF00644
(PARP) 		3 ASP A1731
ARG A1735
ASP A1725
 None
 0.81A 4fp9A-4py4A:
undetectable		 4fp9A-4py4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ASP A 263
ARG A 267
ASP A 298
 None
 0.82A 4fp9A-4q73A:
4.0		 4fp9A-4q73A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 ASP A 482
ARG A 465
ASP A 460
 None
 0.74A 4fp9A-4r4zA:
undetectable		 4fp9A-4r4zA:
18.88