SIMILAR PATTERNS OF AMINO ACIDS FOR 4FOR_A_FLPA711_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ao3 | VON WILLEBRANDFACTOR (Homo sapiens) |
PF00092(VWA) | 4 | VAL A 112PRO A 139ASN A 162GLY A 141 | None | 0.86A | 4forA-1ao3A:undetectable | 4forA-1ao3A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bfo | CAMPATH-1G ANTIBODY (Rattus rattus) |
PF07654(C1-set)PF07686(V-set) | 4 | THR B 87GLY B 16VAL B 12PRO B 14 | None | 0.84A | 4forA-1bfoB:undetectable | 4forA-1bfoB:20.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1biy | LACTOFERRIN (Bubalus bubalis) |
PF00405(Transferrin) | 7 | THR A 430GLY A 432VAL A 591PRO A 593ASN A 594TYR A 660GLY A 662 | None | 0.50A | 4forA-1biyA:55.1 | 4forA-1biyA:91.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLY A 260VAL A 256PRO A 258GLY A 282 | None | 0.69A | 4forA-1bxzA:undetectable | 4forA-1bxzA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cc1 | HYDROGENASE (LARGESUBUNIT) (Desulfomicrobiumbaculatum) |
PF00374(NiFeSe_Hases) | 4 | GLY L 462PRO L 454TYR L 317GLY L 44 | None | 0.71A | 4forA-1cc1L:undetectable | 4forA-1cc1L:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h74 | HOMOSERINE KINASE (Methanocaldococcusjannaschii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | THR A 14GLY A 96ASN A 141GLY A 104 | NoneADP A 400 ( 4.0A)ILE A 500 (-4.2A)None | 0.72A | 4forA-1h74A:undetectable | 4forA-1h74A:22.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h76 | SEROTRANSFERRIN (Sus scrofa) |
PF00405(Transferrin) | 5 | GLY A 430PRO A 592ASN A 593TYR A 658GLY A 660 | None | 0.38A | 4forA-1h76A:50.6 | 4forA-1h76A:31.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1i6q | LACTOFERRIN (Camelusdromedarius) |
PF00405(Transferrin) | 5 | GLY A 432PRO A 593ASN A 594TYR A 660GLY A 662 | None | 0.55A | 4forA-1i6qA:26.1 | 4forA-1i6qA:55.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jnf | SEROTRANSFERRIN (Oryctolaguscuniculus) |
PF00405(Transferrin) | 5 | GLY A 424PRO A 580ASN A 581TYR A 647GLY A 649 | None | 0.46A | 4forA-1jnfA:50.2 | 4forA-1jnfA:30.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqb | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLY A1260VAL A1256PRO A1258GLY A1282 | None | 0.72A | 4forA-1jqbA:undetectable | 4forA-1jqbA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k4q | GLUTATHIONEREDUCTASE (Homo sapiens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | THR A 156GLY A 158PRO A 293ASN A 294 | FAD A 499 (-3.9A)NoneNoneFAD A 499 ( 4.5A) | 0.82A | 4forA-1k4qA:undetectable | 4forA-1k4qA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwm | PROCARBOXYPEPTIDASEB (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | THR A 129GLY A 115ASN A 112GLY A 44 | None | 0.83A | 4forA-1kwmA:undetectable | 4forA-1kwmA:19.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n76 | LACTOFERRIN (Homo sapiens) |
PF00405(Transferrin) | 5 | GLY A 434PRO A 595ASN A 596TYR A 662GLY A 664 | None | 0.48A | 4forA-1n76A:53.0 | 4forA-1n76A:68.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1r | PUTIDAREDOXINREDUCTASE (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 4 | THR A 110GLY A 112PRO A 250ASN A 251 | FAD A 749 (-4.2A)FAD A 749 (-4.6A)NoneFAD A 749 ( 4.6A) | 0.68A | 4forA-1q1rA:undetectable | 4forA-1q1rA:22.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qjm | LACTOFERRIN (Equus caballus) |
PF00405(Transferrin) | 5 | GLY A 432PRO A 593ASN A 594TYR A 660GLY A 662 | None | 0.61A | 4forA-1qjmA:53.4 | 4forA-1qjmA:45.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzv | GLYCOGEN SYNTHASE 1 (Agrobacteriumtumefaciens) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 4 | GLY A 43VAL A 47PRO A 45GLY A 93 | None | 0.83A | 4forA-1rzvA:undetectable | 4forA-1rzvA:23.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1suv | SEROTRANSFERRIN,C-LOBE (Homo sapiens) |
PF00405(Transferrin) | 5 | GLY E 424PRO E 580ASN E 581TYR E 647GLY E 649 | None | 0.46A | 4forA-1suvE:50.0 | 4forA-1suvE:58.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tjy | SUGAR TRANSPORTPROTEIN (Salmonellaenterica) |
PF13407(Peripla_BP_4) | 4 | GLY A 320VAL A 304PRO A 306ASN A 307 | None | 0.42A | 4forA-1tjyA:2.4 | 4forA-1tjyA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wp5 | TOPOISOMERASE IV (Geobacillusstearothermophilus) |
PF03989(DNA_gyraseA_C) | 4 | THR A 136GLY A 60VAL A 146GLY A 184 | None | 0.52A | 4forA-1wp5A:undetectable | 4forA-1wp5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x99 | LECTIN (Xerocomelluschrysenteron) |
PF07367(FB_lectin) | 4 | THR A 27GLY A 55VAL A 71ASN A 96 | None | 0.80A | 4forA-1x99A:undetectable | 4forA-1x99A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zli | CARBOXYPEPTIDASE B (Homo sapiens) |
PF00246(Peptidase_M14) | 4 | THR A 129GLY A 115ASN A 112GLY A 44 | None | 0.86A | 4forA-1zliA:undetectable | 4forA-1zliA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8y | AMYX PROTEIN (Bacillussubtilis) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | GLY A 561VAL A 213PRO A 563ASN A 519 | None | 0.83A | 4forA-2e8yA:undetectable | 4forA-2e8yA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epg | HYPOTHETICAL PROTEINTTHA1785 (Thermusthermophilus) |
PF01139(RtcB) | 4 | GLY A 279VAL A 87PRO A 273GLY A 84 | None | 0.76A | 4forA-2epgA:undetectable | 4forA-2epgA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpg | SUCCINYL-COA LIGASE[GDP-FORMING]ALPHA-CHAIN,MITOCHONDRIAL (Sus scrofa) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 4 | GLY A 187PRO A 130ASN A 192GLY A 106 | None | 0.84A | 4forA-2fpgA:undetectable | 4forA-2fpgA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g1k | SHIKIMATE KINASE (Mycobacteriumtuberculosis) |
PF01202(SKI) | 4 | GLY A 156VAL A 159ASN A 154GLY A 14 | NoneNoneNoneSO4 A 501 (-3.1A) | 0.73A | 4forA-2g1kA:undetectable | 4forA-2g1kA:20.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hau | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 5 | GLY A 425PRO A 583ASN A 584TYR A 650GLY A 652 | None | 0.65A | 4forA-2hauA:25.7 | 4forA-2hauA:31.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iv2 | FORMATEDEHYDROGENASE H (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 4 | THR X 130GLY X 380ASN X 132GLY X 345 | None | 0.74A | 4forA-2iv2X:undetectable | 4forA-2iv2X:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3h | NADP-DEPENDENTOXIDOREDUCTASE P1 (Arabidopsisthaliana) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 4 | GLY A 173VAL A 161TYR A 148GLY A 146 | None | 0.85A | 4forA-2j3hA:undetectable | 4forA-2j3hA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf4 | PERIPLASMICTREHALASE (Escherichiacoli) |
PF01204(Trehalase) | 4 | THR A 439VAL A 500PRO A 450GLY A 508 | None | 0.85A | 4forA-2jf4A:undetectable | 4forA-2jf4A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | THR A 154GLY A 221ASN A 267GLY A 258 | None | 0.80A | 4forA-2o5pA:undetectable | 4forA-2o5pA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9z | GLUTATHIONE AMIDEREDUCTASE (Marichromatiumgracile) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 140PRO A 264ASN A 265GLY A 305 | NoneNoneFAD A 500 ( 4.7A)None | 0.83A | 4forA-2r9zA:undetectable | 4forA-2r9zA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjt | BETA-KETOACYL-ACPSYNTHASE II (Streptococcuspneumoniae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | THR A 393GLY A 343ASN A 168GLY A 108 | None | 0.83A | 4forA-2rjtA:undetectable | 4forA-2rjtA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | GLY A 264PRO A 261TYR A 254GLY A 257 | None | 0.87A | 4forA-2v4jA:undetectable | 4forA-2v4jA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6o | THIOREDOXINGLUTATHIONEREDUCTASE (Schistosomamansoni) |
PF00462(Glutaredoxin)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | THR A 471GLY A 480VAL A 539GLY A 536 | None | 0.82A | 4forA-2v6oA:undetectable | 4forA-2v6oA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8j | PECTATE LYASE (Yersiniaenterocolitica) |
PF06917(Pectate_lyase_2) | 4 | GLY A 42VAL A 37PRO A 39GLY A 469 | None | 0.76A | 4forA-2v8jA:undetectable | 4forA-2v8jA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vnr | CPE0329 (Clostridiumperfringens) |
PF08305(NPCBM) | 4 | THR A 165GLY A 123VAL A 197GLY A 193 | None | 0.82A | 4forA-2vnrA:undetectable | 4forA-2vnrA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wan | PULLULANASE (Bacillusacidopullulyticus) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | GLY A 772VAL A 431PRO A 774ASN A 730 | None | 0.80A | 4forA-2wanA:undetectable | 4forA-2wanA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wc1 | FLAVODOXIN (Rhodobactercapsulatus) |
PF00258(Flavodoxin_1) | 4 | GLY A 98VAL A 108PRO A 56GLY A 54 | FMN A 183 (-3.2A)FMN A 183 (-4.1A)FMN A 183 (-4.2A)None | 0.85A | 4forA-2wc1A:undetectable | 4forA-2wc1A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xc8 | GENE 22 PRODUCT (Bacillus phageSPP1) |
no annotation | 4 | GLY A 107VAL A 103PRO A 105ASN A 106 | None | 0.87A | 4forA-2xc8A:undetectable | 4forA-2xc8A:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y27 | PHENYLACETATE-COENZYME A LIGASE (Burkholderiacenocepacia) |
PF00501(AMP-binding)PF14535(AMP-binding_C_2) | 4 | GLY A 238VAL A 247TYR A 136GLY A 146 | GOL A 505 ( 3.4A)NoneNoneNone | 0.83A | 4forA-2y27A:undetectable | 4forA-2y27A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ya1 | PUTATIVE ALKALINEAMYLOPULLULANASE (Streptococcuspneumoniae) |
PF00128(Alpha-amylase)PF02922(CBM_48)PF03714(PUD) | 4 | THR A 751GLY A 749TYR A 812GLY A 781 | None | 0.84A | 4forA-2ya1A:undetectable | 4forA-2ya1A:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ya2 | PUTATIVE ALKALINEAMYLOPULLULANASE (Streptococcuspneumoniae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | THR A 296GLY A 294TYR A 357GLY A 326 | None | 0.84A | 4forA-2ya2A:undetectable | 4forA-2ya2A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0h | PHOTOSYSTEM II CORELIGHT HARVESTINGPROTEIN (Thermosynechococcusvulcanus) |
PF00421(PSII) | 4 | GLY B 196VAL B 181PRO B 183GLY B 154 | None | 0.82A | 4forA-3a0hB:undetectable | 4forA-3a0hB:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5i | FLAGELLARBIOSYNTHESIS PROTEINFLHA (Salmonellaenterica) |
PF00771(FHIPEP) | 4 | GLY A 460VAL A 455PRO A 457GLY A 430 | None | 0.87A | 4forA-3a5iA:undetectable | 4forA-3a5iA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3crw | XPD/RAD3 RELATED DNAHELICASE (Sulfolobusacidocaldarius) |
PF06733(DEAD_2)PF13307(Helicase_C_2) | 4 | GLY 1 323PRO 1 30ASN 1 28GLY 1 34 | None | 0.82A | 4forA-3crw1:undetectable | 4forA-3crw1:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctp | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Alkaliphilusmetalliredigens) |
PF13377(Peripla_BP_3) | 4 | THR A 280GLY A 265VAL A 237GLY A 234 | None | 0.87A | 4forA-3ctpA:undetectable | 4forA-3ctpA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv3 | GLUCURONOSYLTRANSFERASE GUMK (Xanthomonascampestris) |
no annotation | 4 | GLY A 333VAL A 319PRO A 321ASN A 322 | None | 0.77A | 4forA-3cv3A:undetectable | 4forA-3cv3A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dlc | PUTATIVES-ADENOSYL-L-METHIONINE-DEPENDENTMETHYLTRANSFERASE (Methanococcusmaripaludis) |
PF08241(Methyltransf_11) | 4 | GLY A 150ASN A 34TYR A 144GLY A 146 | None | 0.84A | 4forA-3dlcA:undetectable | 4forA-3dlcA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLY A 260VAL A 256PRO A 258GLY A 282 | None | 0.69A | 4forA-3fplA:undetectable | 4forA-3fplA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsr | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLY A 260VAL A 256PRO A 258GLY A 282 | ZN A 354 (-4.3A)NoneNoneNone | 0.74A | 4forA-3fsrA:undetectable | 4forA-3fsrA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdo | UNCHARACTERIZEDOXIDOREDUCTASE YVAA (Bacillussubtilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | THR A 330GLY A 334VAL A 337GLY A 199 | None | 0.73A | 4forA-3gdoA:undetectable | 4forA-3gdoA:19.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mc2 | INHIBITOR OFCARBONIC ANHYDRASE (Mus musculus) |
PF00405(Transferrin) | 4 | GLY A 426PRO A 586TYR A 652GLY A 654 | None | 0.36A | 4forA-3mc2A:15.6 | 4forA-3mc2A:33.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0h | GLUTATHIONEREDUCTASE (Bartonellahenselae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | THR A 342GLY A 351VAL A 406GLY A 403 | None | 0.81A | 4forA-3o0hA:undetectable | 4forA-3o0hA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3u | MALTOSE-BINDINGPERIPLASMIC PROTEIN,ADVANCEDGLYCOSYLATION ENDPRODUCT-SPECIFICRECEPTOR (Escherichiacoli;Homo sapiens) |
PF08205(C2-set_2)PF13416(SBP_bac_8) | 4 | GLY N1082VAL N1078PRO N1080ASN N1081 | None | 0.85A | 4forA-3o3uN:4.9 | 4forA-3o3uN:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00365(PFK) | 4 | GLY A 632VAL A 599ASN A 664GLY A 692 | None | 0.87A | 4forA-3o8oA:undetectable | 4forA-3o8oA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oj0 | GLUTAMYL-TRNAREDUCTASE (Thermoplasmavolcanium) |
PF01488(Shikimate_DH) | 4 | THR A 83GLY A 107PRO A 110ASN A 111 | NoneGOL A 146 (-3.9A)NoneNone | 0.79A | 4forA-3oj0A:undetectable | 4forA-3oj0A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooq | AMIDOHYDROLASE (Thermotogamaritima) |
PF01979(Amidohydro_1) | 4 | GLY A 120VAL A 118ASN A 81GLY A 67 | None | 0.81A | 4forA-3ooqA:undetectable | 4forA-3ooqA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbr | SJCHGC06286 PROTEIN (Schistosomajaponicum) |
PF00452(Bcl-2) | 4 | GLY A 110VAL A 113ASN A 108GLY A 162 | None | 0.70A | 4forA-3qbrA:undetectable | 4forA-3qbrA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qdt | BOLETUS EDULISLECTIN (Boletus edulis) |
PF07367(FB_lectin) | 4 | THR A 24GLY A 52VAL A 68ASN A 93 | None | 0.76A | 4forA-3qdtA:undetectable | 4forA-3qdtA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwk | INULINASE (Aspergillusficuum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | GLY X 114VAL X 143PRO X 119ASN X 109 | None | 0.65A | 4forA-3rwkX:undetectable | 4forA-3rwkX:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sfw | DIHYDROPYRIMIDINASE (Brevibacillusagri) |
PF01979(Amidohydro_1) | 4 | GLY A 425VAL A 400PRO A 398GLY A 47 | NoneNoneACT A 463 ( 4.7A)ACT A 463 (-3.8A) | 0.83A | 4forA-3sfwA:undetectable | 4forA-3sfwA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 4 | THR A 33GLY A 248ASN A 246GLY A 162 | NoneFMN A 401 (-3.3A)NoneNone | 0.72A | 4forA-3sgzA:undetectable | 4forA-3sgzA:21.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3skp | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 4 | GLY A 425PRO A 583ASN A 584TYR A 650 | None | 0.48A | 4forA-3skpA:24.5 | 4forA-3skpA:59.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3skp | SEROTRANSFERRIN (Homo sapiens) |
PF00405(Transferrin) | 4 | PRO A 583ASN A 584TYR A 650GLY A 652 | NoneNoneNoneSO4 A 683 (-3.4A) | 0.46A | 4forA-3skpA:24.5 | 4forA-3skpA:59.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t95 | AUTOINDUCER2-BINDING PROTEINLSRB (Yersinia pestis) |
PF13407(Peripla_BP_4) | 4 | GLY A 319VAL A 303PRO A 305ASN A 306 | None | 0.35A | 4forA-3t95A:2.5 | 4forA-3t95A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufb | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLTRANSFERASESUBUNIT (Vibriovulnificus) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | GLY A 405VAL A 361PRO A 363GLY A 313 | None | 0.78A | 4forA-3ufbA:undetectable | 4forA-3ufbA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ze7 | PERIPLASMIC [NIFESE]HYDROGENASE, LARGESUBUNIT,SELENOCYSTEINE-CONTAINING (Desulfovibriovulgaris) |
PF00374(NiFeSe_Hases) | 4 | GLY B 459PRO B 451TYR B 313GLY B 49 | None | 0.68A | 4forA-3ze7B:undetectable | 4forA-3ze7B:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bv6 | APOPTOSIS-INDUCINGFACTOR 1,MITOCHONDRIAL (Homo sapiens) |
PF07992(Pyr_redox_2)PF14721(AIF_C) | 4 | THR A 260GLY A 262PRO A 402ASN A 403 | FAD A1449 (-4.1A)NoneNoneFAD A1449 ( 4.5A) | 0.84A | 4forA-4bv6A:undetectable | 4forA-4bv6A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 4 | GLY A 372VAL A 364PRO A 358GLY A 400 | None | 0.84A | 4forA-4dwqA:undetectable | 4forA-4dwqA:21.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fim | LACTOTRANSFERRIN (Bos taurus) |
PF00405(Transferrin) | 7 | THR A 430GLY A 432VAL A 591PRO A 593ASN A 594TYR A 660GLY A 662 | NoneCEL A 711 (-3.7A)NoneCEL A 711 (-4.3A)NoneCEL A 711 (-4.4A)CEL A 711 (-3.3A) | 0.08A | 4forA-4fimA:61.0 | 4forA-4fimA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpr | THIOREDOXINREDUCTASE 1,CYTOPLASMIC (Rattusnorvegicus) |
no annotation | 4 | THR E 372GLY E 381VAL E 440GLY E 437 | None | 0.75A | 4forA-4kprE:undetectable | 4forA-4kprE:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lp4 | ADVANCEDGLYCOSYLATION ENDPRODUCT-SPECIFICRECEPTOR (Homo sapiens) |
PF00047(ig)PF08205(C2-set_2) | 4 | GLY A 82VAL A 78PRO A 80ASN A 81 | None | 0.83A | 4forA-4lp4A:undetectable | 4forA-4lp4A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nen | INTEGRIN ALPHA-X (Homo sapiens) |
PF00092(VWA)PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | GLY A 105VAL A 93PRO A 91GLY A 74 | None | 0.64A | 4forA-4nenA:undetectable | 4forA-4nenA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pz0 | SUGAR ABCTRANSPORTER,SUGAR-BINDINGPROTEIN (Bacillusanthracis) |
PF13407(Peripla_BP_4) | 4 | GLY A 327VAL A 311PRO A 313ASN A 314 | None | 0.38A | 4forA-4pz0A:undetectable | 4forA-4pz0A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q1v | PUTATIVE DIPEPTIDYLAMINOPEPTIDASE IV (Bacteroidesovatus) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | GLY A 38VAL A 718PRO A 36GLY A 536 | None | 0.67A | 4forA-4q1vA:undetectable | 4forA-4q1vA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q7a | N-ACETYL-ORNITHINE/N-ACETYL-LYSINEDEACETYLASE (Sphaerobacterthermophilus) |
PF01546(Peptidase_M20) | 4 | GLY A 323VAL A 94TYR A 320GLY A 150 | None | 0.85A | 4forA-4q7aA:undetectable | 4forA-4q7aA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlz | CAPSID PROTEIN (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 4 | GLY A 308VAL A 304PRO A 306ASN A 307 | None | 0.81A | 4forA-4rlzA:undetectable | 4forA-4rlzA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rsh | LIPOLYTIC PROTEING-D-S-L FAMILY (Desulfitobacteriumhafniense) |
PF13472(Lipase_GDSL_2) | 4 | GLY A 220VAL A 78PRO A 76GLY A 66 | None | 0.81A | 4forA-4rshA:undetectable | 4forA-4rshA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yam | BETA-ETHERASE (Sphingobium sp.SYK-6) |
PF13417(GST_N_3) | 5 | GLY A 180PRO A 184ASN A 185TYR A 189GLY A 220 | None | 0.95A | 4forA-4yamA:undetectable | 4forA-4yamA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywk | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 4 | GLY A 67VAL A 60PRO A 64GLY A 225 | None | 0.77A | 4forA-4ywkA:undetectable | 4forA-4ywkA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 4 | THR A 357GLY A 488PRO A 485GLY A 275 | NoneNoneNoneFMN A 602 ( 4.3A) | 0.82A | 4forA-4z9rA:undetectable | 4forA-4z9rA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f75 | THIOCYANATEDEHYDROGENASE (Thioalkalivibrioparadoxus) |
no annotation | 4 | THR A 483GLY A 495VAL A 508ASN A 530 | None | 0.67A | 4forA-5f75A:undetectable | 4forA-5f75A:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0a | TRANSAMINASE (Bacillusmegaterium) |
PF00202(Aminotran_3) | 4 | GLY A 65VAL A 62ASN A 448GLY A 444 | None | 0.83A | 4forA-5g0aA:undetectable | 4forA-5g0aA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ik2 | ATP SYNTHASE EPSILONCHAINATP SYNTHASE GAMMACHAIN (Caldalkalibacillusthermarum) |
PF00231(ATP-synt)PF02823(ATP-synt_DE_N) | 4 | THR G 38VAL H 9PRO H 11TYR G 227 | None | 0.75A | 4forA-5ik2G:undetectable | 4forA-5ik2G:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j0a | LYMPHOKINE-ACTIVATEDKILLERT-CELL-ORIGINATEDPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | GLY A 276VAL A 218PRO A 214GLY A 208 | None | 0.82A | 4forA-5j0aA:undetectable | 4forA-5j0aA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1q | CARBOXYPEPTIDASE B (Sus scrofa) |
PF00246(Peptidase_M14) | 4 | THR A 129GLY A 115ASN A 112GLY A 44 | None | 0.83A | 4forA-5j1qA:undetectable | 4forA-5j1qA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5knl | UBIQUITIN-CONJUGATING ENZYME E2 15 (Schizosaccharomycespombe) |
PF00179(UQ_con) | 4 | GLY C 87VAL C 83PRO C 85ASN C 86 | None | 0.87A | 4forA-5knlC:undetectable | 4forA-5knlC:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3h | POLYMERASE ACIDICPROTEIN (Influenza Avirus) |
PF00603(Flu_PA) | 4 | GLY A 564VAL A 512ASN A 563GLY A 366 | U V 3 ( 3.6A) C V 9 ( 3.9A) U V 3 ( 4.2A) A V 1 ( 3.0A) | 0.85A | 4forA-5m3hA:undetectable | 4forA-5m3hA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF03814(KdpA) | 4 | THR A 424GLY A 369VAL A 371ASN A 465 | None | 0.85A | 4forA-5mrwA:undetectable | 4forA-5mrwA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n05 | AUXILIARY ACTIVITY 9 (Lentinussimilis) |
PF03443(Glyco_hydro_61) | 4 | GLY A 57VAL A 128PRO A 130GLY A 220 | None | 0.66A | 4forA-5n05A:undetectable | 4forA-5n05A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbs | BETA-GLUCOSIDASE (Neurosporacrassa) |
no annotation | 4 | THR A 159GLY A 145PRO A 148GLY A 604 | None | 0.87A | 4forA-5nbsA:undetectable | 4forA-5nbsA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oex | - (-) |
no annotation | 4 | THR A 483GLY A 495VAL A 508ASN A 530 | CU A 604 ( 4.8A)NoneNoneNone | 0.67A | 4forA-5oexA:undetectable | 4forA-5oexA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tx7 | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASE FAMILYPROTEIN (Desulfovibriovulgaris) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | THR A 10GLY A 8VAL A 29PRO A 31 | None | 0.83A | 4forA-5tx7A:undetectable | 4forA-5tx7A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1j | THIOREDOXINGLUTATHIONEREDUCTASE (Echinococcusgranulosus) |
no annotation | 4 | THR A 470GLY A 479VAL A 538GLY A 535 | None | 0.79A | 4forA-5w1jA:undetectable | 4forA-5w1jA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1y | MERCURIC REDUCTASE (Lysinibacillussphaericus) |
no annotation | 4 | THR B 117GLY B 119ASN B 124GLY B 220 | NoneNoneNoneFAD B 601 (-3.1A) | 0.83A | 4forA-5x1yB:undetectable | 4forA-5x1yB:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xeb | ENVELOPEGLYCOPROTEIN (Dhorithogotovirus) |
PF03273(Baculo_gp64) | 4 | GLY A 190VAL A 186PRO A 188ASN A 189 | NoneNoneNoneNAG A 601 (-1.9A) | 0.86A | 4forA-5xebA:undetectable | 4forA-5xebA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xh9 | EXTRACELLULARINVERTASE (Aspergilluskawachii) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | GLY A 132PRO A 134ASN A 128GLY A 167 | None | 0.85A | 4forA-5xh9A:undetectable | 4forA-5xh9A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoy | [LYSW]-LYSINEHYDROLASE (Thermusthermophilus) |
PF01546(Peptidase_M20) | 4 | GLY A 320VAL A 90TYR A 317GLY A 147 | None | 0.84A | 4forA-5xoyA:undetectable | 4forA-5xoyA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xym | 50S RIBOSOMALPROTEIN L2 (Mycolicibacteriumsmegmatis) |
PF00181(Ribosomal_L2)PF03947(Ribosomal_L2_C) | 4 | GLY C 251VAL C 247PRO C 249GLY C 223 | G A2466 ( 3.7A)None A A2045 ( 3.9A) C A2046 ( 3.3A) | 0.83A | 4forA-5xymC:undetectable | 4forA-5xymC:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 4 | GLY A1583VAL A1579PRO A1581GLY A1003 | None | 0.51A | 4forA-6fb3A:undetectable | 4forA-6fb3A:12.84 |