SIMILAR PATTERNS OF AMINO ACIDS FOR 4FOR_A_FLPA711

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR


(Homo sapiens)
PF00092
(VWA)
4 VAL A 112
PRO A 139
ASN A 162
GLY A 141
None
0.86A 4forA-1ao3A:
undetectable
4forA-1ao3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bfo CAMPATH-1G ANTIBODY

(Rattus rattus)
PF07654
(C1-set)
PF07686
(V-set)
4 THR B  87
GLY B  16
VAL B  12
PRO B  14
None
0.84A 4forA-1bfoB:
undetectable
4forA-1bfoB:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis)
PF00405
(Transferrin)
7 THR A 430
GLY A 432
VAL A 591
PRO A 593
ASN A 594
TYR A 660
GLY A 662
None
0.50A 4forA-1biyA:
55.1
4forA-1biyA:
91.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLY A 260
VAL A 256
PRO A 258
GLY A 282
None
0.69A 4forA-1bxzA:
undetectable
4forA-1bxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)


(Desulfomicrobium
baculatum)
PF00374
(NiFeSe_Hases)
4 GLY L 462
PRO L 454
TYR L 317
GLY L  44
None
0.71A 4forA-1cc1L:
undetectable
4forA-1cc1L:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 THR A  14
GLY A  96
ASN A 141
GLY A 104
None
ADP  A 400 ( 4.0A)
ILE  A 500 (-4.2A)
None
0.72A 4forA-1h74A:
undetectable
4forA-1h74A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h76 SEROTRANSFERRIN

(Sus scrofa)
PF00405
(Transferrin)
5 GLY A 430
PRO A 592
ASN A 593
TYR A 658
GLY A 660
None
0.38A 4forA-1h76A:
50.6
4forA-1h76A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i6q LACTOFERRIN

(Camelus
dromedarius)
PF00405
(Transferrin)
5 GLY A 432
PRO A 593
ASN A 594
TYR A 660
GLY A 662
None
0.55A 4forA-1i6qA:
26.1
4forA-1i6qA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus)
PF00405
(Transferrin)
5 GLY A 424
PRO A 580
ASN A 581
TYR A 647
GLY A 649
None
0.46A 4forA-1jnfA:
50.2
4forA-1jnfA:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLY A1260
VAL A1256
PRO A1258
GLY A1282
None
0.72A 4forA-1jqbA:
undetectable
4forA-1jqbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE


(Homo sapiens)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 THR A 156
GLY A 158
PRO A 293
ASN A 294
FAD  A 499 (-3.9A)
None
None
FAD  A 499 ( 4.5A)
0.82A 4forA-1k4qA:
undetectable
4forA-1k4qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B


(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
4 THR A 129
GLY A 115
ASN A 112
GLY A  44
None
0.83A 4forA-1kwmA:
undetectable
4forA-1kwmA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n76 LACTOFERRIN

(Homo sapiens)
PF00405
(Transferrin)
5 GLY A 434
PRO A 595
ASN A 596
TYR A 662
GLY A 664
None
0.48A 4forA-1n76A:
53.0
4forA-1n76A:
68.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE


(Pseudomonas
putida)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
4 THR A 110
GLY A 112
PRO A 250
ASN A 251
FAD  A 749 (-4.2A)
FAD  A 749 (-4.6A)
None
FAD  A 749 ( 4.6A)
0.68A 4forA-1q1rA:
undetectable
4forA-1q1rA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjm LACTOFERRIN

(Equus caballus)
PF00405
(Transferrin)
5 GLY A 432
PRO A 593
ASN A 594
TYR A 660
GLY A 662
None
0.61A 4forA-1qjmA:
53.4
4forA-1qjmA:
45.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
4 GLY A  43
VAL A  47
PRO A  45
GLY A  93
None
0.83A 4forA-1rzvA:
undetectable
4forA-1rzvA:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1suv SEROTRANSFERRIN,
C-LOBE


(Homo sapiens)
PF00405
(Transferrin)
5 GLY E 424
PRO E 580
ASN E 581
TYR E 647
GLY E 649
None
0.46A 4forA-1suvE:
50.0
4forA-1suvE:
58.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN


(Salmonella
enterica)
PF13407
(Peripla_BP_4)
4 GLY A 320
VAL A 304
PRO A 306
ASN A 307
None
0.42A 4forA-1tjyA:
2.4
4forA-1tjyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus)
PF03989
(DNA_gyraseA_C)
4 THR A 136
GLY A  60
VAL A 146
GLY A 184
None
0.52A 4forA-1wp5A:
undetectable
4forA-1wp5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x99 LECTIN

(Xerocomellus
chrysenteron)
PF07367
(FB_lectin)
4 THR A  27
GLY A  55
VAL A  71
ASN A  96
None
0.80A 4forA-1x99A:
undetectable
4forA-1x99A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens)
PF00246
(Peptidase_M14)
4 THR A 129
GLY A 115
ASN A 112
GLY A  44
None
0.86A 4forA-1zliA:
undetectable
4forA-1zliA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 GLY A 561
VAL A 213
PRO A 563
ASN A 519
None
0.83A 4forA-2e8yA:
undetectable
4forA-2e8yA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785


(Thermus
thermophilus)
PF01139
(RtcB)
4 GLY A 279
VAL A  87
PRO A 273
GLY A  84
None
0.76A 4forA-2epgA:
undetectable
4forA-2epgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL


(Sus scrofa)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
4 GLY A 187
PRO A 130
ASN A 192
GLY A 106
None
0.84A 4forA-2fpgA:
undetectable
4forA-2fpgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1k SHIKIMATE KINASE

(Mycobacterium
tuberculosis)
PF01202
(SKI)
4 GLY A 156
VAL A 159
ASN A 154
GLY A  14
None
None
None
SO4  A 501 (-3.1A)
0.73A 4forA-2g1kA:
undetectable
4forA-2g1kA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hau SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
5 GLY A 425
PRO A 583
ASN A 584
TYR A 650
GLY A 652
None
0.65A 4forA-2hauA:
25.7
4forA-2hauA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
4 THR X 130
GLY X 380
ASN X 132
GLY X 345
None
0.74A 4forA-2iv2X:
undetectable
4forA-2iv2X:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1


(Arabidopsis
thaliana)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
4 GLY A 173
VAL A 161
TYR A 148
GLY A 146
None
0.85A 4forA-2j3hA:
undetectable
4forA-2j3hA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE


(Escherichia
coli)
PF01204
(Trehalase)
4 THR A 439
VAL A 500
PRO A 450
GLY A 508
None
0.85A 4forA-2jf4A:
undetectable
4forA-2jf4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 THR A 154
GLY A 221
ASN A 267
GLY A 258
None
0.80A 4forA-2o5pA:
undetectable
4forA-2o5pA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE


(Marichromatium
gracile)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 140
PRO A 264
ASN A 265
GLY A 305
None
None
FAD  A 500 ( 4.7A)
None
0.83A 4forA-2r9zA:
undetectable
4forA-2r9zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II


(Streptococcus
pneumoniae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 THR A 393
GLY A 343
ASN A 168
GLY A 108
None
0.83A 4forA-2rjtA:
undetectable
4forA-2rjtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 GLY A 264
PRO A 261
TYR A 254
GLY A 257
None
0.87A 4forA-2v4jA:
undetectable
4forA-2v4jA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE


(Schistosoma
mansoni)
PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 THR A 471
GLY A 480
VAL A 539
GLY A 536
None
0.82A 4forA-2v6oA:
undetectable
4forA-2v6oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica)
PF06917
(Pectate_lyase_2)
4 GLY A  42
VAL A  37
PRO A  39
GLY A 469
None
0.76A 4forA-2v8jA:
undetectable
4forA-2v8jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnr CPE0329

(Clostridium
perfringens)
PF08305
(NPCBM)
4 THR A 165
GLY A 123
VAL A 197
GLY A 193
None
0.82A 4forA-2vnrA:
undetectable
4forA-2vnrA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 GLY A 772
VAL A 431
PRO A 774
ASN A 730
None
0.80A 4forA-2wanA:
undetectable
4forA-2wanA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus)
PF00258
(Flavodoxin_1)
4 GLY A  98
VAL A 108
PRO A  56
GLY A  54
FMN  A 183 (-3.2A)
FMN  A 183 (-4.1A)
FMN  A 183 (-4.2A)
None
0.85A 4forA-2wc1A:
undetectable
4forA-2wc1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xc8 GENE 22 PRODUCT

(Bacillus phage
SPP1)
no annotation 4 GLY A 107
VAL A 103
PRO A 105
ASN A 106
None
0.87A 4forA-2xc8A:
undetectable
4forA-2xc8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE


(Burkholderia
cenocepacia)
PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2)
4 GLY A 238
VAL A 247
TYR A 136
GLY A 146
GOL  A 505 ( 3.4A)
None
None
None
0.83A 4forA-2y27A:
undetectable
4forA-2y27A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE


(Streptococcus
pneumoniae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD)
4 THR A 751
GLY A 749
TYR A 812
GLY A 781
None
0.84A 4forA-2ya1A:
undetectable
4forA-2ya1A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE


(Streptococcus
pneumoniae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 THR A 296
GLY A 294
TYR A 357
GLY A 326
None
0.84A 4forA-2ya2A:
undetectable
4forA-2ya2A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN


(Thermosynechococcus
vulcanus)
PF00421
(PSII)
4 GLY B 196
VAL B 181
PRO B 183
GLY B 154
None
0.82A 4forA-3a0hB:
undetectable
4forA-3a0hB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA


(Salmonella
enterica)
PF00771
(FHIPEP)
4 GLY A 460
VAL A 455
PRO A 457
GLY A 430
None
0.87A 4forA-3a5iA:
undetectable
4forA-3a5iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crw XPD/RAD3 RELATED DNA
HELICASE


(Sulfolobus
acidocaldarius)
PF06733
(DEAD_2)
PF13307
(Helicase_C_2)
4 GLY 1 323
PRO 1  30
ASN 1  28
GLY 1  34
None
0.82A 4forA-3crw1:
undetectable
4forA-3crw1:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctp PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Alkaliphilus
metalliredigens)
PF13377
(Peripla_BP_3)
4 THR A 280
GLY A 265
VAL A 237
GLY A 234
None
0.87A 4forA-3ctpA:
undetectable
4forA-3ctpA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK


(Xanthomonas
campestris)
no annotation 4 GLY A 333
VAL A 319
PRO A 321
ASN A 322
None
0.77A 4forA-3cv3A:
undetectable
4forA-3cv3A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE


(Methanococcus
maripaludis)
PF08241
(Methyltransf_11)
4 GLY A 150
ASN A  34
TYR A 144
GLY A 146
None
0.84A 4forA-3dlcA:
undetectable
4forA-3dlcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLY A 260
VAL A 256
PRO A 258
GLY A 282
None
0.69A 4forA-3fplA:
undetectable
4forA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLY A 260
VAL A 256
PRO A 258
GLY A 282
ZN  A 354 (-4.3A)
None
None
None
0.74A 4forA-3fsrA:
undetectable
4forA-3fsrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA


(Bacillus
subtilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 THR A 330
GLY A 334
VAL A 337
GLY A 199
None
0.73A 4forA-3gdoA:
undetectable
4forA-3gdoA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE


(Mus musculus)
PF00405
(Transferrin)
4 GLY A 426
PRO A 586
TYR A 652
GLY A 654
None
0.36A 4forA-3mc2A:
15.6
4forA-3mc2A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE


(Bartonella
henselae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 THR A 342
GLY A 351
VAL A 406
GLY A 403
None
0.81A 4forA-3o0hA:
undetectable
4forA-3o0hA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR


(Escherichia
coli;
Homo sapiens)
PF08205
(C2-set_2)
PF13416
(SBP_bac_8)
4 GLY N1082
VAL N1078
PRO N1080
ASN N1081
None
0.85A 4forA-3o3uN:
4.9
4forA-3o3uN:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
4 GLY A 632
VAL A 599
ASN A 664
GLY A 692
None
0.87A 4forA-3o8oA:
undetectable
4forA-3o8oA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj0 GLUTAMYL-TRNA
REDUCTASE


(Thermoplasma
volcanium)
PF01488
(Shikimate_DH)
4 THR A  83
GLY A 107
PRO A 110
ASN A 111
None
GOL  A 146 (-3.9A)
None
None
0.79A 4forA-3oj0A:
undetectable
4forA-3oj0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima)
PF01979
(Amidohydro_1)
4 GLY A 120
VAL A 118
ASN A  81
GLY A  67
None
0.81A 4forA-3ooqA:
undetectable
4forA-3ooqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbr SJCHGC06286 PROTEIN

(Schistosoma
japonicum)
PF00452
(Bcl-2)
4 GLY A 110
VAL A 113
ASN A 108
GLY A 162
None
0.70A 4forA-3qbrA:
undetectable
4forA-3qbrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdt BOLETUS EDULIS
LECTIN


(Boletus edulis)
PF07367
(FB_lectin)
4 THR A  24
GLY A  52
VAL A  68
ASN A  93
None
0.76A 4forA-3qdtA:
undetectable
4forA-3qdtA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 GLY X 114
VAL X 143
PRO X 119
ASN X 109
None
0.65A 4forA-3rwkX:
undetectable
4forA-3rwkX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri)
PF01979
(Amidohydro_1)
4 GLY A 425
VAL A 400
PRO A 398
GLY A  47
None
None
ACT  A 463 ( 4.7A)
ACT  A 463 (-3.8A)
0.83A 4forA-3sfwA:
undetectable
4forA-3sfwA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
4 THR A  33
GLY A 248
ASN A 246
GLY A 162
None
FMN  A 401 (-3.3A)
None
None
0.72A 4forA-3sgzA:
undetectable
4forA-3sgzA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3skp SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
4 GLY A 425
PRO A 583
ASN A 584
TYR A 650
None
0.48A 4forA-3skpA:
24.5
4forA-3skpA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3skp SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
4 PRO A 583
ASN A 584
TYR A 650
GLY A 652
None
None
None
SO4  A 683 (-3.4A)
0.46A 4forA-3skpA:
24.5
4forA-3skpA:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB


(Yersinia pestis)
PF13407
(Peripla_BP_4)
4 GLY A 319
VAL A 303
PRO A 305
ASN A 306
None
0.35A 4forA-3t95A:
2.5
4forA-3t95A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT


(Vibrio
vulnificus)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
4 GLY A 405
VAL A 361
PRO A 363
GLY A 313
None
0.78A 4forA-3ufbA:
undetectable
4forA-3ufbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
4 GLY B 459
PRO B 451
TYR B 313
GLY B  49
None
0.68A 4forA-3ze7B:
undetectable
4forA-3ze7B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL


(Homo sapiens)
PF07992
(Pyr_redox_2)
PF14721
(AIF_C)
4 THR A 260
GLY A 262
PRO A 402
ASN A 403
FAD  A1449 (-4.1A)
None
None
FAD  A1449 ( 4.5A)
0.84A 4forA-4bv6A:
undetectable
4forA-4bv6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB


(Pyrococcus
horikoshii)
PF01139
(RtcB)
4 GLY A 372
VAL A 364
PRO A 358
GLY A 400
None
0.84A 4forA-4dwqA:
undetectable
4forA-4dwqA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus)
PF00405
(Transferrin)
7 THR A 430
GLY A 432
VAL A 591
PRO A 593
ASN A 594
TYR A 660
GLY A 662
None
CEL  A 711 (-3.7A)
None
CEL  A 711 (-4.3A)
None
CEL  A 711 (-4.4A)
CEL  A 711 (-3.3A)
0.08A 4forA-4fimA:
61.0
4forA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC


(Rattus
norvegicus)
no annotation 4 THR E 372
GLY E 381
VAL E 440
GLY E 437
None
0.75A 4forA-4kprE:
undetectable
4forA-4kprE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp4 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR


(Homo sapiens)
PF00047
(ig)
PF08205
(C2-set_2)
4 GLY A  82
VAL A  78
PRO A  80
ASN A  81
None
0.83A 4forA-4lp4A:
undetectable
4forA-4lp4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens)
PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 GLY A 105
VAL A  93
PRO A  91
GLY A  74
None
0.64A 4forA-4nenA:
undetectable
4forA-4nenA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN


(Bacillus
anthracis)
PF13407
(Peripla_BP_4)
4 GLY A 327
VAL A 311
PRO A 313
ASN A 314
None
0.38A 4forA-4pz0A:
undetectable
4forA-4pz0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV


(Bacteroides
ovatus)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
4 GLY A  38
VAL A 718
PRO A  36
GLY A 536
None
0.67A 4forA-4q1vA:
undetectable
4forA-4q1vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE


(Sphaerobacter
thermophilus)
PF01546
(Peptidase_M20)
4 GLY A 323
VAL A  94
TYR A 320
GLY A 150
None
0.85A 4forA-4q7aA:
undetectable
4forA-4q7aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlz CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
4 GLY A 308
VAL A 304
PRO A 306
ASN A 307
None
0.81A 4forA-4rlzA:
undetectable
4forA-4rlzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY


(Desulfitobacterium
hafniense)
PF13472
(Lipase_GDSL_2)
4 GLY A 220
VAL A  78
PRO A  76
GLY A  66
None
0.81A 4forA-4rshA:
undetectable
4forA-4rshA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6)
PF13417
(GST_N_3)
5 GLY A 180
PRO A 184
ASN A 185
TYR A 189
GLY A 220
None
0.95A 4forA-4yamA:
undetectable
4forA-4yamA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywk CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus)
PF14551
(MCM_N)
PF17207
(MCM_OB)
4 GLY A  67
VAL A  60
PRO A  64
GLY A 225
None
0.77A 4forA-4ywkA:
undetectable
4forA-4ywkA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD


(Shewanella
oneidensis)
PF03060
(NMO)
4 THR A 357
GLY A 488
PRO A 485
GLY A 275
None
None
None
FMN  A 602 ( 4.3A)
0.82A 4forA-4z9rA:
undetectable
4forA-4z9rA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE


(Thioalkalivibrio
paradoxus)
no annotation 4 THR A 483
GLY A 495
VAL A 508
ASN A 530
None
0.67A 4forA-5f75A:
undetectable
4forA-5f75A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium)
PF00202
(Aminotran_3)
4 GLY A  65
VAL A  62
ASN A 448
GLY A 444
None
0.83A 4forA-5g0aA:
undetectable
4forA-5g0aA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE EPSILON
CHAIN
ATP SYNTHASE GAMMA
CHAIN


(Caldalkalibacillus
thermarum)
PF00231
(ATP-synt)
PF02823
(ATP-synt_DE_N)
4 THR G  38
VAL H   9
PRO H  11
TYR G 227
None
0.75A 4forA-5ik2G:
undetectable
4forA-5ik2G:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 GLY A 276
VAL A 218
PRO A 214
GLY A 208
None
0.82A 4forA-5j0aA:
undetectable
4forA-5j0aA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa)
PF00246
(Peptidase_M14)
4 THR A 129
GLY A 115
ASN A 112
GLY A  44
None
0.83A 4forA-5j1qA:
undetectable
4forA-5j1qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knl UBIQUITIN-CONJUGATIN
G ENZYME E2 15


(Schizosaccharomyces
pombe)
PF00179
(UQ_con)
4 GLY C  87
VAL C  83
PRO C  85
ASN C  86
None
0.87A 4forA-5knlC:
undetectable
4forA-5knlC:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN


(Influenza A
virus)
PF00603
(Flu_PA)
4 GLY A 564
VAL A 512
ASN A 563
GLY A 366
U  V   3 ( 3.6A)
C  V   9 ( 3.9A)
U  V   3 ( 4.2A)
A  V   1 ( 3.0A)
0.85A 4forA-5m3hA:
undetectable
4forA-5m3hA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT


(Escherichia
coli)
PF03814
(KdpA)
4 THR A 424
GLY A 369
VAL A 371
ASN A 465
None
0.85A 4forA-5mrwA:
undetectable
4forA-5mrwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis)
PF03443
(Glyco_hydro_61)
4 GLY A  57
VAL A 128
PRO A 130
GLY A 220
None
0.66A 4forA-5n05A:
undetectable
4forA-5n05A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa)
no annotation 4 THR A 159
GLY A 145
PRO A 148
GLY A 604
None
0.87A 4forA-5nbsA:
undetectable
4forA-5nbsA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-)
no annotation 4 THR A 483
GLY A 495
VAL A 508
ASN A 530
CU  A 604 ( 4.8A)
None
None
None
0.67A 4forA-5oexA:
undetectable
4forA-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN


(Desulfovibrio
vulgaris)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 THR A  10
GLY A   8
VAL A  29
PRO A  31
None
0.83A 4forA-5tx7A:
undetectable
4forA-5tx7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE


(Echinococcus
granulosus)
no annotation 4 THR A 470
GLY A 479
VAL A 538
GLY A 535
None
0.79A 4forA-5w1jA:
undetectable
4forA-5w1jA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus)
no annotation 4 THR B 117
GLY B 119
ASN B 124
GLY B 220
None
None
None
FAD  B 601 (-3.1A)
0.83A 4forA-5x1yB:
undetectable
4forA-5x1yB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeb ENVELOPE
GLYCOPROTEIN


(Dhori
thogotovirus)
PF03273
(Baculo_gp64)
4 GLY A 190
VAL A 186
PRO A 188
ASN A 189
None
None
None
NAG  A 601 (-1.9A)
0.86A 4forA-5xebA:
undetectable
4forA-5xebA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE


(Aspergillus
kawachii)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 GLY A 132
PRO A 134
ASN A 128
GLY A 167
None
0.85A 4forA-5xh9A:
undetectable
4forA-5xh9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE


(Thermus
thermophilus)
PF01546
(Peptidase_M20)
4 GLY A 320
VAL A  90
TYR A 317
GLY A 147
None
0.84A 4forA-5xoyA:
undetectable
4forA-5xoyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L2


(Mycolicibacterium
smegmatis)
PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C)
4 GLY C 251
VAL C 247
PRO C 249
GLY C 223
G  A2466 ( 3.7A)
None
A  A2045 ( 3.9A)
C  A2046 ( 3.3A)
0.83A 4forA-5xymC:
undetectable
4forA-5xymC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 4 GLY A1583
VAL A1579
PRO A1581
GLY A1003
None
0.51A 4forA-6fb3A:
undetectable
4forA-6fb3A:
12.84