SIMILAR PATTERNS OF AMINO ACIDS FOR 4FO4_B_MOAB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		4 SER A 173
ASN A 201
GLY A 224
THR A 231
 None
 0.67A 4fo4B-1eepA:
44.3		 4fo4B-1eepA:
50.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 SER A 275
SER A 276
ASN A 303
GLY A 326
 None
None
CPR  A 631 ( 4.5A)
None
 0.50A 4fo4B-1jcnA:
39.9		 4fo4B-1jcnA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 SER A 275
ASN A 303
GLY A 326
CYH A 331
THR A 333
GLY A 415
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 ( 3.1A)
 0.74A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 SER A 275
ASN A 303
GLY A 326
THR A 333
MET A 414
GLY A 415
 None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.69A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 SER A 276
ASN A 303
GLY A 326
CYH A 331
THR A 333
GLY A 415
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
IMP  A1331 ( 3.1A)
 0.53A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 SER A 276
ASN A 303
GLY A 326
THR A 333
MET A 414
GLY A 415
 MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.46A 4fo4B-1jr1A:
50.8		 4fo4B-1jr1A:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgb LACTOTRANSFERRIN (N2
FRAGMENT)

(Homo sapiens) 		PF00405
(Transferrin) 		4 SER C 185
SER C 184
GLY C 160
GLY C 175
 None
 0.84A 4fo4B-1lgbC:
undetectable		 4fo4B-1lgbC:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		6 SER A 262
SER A 263
ASN A 291
GLY A 314
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.66A 4fo4B-1lrtA:
46.3		 4fo4B-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 262
SER A 263
ASN A 291
GLY A 314
GLY A 409
 NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.1A)
XMP  A 602 ( 3.1A)
 0.58A 4fo4B-1mewA:
45.5		 4fo4B-1mewA:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 SER B 215
ASN B 273
GLY B 269
GLY A  41
 None
None
MCN  B4920 ( 3.7A)
FES  A4908 (-4.3A)
 0.74A 4fo4B-1n60B:
undetectable		 4fo4B-1n60B:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 234
THR A 237
MET A 372
GLY A 373
 None
None
None
CA  A1658 (-4.0A)
 0.84A 4fo4B-1qlbA:
undetectable		 4fo4B-1qlbA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		4 SER A  41
SER A 112
GLY A 109
GLY A  99
 None
 0.85A 4fo4B-1u10A:
undetectable		 4fo4B-1u10A:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASN A 273
GLY A 296
CYH A 301
THR A 303
 None
 0.76A 4fo4B-1vrdA:
46.1		 4fo4B-1vrdA:
46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 ASN A  90
GLY A 390
THR A 487
GLY A 323
 None
 0.86A 4fo4B-1xjeA:
2.1		 4fo4B-1xjeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		4 SER A 137
GLY A  97
THR A  56
GLY A 111
 None
FMN  A1200 (-3.3A)
FMN  A1200 (-3.7A)
None
 0.69A 4fo4B-1yobA:
undetectable		 4fo4B-1yobA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 112
SER A  89
GLY A  21
GLY A  12
 None
 0.88A 4fo4B-1ys4A:
undetectable		 4fo4B-1ys4A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASN A 282
GLY A 305
CYH A 310
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
None
None
IMP  A 500 (-3.0A)
 0.24A 4fo4B-1zfjA:
51.0		 4fo4B-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ASN A 158
GLY A 181
CYH A 186
THR A 188
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
 0.87A 4fo4B-2bwgA:
41.5		 4fo4B-2bwgA:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ASN A 158
GLY A 181
THR A 188
GLY A 290
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.1A)
 0.88A 4fo4B-2bwgA:
41.5		 4fo4B-2bwgA:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		5 ASN A 158
GLY A 181
CYH A 186
THR A 188
MET A 269
 IMP  A1338 ( 4.3A)
None
IMP  A1338 (-2.5A)
None
None
 0.48A 4fo4B-2bznA:
42.0		 4fo4B-2bznA:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 ASN A 151
GLY A 106
THR A 108
GLY A  80
 None
None
None
PLP  A1202 (-3.0A)
 0.79A 4fo4B-2cb1A:
undetectable		 4fo4B-2cb1A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 GLY A  35
THR A   2
MET A 203
GLY A 204
 None
 0.87A 4fo4B-2cfoA:
undetectable		 4fo4B-2cfoA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASN A 275
GLY A 296
CYH A 301
THR A 303
MET A 384
GLY A 385
 XMP  A1001 ( 4.4A)
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
None
XMP  A1001 (-3.1A)
 0.32A 4fo4B-2cu0A:
49.1		 4fo4B-2cu0A:
41.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.85A 4fo4B-2d0vA:
undetectable		 4fo4B-2d0vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 106
ASN A 148
GLY A 332
GLY A  17
 None
 0.63A 4fo4B-2ep5A:
undetectable		 4fo4B-2ep5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		4 SER A 100
GLY A  77
THR A  74
GLY B 212
 None
 0.82A 4fo4B-2gezA:
undetectable		 4fo4B-2gezA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ASN A  47
GLY A  77
THR A 236
GLY A  88
 None
 0.69A 4fo4B-2gkoA:
undetectable		 4fo4B-2gkoA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 SER A 175
SER A 207
THR A 248
GLY A 140
 None
None
PMS  A 601 (-4.7A)
None
 0.84A 4fo4B-2gkoA:
undetectable		 4fo4B-2gkoA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 231
THR A 234
MET A 367
GLY A 368
 None
None
None
K  A 622 (-4.4A)
 0.77A 4fo4B-2h88A:
undetectable		 4fo4B-2h88A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASN A 473
GLY A 446
THR A 398
GLY A 547
 None
TPP  A3001 (-3.4A)
TPP  A3001 (-3.7A)
None
 0.67A 4fo4B-2q27A:
undetectable		 4fo4B-2q27A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		4 SER A  44
ASN A  74
GLY A  72
GLY A 108
 None
PLP  A 400 (-3.3A)
None
None
 0.88A 4fo4B-2rkbA:
undetectable		 4fo4B-2rkbA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4i GLUTAMATE RACEMASE

(Helicobacter
pylori) 		PF01177
(Asp_Glu_race) 		4 SER A 143
CYH A  70
THR A  72
GLY A 180
 None
DGL  A1256 (-3.1A)
DGL  A1256 (-3.8A)
None
 0.77A 4fo4B-2w4iA:
undetectable		 4fo4B-2w4iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 501 (-2.2A)
SF4  A 501 ( 4.2A)
None
 0.73A 4fo4B-2xsjA:
undetectable		 4fo4B-2xsjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 SER A 443
SER A 409
GLY A 352
GLY A 412
 None
 0.67A 4fo4B-2y8nA:
undetectable		 4fo4B-2y8nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 SER A 267
GLY A 260
THR A 248
GLY A 274
 SAH  A 376 ( 4.4A)
None
None
None
 0.86A 4fo4B-2zwvA:
undetectable		 4fo4B-2zwvA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 SER A 149
SER A 150
GLY A 156
GLY A 174
 None
 0.78A 4fo4B-3a1iA:
undetectable		 4fo4B-3a1iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 410 (-2.4A)
PLP  A 410 (-3.2A)
None
None
 0.87A 4fo4B-3aatA:
undetectable		 4fo4B-3aatA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 ASN B  60
GLY B 356
THR B 360
GLY B  32
 FAD  B   1 (-3.9A)
FAD  B   1 (-3.0A)
None
None
 0.84A 4fo4B-3adaB:
undetectable		 4fo4B-3adaB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		4 ASN A  47
GLY A  77
THR A 237
GLY A  89
 None
 0.69A 4fo4B-3d43A:
undetectable		 4fo4B-3d43A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		4 SER A 478
GLY A 427
CYH A 421
GLY A 481
 FMN  A 700 (-3.3A)
None
None
FMN  A 700 (-3.7A)
 0.88A 4fo4B-3eo7A:
undetectable		 4fo4B-3eo7A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE

(Eubacterium
barkeri) 		PF04303
(PrpF) 		4 SER A  17
GLY A 154
THR A 302
GLY A 305
 None
 0.80A 4fo4B-3g7kA:
undetectable		 4fo4B-3g7kA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 GLY D  45
CYH D  63
THR D  60
GLY C  32
 FES  D 908 ( 3.2A)
FAD  C 900 ( 3.9A)
FES  D 908 (-4.2A)
FAD  C 900 (-3.4A)
 0.75A 4fo4B-3hrdD:
undetectable		 4fo4B-3hrdD:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 GLY A 254
THR A 258
MET A 301
GLY A 300
 None
 0.81A 4fo4B-3iupA:
undetectable		 4fo4B-3iupA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 SER A 164
ASN A 191
GLY A 214
THR A 221
 None
IMP  A 801 ( 4.2A)
None
None
 0.54A 4fo4B-3khjA:
45.5		 4fo4B-3khjA:
57.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLY A  18
THR A  21
MET A 232
GLY A 231
 None
 0.81A 4fo4B-3lmdA:
undetectable		 4fo4B-3lmdA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASN A  53
GLY A 111
THR A 257
GLY A 122
 None
None
None
CA  A   1 ( 4.3A)
 0.64A 4fo4B-3lpdA:
undetectable		 4fo4B-3lpdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASN A 282
CYH A 266
THR A 268
MET A 289
 None
SF4  A 576 (-2.2A)
SF4  A 576 ( 4.4A)
None
 0.84A 4fo4B-3mm5A:
undetectable		 4fo4B-3mm5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 801 (-2.4A)
SF4  A 801 ( 4.1A)
None
 0.75A 4fo4B-3or2A:
undetectable		 4fo4B-3or2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 4 SER A  43
ASN A  42
GLY A 131
MET A  38
 None
 0.83A 4fo4B-3pf7A:
undetectable		 4fo4B-3pf7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 SER A 179
SER A 178
GLY A 175
GLY A 219
 None
 0.89A 4fo4B-3q6dA:
undetectable		 4fo4B-3q6dA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 SER A 336
GLY A 156
MET A 333
GLY A 326
 None
 0.79A 4fo4B-3qboA:
undetectable		 4fo4B-3qboA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASN A  53
GLY A 111
THR A 257
GLY A 122
 None
None
None
CA  A 353 ( 4.3A)
 0.64A 4fo4B-3ti7A:
undetectable		 4fo4B-3ti7A:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASN A 280
GLY A 303
CYH A 308
THR A 310
 XMP  A 500 ( 4.4A)
None
XMP  A 500 (-3.3A)
XMP  A 500 (-4.5A)
 0.58A 4fo4B-3tsdA:
46.7		 4fo4B-3tsdA:
47.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE

(Oleispira
antarctica) 		PF01557
(FAA_hydrolase) 		4 SER A 206
GLY A  98
THR A 130
GLY A  54
 None
 0.82A 4fo4B-3v77A:
undetectable		 4fo4B-3v77A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 SER A 677
ASN A 554
GLY A 617
THR A 613
 None
 0.83A 4fo4B-3ve2A:
undetectable		 4fo4B-3ve2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 254
THR A 257
MET A 390
GLY A 391
 None
 0.76A 4fo4B-3vrbA:
undetectable		 4fo4B-3vrbA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASN B 317
GLY B 340
CYH B 345
GLY B 427
 MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 (-3.2A)
 0.82A 4fo4B-4af0B:
48.1		 4fo4B-4af0B:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 SER B 289
SER B 290
ASN B 317
GLY B 340
CYH B 345
MET B 428
GLY B 429
 MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
None
IMP  B1527 ( 3.3A)
 0.37A 4fo4B-4af0B:
48.1		 4fo4B-4af0B:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 SER A 413
GLY A 408
MET A 314
GLY A 315
 None
 0.69A 4fo4B-4af1A:
undetectable		 4fo4B-4af1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 SER A 285
SER A 304
GLY A 323
GLY A 416
 None
 0.86A 4fo4B-4c60A:
3.8		 4fo4B-4c60A:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASN A 279
GLY A 341
MET A 390
GLY A 389
 MOA  A 702 (-3.5A)
IMP  A 701 (-3.5A)
None
IMP  A 701 (-3.1A)
 0.88A 4fo4B-4fxsA:
59.5		 4fo4B-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		8 SER A 251
SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.23A 4fo4B-4fxsA:
59.5		 4fo4B-4fxsA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 SER A 268
ASN A 267
GLY A 470
GLY A 427
 None
HEM  A 701 ( 3.4A)
None
None
 0.87A 4fo4B-4hhrA:
undetectable		 4fo4B-4hhrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
 0.68A 4fo4B-4hucA:
undetectable		 4fo4B-4hucA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		7 SER A 251
SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
MET A 390
 None
None
IMP  A 501 ( 4.4A)
None
IMP  A 501 (-4.9A)
None
None
 0.43A 4fo4B-4ix2A:
57.2		 4fo4B-4ix2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmn PROBABLE
L,D-TRANSPEPTIDASE
LDTA

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASN A 228
GLY A 153
THR A 159
GLY A 204
 None
 0.80A 4fo4B-4jmnA:
undetectable		 4fo4B-4jmnA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		4 SER A 261
ASN A 260
GLY A 463
GLY A 420
 None
HEM  A 701 ( 3.3A)
None
None
 0.85A 4fo4B-4kvlA:
undetectable		 4fo4B-4kvlA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius) 		no annotation 4 ASN A  15
GLY A 170
THR A 133
GLY A 116
 None
 0.82A 4fo4B-4l1yA:
undetectable		 4fo4B-4l1yA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		7 SER A 245
ASN A 273
GLY A 296
CYH A 301
THR A 303
MET A 384
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
None
IMP  A 500 ( 3.3A)
 0.31A 4fo4B-4mz1A:
51.3		 4fo4B-4mz1A:
59.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		4 SER A  72
GLY A  34
THR A 172
GLY A  42
 None
NA  A 406 ( 4.4A)
None
None
 0.71A 4fo4B-4py9A:
undetectable		 4fo4B-4py9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
None
None
3V5  A 502 (-3.3A)
 0.69A 4fo4B-4qtfA:
undetectable		 4fo4B-4qtfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 SER A 288
SER A 289
ASN A 367
GLY A 315
 None
None
None
EDO  A 510 ( 3.7A)
 0.89A 4fo4B-4tlgA:
undetectable		 4fo4B-4tlgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x90 GROUP XV
PHOSPHOLIPASE A2

(Homo sapiens) 		PF02450
(LCAT) 		4 SER A 334
GLY A 324
THR A 305
GLY A 300
 None
 0.83A 4fo4B-4x90A:
undetectable		 4fo4B-4x90A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		4 SER A 179
GLY A 145
THR A  90
GLY A 118
 FMN  A 401 (-3.6A)
None
FMN  A 401 (-4.0A)
CL  A 402 ( 3.8A)
 0.85A 4fo4B-4xq6A:
19.1		 4fo4B-4xq6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvo L,D-TRANSPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF03734
(YkuD) 		4 ASN A 236
GLY A 161
THR A 167
GLY A 212
 PO4  A 501 (-3.5A)
None
None
None
 0.79A 4fo4B-4xvoA:
undetectable		 4fo4B-4xvoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 SER A  38
ASN A  33
GLY A  35
GLY A  65
 None
None
CSO  A  42 ( 3.8A)
None
 0.86A 4fo4B-4y1yA:
undetectable		 4fo4B-4y1yA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 ASN A 362
GLY A 291
THR A 300
GLY A 338
 None
None
None
DWZ  A 503 (-2.8A)
 0.75A 4fo4B-4zfqA:
undetectable		 4fo4B-4zfqA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		4 GLY A 351
CYH A 326
THR A 322
GLY A 295
 None
 0.72A 4fo4B-5aexA:
undetectable		 4fo4B-5aexA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		6 ASN A 276
GLY A 299
CYH A 304
THR A 306
MET A 387
GLY A 388
 IMP  A 501 ( 4.3A)
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
 0.26A 4fo4B-5ahmA:
55.1		 4fo4B-5ahmA:
65.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Stackebrandtia
nassauensis) 		PF03734
(YkuD) 		4 ASN A 275
GLY A 215
THR A 221
GLY A 253
 None
 0.78A 4fo4B-5bmqA:
undetectable		 4fo4B-5bmqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 SER A 166
GLY A  54
THR A  48
GLY A 439
 None
 0.78A 4fo4B-5cd6A:
undetectable		 4fo4B-5cd6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		4 SER A 164
ASN A 163
GLY A 194
GLY A 200
 None
None
PLP  A 402 (-3.5A)
None
 0.61A 4fo4B-5cvcA:
undetectable		 4fo4B-5cvcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  21
SER H   7
GLY H  10
GLY H 114
 None
 0.88A 4fo4B-5fuzH:
undetectable		 4fo4B-5fuzH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h69 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF06470
(SMC_hinge) 		4 SER A 674
SER A 671
GLY A 544
GLY A 502
 None
 0.87A 4fo4B-5h69A:
undetectable		 4fo4B-5h69A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 GLY A 497
THR A 549
MET A 584
GLY A 585
 None
 0.82A 4fo4B-5n4cA:
undetectable		 4fo4B-5n4cA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 6 ASN A 173
GLY A 196
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.32A 4fo4B-5ou3A:
51.9		 4fo4B-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 SER A 278
SER A 279
ASN A 306
GLY A 329
THR A 336
GLY A 418
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-3.1A)
 0.63A 4fo4B-5tc3A:
47.8		 4fo4B-5tc3A:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		4 GLY A  36
THR A   3
MET A 206
GLY A 207
 None
 0.86A 4fo4B-5tgtA:
undetectable		 4fo4B-5tgtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		4 GLY A 197
THR A 201
MET A 183
GLY A 182
 None
 0.76A 4fo4B-5tsbA:
undetectable		 4fo4B-5tsbA:
25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		6 ASN A 280
GLY A 303
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 500 ( 4.3A)
None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
None
IMP  A 500 ( 3.3A)
 0.22A 4fo4B-5upyA:
52.7		 4fo4B-5upyA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		6 ASN A 280
GLY A 303
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
None
IMP  A 501 ( 3.2A)
 0.24A 4fo4B-5uuwA:
52.6		 4fo4B-5uuwA:
63.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwv L,D-TRANSPEPTIDASE 2

(Mycobacteroides
abscessus) 		no annotation 4 ASN B 353
GLY B 278
THR B 284
GLY B 329
 None
 0.74A 4fo4B-5uwvB:
undetectable		 4fo4B-5uwvB:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		6 ASN A 275
GLY A 298
CYH A 303
THR A 305
MET A 386
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.27A 4fo4B-5uzeA:
55.0		 4fo4B-5uzeA:
62.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 ASN A 290
GLY A 313
CYH A 318
THR A 320
 None
 0.76A 4fo4B-5x8oA:
42.3		 4fo4B-5x8oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Pyrococcus
furiosus) 		PF02463
(SMC_N)
no annotation 		4 SER A1144
GLY A1148
MET C 193
GLY C 194
 None
 0.87A 4fo4B-5xnsA:
undetectable		 4fo4B-5xnsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 SER B  98
SER B  99
ASN B 100
GLY B 102
 None
 0.65A 4fo4B-5y59B:
undetectable		 4fo4B-5y59B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 ASN A 197
GLY A 250
THR A 405
GLY A 261
 None
None
None
CA  A 801 ( 4.3A)
 0.64A 4fo4B-5yl7A:
undetectable		 4fo4B-5yl7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 MR191 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 SER H  81
GLY H  57
THR H  59
GLY H  37
 None
 0.88A 4fo4B-6bp2H:
undetectable		 4fo4B-6bp2H:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 SER A 319
ASN A 116
GLY A 322
CYH A 367
 FMT  A 613 (-4.5A)
LLP  A 318 ( 3.9A)
None
None
 0.83A 4fo4B-6cczA:
undetectable		 4fo4B-6cczA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 SER A 405
GLY A 224
MET A 402
GLY A 395
 None
 0.76A 4fo4B-6czxA:
undetectable		 4fo4B-6czxA:
13.02