SIMILAR PATTERNS OF AMINO ACIDS FOR 4FO4_A_MOAA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 SER A   8
SER A   9
THR A 153
MET A 334
 None
None
LLP  A 198 ( 3.5A)
None
 1.01A 4fo4A-1bjnA:
undetectable		 4fo4A-1bjnA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		4 ASP A 172
SER A 173
ASN A 201
THR A 231
 None
 0.83A 4fo4A-1eepA:
44.8		 4fo4A-1eepA:
50.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 SER A 462
ASN A 460
CYH A 500
GLY A 490
 None
 1.00A 4fo4A-1f4hA:
9.1		 4fo4A-1f4hA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 ASP A 186
CYH A 157
THR A 161
GLY A 194
 None
SF4  A 582 (-2.2A)
SF4  A 582 ( 3.9A)
SF4  A 582 (-3.9A)
 0.98A 4fo4A-1fehA:
undetectable		 4fo4A-1fehA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gau ERYTHROID
TRANSCRIPTION FACTOR
GATA-1

(Gallus gallus) 		PF00320
(GATA) 		4 ASN A  29
CYH A  10
THR A  12
MET A  46
 None
 0.95A 4fo4A-1gauA:
undetectable		 4fo4A-1gauA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		4 ASP L 255
SER L 230
THR L 145
GLY L 205
 None
None
CMO  L 431 ( 4.9A)
None
 0.97A 4fo4A-1hfeL:
undetectable		 4fo4A-1hfeL:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASP A 274
SER A 275
SER A 276
ASN A 303
 None
None
None
CPR  A 631 ( 4.5A)
 0.79A 4fo4A-1jcnA:
40.2		 4fo4A-1jcnA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 SER A 276
SER A 275
THR A 252
GLY A 301
 None
 0.99A 4fo4A-1jcnA:
40.2		 4fo4A-1jcnA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 ASP A 274
SER A 275
SER A 276
ASN A 303
THR A 333
MET A 414
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 1.14A 4fo4A-1jr1A:
51.1		 4fo4A-1jr1A:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 SER A 275
SER A 276
ASN A 303
CYH A 331
THR A 333
MET A 414
GLY A 415
 None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
None
IMP  A1331 ( 3.1A)
 0.81A 4fo4A-1jr1A:
51.1		 4fo4A-1jr1A:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 SER A 839
SER A 840
THR A 767
GLY A 809
 None
 1.00A 4fo4A-1kblA:
10.8		 4fo4A-1kblA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 ASP A 261
SER A 262
SER A 263
ASN A 291
CYH A 319
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
 0.88A 4fo4A-1lrtA:
47.0		 4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 SER A 262
SER A 263
ASN A 291
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.69A 4fo4A-1lrtA:
47.0		 4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASP A 261
SER A 262
SER A 263
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 3.1A)
 0.89A 4fo4A-1mewA:
46.1		 4fo4A-1mewA:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 SER A 262
SER A 263
ASN A 291
GLY A 409
 NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.1A)
 0.61A 4fo4A-1mewA:
46.1		 4fo4A-1mewA:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A 340
SER A 362
SER A 361
GLY A 337
 None
 0.95A 4fo4A-1ot5A:
undetectable		 4fo4A-1ot5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 ASP A 410
SER A 408
ASN A 411
GLY A 402
 None
 0.94A 4fo4A-1w27A:
undetectable		 4fo4A-1w27A:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASN A 282
CYH A 310
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.5A)
IMP  A 500 ( 3.2A)
None
None
IMP  A 500 (-3.0A)
 0.19A 4fo4A-1zfjA:
54.7		 4fo4A-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 253
ASN A 282
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.84A 4fo4A-1zfjA:
54.7		 4fo4A-1zfjA:
47.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A

(Homo sapiens) 		PF01466
(Skp1)
PF03931
(Skp1_POZ) 		5 ASP A1111
ASN A1108
CYH A1120
THR A1119
GLY A1114
 None
 1.46A 4fo4A-2astA:
undetectable		 4fo4A-2astA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		4 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 413 (-2.7A)
PLP  A 413 (-2.6A)
None
None
 0.95A 4fo4A-2ay9A:
undetectable		 4fo4A-2ay9A:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 ASN A 158
CYH A 186
THR A 188
MET A 269
 IMP  A1338 ( 4.3A)
IMP  A1338 (-2.5A)
None
None
 0.50A 4fo4A-2bznA:
41.7		 4fo4A-2bznA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 247
ASN A 275
CYH A 301
THR A 303
MET A 384
GLY A 385
 None
XMP  A1001 ( 4.4A)
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
None
XMP  A1001 (-3.1A)
 0.66A 4fo4A-2cu0A:
51.4		 4fo4A-2cu0A:
41.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 SER A  69
SER A  70
ASN A 108
GLY A 536
 None
 0.86A 4fo4A-2d0vA:
undetectable		 4fo4A-2d0vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 SER A 388
ASN A 389
THR A 409
GLY A 415
 None
 1.00A 4fo4A-2e0wA:
undetectable		 4fo4A-2e0wA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 SER A 175
SER A 207
THR A 248
GLY A 140
 None
None
PMS  A 601 (-4.7A)
None
 0.90A 4fo4A-2gkoA:
undetectable		 4fo4A-2gkoA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzc HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		no annotation 4 ASP A  58
ASN A  57
THR A  77
GLY A  65
 None
 0.93A 4fo4A-2nzcA:
undetectable		 4fo4A-2nzcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ASP A 105
ASN A 102
THR A  34
GLY A  28
 None
 0.92A 4fo4A-2okcA:
undetectable		 4fo4A-2okcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		4 ASP A 302
ASN A 304
THR A 221
GLY A  85
 None
 1.01A 4fo4A-2qzwA:
undetectable		 4fo4A-2qzwA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4i GLUTAMATE RACEMASE

(Helicobacter
pylori) 		PF01177
(Asp_Glu_race) 		4 SER A 143
CYH A  70
THR A  72
GLY A 180
 None
DGL  A1256 (-3.1A)
DGL  A1256 (-3.8A)
None
 0.78A 4fo4A-2w4iA:
undetectable		 4fo4A-2w4iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 501 (-2.2A)
SF4  A 501 ( 4.2A)
None
 0.72A 4fo4A-2xsjA:
undetectable		 4fo4A-2xsjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 410 (-2.4A)
PLP  A 410 (-3.2A)
None
None
 0.89A 4fo4A-3aatA:
undetectable		 4fo4A-3aatA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A 452
ASN A 490
MET A 442
GLY A 443
 None
 0.94A 4fo4A-3bgaA:
5.5		 4fo4A-3bgaA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		4 ASP A  50
SER A  51
ASN A  49
GLY A  98
 ZN  A 183 (-2.6A)
None
None
None
 0.99A 4fo4A-3eefA:
undetectable		 4fo4A-3eefA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 SER A 180
SER A 181
ASN A 186
GLY A 358
 None
 0.87A 4fo4A-3f11A:
undetectable		 4fo4A-3f11A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 ASP A 115
ASN A 119
THR A  10
GLY A  91
 None
 0.97A 4fo4A-3gk3A:
undetectable		 4fo4A-3gk3A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ASP A  22
CYH A 120
THR A  84
GLY A  12
 None
 0.91A 4fo4A-3h2zA:
undetectable		 4fo4A-3h2zA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 SER A 698
ASN A 697
THR A 754
GLY A 735
 None
 0.94A 4fo4A-3i6sA:
undetectable		 4fo4A-3i6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ASP A 236
SER A 238
ASN A 237
GLY A 176
 None
 0.78A 4fo4A-3jbhA:
undetectable		 4fo4A-3jbhA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		4 SER A  44
SER A  45
THR A 152
GLY A 182
 None
 0.99A 4fo4A-3l7yA:
undetectable		 4fo4A-3l7yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0o MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
B-0618) 		PF01266
(DAO) 		4 SER A 258
ASN A 237
THR A  48
GLY A 255
 None
 1.00A 4fo4A-3m0oA:
undetectable		 4fo4A-3m0oA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASN A 282
CYH A 266
THR A 268
MET A 289
 None
SF4  A 576 (-2.2A)
SF4  A 576 ( 4.4A)
None
 0.82A 4fo4A-3mm5A:
undetectable		 4fo4A-3mm5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		4 SER A 424
ASN A 498
THR A 421
GLY A 460
 None
 0.89A 4fo4A-3njxA:
undetectable		 4fo4A-3njxA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 SER B 259
SER B 213
ASN B 212
CYH B 298
GLY B 500
 None
 1.35A 4fo4A-3o8oB:
undetectable		 4fo4A-3o8oB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 801 (-2.4A)
SF4  A 801 ( 4.1A)
None
 0.74A 4fo4A-3or2A:
undetectable		 4fo4A-3or2A:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASP A 251
ASN A 280
CYH A 308
THR A 310
 None
XMP  A 500 ( 4.4A)
XMP  A 500 (-3.3A)
XMP  A 500 (-4.5A)
 0.55A 4fo4A-3tsdA:
37.1		 4fo4A-3tsdA:
47.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASN A 252
THR A 257
MET A 390
GLY A 391
 FAD  A 702 ( 3.7A)
None
None
None
 0.95A 4fo4A-3vrbA:
undetectable		 4fo4A-3vrbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 SER A 255
SER A 257
ASN A 259
GLY A 302
 None
 0.93A 4fo4A-3wzfA:
undetectable		 4fo4A-3wzfA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		4 ASN A 217
CYH A 239
MET A 233
GLY A 234
 None
 0.81A 4fo4A-3x0uA:
undetectable		 4fo4A-3x0uA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 ASP B 288
SER B 289
SER B 290
ASN B 317
CYH B 345
MET B 428
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
IMP  B1527 (-3.3A)
None
IMP  B1527 ( 3.3A)
 0.86A 4fo4A-4af0B:
48.2		 4fo4A-4af0B:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)

(Trypanosoma
brucei) 		PF00025
(Arf) 		4 ASP A  85
SER A  18
ASN A  17
GLY A 160
 None
GNP  A1182 (-3.3A)
GNP  A1182 (-3.9A)
GNP  A1182 (-3.7A)
 0.93A 4fo4A-4basA:
undetectable		 4fo4A-4basA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beq ALANINE RACEMASE 2

(Vibrio cholerae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 SER A 346
THR A 302
MET A 326
GLY A 327
 None
 0.96A 4fo4A-4beqA:
6.5		 4fo4A-4beqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASP A  28
ASN A 378
THR A 384
GLY A 399
 None
 1.01A 4fo4A-4cntA:
5.3		 4fo4A-4cntA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		4 SER C 277
SER C 276
THR C 272
GLY C 111
 FAD  C 500 (-4.3A)
FAD  C 500 ( 4.1A)
None
FAD  C 500 (-3.5A)
 0.89A 4fo4A-4fk1C:
undetectable		 4fo4A-4fk1C:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 250
SER A 251
SER A 252
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.86A 4fo4A-4fxsA:
59.8		 4fo4A-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		7 SER A 251
SER A 252
ASN A 279
CYH A 307
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.16A 4fo4A-4fxsA:
59.8		 4fo4A-4fxsA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmy ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf) 		5 ASP C  96
ASN C  95
CYH C 159
THR C 161
GLY C  29
 None
None
GTP  C1001 ( 4.0A)
GTP  C1001 (-3.3A)
GTP  C1001 (-3.3A)
 1.37A 4fo4A-4hmyC:
undetectable		 4fo4A-4hmyC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		4 ASP A 265
SER A 264
SER A 268
GLY A 272
 None
 0.67A 4fo4A-4iggA:
undetectable		 4fo4A-4iggA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		6 ASP A 250
SER A 251
SER A 252
ASN A 279
THR A 309
MET A 390
 None
None
None
IMP  A 501 ( 4.4A)
None
None
 0.82A 4fo4A-4ix2A:
57.3		 4fo4A-4ix2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		6 SER A 251
SER A 252
ASN A 279
CYH A 307
THR A 309
MET A 390
 None
None
IMP  A 501 ( 4.4A)
IMP  A 501 (-4.9A)
None
None
 0.46A 4fo4A-4ix2A:
57.3		 4fo4A-4ix2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6c ACETOACETYL-COA
REDUCTASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 ASP A 114
ASN A 118
THR A   9
GLY A  90
 None
 0.85A 4fo4A-4k6cA:
undetectable		 4fo4A-4k6cA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		7 ASP A 244
SER A 245
ASN A 273
CYH A 301
THR A 303
MET A 384
GLY A 385
 None
None
IMP  A 500 ( 4.1A)
IMP  A 500 ( 3.1A)
2F1  A 501 (-4.1A)
None
IMP  A 500 ( 3.3A)
 0.37A 4fo4A-4mz1A:
55.9		 4fo4A-4mz1A:
59.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 ASP A 240
SER A 238
THR A  99
MET A 162
 None
 0.86A 4fo4A-4p48A:
undetectable		 4fo4A-4p48A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 ASP A 522
ASN A 562
MET A 515
GLY A 514
 None
 0.97A 4fo4A-4p7hA:
undetectable		 4fo4A-4p7hA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 4 ASP A 505
THR A 511
MET A 395
GLY A 396
 None
 1.00A 4fo4A-4rkmA:
undetectable		 4fo4A-4rkmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Human
coronavirus
229E) 		PF06471
(NSP11) 		4 ASP A 274
SER A  70
CYH A 114
GLY A  76
 None
 0.90A 4fo4A-4s1tA:
undetectable		 4fo4A-4s1tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0k ARF-LIKE SMALL
GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 ASP A  95
SER A  28
ASN A  27
GLY A 162
 None
GDP  A 700 (-3.1A)
GDP  A 700 (-4.2A)
GDP  A 700 (-3.7A)
 0.96A 4fo4A-4v0kA:
undetectable		 4fo4A-4v0kA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 SER A 254
SER A 256
ASN A 258
GLY A 301
 CAC  A 501 (-2.1A)
CAC  A 501 (-2.6A)
None
None
 1.00A 4fo4A-4wb0A:
undetectable		 4fo4A-4wb0A:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		4 ASP A 277
SER A 278
SER A 279
ASN A 306
 None
 0.74A 4fo4A-4xwuA:
38.8		 4fo4A-4xwuA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		5 ASN A 276
CYH A 304
THR A 306
MET A 387
GLY A 388
 IMP  A 501 ( 4.3A)
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
 0.26A 4fo4A-5ahmA:
55.1		 4fo4A-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		4 ASP A 247
THR A 306
MET A 387
GLY A 388
 None
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
 0.88A 4fo4A-5ahmA:
55.1		 4fo4A-5ahmA:
65.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		4 ASP C 562
ASN C 544
THR C 396
GLY C 472
 None
None
None
4UD  C 701 (-4.4A)
 0.93A 4fo4A-5bpkC:
undetectable		 4fo4A-5bpkC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGK

(Escherichia
coli) 		PF02626
(CT_A_B) 		4 ASP A 131
SER A 129
MET A 125
GLY A 126
 None
 0.92A 4fo4A-5dudA:
undetectable		 4fo4A-5dudA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 SER A 238
ASN A 236
CYH A 305
GLY A 303
 FUC  A 616 ( 4.2A)
NAG  A 615 (-1.9A)
None
None
 1.00A 4fo4A-5dzvA:
undetectable		 4fo4A-5dzvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffp IMMUNITY 23 FAMILY
PROTEIN

(Burkholderia
dolosa) 		PF15593
(Imm42) 		4 ASP A 107
SER A 104
SER A  43
ASN A  42
 None
 0.96A 4fo4A-5ffpA:
undetectable		 4fo4A-5ffpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		4 ASP C 330
SER C 329
ASN C 289
THR C 247
 None
 0.88A 4fo4A-5fttC:
undetectable		 4fo4A-5fttC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1n CAD PROTEIN

(Homo sapiens) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A1977
THR A2054
MET A2211
GLY A2210
 None
 0.91A 4fo4A-5g1nA:
undetectable		 4fo4A-5g1nA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 SER A 141
ASN A  98
CYH A 180
GLY A 158
 None
 0.90A 4fo4A-5gvaA:
undetectable		 4fo4A-5gvaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ASP A 502
ASN A 519
THR A 843
GLY A 513
 None
 0.92A 4fo4A-5gz4A:
undetectable		 4fo4A-5gz4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		4 SER A 315
ASN A 318
MET A 261
GLY A 262
 None
 0.76A 4fo4A-5hasA:
undetectable		 4fo4A-5hasA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ASP A 135
SER A 139
ASN A 137
GLY A 154
 None
 0.99A 4fo4A-5iq0A:
undetectable		 4fo4A-5iq0A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 SER A 580
ASN A 397
CYH A 517
GLY A 583
 None
 0.94A 4fo4A-5l9wA:
undetectable		 4fo4A-5l9wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 4 SER A 273
SER A 272
ASN A 293
GLY A 219
 None
 0.99A 4fo4A-5lw3A:
undetectable		 4fo4A-5lw3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		4 SER A  56
ASN A  54
MET A 286
GLY A 287
 None
 0.89A 4fo4A-5m8jA:
undetectable		 4fo4A-5m8jA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 5 ASN A 173
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.24A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 5 ASP A 143
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 (-3.5A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.77A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t96 HE PROTEIN

(Salmon isavirus) 		PF06215
(ISAV_HA) 		4 ASP A  35
SER A  34
THR A  88
GLY A  61
 None
 0.96A 4fo4A-5t96A:
undetectable		 4fo4A-5t96A:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 277
SER A 278
SER A 279
ASN A 306
THR A 336
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-2.6A)
 0.88A 4fo4A-5tc3A:
47.9		 4fo4A-5tc3A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 278
SER A 279
ASN A 306
THR A 336
GLY A 418
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-3.1A)
 0.73A 4fo4A-5tc3A:
47.9		 4fo4A-5tc3A:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tt0 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Burkholderia
thailandensis) 		PF13561
(adh_short_C2) 		4 ASP A 222
SER A 221
THR A   7
GLY A 126
 None
EDO  A 304 (-4.6A)
None
None
 0.98A 4fo4A-5tt0A:
undetectable		 4fo4A-5tt0A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 ASP A 122
ASN A 126
THR A  18
GLY A  98
 EDO  A 304 ( 4.1A)
EDO  A 304 (-2.9A)
None
NAP  A 301 (-3.8A)
 0.93A 4fo4A-5u9pA:
undetectable		 4fo4A-5u9pA:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 ASN A 280
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 500 ( 4.3A)
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
None
IMP  A 500 ( 3.3A)
 0.18A 4fo4A-5upyA:
56.0		 4fo4A-5upyA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 ASP A 251
CYH A 308
THR A 310
MET A 391
GLY A 392
 None
IMP  A 500 (-3.2A)
Q21  A 501 (-4.3A)
None
IMP  A 500 ( 3.3A)
 0.83A 4fo4A-5upyA:
56.0		 4fo4A-5upyA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 ASN A 280
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 501 (-4.1A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
None
IMP  A 501 ( 3.2A)
 0.23A 4fo4A-5uuwA:
56.3		 4fo4A-5uuwA:
63.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		6 ASP A 246
ASN A 275
CYH A 303
THR A 305
MET A 386
GLY A 387
 None
IMP  A 500 (-4.0A)
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.38A 4fo4A-5uzeA:
55.5		 4fo4A-5uzeA:
62.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 ASP C 662
SER C 663
ASN C 724
GLY C 736
 None
 0.98A 4fo4A-5y6qC:
undetectable		 4fo4A-5y6qC:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 ASP A  71
SER A 224
ASN A  45
GLY A 188
 ZN  A 302 (-2.7A)
None
None
None
 0.97A 4fo4A-6brmA:
undetectable		 4fo4A-6brmA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byv VERY LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		no annotation 4 ASP A  33
SER A  32
SER A  35
THR A  56
 CA  A 201 (-3.5A)
None
None
None
 0.99A 4fo4A-6byvA:
undetectable		 4fo4A-6byvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 ASP A 523
ASN A 540
THR A 866
GLY A 534
 None
 0.99A 4fo4A-6c01A:
undetectable		 4fo4A-6c01A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ASP A 170
SER A 171
THR A  52
GLY A 207
 None
 0.94A 4fo4A-6ewjA:
undetectable		 4fo4A-6ewjA:
13.77