SIMILAR PATTERNS OF AMINO ACIDS FOR 4FN9_B_STRB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A 484
LEU A 487
LEU A  32
ALA A 491
THR A 498
 None
 1.28A 4fn9B-1aorA:
undetectable		 4fn9B-1aorA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 LEU A  50
LEU A  36
LEU A 150
ALA A 155
THR A 182
 None
 1.23A 4fn9B-1dppA:
undetectable		 4fn9B-1dppA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 LEU A  67
LEU A  64
LEU A  61
MET A  21
THR A 506
 None
 1.19A 4fn9B-1fohA:
undetectable		 4fn9B-1fohA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 LEU A  82
ASN A  88
LEU A  87
ALA A  90
MET A  94
 None
CA  A1101 ( 4.6A)
None
CA  A1102 (-4.4A)
None
 0.97A 4fn9B-1hdfA:
undetectable		 4fn9B-1hdfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
LEU A 349
ALA A 350
TRP A 383
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.66A 4fn9B-1pcgA:
28.1		 4fn9B-1pcgA:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx8 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A  23
LEU A  26
ASN A  27
LEU A  29
ALA A  30
 None
 0.39A 4fn9B-1qx8A:
undetectable		 4fn9B-1qx8A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE

(Cryptococcus
neoformans) 		PF00475
(IGPD) 		5 LEU A 156
LEU A 145
LEU A 144
ALA A  78
MET A  46
 None
 1.32A 4fn9B-1rhyA:
undetectable		 4fn9B-1rhyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		5 LEU B  59
LEU B  45
ALA B  76
GLN B  79
MET B  88
 None
 1.30A 4fn9B-1s70B:
undetectable		 4fn9B-1s70B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.67A 4fn9B-1twdA:
undetectable		 4fn9B-1twdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		5 LEU A 107
ASN A 108
LEU A 110
ALA A 111
MET A  99
 None
 1.11A 4fn9B-1vhhA:
undetectable		 4fn9B-1vhhA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 180
LEU A 135
LEU A  94
ALA A  95
MET A  61
 None
 1.00A 4fn9B-1wb0A:
undetectable		 4fn9B-1wb0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 LEU A  83
LEU A  69
LEU A  72
ALA A  73
GLN A  76
 None
 0.88A 4fn9B-1x9sA:
undetectable		 4fn9B-1x9sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
TRP A 361
MET A 362
ARG A 372
 None
 0.53A 4fn9B-1xb7A:
26.4		 4fn9B-1xb7A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A 111
LEU A 114
ASN A 115
LEU A 117
ALA A 118
 None
 0.91A 4fn9B-1yo7A:
undetectable		 4fn9B-1yo7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 LEU A 183
LEU A 186
LEU A 156
ALA A 157
THR A 162
 None
 1.13A 4fn9B-2a14A:
undetectable		 4fn9B-2a14A:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 701
ASN A 705
TRP A 741
MET A 742
MET A 780
 None
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
BHM  A   1 ( 4.3A)
 1.28A 4fn9B-2ax9A:
36.0		 4fn9B-2ax9A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 749
ARG A 752
MET A 780
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
 0.67A 4fn9B-2ax9A:
36.0		 4fn9B-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  52
LEU A  48
LEU A 268
ALA A 269
TRP A 190
 None
 1.28A 4fn9B-2bi0A:
undetectable		 4fn9B-2bi0A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.77A 4fn9B-2bkuB:
undetectable		 4fn9B-2bkuB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		5 LEU A 293
LEU A 292
ASN A  50
ALA A  49
MET A 263
 None
 1.20A 4fn9B-2cc1A:
undetectable		 4fn9B-2cc1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.29A 4fn9B-2dpnA:
undetectable		 4fn9B-2dpnA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 265
LEU A 268
LEU A 271
ALA A 272
TRP A 305
MET A 306
ARG A 316
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.65A 4fn9B-2gpvA:
26.4		 4fn9B-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibg PROTEIN HEDGEHOG

(Drosophila
melanogaster) 		PF01085
(HH_signal) 		5 LEU E 166
ASN E 167
LEU E 169
ALA E 170
MET E 158
 None
 1.05A 4fn9B-2ibgE:
undetectable		 4fn9B-2ibgE:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA

(Encephalitozoon
cuniculi) 		PF04494
(TFIID_NTD2) 		5 LEU A 134
LEU A 137
ASN A 138
LEU A 141
MET A 113
 None
 0.96A 4fn9B-2j4bA:
undetectable		 4fn9B-2j4bA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		5 LEU A  58
LEU A  61
ASN A  62
LEU A  64
ALA A  65
 None
 0.84A 4fn9B-2k5eA:
undetectable		 4fn9B-2k5eA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		5 LEU A  61
ASN A  62
LEU A  64
ALA A  65
MET A   9
 None
 1.20A 4fn9B-2k5eA:
undetectable		 4fn9B-2k5eA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l35 DAP12-NKG2C_TM
TYRO PROTEIN
TYROSINE
KINASE-BINDING
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A  19
LEU A  22
LEU A  25
ALA A  26
THR B  20
 None
 1.22A 4fn9B-2l35A:
undetectable		 4fn9B-2l35A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 346
LEU A 349
ALA A 350
TRP A 383
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
None
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.69A 4fn9B-2ocfA:
28.9		 4fn9B-2ocfA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		5 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 0.96A 4fn9B-2pl2A:
undetectable		 4fn9B-2pl2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 LEU A 144
LEU A 141
LEU A 138
ALA A 137
THR A 330
 None
 1.17A 4fn9B-2puzA:
undetectable		 4fn9B-2puzA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  83
LEU A  86
LEU A  89
ALA A  90
TRP A 420
 None
 1.03A 4fn9B-2q27A:
undetectable		 4fn9B-2q27A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
ALA A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 108
THR A 208
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 (-3.4A)
 0.38A 4fn9B-2q3yA:
40.0		 4fn9B-2q3yA:
90.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 LEU A  52
LEU A  55
LEU A  58
ALA A  59
THR A  86
 EDO  A 714 ( 4.0A)
None
None
None
None
 1.24A 4fn9B-2q66A:
undetectable		 4fn9B-2q66A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
LEU A 375
LEU A 378
ALA A 379
GLN A 382
 None
 0.54A 4fn9B-2qveA:
undetectable		 4fn9B-2qveA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 521
LEU A 524
LEU A 527
ALA A 528
MET A 607
 None
 1.31A 4fn9B-2va8A:
undetectable		 4fn9B-2va8A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 728
ASN A 731
LEU A 729
ALA A 730
GLN A 766
 None
 1.20A 4fn9B-2vcaA:
undetectable		 4fn9B-2vcaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		5 LEU A  90
LEU A  87
LEU A  84
ALA A  83
TRP A  61
 None
 1.28A 4fn9B-2wj3A:
undetectable		 4fn9B-2wj3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		5 LEU A 114
LEU A 109
LEU A 106
ALA A 107
MET A  35
 None
 1.23A 4fn9B-2xt0A:
undetectable		 4fn9B-2xt0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 599
LEU A 574
ASN A 573
LEU A 550
ALA A 551
 None
 1.23A 4fn9B-3b2dA:
undetectable		 4fn9B-3b2dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 LEU A 422
LEU A 425
ALA A 428
GLN A 432
MET A 435
 None
None
None
GOL  A 463 ( 3.8A)
None
 1.20A 4fn9B-3bq9A:
undetectable		 4fn9B-3bq9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		5 LEU A 219
LEU A 216
LEU A 213
ALA A 212
MET A 236
 None
 1.25A 4fn9B-3cjmA:
undetectable		 4fn9B-3cjmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		5 LEU A 202
ASN A 203
LEU A 205
ALA A 206
THR A 111
 None
 1.29A 4fn9B-3d62A:
undetectable		 4fn9B-3d62A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE

(Bacillus
anthracis) 		PF13529
(Peptidase_C39_2) 		5 LEU A 134
LEU A 137
ALA A 138
MET A  80
THR A 150
 None
 1.20A 4fn9B-3ervA:
undetectable		 4fn9B-3ervA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		5 LEU A 150
LEU A 153
LEU A 156
ALA A 162
THR A 166
 None
 1.20A 4fn9B-3htuA:
undetectable		 4fn9B-3htuA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 LEU B 362
LEU B 365
LEU B 401
ALA B 368
MET B1305
 None
 1.31A 4fn9B-3iz3B:
undetectable		 4fn9B-3iz3B:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1
VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 LEU D 205
LEU D 202
LEU D 199
ALA D 200
ARG B1272
 None
 1.30A 4fn9B-3iz3D:
undetectable		 4fn9B-3iz3D:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 LEU A 315
LEU A 321
LEU A 324
ALA A 323
THR A 287
 None
 1.31A 4fn9B-3j31A:
undetectable		 4fn9B-3j31A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7h INDIAN HEDGEHOG
PROTEIN

(Homo sapiens) 		PF01085
(HH_signal) 		5 LEU B 111
ASN B 112
LEU B 114
ALA B 115
MET B 103
 None
 1.10A 4fn9B-3k7hB:
undetectable		 4fn9B-3k7hB:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
ARG A 766
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.9A)
 0.76A 4fn9B-3kbaA:
36.1		 4fn9B-3kbaA:
66.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 715
ASN A 719
TRP A 755
MET A 756
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.9A)
 1.14A 4fn9B-3kbaA:
36.1		 4fn9B-3kbaA:
66.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
ARG A 766
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.9A)
 0.56A 4fn9B-3kbaA:
36.1		 4fn9B-3kbaA:
66.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		5 LEU A 570
ASN A 571
LEU A 574
ALA A 575
THR A 734
 None
 1.21A 4fn9B-3kflA:
undetectable		 4fn9B-3kflA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 137
LEU A 140
ALA A 141
GLN A 144
THR A  88
 None
 0.86A 4fn9B-3kq4A:
undetectable		 4fn9B-3kq4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 193
LEU A 205
LEU A 206
MET A 219
THR A 197
 None
 1.32A 4fn9B-3l06A:
undetectable		 4fn9B-3l06A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 0.99A 4fn9B-3l6aA:
undetectable		 4fn9B-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 LEU A 250
ALA A 251
GLN A 257
MET A 366
ARG A 261
 None
 1.12A 4fn9B-3oftA:
undetectable		 4fn9B-3oftA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 435
LEU A 432
ASN A 431
LEU A 429
THR A 472
 None
 1.31A 4fn9B-3pocA:
undetectable		 4fn9B-3pocA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 108
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.46A 4fn9B-3ry9A:
37.6		 4fn9B-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A 336
LEU A 333
LEU A  92
MET A 309
MET A 217
 None
 1.22A 4fn9B-3se7A:
undetectable		 4fn9B-3se7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 LEU A 406
LEU A 403
ASN A 402
LEU A 400
THR A 343
 None
 1.10A 4fn9B-3x0vA:
undetectable		 4fn9B-3x0vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		5 LEU A  36
LEU A  39
LEU A  42
ALA A  43
GLN A  46
 None
 0.65A 4fn9B-4am9A:
undetectable		 4fn9B-4am9A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl6 PROTEIN BICAUDAL D

(Drosophila
melanogaster) 		PF09730
(BicD) 		5 LEU A 719
LEU A 722
LEU A 725
ALA A 726
GLN A 729
 None
 0.66A 4fn9B-4bl6A:
undetectable		 4fn9B-4bl6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A  65
LEU A 155
LEU A 184
ALA A 183
THR A 116
 None
 1.13A 4fn9B-4c7vA:
undetectable		 4fn9B-4c7vA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq8 ACETATE KINASE

(Mycobacterium
marinum) 		PF00871
(Acetate_kinase) 		5 LEU A 102
LEU A 105
ASN A 113
LEU A 108
ALA A 109
 None
 1.22A 4fn9B-4dq8A:
undetectable		 4fn9B-4dq8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 LEU A 590
ASN A 593
LEU A 591
ALA A 592
THR A 609
 None
 1.23A 4fn9B-4dwsA:
undetectable		 4fn9B-4dwsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.14A 4fn9B-4fdhA:
undetectable		 4fn9B-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 LEU A 170
LEU A 167
ASN A 166
LEU A 164
ALA A 163
 None
 1.19A 4fn9B-4i2wA:
undetectable		 4fn9B-4i2wA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A3339
ASN A3484
LEU A3342
ALA A3343
GLN A3346
 None
 1.25A 4fn9B-4kc5A:
undetectable		 4fn9B-4kc5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 LEU A 124
LEU A 127
ALA A 130
MET A 135
THR A 174
 None
 1.27A 4fn9B-4m87A:
undetectable		 4fn9B-4m87A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 LEU A 360
ASN A 361
LEU A 363
ALA A 364
ARG A 271
 None
 1.32A 4fn9B-4m9dA:
undetectable		 4fn9B-4m9dA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		8 LEU A 280
LEU A 283
LEU A 286
ALA A 287
TRP A 320
MET A 321
ARG A 331
MET A 358
 None
 0.79A 4fn9B-4n1yA:
29.5		 4fn9B-4n1yA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 563
ASN A 564
LEU A 566
GLN A 570
TRP A 600
MET A 601
ARG A 611
THR A 739
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.9A)
 0.58A 4fn9B-4p6wA:
36.1		 4fn9B-4p6wA:
62.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 501
LEU A 498
ASN A 497
LEU A 495
ALA A 494
 None
 1.22A 4fn9B-4qmkA:
undetectable		 4fn9B-4qmkA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.07A 4fn9B-4u33A:
undetectable		 4fn9B-4u33A:
14.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
TRP A 806
MET A 807
ARG A 817
THR A 945
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-3.1A)
 0.46A 4fn9B-4udbA:
36.0		 4fn9B-4udbA:
68.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.10A 4fn9B-4xmvA:
undetectable		 4fn9B-4xmvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU B 165
LEU B 170
ASN B 191
LEU B 171
MET B 196
 None
 1.23A 4fn9B-4y61B:
undetectable		 4fn9B-4y61B:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.15A 4fn9B-5bswA:
undetectable		 4fn9B-5bswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 LEU A 467
LEU A 497
LEU A 518
ALA A 519
TRP A 549
 None
 1.29A 4fn9B-5hzwA:
undetectable		 4fn9B-5hzwA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1

(Mus musculus) 		PF10250
(O-FucT) 		5 LEU A  70
LEU A  40
LEU A 195
ALA A 196
TRP A 157
 None
 0.98A 4fn9B-5kxqA:
undetectable		 4fn9B-5kxqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 LEU A 752
LEU A 647
LEU A 650
ALA A 649
TRP A 577
 None
 1.20A 4fn9B-5loiA:
undetectable		 4fn9B-5loiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 LEU A 739
LEU A 742
ALA A 746
MET A 722
THR A 663
 None
 1.16A 4fn9B-5m41A:
undetectable		 4fn9B-5m41A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 LEU A 360
LEU A 362
ASN A 355
LEU A 363
ALA A 364
 None
None
NAG  A 807 (-2.0A)
None
NAG  A 807 (-3.8A)
 1.16A 4fn9B-5mfaA:
undetectable		 4fn9B-5mfaA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		5 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.68A 4fn9B-5mgxE:
undetectable		 4fn9B-5mgxE:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 845
THR A 945
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.49A 4fn9B-5mwpA:
37.6		 4fn9B-5mwpA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 5 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.58A 4fn9B-5n1tM:
undetectable		 4fn9B-5n1tM:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
 None
 1.21A 4fn9B-5o0jA:
undetectable		 4fn9B-5o0jA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 556
LEU A 559
LEU A 562
ALA A 563
MET A 545
 None
 1.06A 4fn9B-5o7eA:
undetectable		 4fn9B-5o7eA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 559
ASN A 560
LEU A 562
ALA A 563
MET A 545
 None
 1.04A 4fn9B-5o7eA:
undetectable		 4fn9B-5o7eA:
14.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 298
LEU A 301
ALA A 302
TRP A 335
MET A 336
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
None
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 0.55A 4fn9B-5toaA:
26.9		 4fn9B-5toaA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.00A 4fn9B-5uc1A:
25.4		 4fn9B-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.76A 4fn9B-5uc1A:
25.4		 4fn9B-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 562
GLN A 566
TRP A 596
MET A 597
ARG A 607
 486  A 801 ( 4.8A)
486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.74A 4fn9B-5uc1A:
25.4		 4fn9B-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-3.0A)
 1.02A 4fn9B-5ufsA:
38.0		 4fn9B-5ufsA:
73.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
ARG A  80
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
 0.48A 4fn9B-5ufsA:
38.0		 4fn9B-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 LEU A 360
LEU A 362
ASN A 355
LEU A 363
ALA A 364
 None
None
NAG  A 802 (-1.6A)
None
NAG  A 802 (-3.7A)
 1.22A 4fn9B-6azpA:
undetectable		 4fn9B-6azpA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz DAM1
DUO1

(Chaetomium
thermophilum) 		no annotation 5 LEU H  94
LEU H  97
ASN H  98
ALA H 101
THR D  99
 None
 1.19A 4fn9B-6cfzH:
undetectable		 4fn9B-6cfzH:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 610
LEU K 613
ASN K 614
ALA K 617
MET K 667
 None
None
None
None
A  O  61 ( 4.6A)
 1.01A 4fn9B-6d6qK:
undetectable		 4fn9B-6d6qK:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.80A 4fn9B-6d6qK:
undetectable		 4fn9B-6d6qK:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 5 LEU B  11
LEU B  12
ALA B 161
TRP B  98
MET B 153
 None
 1.18A 4fn9B-6dexB:
undetectable		 4fn9B-6dexB:
17.95