SIMILAR PATTERNS OF AMINO ACIDS FOR 4FN9_A_STRA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		5 LEU A 377
LEU A 374
LEU A 371
ALA A 370
ALA A 330
 None
 1.04A 4fn9A-1bxcA:
undetectable		 4fn9A-1bxcA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 LEU A 341
LEU A 340
ALA A 339
ALA A 285
THR A 366
 None
 0.93A 4fn9A-1dabA:
undetectable		 4fn9A-1dabA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 LEU A 201
LEU A 198
LEU A 195
ALA A 194
ALA A 231
 None
 1.10A 4fn9A-1drkA:
undetectable		 4fn9A-1drkA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hci ALPHA-ACTININ 2

(Homo sapiens) 		PF00435
(Spectrin) 		5 LEU A 396
LEU A 399
LEU A 402
ALA A 403
ALA A 476
 None
 0.84A 4fn9A-1hciA:
undetectable		 4fn9A-1hciA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 184
LEU A 187
LEU A 190
ALA A 191
ALA A 165
 None
 0.69A 4fn9A-1o4sA:
undetectable		 4fn9A-1o4sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 406
LEU A 409
ASN A 410
LEU A 412
ALA A 182
 None
 1.01A 4fn9A-1p43A:
undetectable		 4fn9A-1p43A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.51A 4fn9A-1pcgA:
28.3		 4fn9A-1pcgA:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx8 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A  23
LEU A  26
ASN A  27
LEU A  29
ALA A  30
 None
 0.45A 4fn9A-1qx8A:
undetectable		 4fn9A-1qx8A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4t EXOENZYME S

(Pseudomonas
aeruginosa) 		PF03545
(YopE) 		5 LEU A 152
LEU A 148
LEU A 145
ALA A 144
ALA A 124
 None
 1.00A 4fn9A-1r4tA:
undetectable		 4fn9A-1r4tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.72A 4fn9A-1twdA:
undetectable		 4fn9A-1twdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 LEU A 197
LEU A 200
LEU A 203
ALA A 204
ALA A  58
 None
 1.06A 4fn9A-1v9cA:
undetectable		 4fn9A-1v9cA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 LEU A  36
LEU A  33
LEU A  61
ALA A  30
GLN A  27
 None
 1.04A 4fn9A-1xviA:
undetectable		 4fn9A-1xviA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		5 LEU A 406
LEU A  40
ALA A  41
GLN A  44
ALA A 358
 None
 1.13A 4fn9A-1yniA:
undetectable		 4fn9A-1yniA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A 111
LEU A 114
ASN A 115
LEU A 117
ALA A 118
 None
 0.87A 4fn9A-1yo7A:
undetectable		 4fn9A-1yo7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 LEU A 186
LEU A 183
LEU A 180
ALA A 179
ALA A 165
 None
None
None
None
SAH  A4001 (-3.4A)
 1.00A 4fn9A-2a14A:
undetectable		 4fn9A-2a14A:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
 0.67A 4fn9A-2ax9A:
36.1		 4fn9A-2ax9A:
60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.72A 4fn9A-2bkuB:
undetectable		 4fn9A-2bkuB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.93A 4fn9A-2d4pA:
undetectable		 4fn9A-2d4pA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 268
LEU A 271
ALA A 272
MET A 306
ARG A 316
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.51A 4fn9A-2gpvA:
26.4		 4fn9A-2gpvA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 330
LEU A 333
GLN A 340
ALA A 509
CYH A 504
 None
 1.11A 4fn9A-2hi4A:
undetectable		 4fn9A-2hi4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		5 LEU B 241
LEU B 238
LEU B 234
ALA B 233
ALA B 198
 None
 1.06A 4fn9A-2incB:
undetectable		 4fn9A-2incB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		5 LEU G 374
LEU G 373
ALA G 372
ALA G 317
THR G 399
 None
 1.12A 4fn9A-2iouG:
undetectable		 4fn9A-2iouG:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j48 TWO-COMPONENT SENSOR
KINASE

(Synechococcus
elongatus) 		PF00072
(Response_reg) 		5 LEU A 687
LEU A 690
LEU A 693
GLN A 697
ALA A 719
 None
 0.90A 4fn9A-2j48A:
undetectable		 4fn9A-2j48A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		5 LEU A  58
LEU A  61
ASN A  62
LEU A  64
ALA A  65
 None
 0.80A 4fn9A-2k5eA:
undetectable		 4fn9A-2k5eA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.51A 4fn9A-2ocfA:
29.1		 4fn9A-2ocfA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		5 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 1.08A 4fn9A-2pl2A:
undetectable		 4fn9A-2pl2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 LEU A 144
LEU A 141
LEU A 138
ALA A 137
ALA A 172
 None
 1.02A 4fn9A-2puzA:
undetectable		 4fn9A-2puzA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 LEU A 144
LEU A 141
LEU A 138
ALA A 172
THR A 330
 None
 1.07A 4fn9A-2puzA:
undetectable		 4fn9A-2puzA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
ALA A  36
GLN A  39
MET A  70
ALA A  74
ARG A  80
MET A 108
CYH A 205
THR A 208
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.33A 4fn9A-2q3yA:
40.1		 4fn9A-2q3yA:
90.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 LEU A 168
LEU A 171
LEU A 174
ALA A 175
ALA A 133
 None
 0.88A 4fn9A-2qc3A:
undetectable		 4fn9A-2qc3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
LEU A 375
LEU A 378
ALA A 379
GLN A 382
 None
 0.58A 4fn9A-2qveA:
undetectable		 4fn9A-2qveA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 585
LEU A 566
LEU A 519
ALA A 518
ALA A 539
 None
 0.95A 4fn9A-2vsqA:
undetectable		 4fn9A-2vsqA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF00355
(Rieske)
PF02167
(Cytochrom_C1)
PF10399
(UCR_Fe-S_N) 		5 LEU A 253
LEU A 256
ALA A 257
ALA C  30
THR B 272
 None
 0.71A 4fn9A-2yiuA:
undetectable		 4fn9A-2yiuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		5 LEU A 705
LEU A 702
ALA A 701
ALA A 659
MET A 676
 None
 1.12A 4fn9A-3ebbA:
undetectable		 4fn9A-3ebbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 LEU 3 638
LEU 3 641
LEU 3 644
ALA 3 645
ALA 3 361
 None
 0.96A 4fn9A-3i9v3:
undetectable		 4fn9A-3i9v3:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
ARG A 766
CYH A 891
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.48A 4fn9A-3kbaA:
36.2		 4fn9A-3kbaA:
66.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 721
GLN A 725
MET A 756
ARG A 766
CYH A 891
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.5A)
 0.70A 4fn9A-3kbaA:
36.2		 4fn9A-3kbaA:
66.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 137
LEU A 140
ALA A 141
GLN A 144
ALA A  98
 None
 0.92A 4fn9A-3kq4A:
undetectable		 4fn9A-3kq4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A 138
LEU A 141
LEU A 144
ALA A 145
MET A 164
 None
 0.95A 4fn9A-3l6aA:
undetectable		 4fn9A-3l6aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica) 		PF00923
(TAL_FSA) 		5 LEU A 122
LEU A 125
ALA A 129
ALA A  59
THR A 102
 None
 1.07A 4fn9A-3m16A:
undetectable		 4fn9A-3m16A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 LEU A 411
LEU A 418
ALA A 419
GLN A 422
ALA A 282
 None
 0.99A 4fn9A-3ps9A:
undetectable		 4fn9A-3ps9A:
17.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ALA A  74
ARG A  80
MET A 108
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.7A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.38A 4fn9A-3ry9A:
38.0		 4fn9A-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLB

(Thermus
thermophilus) 		PF03259
(Robl_LC7) 		5 LEU B 105
LEU B  34
LEU B  42
ALA B  43
THR B  23
 None
 1.13A 4fn9A-3t12B:
undetectable		 4fn9A-3t12B:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR

(Homo sapiens) 		PF11467
(LEDGF) 		5 LEU C 383
LEU C 380
LEU C 377
ALA C 376
ALA C 357
 None
 1.07A 4fn9A-3u88C:
undetectable		 4fn9A-3u88C:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A  94
LEU A  97
LEU A 100
ALA A 101
ALA A  73
 None
 0.70A 4fn9A-3umvA:
undetectable		 4fn9A-3umvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vp7 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 30

(Saccharomyces
cerevisiae) 		PF04111
(APG6) 		5 LEU A 366
LEU A 363
LEU A 360
ALA A 359
ALA A 336
 None
 1.03A 4fn9A-3vp7A:
undetectable		 4fn9A-3vp7A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Mus musculus) 		PF16669
(TTC5_OB) 		5 LEU A 274
LEU A 271
LEU A 268
ALA A 243
THR A 354
 None
 0.87A 4fn9A-4abnA:
undetectable		 4fn9A-4abnA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		6 LEU A  36
LEU A  39
LEU A  42
ALA A  43
GLN A  46
CYH A  63
 None
 0.84A 4fn9A-4am9A:
undetectable		 4fn9A-4am9A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl6 PROTEIN BICAUDAL D

(Drosophila
melanogaster) 		PF09730
(BicD) 		5 LEU A 719
LEU A 722
LEU A 725
ALA A 726
GLN A 729
 None
 0.59A 4fn9A-4bl6A:
undetectable		 4fn9A-4bl6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 575
LEU A 578
GLN A 585
ALA A 448
THR A 508
 None
 0.97A 4fn9A-4bocA:
undetectable		 4fn9A-4bocA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 616
ASN A 615
LEU A 617
ALA A 614
ALA A 591
 None
 1.05A 4fn9A-4c51A:
undetectable		 4fn9A-4c51A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c79 SMOOTHENED

(Danio rerio) 		PF01392
(Fz) 		5 LEU A  57
LEU A 104
LEU A 103
ALA A 106
ALA A  71
 None
None
None
None
NA  A1160 (-4.8A)
 1.12A 4fn9A-4c79A:
undetectable		 4fn9A-4c79A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccs CBIX

(Paracoccus
pantotrophus) 		PF01903
(CbiX) 		5 LEU A 206
LEU A 178
LEU A 180
ALA A 125
ALA A 153
 None
 1.09A 4fn9A-4ccsA:
undetectable		 4fn9A-4ccsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		5 LEU A 396
LEU A 399
LEU A 402
ALA A 403
ALA A 476
 None
 0.97A 4fn9A-4d1eA:
undetectable		 4fn9A-4d1eA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 LEU A  12
LEU A  32
ALA A  31
MET A  49
ALA A  53
 None
 1.09A 4fn9A-4dykA:
undetectable		 4fn9A-4dykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 LEU A 362
LEU A 359
LEU A 357
GLN A 255
ALA A 216
 None
 1.10A 4fn9A-4dykA:
undetectable		 4fn9A-4dykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.15A 4fn9A-4fdhA:
undetectable		 4fn9A-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 LEU A 574
LEU A 577
LEU A 580
ALA A 581
ALA A 593
 None
 1.02A 4fn9A-4i2wA:
undetectable		 4fn9A-4i2wA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU A 993
LEU A 990
ALA A1033
ALA A 984
THR A 930
 None
 1.11A 4fn9A-4lnvA:
undetectable		 4fn9A-4lnvA:
11.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
LEU A 283
LEU A 286
ALA A 287
MET A 321
ARG A 331
MET A 358
 None
 0.75A 4fn9A-4n1yA:
29.3		 4fn9A-4n1yA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		5 LEU A 120
LEU A 124
LEU A 127
ALA A 128
ALA A  73
 None
 0.95A 4fn9A-4o8uA:
undetectable		 4fn9A-4o8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ASN A 181
LEU A 183
ALA A 184
MET A 243
ALA A 239
 OXM  A 302 (-3.2A)
None
None
None
None
 0.99A 4fn9A-4ol9A:
undetectable		 4fn9A-4ol9A:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ALA A 605
ARG A 611
CYH A 736
THR A 739
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.8A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.64A 4fn9A-4p6wA:
35.7		 4fn9A-4p6wA:
62.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 606
LEU A 609
LEU A 661
ALA A 662
ALA A 580
 None
 1.07A 4fn9A-4q73A:
undetectable		 4fn9A-4q73A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.10A 4fn9A-4u33A:
undetectable		 4fn9A-4u33A:
14.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
CYH A 942
THR A 945
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.42A 4fn9A-4udbA:
35.7		 4fn9A-4udbA:
68.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 LEU A 201
LEU A 189
LEU A 192
MET A 283
ALA A 279
 None
 1.01A 4fn9A-4xaeA:
undetectable		 4fn9A-4xaeA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.04A 4fn9A-4xmvA:
undetectable		 4fn9A-4xmvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 5 LEU A 258
LEU A 261
LEU A 264
ALA A 265
CYH A 203
 None
None
None
None
ZN  A 500 (-2.5A)
 0.94A 4fn9A-5b5xA:
undetectable		 4fn9A-5b5xA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.11A 4fn9A-5bswA:
undetectable		 4fn9A-5bswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 5 LEU A1631
LEU A1628
LEU A1625
ALA A1624
ALA A1586
 None
 1.09A 4fn9A-5cwuA:
undetectable		 4fn9A-5cwuA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 1.00A 4fn9A-5ddbA:
undetectable		 4fn9A-5ddbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 LEU A 297
ASN A 298
LEU A 300
ALA A 301
ALA A 282
 None
 0.95A 4fn9A-5ezrA:
undetectable		 4fn9A-5ezrA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		5 LEU A 227
ASN A 231
LEU A 233
ALA A 234
ALA A 300
 None
 0.91A 4fn9A-5fclA:
undetectable		 4fn9A-5fclA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		5 LEU A 321
LEU A 324
LEU A 327
ALA A 328
ALA A 180
 None
 0.88A 4fn9A-5gy3A:
undetectable		 4fn9A-5gy3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4o SPECTRIN ALPHA
CHAIN, ERYTHROCYTIC
1

(Homo sapiens) 		PF00435
(Spectrin) 		5 LEU A  65
LEU A  68
ASN A  69
LEU A  71
ALA A  72
 None
 0.72A 4fn9A-5j4oA:
undetectable		 4fn9A-5j4oA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5l UNCHARACTERIZED
PROTEIN

(Aspergillus
fumigatus) 		PF12296
(HsbA) 		5 LEU A 128
LEU A 131
ASN A 132
LEU A 134
ALA A 167
 None
ACD  A 201 ( 4.6A)
None
ACD  A 201 (-4.2A)
None
 1.09A 4fn9A-5j5lA:
undetectable		 4fn9A-5j5lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		5 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.64A 4fn9A-5mgxE:
undetectable		 4fn9A-5mgxE:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
MET A 845
CYH A 942
THR A 945
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.46A 4fn9A-5mwpA:
37.6		 4fn9A-5mwpA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 5 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.62A 4fn9A-5n1tM:
undetectable		 4fn9A-5n1tM:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na2 CAPSID PROTEIN (P24)

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A 126
LEU A 129
LEU A 132
ALA A 133
ALA A  26
 None
 1.06A 4fn9A-5na2A:
undetectable		 4fn9A-5na2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 556
LEU A 559
LEU A 562
ALA A 563
MET A 545
 None
 1.09A 4fn9A-5o7eA:
undetectable		 4fn9A-5o7eA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 559
ASN A 560
LEU A 562
ALA A 563
MET A 545
 None
 1.10A 4fn9A-5o7eA:
undetectable		 4fn9A-5o7eA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LEU B 253
LEU B 256
LEU B 259
ALA B 260
ALA B 277
 None
 0.88A 4fn9A-5ovnB:
undetectable		 4fn9A-5ovnB:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		6 LEU A  93
LEU A  82
LEU A  77
ALA A  76
ALA A  18
CYH A  90
 None
 1.30A 4fn9A-5tf2A:
undetectable		 4fn9A-5tf2A:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 301
ALA A 302
MET A 336
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 0.42A 4fn9A-5toaA:
27.2		 4fn9A-5toaA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A 227
LEU A 230
LEU A 233
ALA A 234
GLN A 237
 None
 0.82A 4fn9A-5uakA:
undetectable		 4fn9A-5uakA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 0.92A 4fn9A-5uc1A:
25.1		 4fn9A-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
ALA A 601
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.76A 4fn9A-5uc1A:
25.1		 4fn9A-5uc1A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-3.0A)
 0.87A 4fn9A-5ufsA:
38.0		 4fn9A-5ufsA:
73.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ALA A  74
ARG A  80
CYH A 205
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.7A)
1TA  A 301 (-3.5A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 0.49A 4fn9A-5ufsA:
38.0		 4fn9A-5ufsA:
73.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A  17
ASN A  21
LEU A  23
ALA A  24
ALA A 507
 None
 1.10A 4fn9A-5w0sA:
undetectable		 4fn9A-5w0sA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 333
LEU A 336
LEU A 339
ALA A 340
ALA A 352
 None
 1.03A 4fn9A-5xgcA:
undetectable		 4fn9A-5xgcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 LEU A 396
LEU A 393
LEU A 420
ALA A 417
ALA A 387
 None
 1.10A 4fn9A-6cc4A:
undetectable		 4fn9A-6cc4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 5 LEU A  43
LEU A  46
LEU A  49
ALA A  50
ALA A  21
 None
 0.85A 4fn9A-6cjqA:
undetectable		 4fn9A-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 LEU A  52
LEU A  99
LEU A  98
ALA A 101
ALA A  66
 None
 1.08A 4fn9A-6d35A:
undetectable		 4fn9A-6d35A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.84A 4fn9A-6d6qK:
undetectable		 4fn9A-6d6qK:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 LEU A 855
LEU A 859
LEU A 865
MET A 871
ALA A 876
 None
 1.11A 4fn9A-6dbrA:
undetectable		 4fn9A-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emo -

(-) 		no annotation 5 LEU A 383
LEU A 380
LEU A 377
ALA A 376
ALA A 357
 None
 1.12A 4fn9A-6emoA:
undetectable		 4fn9A-6emoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 6 LEU B 181
LEU B 184
ALA B 188
GLN B 191
ALA B 202
CYH B 269
 None
 1.32A 4fn9A-6ez8B:
undetectable		 4fn9A-6ez8B:
18.02