SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGZ_B_CQAB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		5 GLY A 447
GLY A 335
GLU A 454
LEU A 356
VAL A 359
 None
 1.07A 4fgzB-1b7eA:
undetectable		 4fgzB-1b7eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		4 GLY A 210
VAL A 206
GLU A 208
TYR A 207
 None
 0.88A 4fgzB-1bwzA:
undetectable		 4fgzB-1bwzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  36
GLY A 105
GLU A  55
LEU A 109
 None
None
FAD  A 600 (-2.6A)
None
 0.91A 4fgzB-1gpeA:
2.1		 4fgzB-1gpeA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		4 GLY A 151
GLY A 180
LEU A 181
VAL A 198
 SO4  A1224 (-3.6A)
SO4  A1224 (-3.7A)
None
None
 0.87A 4fgzB-1h1yA:
undetectable		 4fgzB-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 GLY A 131
GLY A 192
TYR A 148
VAL A 197
 None
 0.77A 4fgzB-1o0sA:
3.7		 4fgzB-1o0sA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		4 GLY A   9
GLY A 100
LEU A 105
VAL A  49
 None
 0.91A 4fgzB-1o6dA:
undetectable		 4fgzB-1o6dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLY A  12
TYR A 296
LEU A 300
VAL A 303
 NAD  A 500 (-3.0A)
MAL  A 900 (-4.2A)
NAD  A 500 ( 4.9A)
None
 0.50A 4fgzB-1obbA:
4.0		 4fgzB-1obbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLY A  38
LEU A  16
VAL A  42
TYR A  94
 None
 0.91A 4fgzB-1oseA:
undetectable		 4fgzB-1oseA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 TYR A 254
LEU A 258
GLU A 262
TYR A 265
 None
 0.64A 4fgzB-1p8rA:
undetectable		 4fgzB-1p8rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		4 GLY D 779
GLY D 815
LEU D 814
VAL D 812
 None
 0.89A 4fgzB-1pytD:
undetectable		 4fgzB-1pytD:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		4 GLY A 152
GLY A 181
LEU A 182
VAL A 199
 SO4  A2224 (-3.4A)
SO4  A2224 (-3.3A)
None
None
 0.89A 4fgzB-1tqxA:
undetectable		 4fgzB-1tqxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu7 GLUTATHIONE
S-TRANSFERASE 2

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A 144
GLY A 138
LEU A 174
VAL A 177
 None
 0.92A 4fgzB-1tu7A:
undetectable		 4fgzB-1tu7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 GLY A 121
LEU A 122
VAL A 124
GLU A 174
 None
None
None
AMP  A 700 (-4.0A)
 0.92A 4fgzB-1v9pA:
undetectable		 4fgzB-1v9pA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 GLY B   7
GLY B 188
VAL B  11
TYR B  10
 None
 0.92A 4fgzB-1wdwB:
undetectable		 4fgzB-1wdwB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		4 GLY A  40
GLY A  45
TYR A  52
LEU A  33
 None
 0.79A 4fgzB-1x0aA:
undetectable		 4fgzB-1x0aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yox HYPOTHETICAL PROTEIN
PA3696

(Pseudomonas
aeruginosa) 		PF01987
(AIM24) 		4 GLY A 123
GLY A 153
GLU A   5
LEU A 154
 None
 0.88A 4fgzB-1yoxA:
undetectable		 4fgzB-1yoxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		4 GLY A 175
GLY A  73
VAL A 233
TYR A 232
 None
 0.84A 4fgzB-1zbmA:
undetectable		 4fgzB-1zbmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		4 GLY A 202
GLY A 200
LEU A 107
VAL A 110
 None
 0.71A 4fgzB-2au3A:
undetectable		 4fgzB-2au3A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 GLY A  73
GLY A  68
LEU A 104
TYR A 107
 None
 0.64A 4fgzB-2b3bA:
undetectable		 4fgzB-2b3bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 GLY A  46
GLY A 256
LEU A 257
VAL A 259
 None
 0.87A 4fgzB-2cfbA:
undetectable		 4fgzB-2cfbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 412
VAL A 408
GLU A 410
TYR A 409
 None
 0.91A 4fgzB-2cfmA:
undetectable		 4fgzB-2cfmA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 GLY A 258
GLY B 274
GLU A 217
LEU A 165
 None
PO4  A 401 (-3.7A)
None
None
 0.91A 4fgzB-2fpgA:
3.7		 4fgzB-2fpgA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 GLY A  15
TYR A 308
LEU A 288
TYR A 170
 U2F  A 900 (-3.2A)
None
None
None
 0.81A 4fgzB-2iw1A:
3.0		 4fgzB-2iw1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohc TRNA-SPLICING
ENDONUCLEASE

(Thermoplasma
acidophilum) 		PF01974
(tRNA_int_endo) 		4 GLY A  90
VAL A  85
GLU A  87
TYR A  93
 None
 0.90A 4fgzB-2ohcA:
undetectable		 4fgzB-2ohcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 TYR A 240
LEU A 244
VAL A 247
TYR A 263
 None
 0.69A 4fgzB-2oipA:
undetectable		 4fgzB-2oipA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL

(Strongylocentrotus
purpuratus) 		PF00027
(cNMP_binding) 		4 TYR A 477
LEU A 481
VAL A 484
GLU A 485
 None
 0.78A 4fgzB-2ptmA:
undetectable		 4fgzB-2ptmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 GLY A  11
GLY A 205
TYR A 221
VAL A 350
 FAD  A 401 ( 3.3A)
FAD  A 401 ( 4.1A)
None
None
 0.84A 4fgzB-2q6uA:
3.2		 4fgzB-2q6uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 338
GLY A 369
GLU A 335
LEU A 422
 None
 0.87A 4fgzB-2qo3A:
undetectable		 4fgzB-2qo3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		4 GLY A  62
GLY A  98
GLU A 239
VAL A  66
 None
 0.86A 4fgzB-2y6vA:
undetectable		 4fgzB-2y6vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		4 GLY A 367
GLY A 372
GLU A 374
VAL A 169
 None
 0.91A 4fgzB-2ychA:
undetectable		 4fgzB-2ychA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 GLY A 291
GLY A 310
TYR A 331
LEU A 365
 None
 0.81A 4fgzB-3a3jA:
undetectable		 4fgzB-3a3jA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 GLY A 396
GLY A 399
TYR A  38
GLU A 405
 None
 0.92A 4fgzB-3b40A:
undetectable		 4fgzB-3b40A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 GLY A  63
GLY A 273
LEU A 274
VAL A 276
 None
 0.79A 4fgzB-3bs8A:
undetectable		 4fgzB-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 GLY A 324
GLY A 215
LEU A 196
GLU A 175
 None
FMN  A 370 (-3.6A)
None
None
 0.91A 4fgzB-3bw2A:
undetectable		 4fgzB-3bw2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 GLY A 193
LEU A 225
VAL A 228
TYR A 232
 None
 0.70A 4fgzB-3dadA:
undetectable		 4fgzB-3dadA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 GLY A1068
GLY A1278
LEU A1279
VAL A1281
 None
 0.82A 4fgzB-3fq8A:
undetectable		 4fgzB-3fq8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		4 GLY C 205
GLY C  71
VAL C 358
TYR C 355
 None
 0.88A 4fgzB-3gi8C:
undetectable		 4fgzB-3gi8C:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		4 GLY A  46
GLY A  51
TYR A  59
LEU A  39
 None
 0.87A 4fgzB-3i0pA:
undetectable		 4fgzB-3i0pA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		4 GLY A 212
VAL A 131
GLU A  89
TYR A 132
 None
 0.81A 4fgzB-3isrA:
undetectable		 4fgzB-3isrA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ist GLUTAMATE RACEMASE

(Listeria
monocytogenes) 		PF01177
(Asp_Glu_race) 		4 GLY A  34
GLY A  13
GLU A 151
TYR A  41
 None
 0.76A 4fgzB-3istA:
undetectable		 4fgzB-3istA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		4 GLY A 125
GLY A 128
VAL A 184
GLU A 179
 None
 0.53A 4fgzB-3kgwA:
3.3		 4fgzB-3kgwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 TYR A 231
LEU A 235
VAL A 238
TYR A 254
 None
 0.73A 4fgzB-3kjrA:
undetectable		 4fgzB-3kjrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpc FN3-LIKE PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 GLY A  44
VAL A  73
GLU A  88
TYR A  72
 None
 0.88A 4fgzB-3mpcA:
undetectable		 4fgzB-3mpcA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLY A 356
GLU A 355
TYR A 292
LEU A 320
 None
 0.89A 4fgzB-3muoA:
2.4		 4fgzB-3muoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 GLY A  93
TYR A  34
LEU A  53
TYR A  49
 None
 0.90A 4fgzB-3oosA:
undetectable		 4fgzB-3oosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY B  13
GLY B 193
TYR B 186
VAL B  17
TYR B  16
 None
 1.49A 4fgzB-3pr2B:
undetectable		 4fgzB-3pr2B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 280
GLY A 284
VAL A 133
TYR A 134
 None
 0.66A 4fgzB-3qo6A:
undetectable		 4fgzB-3qo6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 GLY A 111
VAL A 264
GLU A 109
TYR A 260
 None
None
None
NAD  A 396 (-3.9A)
 0.82A 4fgzB-3qw2A:
undetectable		 4fgzB-3qw2A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50

(Plasmodium
falciparum) 		PF00149
(Metallophos) 		4 GLY A 276
GLY A  36
LEU A  83
VAL A  87
 None
 0.86A 4fgzB-3tghA:
undetectable		 4fgzB-3tghA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 TYR A 558
LEU A 562
VAL A 565
TYR A 569
 None
 0.67A 4fgzB-3vuoA:
undetectable		 4fgzB-3vuoA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuy TRANSPORTER

(Neisseria
meningitidis) 		PF01758
(SBF) 		4 GLY A  45
GLY A  50
LEU A 195
VAL A 198
 LDA  A1316 ( 3.8A)
None
None
None
 0.92A 4fgzB-3zuyA:
undetectable		 4fgzB-3zuyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		4 GLY A  10
GLY A  35
LEU A  42
TYR A  39
 None
 0.90A 4fgzB-4bduA:
undetectable		 4fgzB-4bduA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 GLU A 491
TYR A 506
LEU A 510
GLU A 514
 None
None
NAG  A1956 (-4.3A)
NAG  A1956 (-2.8A)
 0.78A 4fgzB-4cvuA:
undetectable		 4fgzB-4cvuA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		4 GLY A 170
GLY A 343
GLU A 340
GLU A 373
 None
 0.75A 4fgzB-4d59A:
undetectable		 4fgzB-4d59A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		4 GLY A 131
GLY A  53
VAL A 185
GLU A  55
 None
 0.58A 4fgzB-4dqnA:
undetectable		 4fgzB-4dqnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLY A 242
GLY A 266
VAL A 246
GLU A 244
 None
 0.73A 4fgzB-4e2zA:
14.5		 4fgzB-4e2zA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 GLY A  74
LEU A 105
VAL A 108
TYR A 112
 None
 0.50A 4fgzB-4fxqA:
undetectable		 4fgzB-4fxqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Campylobacter
jejuni) 		PF00977
(His_biosynth) 		4 GLY A  83
GLY A 104
TYR A 160
LEU A 128
 None
 0.76A 4fgzB-4gj1A:
undetectable		 4fgzB-4gj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 GLY A  68
GLY A 100
VAL A 154
TYR A 156
 KPI  A 184 ( 3.5A)
None
None
KPI  A 184 ( 3.8A)
 0.71A 4fgzB-4hnnA:
undetectable		 4fgzB-4hnnA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		4 GLY A 310
TYR A 254
LEU A 258
GLU A 262
 None
 0.85A 4fgzB-4hxqA:
undetectable		 4fgzB-4hxqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		4 TYR A 254
LEU A 258
GLU A 262
TYR A 265
 None
 0.57A 4fgzB-4hxqA:
undetectable		 4fgzB-4hxqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN

(gamma
proteobacterium
'Hot 75m4') 		PF01036
(Bac_rhodopsin) 		4 GLY A 212
GLY A 207
TYR A 224
LEU A 220
 None
 0.73A 4fgzB-4klyA:
undetectable		 4fgzB-4klyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 4 GLY A  11
TYR A 400
LEU A 404
VAL A 407
 GAI  A 502 (-3.2A)
None
None
None
 0.77A 4fgzB-4lypA:
undetectable		 4fgzB-4lypA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		4 GLY A 255
VAL A 364
GLU A 362
TYR A 363
 None
 0.86A 4fgzB-4mptA:
undetectable		 4fgzB-4mptA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLY A 268
GLY A 304
TYR A 430
GLU A 303
 None
 0.89A 4fgzB-4mrmA:
undetectable		 4fgzB-4mrmA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		5 GLY A  29
GLY A  36
TYR A 206
LEU A 210
GLU A 214
 None
 0.23A 4fgzB-4mwzA:
41.8		 4fgzB-4mwzA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		4 GLY A  51
GLY A  47
TYR A 125
LEU A 113
 None
SAH  A 401 (-3.9A)
None
SAH  A 401 (-4.1A)
 0.92A 4fgzB-4necA:
16.6		 4fgzB-4necA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 GLY A  22
GLU A 158
VAL A   6
GLU A   7
 None
 0.80A 4fgzB-4nqyA:
undetectable		 4fgzB-4nqyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		4 GLY A 155
GLY A 184
LEU A 185
VAL A 202
 SO4  A 304 (-3.3A)
SO4  A 304 (-3.8A)
None
None
 0.86A 4fgzB-4nu7A:
undetectable		 4fgzB-4nu7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2
HISTONE H4 TYPE VIII

(Saccharomyces
cerevisiae;
Ophiophagus
hannah) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
no annotation 		4 GLY C  15
GLY C   9
TYR B 275
VAL B 341
 None
 0.86A 4fgzB-4pswC:
undetectable		 4fgzB-4pswC:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 133
GLY A 102
GLU A 101
VAL A 144
 None
 0.91A 4fgzB-4q73A:
4.6		 4fgzB-4q73A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvr UNCHARACTERIZED
HYPOTHETICAL PROTEIN
FTT_1539C

(Francisella
tularensis) 		no annotation 4 GLY A 244
LEU A  74
VAL A  77
TYR A  81
 None
 0.45A 4fgzB-4qvrA:
undetectable		 4fgzB-4qvrA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		7 GLY A  32
GLY A  39
TYR A 209
LEU A 213
VAL A 216
GLU A 217
TYR A 220
 None
 0.44A 4fgzB-4r6wA:
44.8		 4fgzB-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Colwellia
psychrerythraea) 		PF02441
(Flavoprotein) 		4 GLY A  15
GLY A  18
VAL A  52
GLU A  51
 FMN  A 301 (-3.5A)
None
None
None
 0.69A 4fgzB-4rheA:
undetectable		 4fgzB-4rheA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN A CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 GLY A  34
TYR A  64
LEU A  68
VAL A  71
 None
None
None
HEM  A 201 ( 4.3A)
 0.73A 4fgzB-4u8uA:
undetectable		 4fgzB-4u8uA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		4 GLY A 319
TYR A 114
LEU A 118
VAL A 121
 None
 0.86A 4fgzB-4ut1A:
undetectable		 4fgzB-4ut1A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB
SOXY PROTEIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02872
(5_nucleotid_C)
PF13501
(SoxY) 		4 GLY A 474
GLY B 150
TYR A 440
TYR A 232
 None
 0.91A 4fgzB-4uwqA:
undetectable		 4fgzB-4uwqA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 GLY A 110
GLY A 650
GLU A 678
VAL A 684
 None
 0.81A 4fgzB-4xhbA:
undetectable		 4fgzB-4xhbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		4 GLY A 367
GLY A  76
GLU A  75
LEU A  79
 None
 0.90A 4fgzB-4yn5A:
undetectable		 4fgzB-4yn5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 GLY A 555
GLY A 599
LEU A 605
VAL A 550
 GLY  A 555 ( 0.0A)
GLY  A 599 ( 0.0A)
LEU  A 605 ( 0.6A)
VAL  A 550 ( 0.6A)
 0.92A 4fgzB-4zkeA:
2.2		 4fgzB-4zkeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		4 GLY B 327
GLY B 324
TYR B 193
VAL B 200
 None
 0.86A 4fgzB-4ztuB:
undetectable		 4fgzB-4ztuB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		4 GLY A 100
GLY A  97
TYR A 110
LEU A 117
 None
 0.88A 4fgzB-5ao5A:
undetectable		 4fgzB-5ao5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5s UNCONVENTIONAL
MYOSIN-IXB

(Homo sapiens) 		PF00620
(RhoGAP) 		4 TYR A 207
LEU A 211
VAL A 214
GLU A 215
 None
 0.46A 4fgzB-5c5sA:
undetectable		 4fgzB-5c5sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 GLY A 103
GLY A 106
VAL A 162
GLU A 157
 None
 0.56A 4fgzB-5f9sA:
3.3		 4fgzB-5f9sA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A  64
LEU A  27
VAL A  30
TYR A  34
 None
 0.61A 4fgzB-5gjnA:
undetectable		 4fgzB-5gjnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3) 		4 GLY A  69
GLY A 279
LEU A 280
VAL A 282
 None
 0.81A 4fgzB-5hdmA:
undetectable		 4fgzB-5hdmA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i10 PROBABLE
O-METHYLTRANSFERASE

(Saccharopolyspora
spinosa) 		PF05711
(TylF) 		4 GLY A  87
TYR A   8
LEU A  12
VAL A  15
 None
 0.90A 4fgzB-5i10A:
10.5		 4fgzB-5i10A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		4 TYR D 294
LEU D 298
VAL D 301
GLU D 302
 None
 0.40A 4fgzB-5lc5D:
undetectable		 4fgzB-5lc5D:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 GLY A1861
GLU A1801
VAL A1841
GLU A1842
 None
 0.91A 4fgzB-5m59A:
4.1		 4fgzB-5m59A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 GLY E 340
GLY E 282
VAL E 348
GLU E 347
 None
 0.76A 4fgzB-5n6yE:
undetectable		 4fgzB-5n6yE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		4 GLY A 259
GLU A  27
LEU A  71
VAL A  67
 None
 0.87A 4fgzB-5nciA:
undetectable		 4fgzB-5nciA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		4 GLY F  14
LEU F 443
VAL F  36
GLU F  37
 None
 0.92A 4fgzB-5odrF:
undetectable		 4fgzB-5odrF:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLY A 242
GLY A 266
VAL A 246
GLU A 244
 None
MG  A 508 ( 4.2A)
None
MG  A 508 ( 3.9A)
 0.76A 4fgzB-5t67A:
13.9		 4fgzB-5t67A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		4 GLY A 149
GLY A  79
LEU A 205
VAL A 215
 None
 0.87A 4fgzB-5x15A:
undetectable		 4fgzB-5x15A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 GLY A 234
GLY A 111
GLU A 275
LEU A 112
 None
 0.85A 4fgzB-5xfaA:
undetectable		 4fgzB-5xfaA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLY A 215
GLY A 225
GLU A 187
LEU A 223
 None
SIA  A 603 ( 4.4A)
SIA  A 603 (-3.1A)
SIA  A 603 (-4.3A)
 0.88A 4fgzB-5xl6A:
undetectable		 4fgzB-5xl6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys6 PRV GLYCOPROTEN B

(Suid
alphaherpesvirus
1) 		no annotation 4 GLY A 606
LEU A 643
VAL A 610
TYR A 609
 None
 0.87A 4fgzB-5ys6A:
undetectable		 4fgzB-5ys6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 GLY A2107
VAL A2155
GLU A2156
TYR A2159
 None
 0.55A 4fgzB-6b3rA:
undetectable		 4fgzB-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 GLY A2107
VAL A2155
GLU A2156
TYR A2159
 None
 0.72A 4fgzB-6bpzA:
undetectable		 4fgzB-6bpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 GLY A 845
GLU A 835
LEU A 810
VAL A 814
 None
 0.89A 4fgzB-6d6yA:
15.3		 4fgzB-6d6yA:
undetectable