SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGZ_A_CQAA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLU A 327
TYR A 326
ARG A 318
GLY A 342
 None
 0.78A 4fgzA-1bf2A:
undetectable		 4fgzA-1bf2A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpv TITIN

(Homo sapiens) 		PF00041
(fn3) 		4 GLU A  73
TYR A  72
GLY A  46
ARG A  41
 None
 0.98A 4fgzA-1bpvA:
undetectable		 4fgzA-1bpvA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)
PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN)

(Cupriavidus
necator;
Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
PF00101
(RuBisCO_small) 		4 GLU A 435
TYR I  25
ARG A 433
GLY A 169
 None
 1.08A 4fgzA-1bxnA:
undetectable		 4fgzA-1bxnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		4 GLU A  69
GLU A  70
TYR A  71
GLY A  66
 None
 1.06A 4fgzA-1c7oA:
4.3		 4fgzA-1c7oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cul TYPE II ADENYLYL
CYCLASE

(Rattus
norvegicus) 		PF00211
(Guanylate_cyc) 		4 TYR B1073
GLY B1060
ARG B1059
LYS B1071
 None
 0.97A 4fgzA-1culB:
undetectable		 4fgzA-1culB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)

(Escherichia
coli) 		PF03852
(Vsr) 		4 GLU A 132
GLU A 136
GLY A 151
ARG A 133
 None
 0.99A 4fgzA-1cw0A:
undetectable		 4fgzA-1cw0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		4 GLU A  98
TYR A  96
GLY A 117
ARG A  90
 None
 1.02A 4fgzA-1epzA:
undetectable		 4fgzA-1epzA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLU A 377
ARG A 326
ARG A 333
LYS A 467
 None
 1.05A 4fgzA-1ex0A:
undetectable		 4fgzA-1ex0A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541

(Methanocaldococcus
jannaschii) 		PF01467
(CTP_transf_like) 		4 GLU A 112
GLU A 107
TYR A 111
GLY A   3
 None
 0.99A 4fgzA-1f9aA:
2.4		 4fgzA-1f9aA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		4 GLU A 369
GLU A 366
TYR A 368
GLY A 218
 None
 1.03A 4fgzA-1fbvA:
undetectable		 4fgzA-1fbvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npr TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Aquifex
aeolicus) 		PF00467
(KOW)
PF02357
(NusG)
PF07009
(NusG_II) 		4 GLU A  52
GLU A  51
ARG A  65
LYS A 127
 None
 1.05A 4fgzA-1nprA:
undetectable		 4fgzA-1nprA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0w RIBONUCLEASE III

(Thermotoga
maritima) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		4 GLU A 114
GLU A 113
GLY A 104
ARG A 119
 None
 1.01A 4fgzA-1o0wA:
undetectable		 4fgzA-1o0wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyb METHIONYL-TRNA
SYNTHETASE BETA
SUBUNIT

(Aquifex
aeolicus) 		PF01588
(tRNA_bind) 		4 GLU A  44
GLU A  45
GLY A  84
ARG A  46
 None
 1.02A 4fgzA-1pybA:
undetectable		 4fgzA-1pybA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8h OSTEOCALCIN

(Sus scrofa) 		no annotation 5 GLU A  40
TYR A  42
ARG A  19
GLY A  47
ARG A  43
 None
 1.46A 4fgzA-1q8hA:
undetectable		 4fgzA-1q8hA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leishmania
donovani) 		PF00156
(Pribosyltran) 		4 GLU A 120
GLU A 118
TYR A 117
GLY A 153
 None
None
None
SO4  A 602 (-3.6A)
 1.00A 4fgzA-1qcdA:
2.6		 4fgzA-1qcdA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)
RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (SMALL CHAIN)

(Synechococcus
elongatus;
Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
no annotation 		4 GLU A 433
TYR M  32
ARG A 431
GLY A 166
 None
 0.95A 4fgzA-1rblA:
undetectable		 4fgzA-1rblA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shs SMALL HEAT SHOCK
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00011
(HSP20) 		4 GLU A 102
GLU A 104
GLY A  62
ARG A  83
 None
 0.84A 4fgzA-1shsA:
undetectable		 4fgzA-1shsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLU A 206
TYR A 215
ARG A 349
GLY A 391
 PMP  A1271 ( 3.9A)
None
None
None
 1.07A 4fgzA-1szsA:
undetectable		 4fgzA-1szsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU B 139
GLU B 140
TYR B 138
GLY B 107
 None
 0.87A 4fgzA-1t3qB:
undetectable		 4fgzA-1t3qB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		4 GLU A  87
GLU A  89
GLY A  80
ARG A  83
 None
 0.95A 4fgzA-1wloA:
undetectable		 4fgzA-1wloA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		4 GLU A  62
TYR A  64
GLY A 316
ARG A  63
 None
 0.96A 4fgzA-1x2bA:
2.2		 4fgzA-1x2bA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 GLU A 258
TYR A 260
ARG A 263
GLY A 290
 None
 0.82A 4fgzA-1y8pA:
undetectable		 4fgzA-1y8pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 GLU A 261
TYR A 260
ARG A 263
GLY A 290
 None
 1.05A 4fgzA-1y8pA:
undetectable		 4fgzA-1y8pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqm PHD FINGER PROTEIN
20-LIKE 1

(Homo sapiens) 		PF02820
(MBT) 		4 GLU A  55
GLU A  27
GLY A  23
ARG A  39
 None
 0.90A 4fgzA-2eqmA:
undetectable		 4fgzA-2eqmA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npr MEROZOITE SURFACE
PROTEIN 1

(Plasmodium
vivax) 		PF12946
(EGF_MSP1_1)
PF12947
(EGF_3) 		4 GLU A  27
GLU A  28
TYR A  20
ARG A  21
 None
 1.05A 4fgzA-2nprA:
undetectable		 4fgzA-2nprA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		4 GLU A 548
GLY A 515
ARG A 518
LYS A 519
 None
SO4  A 901 (-3.4A)
None
None
 0.94A 4fgzA-2nrxA:
undetectable		 4fgzA-2nrxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 GLU A 105
GLU A 108
TYR A 109
ARG A 113
 None
 0.82A 4fgzA-2qw5A:
undetectable		 4fgzA-2qw5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 GLU A 459
TYR A 461
ARG A 542
GLY A 724
 None
 1.04A 4fgzA-2rdyA:
undetectable		 4fgzA-2rdyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 GLU A 352
GLU A 349
TYR A 350
GLY A 301
 None
 1.01A 4fgzA-2rgjA:
undetectable		 4fgzA-2rgjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLU B 580
GLU B 598
TYR B 599
ARG B 554
 None
 0.97A 4fgzA-2rhqB:
undetectable		 4fgzA-2rhqB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 382
GLU A 383
GLY A 372
LYS A 379
 None
 0.88A 4fgzA-2v6oA:
2.1		 4fgzA-2v6oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 GLU A  84
TYR A  85
GLY A 138
ARG A  86
 None
 1.02A 4fgzA-2w8iA:
undetectable		 4fgzA-2w8iA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 109
GLU A 106
GLY A 157
ARG A 108
 None
 0.97A 4fgzA-2x40A:
undetectable		 4fgzA-2x40A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvx CHELATASE, PUTATIVE

(Desulfovibrio
vulgaris) 		PF06180
(CbiK) 		4 GLU A  23
GLU A  22
GLY A 214
ARG A 218
 None
None
GOL  A1284 ( 3.1A)
None
 1.02A 4fgzA-2xvxA:
2.1		 4fgzA-2xvxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 GLU A 175
GLU A 171
GLY A 844
ARG A 178
 None
 0.87A 4fgzA-3abzA:
undetectable		 4fgzA-3abzA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqh PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01625
(PMSR) 		4 GLU A 250
ARG A 291
GLY A 231
LYS A 328
 None
 1.04A 4fgzA-3bqhA:
undetectable		 4fgzA-3bqhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 4 GLU A 198
TYR A 200
GLY A 232
ARG A 197
 None
 0.84A 4fgzA-3c2qA:
undetectable		 4fgzA-3c2qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 GLU A  30
GLU A  29
ARG A  27
GLY A 178
 None
 1.02A 4fgzA-3d4jA:
undetectable		 4fgzA-3d4jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		4 GLU X 149
GLU X 152
ARG X 116
GLY X 145
 None
None
None
SAM  X5452 (-3.7A)
 1.04A 4fgzA-3dcmX:
2.3		 4fgzA-3dcmX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8m GNTR-FAMILY PROTEIN
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 GLU A  87
TYR A 164
ARG A 220
GLY A  81
 None
 1.04A 4fgzA-3f8mA:
undetectable		 4fgzA-3f8mA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		4 GLU A 150
TYR A 152
ARG A  83
GLY A 147
 None
 1.07A 4fgzA-3g8aA:
12.1		 4fgzA-3g8aA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		4 GLU A 307
TYR A 185
GLY A 257
ARG A 186
 None
 1.01A 4fgzA-3hagA:
undetectable		 4fgzA-3hagA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 GLU A 278
TYR A 169
ARG A 170
GLY A 206
 None
None
SAH  A 385 ( 4.8A)
None
 1.04A 4fgzA-3ldgA:
9.6		 4fgzA-3ldgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLU B 361
TYR B 360
GLY B 261
ARG B 359
 None
 1.04A 4fgzA-3pcoB:
undetectable		 4fgzA-3pcoB:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 GLU A 273
GLU A 277
GLY A 212
ARG A 270
 None
 1.01A 4fgzA-3s6hA:
2.8		 4fgzA-3s6hA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 GLU A  45
GLU A  44
GLY A 233
ARG A 236
 None
 1.07A 4fgzA-3tlmA:
undetectable		 4fgzA-3tlmA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		4 GLU A 513
GLU A 516
TYR A 517
ARG A 521
 None
 1.03A 4fgzA-3ty9A:
undetectable		 4fgzA-3ty9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 GLU A  85
GLU A  47
ARG A  49
ARG A  82
 None
 1.02A 4fgzA-3us8A:
undetectable		 4fgzA-3us8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 GLU A 323
GLU A 320
GLY A 290
ARG A 326
 None
 0.91A 4fgzA-3vilA:
undetectable		 4fgzA-3vilA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 GLU A 372
TYR A  11
GLY A  78
ARG A  77
 None
 1.07A 4fgzA-3wq8A:
undetectable		 4fgzA-3wq8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		5 GLU A  62
GLU A  63
ARG A  15
GLY A 113
ARG A 117
 None
None
ANP  A 501 ( 3.8A)
None
None
 1.38A 4fgzA-3zfcA:
undetectable		 4fgzA-3zfcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLU A  65
ARG A  18
GLY A 115
ARG A 119
 None
ADP  A1345 (-3.6A)
None
None
 1.07A 4fgzA-4a14A:
undetectable		 4fgzA-4a14A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 GLU A  52
TYR A  67
GLY A  64
ARG A  66
 None
 1.04A 4fgzA-4bg2A:
undetectable		 4fgzA-4bg2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7)
PF16453
(IQ_SEC7_PH) 		4 GLU A 507
GLY A 457
ARG A 504
LYS A 501
 None
 1.02A 4fgzA-4c0aA:
undetectable		 4fgzA-4c0aA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLU A 196
GLU A 191
TYR A 194
ARG A 155
 None
 1.02A 4fgzA-4cmwA:
undetectable		 4fgzA-4cmwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkd INTERLEUKIN-34

(Homo sapiens) 		PF15036
(IL34) 		4 GLU A 173
TYR A 176
GLY A  39
ARG A  42
 None
 1.02A 4fgzA-4dkdA:
undetectable		 4fgzA-4dkdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euk HISTIDINE KINASE 5

(Arabidopsis
thaliana) 		PF00072
(Response_reg) 		4 GLU A 847
GLU A 848
GLY A 899
ARG A 844
 None
 1.05A 4fgzA-4eukA:
undetectable		 4fgzA-4eukA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0b THIOL TRANSFERASE

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLU A 211
GLU A 208
GLY A 185
ARG A 188
 None
 1.02A 4fgzA-4f0bA:
undetectable		 4fgzA-4f0bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 GLU A  36
TYR A  35
GLY A   5
ARG A   8
 None
 0.89A 4fgzA-4f4cA:
undetectable		 4fgzA-4f4cA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		4 GLU A 123
GLU A 127
TYR A 125
GLY A  98
 None
 1.05A 4fgzA-4fioA:
undetectable		 4fgzA-4fioA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2

(Homo sapiens) 		PF13181
(TPR_8) 		4 GLU A 354
GLU A 351
TYR A 355
LYS A 359
 None
 0.95A 4fgzA-4g1tA:
undetectable		 4fgzA-4g1tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 TYR A 343
ARG A 347
GLY A 411
LYS A 415
 OPE  A 502 (-4.6A)
OPE  A 502 (-3.9A)
None
OPE  A 502 (-2.7A)
 0.52A 4fgzA-4ineA:
38.6		 4fgzA-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		4 GLU A 242
GLU A 186
GLY A 201
ARG A 207
 None
 0.95A 4fgzA-4jipA:
undetectable		 4fgzA-4jipA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 GLU A 338
TYR A 339
GLY A 407
LYS A 411
 None
1SH  A 702 (-4.6A)
None
1SH  A 702 (-2.6A)
 1.08A 4fgzA-4kriA:
38.6		 4fgzA-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 TYR A 339
ARG A 343
GLY A 407
LYS A 411
 1SH  A 702 (-4.6A)
1SH  A 702 (-4.0A)
None
1SH  A 702 (-2.6A)
 0.58A 4fgzA-4kriA:
38.6		 4fgzA-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		4 GLU A 220
ARG A  98
GLY A 123
ARG A 126
 None
 0.99A 4fgzA-4l0cA:
undetectable		 4fgzA-4l0cA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ

(Ruegeria
lacuscaerulensis) 		PF16867
(DMSP_lyase) 		4 GLU A 128
GLU A 129
GLY A  24
ARG A 179
 None
ZN  A 201 ( 1.9A)
None
None
 0.87A 4fgzA-4la2A:
undetectable		 4fgzA-4la2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 3A,
CHLOROPLASTIC

(Pisum sativum;
Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
PF00101
(RuBisCO_small) 		4 GLU A 433
TYR S  32
ARG A 431
GLY A 166
 None
 0.99A 4fgzA-4mkvA:
undetectable		 4fgzA-4mkvA:
18.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		5 GLU A 168
TYR A 172
ARG A 176
GLY A 240
LYS A 244
 None
PO4  A 302 (-4.5A)
PO4  A 302 (-3.8A)
None
PO4  A 302 (-2.7A)
 0.85A 4fgzA-4mwzA:
41.8		 4fgzA-4mwzA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohx PROTEIN CLPF-1

(Caenorhabditis
elegans) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 GLU A  95
GLU A  96
GLY A 114
ARG A  98
 None
 0.95A 4fgzA-4ohxA:
undetectable		 4fgzA-4ohxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 GLU A 229
GLY A  47
ARG A  50
LYS A  45
 None
 1.05A 4fgzA-4p5bA:
undetectable		 4fgzA-4p5bA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		4 TYR B 705
ARG B 709
GLY B 702
ARG B 698
 None
 0.97A 4fgzA-4qlpB:
undetectable		 4fgzA-4qlpB:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		5 GLU A 174
TYR A 175
ARG A 179
GLY A 243
LYS A 247
 None
PC  A 301 (-4.5A)
PC  A 301 (-3.9A)
None
PC  A 301 (-2.7A)
 0.38A 4fgzA-4r6wA:
44.8		 4fgzA-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		4 GLU A 496
GLU A 497
TYR A 498
GLY A 502
 None
 0.88A 4fgzA-4wisA:
undetectable		 4fgzA-4wisA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 GLU A 177
TYR A 176
ARG A  73
GLY A 189
 None
 1.03A 4fgzA-4wlpA:
undetectable		 4fgzA-4wlpA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLU A 314
GLU A 313
GLY A 233
ARG A 311
 None
 0.94A 4fgzA-4wn9A:
undetectable		 4fgzA-4wn9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A 569
GLU A 570
GLY A 574
ARG A 575
 None
 1.03A 4fgzA-4yswA:
undetectable		 4fgzA-4yswA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLU A 253
GLU A 254
ARG A 273
ARG A 256
 None
ZN  A 301 (-2.1A)
None
None
 0.99A 4fgzA-4zfzA:
undetectable		 4fgzA-4zfzA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 GLU A 104
GLU A 103
GLY A 319
LYS A 317
 None
 0.83A 4fgzA-4zwlA:
undetectable		 4fgzA-4zwlA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 GLU A 426
GLU A 429
ARG A 436
GLY A 418
 None
 1.02A 4fgzA-5cwaA:
undetectable		 4fgzA-5cwaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		4 GLU C  80
TYR C  72
GLY C  58
ARG C  73
 None
 0.97A 4fgzA-5czfC:
undetectable		 4fgzA-5czfC:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 437
GLU A 520
GLY A 388
ARG A 519
 None
 0.91A 4fgzA-5h12A:
undetectable		 4fgzA-5h12A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA

(Escherichia
coli) 		PF09481
(CRISPR_Cse1) 		4 GLU A 428
TYR A 424
GLY A 385
LYS A 389
 None
 1.06A 4fgzA-5h9fA:
undetectable		 4fgzA-5h9fA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jg9 DE NOVO DESIGN,
HYPER STABLE,
DISULFIDE-RICH MINI
PROTEIN

(synthetic
construct) 		no annotation 4 GLU A  42
ARG A  16
ARG A  33
LYS A  34
 None
 0.95A 4fgzA-5jg9A:
undetectable		 4fgzA-5jg9A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsi KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens) 		no annotation 4 GLU E  66
GLU E  67
GLY E  61
ARG E  69
 None
 0.92A 4fgzA-5lsiE:
undetectable		 4fgzA-5lsiE:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 GLU A 490
ARG A 438
GLY A 104
ARG A  98
 None
 1.07A 4fgzA-5mhfA:
undetectable		 4fgzA-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		4 GLU A 541
TYR A 556
ARG A 632
LYS A 636
 None
 1.04A 4fgzA-5mswA:
4.1		 4fgzA-5mswA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLU A4206
TYR A4205
GLY A4254
ARG A4255
 None
 0.93A 4fgzA-5nugA:
undetectable		 4fgzA-5nugA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
PF00101
(RuBisCO_small) 		4 GLU A 434
TYR I  25
ARG A 432
GLY A 168
 None
 1.02A 4fgzA-5nv3A:
undetectable		 4fgzA-5nv3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU A 261
TYR A 261
GLY A 116
ARG A 261
 None
 1.02A 4fgzA-5tg8A:
undetectable		 4fgzA-5tg8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdh KINESIN-LIKE PROTEIN
KIFC1

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLU A 386
ARG A 316
GLY A 432
ARG A 436
 None
ADP  A 801 (-3.6A)
None
UNX  A 805 ( 2.9A)
 0.92A 4fgzA-5wdhA:
undetectable		 4fgzA-5wdhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 4 GLU A 338
GLU A 337
GLY A 463
ARG A 462
 None
 0.83A 4fgzA-5wdxA:
undetectable		 4fgzA-5wdxA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLU A 399
TYR A 400
ARG A 404
GLY A 468
LYS A 472
 None
PC  A 702 (-4.5A)
PC  A 702 (-3.9A)
None
PC  A 702 (-2.7A)
 0.49A 4fgzA-5wp4A:
40.1		 4fgzA-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLU A 396
GLU A 399
TYR A 400
ARG A 404
LYS A 472
 None
 0.91A 4fgzA-5wp5A:
33.5		 4fgzA-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLU A 396
TYR A 400
ARG A 404
GLY A 468
LYS A 472
 None
 1.27A 4fgzA-5wp5A:
33.5		 4fgzA-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG

(Homo sapiens) 		PF07574
(SMC_Nse1)
PF08746
(zf-RING-like) 		4 GLU A  30
GLU A  29
ARG A  73
LYS A  72
 None
 0.91A 4fgzA-5wy5A:
undetectable		 4fgzA-5wy5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		no annotation
PF03739
(YjgP_YjgQ) 		4 GLU F  82
ARG B 150
GLY B 135
ARG B  91
 None
 1.03A 4fgzA-5x5yF:
undetectable		 4fgzA-5x5yF:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9a CALAXIN

(Ciona
intestinalis) 		no annotation 4 GLU A  97
GLU A 100
TYR A 101
GLY A  86
 None
 0.71A 4fgzA-5x9aA:
undetectable		 4fgzA-5x9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 GLU A 507
GLY A 457
ARG A 504
LYS A 501
 None
 1.03A 4fgzA-6faeA:
undetectable		 4fgzA-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 4 GLU A 134
GLU A 135
GLY A 140
ARG A 136
 None
GOL  A 303 ( 4.6A)
GOL  A 302 ( 3.1A)
None
 0.96A 4fgzA-6fksA:
undetectable		 4fgzA-6fksA:
undetectable