SIMILAR PATTERNS OF AMINO ACIDS FOR 4FGZ_A_CQAA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 GLY A  93
GLY A  64
LEU A  68
VAL A  84
 None
 0.91A 4fgzA-1a6dA:
undetectable		 4fgzA-1a6dA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		5 GLY A 447
GLY A 335
GLU A 454
LEU A 356
VAL A 359
 None
 1.07A 4fgzA-1b7eA:
undetectable		 4fgzA-1b7eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		4 GLY A 210
VAL A 206
GLU A 208
TYR A 207
 None
 0.91A 4fgzA-1bwzA:
undetectable		 4fgzA-1bwzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN)

(Cupriavidus
necator) 		PF00101
(RuBisCO_small) 		4 GLY I  52
GLY I  34
GLU I  36
TYR I  37
 None
 0.90A 4fgzA-1bxnI:
undetectable		 4fgzA-1bxnI:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		4 GLY A 265
GLY A 293
VAL A 282
GLU A 286
 None
 0.91A 4fgzA-1c7gA:
2.8		 4fgzA-1c7gA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		PF00156
(Pribosyltran) 		4 GLY A 152
GLU A 146
TYR A   9
LEU A 186
 None
MG  A 232 (-3.0A)
None
None
 0.91A 4fgzA-1dbrA:
2.2		 4fgzA-1dbrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 GLY A 304
TYR A 415
LEU A 352
VAL A 351
 None
 0.93A 4fgzA-1dj3A:
undetectable		 4fgzA-1dj3A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A   4
GLY A   1
GLU A  74
VAL A  28
 None
 0.92A 4fgzA-1e3eA:
5.5		 4fgzA-1e3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 GLY A 202
LEU A 280
VAL A 278
TYR A 235
 None
 0.91A 4fgzA-1eceA:
undetectable		 4fgzA-1eceA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 GLY A 193
GLY A 140
LEU A 155
VAL A  73
 None
 0.84A 4fgzA-1fizA:
undetectable		 4fgzA-1fizA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A  36
GLY A 105
GLU A  55
LEU A 109
 None
None
FAD  A 600 (-2.6A)
None
 0.92A 4fgzA-1gpeA:
2.0		 4fgzA-1gpeA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLY A 183
TYR A 123
VAL A 130
GLU A 131
 None
 0.89A 4fgzA-1gytA:
undetectable		 4fgzA-1gytA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		4 GLY A 151
GLY A 180
LEU A 181
VAL A 198
 SO4  A1224 (-3.6A)
SO4  A1224 (-3.7A)
None
None
 0.86A 4fgzA-1h1yA:
undetectable		 4fgzA-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 197
GLY A 170
GLU A  80
VAL A 309
 NAJ  A1361 (-3.5A)
None
None
NAJ  A1361 (-3.7A)
 0.90A 4fgzA-1h2bA:
6.1		 4fgzA-1h2bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		4 GLY A  60
GLY A  24
VAL A 102
TYR A  86
 None
 0.91A 4fgzA-1izeA:
undetectable		 4fgzA-1izeA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLY A  38
LEU A  16
VAL A  42
TYR A  94
 None
 0.92A 4fgzA-1jxkA:
undetectable		 4fgzA-1jxkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlt MITOCHONDRIAL
PROTEIN IMPORT
PROTEIN MAS5

(Saccharomyces
cerevisiae) 		PF00684
(DnaJ_CXXCXGXG)
PF01556
(DnaJ_C) 		4 GLY A 151
GLY A 148
LEU A 142
VAL A 209
 None
 0.78A 4fgzA-1nltA:
undetectable		 4fgzA-1nltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		4 GLY A   9
GLY A 100
LEU A 105
VAL A  49
 None
 0.90A 4fgzA-1o6dA:
undetectable		 4fgzA-1o6dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 GLY A 224
TYR A  25
LEU A 295
VAL A 297
 None
None
None
FMN  A1730 (-3.7A)
 0.89A 4fgzA-1o94A:
undetectable		 4fgzA-1o94A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		5 GLY A 346
GLU A 251
TYR A 221
LEU A 168
VAL A 167
 None
 1.44A 4fgzA-1oa1A:
undetectable		 4fgzA-1oa1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLY A  12
TYR A 296
LEU A 300
VAL A 303
 NAD  A 500 (-3.0A)
MAL  A 900 (-4.2A)
NAD  A 500 ( 4.9A)
None
 0.49A 4fgzA-1obbA:
4.0		 4fgzA-1obbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLY A  38
LEU A  16
VAL A  42
TYR A  94
 None
 0.90A 4fgzA-1oseA:
undetectable		 4fgzA-1oseA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 GLY A 305
TYR A 254
LEU A 258
GLU A 262
 None
 0.86A 4fgzA-1p8rA:
undetectable		 4fgzA-1p8rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 TYR A 254
LEU A 258
GLU A 262
TYR A 265
 None
 0.67A 4fgzA-1p8rA:
undetectable		 4fgzA-1p8rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		4 GLY D 779
GLY D 815
LEU D 814
VAL D 812
 None
 0.90A 4fgzA-1pytD:
undetectable		 4fgzA-1pytD:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 GLY A 169
LEU A 155
VAL A 158
GLU A 159
 None
 0.82A 4fgzA-1pztA:
undetectable		 4fgzA-1pztA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 GLY H 127
LEU H 104
VAL H 121
TYR H 130
 None
 0.81A 4fgzA-1q5qH:
undetectable		 4fgzA-1q5qH:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 GLY H 127
LEU H 104
VAL H 121
TYR H 130
 None
 0.88A 4fgzA-1q5rH:
undetectable		 4fgzA-1q5rH:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 GLY A 226
GLU A 161
LEU A 223
VAL A 218
 None
 0.84A 4fgzA-1qhbA:
undetectable		 4fgzA-1qhbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA

(Escherichia
coli) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		4 GLY A1041
GLY A1071
LEU A1066
VAL A1064
 None
 0.91A 4fgzA-1rc6A:
undetectable		 4fgzA-1rc6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		5 GLY A  52
GLY A  55
GLU A  36
LEU A 178
VAL A 177
 GLY  A  52 ( 0.0A)
GLY  A  55 ( 0.0A)
GLU  A  36 ( 0.5A)
LEU  A 178 ( 0.6A)
VAL  A 177 ( 0.5A)
 1.38A 4fgzA-1rynA:
undetectable		 4fgzA-1rynA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		4 GLY A 152
GLY A 181
LEU A 182
VAL A 199
 SO4  A2224 (-3.4A)
SO4  A2224 (-3.3A)
None
None
 0.88A 4fgzA-1tqxA:
undetectable		 4fgzA-1tqxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu7 GLUTATHIONE
S-TRANSFERASE 2

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A 144
GLY A 138
LEU A 174
VAL A 177
 None
 0.91A 4fgzA-1tu7A:
undetectable		 4fgzA-1tu7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 141
GLY A 137
GLU A 166
TYR A 224
 None
None
None
15P  A1000 (-4.9A)
 0.93A 4fgzA-1u0mA:
undetectable		 4fgzA-1u0mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9n MALATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF02615
(Ldh_2) 		4 GLY A  51
GLY A  56
TYR A  63
LEU A  44
 None
 0.83A 4fgzA-1v9nA:
undetectable		 4fgzA-1v9nA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 GLY A 121
LEU A 122
VAL A 124
GLU A 174
 None
None
None
AMP  A 700 (-4.0A)
 0.92A 4fgzA-1v9pA:
undetectable		 4fgzA-1v9pA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 GLY A  39
GLU A 316
VAL A  45
GLU A  44
 None
 0.93A 4fgzA-1w27A:
undetectable		 4fgzA-1w27A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 GLY B   7
GLY B 188
VAL B  11
TYR B  10
 None
 0.92A 4fgzA-1wdwB:
undetectable		 4fgzA-1wdwB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		4 GLY A  40
GLY A  45
TYR A  52
LEU A  33
 None
 0.80A 4fgzA-1x0aA:
undetectable		 4fgzA-1x0aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 273
GLY A 336
LEU A 351
VAL A 408
 None
 0.92A 4fgzA-1xkwA:
undetectable		 4fgzA-1xkwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yox HYPOTHETICAL PROTEIN
PA3696

(Pseudomonas
aeruginosa) 		PF01987
(AIM24) 		4 GLY A 123
GLY A 153
GLU A   5
LEU A 154
 None
 0.87A 4fgzA-1yoxA:
undetectable		 4fgzA-1yoxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 169
GLY A 342
VAL A 363
TYR A 367
 None
 0.79A 4fgzA-1ysjA:
undetectable		 4fgzA-1ysjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		5 GLY A  78
GLU A  40
VAL A 102
GLU A  36
TYR A  35
 None
 1.34A 4fgzA-1z7aA:
undetectable		 4fgzA-1z7aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		4 GLY A 175
GLY A  73
VAL A 233
TYR A 232
 None
 0.83A 4fgzA-1zbmA:
undetectable		 4fgzA-1zbmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		4 GLY A 550
LEU A 586
VAL A 544
TYR A 553
 None
 0.93A 4fgzA-1zvuA:
undetectable		 4fgzA-1zvuA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01218
(Coprogen_oxidas) 		4 GLY A 336
GLY A 333
LEU A 446
VAL A 445
 None
 0.91A 4fgzA-2aexA:
undetectable		 4fgzA-2aexA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		4 GLY A 202
GLY A 200
LEU A 107
VAL A 110
 None
 0.70A 4fgzA-2au3A:
undetectable		 4fgzA-2au3A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 GLY A  73
GLY A  68
LEU A 104
TYR A 107
 None
 0.65A 4fgzA-2b3bA:
undetectable		 4fgzA-2b3bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		4 GLY A 259
GLY A 341
GLU A 261
TYR A 262
 None
 0.89A 4fgzA-2bjrA:
undetectable		 4fgzA-2bjrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 GLY A  46
GLY A 256
LEU A 257
VAL A 259
 None
 0.87A 4fgzA-2cfbA:
undetectable		 4fgzA-2cfbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY C 126
GLU C  67
VAL C 122
GLU C 123
 None
 0.90A 4fgzA-2d3tC:
undetectable		 4fgzA-2d3tC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01409
(tRNA-synt_2d) 		4 GLY A 246
GLY A 307
TYR A 273
VAL A 323
 None
 0.86A 4fgzA-2du3A:
undetectable		 4fgzA-2du3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		4 GLY A 258
GLY A 311
TYR A 285
VAL A 327
 None
 0.85A 4fgzA-2du7A:
undetectable		 4fgzA-2du7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 528
GLY A 533
TYR A 613
LEU A 575
VAL A 573
 None
 1.31A 4fgzA-2e6kA:
undetectable		 4fgzA-2e6kA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		4 GLY A 178
GLY A 163
LEU A  97
VAL A 100
 None
 0.93A 4fgzA-2evrA:
undetectable		 4fgzA-2evrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 GLY A 258
GLY B 274
GLU A 217
LEU A 165
 None
PO4  A 401 (-3.7A)
None
None
 0.91A 4fgzA-2fpgA:
3.6		 4fgzA-2fpgA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 GLY G 346
GLY G 322
VAL G 382
GLU G 380
 None
 0.84A 4fgzA-2iouG:
undetectable		 4fgzA-2iouG:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 GLY A  15
TYR A 308
LEU A 288
TYR A 170
 U2F  A 900 (-3.2A)
None
None
None
 0.82A 4fgzA-2iw1A:
3.0		 4fgzA-2iw1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlv XISI PROTEIN-LIKE

(Trichormus
variabilis) 		PF08869
(XisI) 		4 GLY A  87
TYR A  18
LEU A  14
TYR A   7
 None
 0.76A 4fgzA-2nlvA:
undetectable		 4fgzA-2nlvA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohc TRNA-SPLICING
ENDONUCLEASE

(Thermoplasma
acidophilum) 		PF01974
(tRNA_int_endo) 		4 GLY A  90
VAL A  85
GLU A  87
TYR A  93
 None
 0.91A 4fgzA-2ohcA:
undetectable		 4fgzA-2ohcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohc TRNA-SPLICING
ENDONUCLEASE

(Thermoplasma
acidophilum) 		PF01974
(tRNA_int_endo) 		4 GLY A 211
GLY A 147
LEU A 230
VAL A 228
 None
 0.83A 4fgzA-2ohcA:
undetectable		 4fgzA-2ohcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 TYR A 240
LEU A 244
VAL A 247
TYR A 263
 None
 0.70A 4fgzA-2oipA:
undetectable		 4fgzA-2oipA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii) 		PF03061
(4HBT) 		4 GLY A 132
TYR A 162
VAL A 129
TYR A 122
 None
 0.88A 4fgzA-2ov9A:
undetectable		 4fgzA-2ov9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6d DIPHTHINE SYNTHASE

(Pyrococcus
horikoshii) 		PF00590
(TP_methylase) 		4 GLY A 121
VAL A 245
GLU A 246
TYR A 249
 None
 0.70A 4fgzA-2p6dA:
undetectable		 4fgzA-2p6dA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL

(Strongylocentrotus
purpuratus) 		PF00027
(cNMP_binding) 		4 TYR A 477
LEU A 481
VAL A 484
GLU A 485
 None
 0.80A 4fgzA-2ptmA:
undetectable		 4fgzA-2ptmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 GLY A  11
GLY A 205
TYR A 221
VAL A 350
 FAD  A 401 ( 3.3A)
FAD  A 401 ( 4.1A)
None
None
 0.83A 4fgzA-2q6uA:
3.1		 4fgzA-2q6uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 GLY A  13
GLY A  43
LEU A 322
VAL A 324
 FAD  A 401 ( 3.5A)
FAD  A 401 ( 3.9A)
None
None
 0.81A 4fgzA-2q6uA:
3.1		 4fgzA-2q6uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 338
GLY A 369
GLU A 335
LEU A 422
 None
 0.87A 4fgzA-2qo3A:
undetectable		 4fgzA-2qo3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 GLY A 443
GLU A 588
LEU A 492
VAL A 490
 None
 0.93A 4fgzA-2qqoA:
undetectable		 4fgzA-2qqoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 GLY A 270
GLY A 249
LEU A  72
VAL A  20
 None
 0.82A 4fgzA-2wknA:
undetectable		 4fgzA-2wknA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		4 GLY A  11
GLY A  66
GLU A 117
VAL A 102
 None
 0.88A 4fgzA-2wl3A:
undetectable		 4fgzA-2wl3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		4 GLY A  62
GLY A  98
GLU A 239
VAL A  66
 None
 0.87A 4fgzA-2y6vA:
undetectable		 4fgzA-2y6vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		4 GLY A  72
GLY A  77
GLU A  17
TYR A  12
 None
 0.84A 4fgzA-2y78A:
undetectable		 4fgzA-2y78A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 532
GLY A 222
LEU A 346
VAL A 225
GLU A 224
 None
 1.40A 4fgzA-2y8nA:
undetectable		 4fgzA-2y8nA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		4 GLY A 367
GLY A 372
GLU A 374
VAL A 169
 None
 0.90A 4fgzA-2ychA:
undetectable		 4fgzA-2ychA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		4 GLY A 683
GLY A 688
LEU A 691
VAL A 678
 None
 0.92A 4fgzA-2yhgA:
undetectable		 4fgzA-2yhgA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 352
GLY A 278
GLU A 251
TYR A 454
LEU A 475
 None
 1.19A 4fgzA-2yl2A:
undetectable		 4fgzA-2yl2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 GLY A 291
GLY A 310
TYR A 331
LEU A 365
 None
 0.79A 4fgzA-3a3jA:
undetectable		 4fgzA-3a3jA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		4 GLY A 188
GLY A 237
GLU A 233
VAL A 182
 None
 0.93A 4fgzA-3ax6A:
3.6		 4fgzA-3ax6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 GLY A 396
GLY A 399
TYR A  38
GLU A 405
 None
 0.93A 4fgzA-3b40A:
undetectable		 4fgzA-3b40A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 285
GLU A 259
TYR A 270
VAL A 305
 None
MG  A 501 (-3.5A)
None
None
 0.85A 4fgzA-3bjsA:
undetectable		 4fgzA-3bjsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn6 LACTADHERIN

(Bos taurus) 		PF00754
(F5_F8_type_C) 		5 GLY A 157
GLY A   6
LEU A   7
VAL A 153
GLU A 154
 None
 1.48A 4fgzA-3bn6A:
undetectable		 4fgzA-3bn6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 GLY A  63
GLY A 273
LEU A 274
VAL A 276
 None
 0.79A 4fgzA-3bs8A:
undetectable		 4fgzA-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 GLY A 322
GLY A 215
LEU A 196
GLU A 175
 FMN  A 370 (-3.4A)
FMN  A 370 (-3.6A)
None
None
 0.92A 4fgzA-3bw2A:
undetectable		 4fgzA-3bw2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 GLY A 324
GLY A 215
LEU A 196
GLU A 175
 None
FMN  A 370 (-3.6A)
None
None
 0.89A 4fgzA-3bw2A:
undetectable		 4fgzA-3bw2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 GLY A  60
GLY A  62
LEU A  53
VAL A   7
 None
 0.77A 4fgzA-3c3wA:
undetectable		 4fgzA-3c3wA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 GLY A  43
GLY A  58
TYR A  88
LEU A  36
VAL A  35
 None
 1.39A 4fgzA-3cc8A:
14.5		 4fgzA-3cc8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 TYR A 159
LEU A 163
VAL A 166
GLU A 167
 None
 0.83A 4fgzA-3cvwA:
undetectable		 4fgzA-3cvwA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 GLY A 193
GLY A 185
LEU A 225
VAL A 228
TYR A 232
 None
 1.26A 4fgzA-3dadA:
undetectable		 4fgzA-3dadA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 GLY A 139
GLY A 156
LEU A 159
VAL A 173
 None
 0.90A 4fgzA-3dlaA:
undetectable		 4fgzA-3dlaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 4 GLY A2142
TYR A2247
LEU A2251
VAL A2254
 None
 0.70A 4fgzA-3dyjA:
undetectable		 4fgzA-3dyjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A  87
GLY A  81
GLU A  85
TYR A  77
LEU A 106
 None
 1.42A 4fgzA-3fhlA:
undetectable		 4fgzA-3fhlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 GLY A1068
GLY A1278
LEU A1279
VAL A1281
 None
 0.84A 4fgzA-3fq8A:
undetectable		 4fgzA-3fq8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwv HSC70/HSP90-ORGANIZI
NG PROTEIN

(Homo sapiens) 		PF00515
(TPR_1)
PF13424
(TPR_12) 		4 GLY A 289
GLU A 294
VAL A 263
TYR A 261
 None
 0.85A 4fgzA-3fwvA:
undetectable		 4fgzA-3fwvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		4 GLY C 205
GLY C  71
VAL C 358
TYR C 355
 None
 0.87A 4fgzA-3gi8C:
undetectable		 4fgzA-3gi8C:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 122
GLU A  63
VAL A 118
GLU A 119
 None
 0.75A 4fgzA-3goaA:
undetectable		 4fgzA-3goaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 288
TYR A 399
LEU A 336
VAL A 335
 None
 0.94A 4fgzA-3hidA:
undetectable		 4fgzA-3hidA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		4 GLY A  46
GLY A  51
TYR A  59
LEU A  39
 None
 0.89A 4fgzA-3i0pA:
undetectable		 4fgzA-3i0pA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		4 GLY A 212
VAL A 131
GLU A  89
TYR A 132
 None
 0.80A 4fgzA-3isrA:
undetectable		 4fgzA-3isrA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ist GLUTAMATE RACEMASE

(Listeria
monocytogenes) 		PF01177
(Asp_Glu_race) 		4 GLY A  34
GLY A  13
GLU A 151
TYR A  41
 None
 0.75A 4fgzA-3istA:
undetectable		 4fgzA-3istA:
22.49